Faculty

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Henry M. Sucov, PhD
Professor of Stem Cell & Regenerative Medicine
Director, MS Program in Stem Cell Biology and Regenerative Medicine
Cell and Neurobiology
BCC 511 1425 San Pablo Street Health Sciences Campus Los Angeles
+1 323 442 2563

Overview

Sucov Lab Website

Henry Sucov has been recognized several times by the American Heart Association for his work in cardiovascular development. He has served on many grant review panels and committees, and is currently a member of the NIH Cardiovascular Development and Differentiation (CDD) study section. In 2007, he was a Visiting Scholar of the Japanese Society for the Promotion of Science.

His scientific program is historically grounded in cardiovascular development, reflecting a longstanding interest is in processes that account for ventricular chamber morphogenesis, including mechanisms that support cardiomyocyte proliferation, coronary vascularization and mesenchymal progenitor cell differentiation. More recently, he has increasingly gravitated to the connection between embryonic heart development and postnatal heart biology, and in particular how the postnatal post-injury repair and regenerative response of the heart recapitulates processes that occur in normal development. His lab primarily studies these processes in mice using molecular genetic and genomic strategies.

Publications

Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration. Nat Genet. 2017 Sep; 49(9):1346-1353. View in: PubMed

Endocardium Minimally Contributes to Coronary Endothelium in the Embryonic Ventricular Free Walls. Circ Res. 2016 Jun 10; 118(12):1880-93. View in: PubMed

Dysregulated endocardial TGFß signaling and mesenchymal transformation result in heart outflow tract septation failure. Dev Biol. 2016 Jan 01; 409(1):272-6. View in: PubMed

Chemokine-guided angiogenesis directs coronary vasculature formation in zebrafish. Dev Cell. 2015 May 26; 33(4):442-54. View in: PubMed

CXCL12 Signaling Is Essential for Maturation of the Ventricular Coronary Endothelial Plexus and Establishment of Functional Coronary Circulation. Dev Cell. 2015 May 26; 33(4):469-77. View in: PubMed

Extracardiac control of embryonic cardiomyocyte proliferation and ventricular wall expansion. Cardiovasc Res. 2015 Mar 01; 105(3):271-8. View in: PubMed

Adipogenesis and epicardial adipose tissue: a novel fate of the epicardium induced by mesenchymal transformation and PPAR? activation. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2070-5. View in: PubMed

Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3. Development. 2014 Aug; 141(15):2959-71. View in: PubMed

MEGF8 is a modifier of BMP signaling in trigeminal sensory neurons. Elife. 2013 Sep 17; 2:e01160. View in: PubMed

Igf Signaling is Required for Cardiomyocyte Proliferation during Zebrafish Heart Development and Regeneration. PLoS One. 2013; 8(6):e67266. View in: PubMed

Mesodermal retinoic acid signaling regulates endothelial cell coalescence in caudal pharyngeal arch artery vasculogenesis. Dev Biol. 2012 Jan 01; 361(1):116-24. View in: PubMed

Endothelial neuropilin disruption in mice causes DiGeorge syndrome-like malformations via mechanisms distinct to those caused by loss of Tbx1. PLoS One. 2012; 7(3):e32429. View in: PubMed

IGF signaling directs ventricular cardiomyocyte proliferation during embryonic heart development. Development. 2011 May; 138(9):1795-805. View in: PubMed

A simplified genetic design for mammalian enamel. Biomaterials. 2011 Apr; 32(12):3151-7. View in: PubMed

Retinoic acid stimulates myocardial expansion by induction of hepatic erythropoietin which activates epicardial Igf2. Development. 2011 Jan; 138(1):139-48. View in: PubMed

Retinoic acid regulates differentiation of the secondary heart field and TGFbeta-mediated outflow tract septation. Dev Cell. 2010 Mar 16; 18(3):480-5. View in: PubMed

Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines. J Exp Med. 2009 Sep 28; 206(10):2131-9. View in: PubMed

Epicardial control of myocardial proliferation and morphogenesis. Pediatr Cardiol. 2009 Jul; 30(5):617-25. View in: PubMed

Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development. Hepatology. 2009 Mar; 49(3):998-1011. View in: PubMed

Absence of TGFbeta signaling in embryonic vascular smooth muscle leads to reduced lysyl oxidase expression, impaired elastogenesis, and aneurysm. Genesis. 2009 Feb; 47(2):115-21. View in: PubMed

Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium. BMC Dev Biol. 2008 Jul 30; 8:75. View in: PubMed

Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons. Nature. 2008 Apr 10; 452(7188):759-63. View in: PubMed

PDGF-A as an epicardial mitogen during heart development. Dev Dyn. 2008 Mar; 237(3):692-701. View in: PubMed

Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium. BMC Dev Biol. 2008; 8:75. View in: PubMed

Expression of the epithelial marker E-cadherin by thyroid C cells and their precursors during murine development. J Histochem Cytochem. 2007 Oct; 55(10):1075-88. View in: PubMed

Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract. Dev Biol. 2007 Aug 15; 308(2):421-37. View in: PubMed

Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects. BMC Dev Biol. 2006 Nov 01; 6:51. View in: PubMed

Cardiovascular malformations with normal smooth muscle differentiation in neural crest-specific type II TGFbeta receptor (Tgfbr2) mutant mice. Dev Biol. 2006 Jan 15; 289(2):420-9. View in: PubMed

Combined deficiencies of Msx1 and Msx2 cause impaired patterning and survival of the cranial neural crest. Development. 2005 Nov; 132(22):4937-50. View in: PubMed

Retinoic acid, hypoxia, and GATA factors cooperatively control the onset of fetal liver erythropoietin expression and erythropoietic differentiation. Dev Biol. 2005 Apr 01; 280(1):59-72. View in: PubMed

Retinoic acid, hypoxia, and GATA factors cooperatively control the onset of fetal liver erythropoietin expression and erythropoietic differentiation. Dev Biol. 2005 Apr 1; 280(1):59-72. View in: PubMed

Convergent proliferative response and divergent morphogenic pathways induced by epicardial and endocardial signaling in fetal heart development. Mech Dev. 2005 Jan; 122(1):57-65. View in: PubMed

The role of erythropoietin in regulating angiogenesis. Dev Biol. 2004 Dec 1; 276(1):101-10. View in: PubMed

The role of erythropoietin in regulating angiogenesis. Dev Biol. 2004 Dec 01; 276(1):101-10. View in: PubMed

Msx2 and Twist cooperatively control the development of the neural crest-derived skeletogenic mesenchyme of the murine skull vault. Development. 2003 Dec; 130(24):6131-42. View in: PubMed

Cranial neural crest-derived mesenchymal proliferation is regulated by Msx1-mediated p19(INK4d) expression during odontogenesis. Dev Biol. 2003 Sep 1; 261(1):183-96. View in: PubMed

Cranial neural crest-derived mesenchymal proliferation is regulated by Msx1-mediated p19(INK4d) expression during odontogenesis. Dev Biol. 2003 Sep 01; 261(1):183-96. View in: PubMed

Epicardial induction of fetal cardiomyocyte proliferation via a retinoic acid-inducible trophic factor. Dev Biol. 2002 Oct 01; 250(1):198-207. View in: PubMed

Epicardial induction of fetal cardiomyocyte proliferation via a retinoic acid-inducible trophic factor. Dev Biol. 2002 Oct 1; 250(1):198-207. View in: PubMed

Normal fate and altered function of the cardiac neural crest cell lineage in retinoic acid receptor mutant embryos. Mech Dev. 2002 Sep; 117(1-2):115-22. View in: PubMed

Prostatic intraepithelial neoplasia in mice with conditional disruption of the retinoid X receptor alpha allele in the prostate epithelium. Cancer Res. 2002 Aug 15; 62(16):4812-9. View in: PubMed

Tissue origins and interactions in the mammalian skull vault. Dev Biol. 2002 Jan 01; 241(1):106-16. View in: PubMed

Requirement for AP-2alpha in cardiac outflow tract morphogenesis. Mech Dev. 2002 Jan; 110(1-2):139-49. View in: PubMed

Tissue origins and interactions in the mammalian skull vault. Dev Biol. 2002 Jan 1; 241(1):106-16. View in: PubMed

Msx2 is an immediate downstream effector of Pax3 in the development of the murine cardiac neural crest. Development. 2002 Jan; 129(2):527-38. View in: PubMed

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