Faculty

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David R. Hinton, MD
Professor of Pathology
Gavin S. Herbert Professorship in Vision Research
Associate Dean for Vision Science
Vice Chair of Pathology
Director, Dean's Research Scholars Program
Exam Committee Facilitator
Pathology
NRT 1450 Biggy Street Off Campus Los Angeles
+1 310 415 6093

Overview

Dr Hinton investigates the pathogenesis of blinding retinal diseases including age related macular degeneration (AMD) and proliferative vitreoretinopathy(PVR). In particular, he is interested in how alterations in the retinal microenvironment can promote the development of intraocular fibrosis, proliferative membranes and neovascular choroidal responses. His work has established the central role of the retinal pigment epithelial (RPE) cell in these disorders, and has demonstrated novel mechanisms for growth factor activation of the RPE with resulting alterations in migration, proliferation and gene expression. He has developed and validated several in vitro and in vivo models of PVR and choroidal neovascularization and has used these models to elucidate basic mechanisms of disease and to evaluate novel therapeutic approaches to the disorders. He is especially interested in therapeutic approaches involving manipulation of growth factor receptors and their intracellular signaling pathways. He has now extended this work into investigating genetic polymorphisms that result in susceptibility to these disorders in human populations. Most recently, Dr Hinton’s lab has been evaluating endogenous neuroprotectants (eg pigment epithelial derived factor) and chaperones (alpha B crystallin) for their therapeutic potential. He has also developed methods for differentiating RPE cells from human embryonic stem cells and is evaluating these cells for their potential for cellular therapy for patients with AMD. In a collaborative Program Project with investigators at the Cleveland Clinic, Dr Hinton investigates the immunopathogenesis of demyelinating diseases of the brain and spinal cord in animal models.

Publications

. Mechanism of cytokinesis failure in ovarian cystadenomas with defective brca1 and p53 pathways Int J Cancer. 2018 Jul 06. View in: PubMed

. Intra-vitreal aB crystallin fused to elastin-like polypeptide provides neuroprotection in a mouse model of age-related macular degeneration J Control Release. 2018 May 18; 283:94-104. View in: PubMed

. A bioengineered retinal pigment epithelial monolayer for advanced, dry age-related macular degeneration Sci Transl Med. 2018 Apr 04; 10(435). View in: PubMed

. cGAS drives noncanonical-inflammasome activation in age-related macular degeneration Nat Med. 2018 Jan; 24(1):50-61. View in: PubMed

. APOPTOSIS AND ANGIOFIBROSIS IN DIABETIC TRACTIONAL MEMBRANES AFTER VASCULAR ENDOTHELIAL GROWTH FACTOR INHIBITION: Results of a Prospective TrialReport No. 2. Retina. 2017 Nov 22. View in: PubMed

. Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer's disease JCI Insight. 2017 Aug 17; 2(16). View in: PubMed

. Development of a new tissue injector for subretinal transplantation of human embryonic stem cell derived retinal pigmented epithelium Int J Retina Vitreous. 2017; 3:41. View in: PubMed

. Protective Mechanisms of the Mitochondrial-Derived Peptide Humanin in Oxidative and Endoplasmic Reticulum Stress in RPE Cells Oxid Med Cell Longev. 2017; 2017:1675230. View in: PubMed

. Endoplasmic reticulum-mitochondrial crosstalk: a novel role for the mitochondrial peptide humanin Neural Regen Res. 2017 Jan; 12(1):35-38. View in: PubMed

. Assessment of Safety and Functional Efficacy of Stem Cell-Based Therapeutic Approaches Using Retinal Degenerative Animal Models Stem Cells Int. 2017; 2017:9428176. View in: PubMed

. Aqueous Angiography with Fluorescein and Indocyanine Green in Bovine Eyes Transl Vis Sci Technol. 2016 Nov; 5(6):5. View in: PubMed

. Subretinal implantation of a monolayer of human embryonic stem cell-derived retinal pigment epithelium: a feasibility and safety study in Yucatán minipigs Graefes Arch Clin Exp Ophthalmol. 2016 Aug; 254(8):1553-65. View in: PubMed

. An Innovative Surgical Technique for Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Pigmented Epithelium in Yucatan Mini Pigs: Preliminary Results Ophthalmic Surg Lasers Imaging Retina. 2016 Apr 01; 47(4):342-51. View in: PubMed

. aB-Crystallin Regulates Subretinal Fibrosis by Modulation of Epithelial-Mesenchymal Transition Am J Pathol. 2016 Apr; 186(4):859-73. View in: PubMed

. The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction Invest Ophthalmol Vis Sci. 2016 Mar; 57(3):1238-53. View in: PubMed

. Sustained TNF production by central nervous system infiltrating macrophages promotes progressive autoimmune encephalomyelitis J Neuroinflammation. 2016 Feb 22; 13:46. View in: PubMed

. Aqueous Angiography-Mediated Guidance of Trabecular Bypass Improves Angiographic Outflow in Human Enucleated Eyes Invest Ophthalmol Vis Sci. 2016 09 01; 57(11):4558-65. View in: PubMed

. Survival and Functionality of hESC-Derived Retinal Pigment Epithelium Cells Cultured as a Monolayer on Polymer Substrates Transplanted in RCS Rats Invest Ophthalmol Vis Sci. 2016 05 01; 57(6):2877-87. View in: PubMed

. Aqueous Angiography: Real-Time and Physiologic Aqueous Humor Outflow Imaging PLoS One. 2016; 11(1):e0147176. View in: PubMed

. Alpha crystallins in the retinal pigment epithelium and implications for the pathogenesis and treatment of age-related macular degeneration Biochim Biophys Acta. 2016 Jan; 1860(1 Pt B):258-68. View in: PubMed

. Targeting of exon VI-skipping human RGR-opsin to the plasma membrane of pigment epithelium and co-localization with terminal complement complex C5b-9 Mol Vis. 2016; 22:213-23. View in: PubMed

. Humanin Protects RPE Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Upregulation of Mitochondrial Glutathione PLoS One. 2016; 11(10):e0165150. View in: PubMed

. Molecular mechanisms of subretinal fibrosis in age-related macular degeneration Exp Eye Res. 2016 Jan; 142:19-25. View in: PubMed

. Differential Regulation of Self-reactive CD4+ T Cells in Cervical Lymph Nodes and Central Nervous System during Viral Encephalomyelitis Front Immunol. 2016; 7:370. View in: PubMed

. SIRT1 mediated inhibition of VEGF/VEGFR2 signaling by Resveratrol and its relevance to choroidal neovascularization Cytokine. 2015 Dec; 76(2):549-552. View in: PubMed

. Resveratrol inhibits epithelial-mesenchymal transition of retinal pigment epithelium and development of proliferative vitreoretinopathy Sci Rep. 2015 Nov 10; 5:16386. View in: PubMed

. Stem cell based therapies for age-related macular degeneration: The promises and the challenges Prog Retin Eye Res. 2015 Sep; 48:1-39. View in: PubMed

. Myd88 Initiates Early Innate Immune Responses and Promotes CD4 T Cells during Coronavirus Encephalomyelitis J Virol. 2015 Sep; 89(18):9299-312. View in: PubMed

. Inhibition of DNA Methylation and Methyl-CpG-Binding Protein 2 Suppresses RPE Transdifferentiation: Relevance to Proliferative Vitreoretinopathy Invest Ophthalmol Vis Sci. 2015 Aug; 56(9):5579-89. View in: PubMed

. Interleukin-10 is a critical regulator of white matter lesion containment following viral induced demyelination Glia. 2015 Jun 30. View in: PubMed

. J Neuroinflammation. 2015 Apr 22; 12:79. View in: PubMed

. Distinct CD4 T-cell effects on primary versus recall CD8 T-cell responses during viral encephalomyelitis Immunology. 2015 Mar; 144(3):374-386. View in: PubMed

. TGF-ß2 secretion from RPE decreases with polarization and becomes apically oriented Cytokine. 2015 Feb; 71(2):394-6. View in: PubMed

. Polarized human embryonic stem cell-derived retinal pigment epithelial cell monolayers have higher resistance to oxidative stress-induced cell death than nonpolarized cultures Stem Cells Transl Med. 2015 Jan; 4(1):10-20. View in: PubMed

. Attenuation of choroidal neovascularization by histone deacetylase inhibitor PLoS One. 2015; 10(3):e0120587. View in: PubMed

. IL-18 is not therapeutic for neovascular age-related macular degeneration Nat Med. 2014 Dec; 20(12):1372-5. View in: PubMed

. Sodium iodate induced retinal degeneration: new insights from an old model Neural Regen Res. 2014 Dec 01; 9(23):2044-5. View in: PubMed

. Pharmacological protection of retinal pigmented epithelial cells by sulindac involves PPAR-a Proc Natl Acad Sci U S A. 2014 Nov 25; 111(47):16754-9. View in: PubMed

. Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity Science. 2014 Nov 21; 346(6212):1000-3. View in: PubMed

. DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration Proc Natl Acad Sci U S A. 2014 Nov 11; 111(45):16082-7. View in: PubMed

. Protein polymer nanoparticles engineered as chaperones protect against apoptosis in human retinal pigment epithelial cells J Control Release. 2014 Oct 10; 191:4-14. View in: PubMed

. Ceramide inhibits connective tissue growth factor expression by human retinal pigment epithelial cells Cytokine. 2014 Aug; 68(2):137-40. View in: PubMed

. IL-27 limits central nervous system viral clearance by promoting IL-10 and enhances demyelination J Immunol. 2014 Jul 01; 193(1):285-94. View in: PubMed

. PKR mediated regulation of inflammation and IL-10 during viral encephalomyelitis J Neuroimmunol. 2014 May 15; 270(1-2):1-12. View in: PubMed

. Protection of retina by aB crystallin in sodium iodate induced retinal degeneration PLoS One. 2014; 9(5):e98275. View in: PubMed

. Ifit2 deficiency results in uncontrolled neurotropic coronavirus replication and enhanced encephalitis via impaired alpha/beta interferon induction in macrophages J Virol. 2014 Jan; 88(2):1051-64. View in: PubMed

. Role of CD25(+) CD4(+) T cells in acute and persistent coronavirus infection of the central nervous system Virology. 2013 Dec; 447(1-2):112-20. View in: PubMed

. MMP-independent role of TIMP-1 at the blood brain barrier during viral encephalomyelitis ASN Neuro. 2013 Nov 26; 5(5):e00127. View in: PubMed

. TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy Invest Ophthalmol Vis Sci. 2013 Nov 11; 54(12):7395-401. View in: PubMed

. IL-21 optimizes T cell and humoral responses in the central nervous system during viral encephalitis J Neuroimmunol. 2013 Oct 15; 263(1-2):43-54. View in: PubMed

. Subretinal implantation of retinal pigment epithelial cells derived from human embryonic stem cells: improved survival when implanted as a monolayer Invest Ophthalmol Vis Sci. 2013 Jul 26; 54(7):5087-96. View in: PubMed

. In vivo detection of hESC-RPE cells via confocal near-infrared fundus reflectance Ophthalmic Surg Lasers Imaging Retina. 2013 Jul-Aug; 44(4):380-4. View in: PubMed

. Antiapoptotic properties of a-crystallin-derived peptide chaperones and characterization of their uptake transporters in human RPE cells Invest Ophthalmol Vis Sci. 2013 Apr 17; 54(4):2787-98. View in: PubMed

. Astrocyte-derived CXCL10 drives accumulation of antibody-secreting cells in the central nervous system during viral encephalomyelitis J Virol. 2013 Mar; 87(6):3382-92. View in: PubMed

. GRP78 plays an essential role in adipogenesis and postnatal growth in mice FASEB J. 2013 Mar; 27(3):955-64. View in: PubMed

. Review: Epigenetic mechanisms in ocular disease Mol Vis. 2013; 19:665-74. View in: PubMed

. Enhanced CD8 T-cell anti-viral function and clinical disease in B7-H1-deficient mice requires CD4 T cells during encephalomyelitis J Neuroinflammation. 2012 Dec 14; 9:269. View in: PubMed

. Novel roles for a-crystallins in retinal function and disease Prog Retin Eye Res. 2012 Nov; 31(6):576-604. View in: PubMed

. Green tea polyphenols precondition against cell death induced by oxygen-glucose deprivation via stimulation of laminin receptor, generation of reactive oxygen species, and activation of protein kinase Ce J Biol Chem. 2012 Oct 05; 287(41):34694-708. View in: PubMed

. Deficiency of aB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction Free Radic Biol Med. 2012 Sep 01; 53(5):1111-22. View in: PubMed

. Angiofibrotic response to vascular endothelial growth factor inhibition in diabetic retinal detachment: report no1. Arch Ophthalmol. 2012 Sep; 130(9):1127-34. View in: PubMed

. ERK1/2 activation is a therapeutic target in age-related macular degeneration Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13781-6. View in: PubMed

. Mesh-supported submicron parylene-C membranes for culturing retinal pigment epithelial cells Biomed Microdevices. 2012 Aug; 14(4):659-67. View in: PubMed

. Over-expression of BMP4 inhibits experimental choroidal neovascularization by modulating VEGF and MMP-9 Angiogenesis. 2012 Jun; 15(2):213-27. View in: PubMed

. J Neuroinflammation. 2012 May 29; 9:104. View in: PubMed

. DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88 Cell. 2012 May 11; 149(4):847-59. View in: PubMed

. CD4 T cells promote CD8 T cell immunity at the priming and effector site during viral encephalitis J Virol. 2012 Mar; 86(5):2416-27. View in: PubMed

. A novel approach for subretinal implantation of ultrathin substrates containing stem cell-derived retinal pigment epithelium monolayer Ophthalmic Res. 2012; 48(4):186-91. View in: PubMed

. PLoS One. 2012; 7(7):e42088. View in: PubMed

. Mechanism of RPE cell death in a-crystallin deficient mice: a novel and critical role for MRP1-mediated GSH efflux PLoS One. 2012; 7(3):e33420. View in: PubMed

. WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing Cancer Cell. 2011 Dec 13; 20(6):768-80. View in: PubMed

. VEGF and PEDF secretion in ARPE-19 and fhRPE cells Invest Ophthalmol Vis Sci. 2011 Nov 21; 52(12):9047. View in: PubMed

. A phase 1/2 study of orally administered synthetic hypericin for treatment of recurrent malignant gliomas Cancer. 2011 Nov 01; 117(21):4905-15. View in: PubMed

. Methionine sulfoxide reductase A: Structure, function and role in ocular pathology World J Biol Chem. 2011 Aug 26; 2(8):184-92. View in: PubMed

. Regulation of fibronectin-EDA through CTGF domain-specific interactions with TGFß2 and its receptor TGFßRII Invest Ophthalmol Vis Sci. 2011 Jul 07; 52(8):5068-78. View in: PubMed

. Transcriptional regulation of bone morphogenetic protein 4 by tumor necrosis factor and its relationship with age-related macular degeneration FASEB J. 2011 Jul; 25(7):2221-33. View in: PubMed

. CXCR3-dependent plasma blast migration to the central nervous system during viral encephalomyelitis J Virol. 2011 Jul; 85(13):6136-47. View in: PubMed

. Shifting hierarchies of interleukin-10-producing T cell populations in the central nervous system during acute and persistent viral encephalomyelitis J Virol. 2011 Jul; 85(13):6702-13. View in: PubMed

. Sonoporation enhances chemotherapeutic efficacy in retinoblastoma cells in vitro Invest Ophthalmol Vis Sci. 2011 Jun 01; 52(6):3868-73. View in: PubMed

. Antenatal maternal stress alters functional brain responses in adult offspring during conditioned fear Brain Res. 2011 Apr 18; 1385:163-74. View in: PubMed

. DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration Nature. 2011 Mar 17; 471(7338):325-30. View in: PubMed

. Factors supporting intrathecal humoral responses following viral encephalomyelitis J Virol. 2011 Mar; 85(6):2589-98. View in: PubMed

. Polarized secretion of PEDF from human embryonic stem cell-derived RPE promotes retinal progenitor cell survival Invest Ophthalmol Vis Sci. 2011 Mar 01; 52(3):1573-85. View in: PubMed

. Transport of hepcidin, an iron-regulatory peptide hormone, into retinal pigment epithelial cells via oligopeptide transporters and its relevance to iron homeostasis Biochem Biophys Res Commun. 2011 Feb 11; 405(2):244-9. View in: PubMed

. Vitreal oxygenation in retinal ischemia reperfusion Invest Ophthalmol Vis Sci. 2011 Feb; 52(2):1035-42. View in: PubMed

. Green tea polyphenols potentiate the action of nerve growth factor to induce neuritogenesis: possible role of reactive oxygen species J Neurosci Res. 2010 Dec; 88(16):3644-55. View in: PubMed

. Grp78 heterozygosity regulates chaperone balance in exocrine pancreas with differential response to cerulein-induced acute pancreatitis Am J Pathol. 2010 Dec; 177(6):2827-36. View in: PubMed

. Enhanced antiviral T cell function in the absence of B7-H1 is insufficient to prevent persistence but exacerbates axonal bystander damage during viral encephalomyelitis J Immunol. 2010 Nov 01; 185(9):5607-18. View in: PubMed

. aB crystallin is apically secreted within exosomes by polarized human retinal pigment epithelium and provides neuroprotection to adjacent cells PLoS One. 2010 Oct 08; 5(10):e12578. View in: PubMed

. A comparison of hypoxia-inducible factor-a in surgically excised neovascular membranes of patients with diabetes compared with idiopathic epiretinal membranes in nondiabetic patients Retina. 2010 Oct; 30(9):1472-8. View in: PubMed

. Recombinant human VEGF165b inhibits experimental choroidal neovascularization Invest Ophthalmol Vis Sci. 2010 Aug; 51(8):4282-8. View in: PubMed

. Aquaporin-1-mediated cerebral edema following traumatic brain injury: effects of acidosis and corticosteroid administration J Neurosurg. 2010 May; 112(5):1095-104. View in: PubMed

. alphaB-crystallin regulation of angiogenesis by modulation of VEGF Blood. 2010 Apr 22; 115(16):3398-406. View in: PubMed

. Expression and regulation of enzymes in the ceramide metabolic pathway in human retinal pigment epithelial cells and their relevance to retinal degeneration Vision Res. 2010 Mar 31; 50(7):643-51. View in: PubMed

. Gamma interferon signaling in oligodendrocytes is critical for protection from neurotropic coronavirus infection J Virol. 2010 Mar; 84(6):3111-5. View in: PubMed

. Soluble EphB4 inhibition of PDGF-induced RPE migration in vitro Invest Ophthalmol Vis Sci. 2010 Jan; 51(1):543-52. View in: PubMed

. Neutrophils compromise retinal pigment epithelial barrier integrity J Biomed Biotechnol. 2010; 2010:289360. View in: PubMed

. Identification of a novel sodium-coupled oligopeptide transporter (SOPT2) in mouse and human retinal pigment epithelial cells Invest Ophthalmol Vis Sci. 2010 Jan; 51(1):413-20. View in: PubMed

. Attainment of polarity promotes growth factor secretion by retinal pigment epithelial cells: relevance to age-related macular degeneration Aging (Albany NY). 2009 Dec 27; 2(1):28-42. View in: PubMed

. RNase L mediated protection from virus induced demyelination PLoS Pathog. 2009 Oct; 5(10):e1000602. View in: PubMed

. Aging (Albany NY). 2009 Aug 12; 1(8):740-5. View in: PubMed

. Regulated secretion of complement factor H by RPE and its role in RPE migration Graefes Arch Clin Exp Ophthalmol. 2009 May; 247(5):651-9. View in: PubMed

. BMP4 mediates oxidative stress-induced retinal pigment epithelial cell senescence and is overexpressed in age-related macular degeneration J Biol Chem. 2009 Apr 03; 284(14):9529-39. View in: PubMed

. Snap-frozen brain tissue sections stored with desiccant at ambient laboratory conditions without chemical fixation are resistant to degradation for a minimum of 6 months Appl Immunohistochem Mol Morphol. 2009 Mar; 17(2):165-71. View in: PubMed

. Regulation of thioredoxin by ceramide in retinal pigment epithelial cells Exp Eye Res. 2009 Mar; 88(3):410-7. View in: PubMed

. Immunocytochemical analysis of retinal neurons under electrical stimulation Brain Res. 2009 Feb 19; 1255:89-97. View in: PubMed

. A protocol for the culture and differentiation of highly polarized human retinal pigment epithelial cells Nat Protoc. 2009; 4(5):662-73. View in: PubMed

. Memory CD4+ T-cell-mediated protection from lethal coronavirus encephalomyelitis J Virol. 2008 Dec; 82(24):12432-40. View in: PubMed

. Toll-like receptor 3 and geographic atrophy in age-related macular degeneration N Engl J Med. 2008 Oct 02; 359(14):1456-63. View in: PubMed

. Connective tissue growth factor as a mediator of intraocular fibrosis Invest Ophthalmol Vis Sci. 2008 Sep; 49(9):4078-88. View in: PubMed

. The immune response to herpes simplex virus type 1 infection in susceptible mice is a major cause of central nervous system pathology resulting in fatal encephalitis J Virol. 2008 Jul; 82(14):7078-88. View in: PubMed

. Endoplasmic reticulum stress induced by oxidative stress in retinal pigment epithelial cells Graefes Arch Clin Exp Ophthalmol. 2008 May; 246(5):677-83. View in: PubMed

. CD4 T cells contribute to virus control and pathology following central nervous system infection with neurotropic mouse hepatitis virus J Virol. 2008 Mar; 82(5):2130-9. View in: PubMed

. N-(4-hydroxyphenyl) retinamide augments laser-induced choroidal neovascularization in mice Invest Ophthalmol Vis Sci. 2008 Mar; 49(3):1210-20. View in: PubMed

. Exacerbation of retinal degeneration in the absence of alpha crystallins in an in vivo model of chemically induced hypoxia Exp Eye Res. 2008 Feb; 86(2):355-65. View in: PubMed

. Type I interferons are essential in controlling neurotropic coronavirus infection irrespective of functional CD8 T cells J Virol. 2008 Jan; 82(1):300-10. View in: PubMed

. alpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress Mol Vis. 2007 Apr 04; 13:566-77. View in: PubMed

. In vivo models of proliferative vitreoretinopathy Nat Protoc. 2007; 2(1):67-77. View in: PubMed

. Population-based study of early age-related macular degeneration: role of the complement factor H Y402H polymorphism in bilateral but not unilateral disease Ophthalmology. 2007 Jan; 114(1):99-103. View in: PubMed

. Stimulation of apical and basolateral VEGF-A and VEGF-C secretion by oxidative stress in polarized retinal pigment epithelial cells Mol Vis. 2006 Dec 22; 12:1649-59. View in: PubMed

. Thrombospondin-1 expression in RPE and choroidal neovascular membranes Yan Ke Xue Bao. 2006 Dec; 22(4):265-74. View in: PubMed

. Liver X receptor activation decreases the severity of experimental autoimmune encephalomyelitis J Neurosci Res. 2006 Nov 01; 84(6):1225-34. View in: PubMed

. Altered neuroantigen-specific cytokine secretion in a Th2 environment reduces experimental autoimmune encephalomyelitis J Neuroimmunol. 2006 Sep; 178(1-2):30-9. View in: PubMed

. Thiol regulation of vascular endothelial growth factor-A and its receptors in human retinal pigment epithelial cells Biochem Biophys Res Commun. 2006 Aug 11; 346(4):1200-6. View in: PubMed

Transforming growth factor beta2-induced myofibroblastic differentiation of human retinal pigment epithelial cells: regulation by extracellular matrix proteins and hepatocyte growth factor. Exp Eye Res. 2006 Jul; 83(1):212-22. View in: PubMed

Transforming growth factor beta2-induced myofibroblastic differentiation of human retinal pigment epithelial cells: regulation by extracellular matrix proteins and hepatocyte growth factor. Exp Eye Res. 2006 Jul; 83(1):212-22. View in: PubMed

. Mouse hepatitis virus pathogenesis in the central nervous system is independent of IL-15 and natural killer cells Virology. 2006 Jun 20; 350(1):206-15. View in: PubMed

Proceedings of the Third International Symposium on Retinopathy of Prematurity: an update on ROP from the lab to the nursery (November 2003, Anaheim, California). Mol Vis. 2006 May 23; 12:532-80. View in: PubMed

Proceedings of the Third International Symposium on Retinopathy of Prematurity: an update on ROP from the lab to the nursery (November 2003, Anaheim, California). Mol Vis. 2006 May 23; 12:532-80. View in: PubMed

Expression of protein kinase CK2 in astroglial cells of normal and neovascularized retina. Am J Pathol. 2006 May; 168(5):1722-36. View in: PubMed

Expression of protein kinase CK2 in astroglial cells of normal and neovascularized retina. Am J Pathol. 2006 May; 168(5):1722-36. View in: PubMed

. MMP-2 and MMP-9 secretion by rpe is stimulated by angiogenic molecules found in choroidal neovascular membranes Retina. 2006 Apr; 26(4):454-61. View in: PubMed

. Inhibition of interferon-gamma signaling in oligodendroglia delays coronavirus clearance without altering demyelination Am J Pathol. 2006 Mar; 168(3):796-804. View in: PubMed

. CNS viral infection diverts homing of antibody-secreting cells from lymphoid organs to the CNS Eur J Immunol. 2006 Mar; 36(3):603-12. View in: PubMed

. Sequential induction of angiogenic growth factors by TNF-alpha in choroidal endothelial cells J Neuroimmunol. 2006 Feb; 171(1-2):45-56. View in: PubMed

. Characterization of brimonidine transport in retinal pigment epithelium Invest Ophthalmol Vis Sci. 2006 Jan; 47(1):287-94. View in: PubMed

. Soluble EphB4 regulates choroidal endothelial cell function and inhibits laser-induced choroidal neovascularization Invest Ophthalmol Vis Sci. 2005 Dec; 46(12):4772-9. View in: PubMed

. Neuropilin-1 expression by endothelial cells and retinal pigment epithelial cells in choroidal neovascular membranes Am J Ophthalmol. 2005 Dec; 140(6):1044-1050. View in: PubMed

. Hepatocyte growth factor protects RPE cells from apoptosis induced by glutathione depletion Invest Ophthalmol Vis Sci. 2005 Nov; 46(11):4311-9. View in: PubMed

. In vivo expression of GFP transgene delivered via a replicating feline leukemia virus Vet Microbiol. 2005 Oct 31; 110(3-4):181-95. View in: PubMed

. Astrocyte expression of a dominant-negative interferon-gamma receptor J Neurosci Res. 2005 Oct 01; 82(1):20-31. View in: PubMed

. Protection from oxidative stress by methionine sulfoxide reductases in RPE cells Biochem Biophys Res Commun. 2005 Aug 19; 334(1):245-53. View in: PubMed

. Expression of a dominant negative IFN-gammareceptor on mouse oligodendrocytes Glia. 2005 Jul; 51(1):22-34. View in: PubMed

. A selective cyclic integrin antagonist blocks the integrin receptors alphavbeta3 and alphavbeta5 and inhibits retinal pigment epithelium cell attachment, migration and invasion BMC Ophthalmol. 2005 Jun 29; 5:16. View in: PubMed

. Neutrophils promote experimental choroidal neovascularization Mol Vis. 2005 Jun 16; 11:414-24. View in: PubMed

. Differential expression of pro- and antiangiogenic factors in mouse strain-dependent hypoxia-induced retinal neovascularization Lab Invest. 2005 Jun; 85(6):721-33. View in: PubMed

. Expression of matrix metalloproteinases and their tissue inhibitor during viral encephalitis J Virol. 2005 Apr; 79(8):4764-73. View in: PubMed

. Long-term stimulation by active epiretinal implants in normal and RCD1 dogs J Neural Eng. 2005 Mar; 2(1):S65-73. View in: PubMed

. Maintenance of CD8+ T cells during acute viral infection of the central nervous system requires CD4+ T cells but not interleukin-2 Viral Immunol. 2005; 18(1):162-9. View in: PubMed

. Differential regulation of primary and secondary CD8+ T cells in the central nervous system J Immunol. 2004 Nov 15; 173(10):6265-73. View in: PubMed

. Ceramide-induced apoptosis: role of catalase and hepatocyte growth factor Free Radic Biol Med. 2004 Jul 15; 37(2):166-75. View in: PubMed

. Accumulation of NH2-terminal fragment of connective tissue growth factor in the vitreous of patients with proliferative diabetic retinopathy Diabetes Care. 2004 Mar; 27(3):758-64. View in: PubMed

. Gene therapy in a murine model for clinical application to multiple sclerosis Ann Neurol. 2004 Mar; 55(3):390-9. View in: PubMed

. Mouse strain-dependent heterogeneity of resting limbal vasculature Invest Ophthalmol Vis Sci. 2004 Feb; 45(2):441-7. View in: PubMed

. Perforin and gamma interferon-mediated control of coronavirus central nervous system infection by CD8 T cells in the absence of CD4 T cells J Virol. 2004 Feb; 78(4):1739-50. View in: PubMed

. Hepatocyte growth factor and its role in the pathogenesis of retinal detachment Invest Ophthalmol Vis Sci. 2004 Jan; 45(1):323-9. View in: PubMed

. Developmental retinal apoptosis in Ku86-/- mice DNA Repair (Amst). 2003 Dec 09; 2(12):1429-34. View in: PubMed

. A role for connective tissue growth factor in the pathogenesis of choroidal neovascularization Arch Ophthalmol. 2003 Sep; 121(9):1283-8. View in: PubMed

. Microphthalmia resulting from MSX2-induced apoptosis in the optic vesicle Invest Ophthalmol Vis Sci. 2003 Jun; 44(6):2404-12. View in: PubMed

. Perforin-mediated effector function within the central nervous system requires IFN-gamma-mediated MHC up-regulation J Immunol. 2003 Mar 15; 170(6):3204-13. View in: PubMed

. Neutrophils promote mononuclear cell infiltration during viral-induced encephalitis J Immunol. 2003 Mar 15; 170(6):3331-6. View in: PubMed

. The art of survival during viral persistence J Neurovirol. 2002 Dec; 8 Suppl 2:53-8. View in: PubMed

. Tamoxifen-induced growth arrest and apoptosis in pituitary tumor cells in vitro via a protein kinase C-independent pathway Cancer Lett. 2002 Nov 28; 185(2):131-8. View in: PubMed

. Regulation of RPE intercellular junction integrity and function by hepatocyte growth factor Invest Ophthalmol Vis Sci. 2002 Aug; 43(8):2782-90. View in: PubMed

. Matrix metalloproteinase expression correlates with virulence following neurotropic mouse hepatitis virus infection J Virol. 2002 Aug; 76(15):7374-84. View in: PubMed

. Oxygen metabolism causes chromosome breaks and is associated with the neuronal apoptosis observed in DNA double-strand break repair mutants Curr Biol. 2002 Mar 05; 12(5):397-402. View in: PubMed

. Translational research in ophthalmology Arch Ophthalmol. 2002 Mar; 120(3):389-90. View in: PubMed

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