Faculty

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Hiroyuki Shimada, MD, PhD
Professor of Pathology (Clinical Scholar)
Pediatrics
CHL Mail Stop 43 Off Campus Los Angeles
+1 323 361 5813

Awards

University of Chicago: Eleanor Humphreys Visiting Professorship, 2005

Society for Pediatric Pathology: Lotte Strauss Prize, 1989

Publications

Conversion and Reversion Rates in Japanese Older People With Mild Cognitive Impairment. J Am Med Dir Assoc. 2017 Sep 01; 18(9):808. e1-808. e6. View in: PubMed

Effects of Mild Cognitive Impairment on the Development of Fear of Falling in Older Adults: A Prospective Cohort Study. J Am Med Dir Assoc. 2015 Dec 1; 16(12):1104. e9-1104. e13. View in: PubMed

Severe hypertriglyceridemia during treatment of acute lymphoblastic leukemia associated with type III hyperlipoproteinemia. Pediatr Blood Cancer. 2017 Nov; 64(11). View in: PubMed

Social Frailty in Community-Dwelling Older Adults as a Risk Factor for Disability. J Am Med Dir Assoc. 2015 Nov 1; 16(11):1003. e7-1003. e11. View in: PubMed

Cancer-Associated Fibroblasts Share Characteristics and Protumorigenic Activity with Mesenchymal Stromal Cells. Cancer Res. 2017 Sep 15; 77(18):5142-5157. View in: PubMed

Expression of Five Neuroblastoma Genes in Bone Marrow or Blood of Patients with Relapsed/Refractory Neuroblastoma Provides a New Biomarker for Disease and Prognosis. Clin Cancer Res. 2017 Sep 15; 23(18):5374-5383. View in: PubMed

The Relationships Between Components of Metabolic Syndrome and Mild Cognitive Impairment Subtypes: A Cross-Sectional Study of Japanese Older Adults. J Alzheimers Dis. 2017 Sep 08. View in: PubMed

Nodular Lymphocyte-predominant Hodgkin Lymphoma in a 15-Year-Old Boy With Li-Fraumeni Syndrome Having a Germline TP53 D49H Mutation. J Pediatr Hematol Oncol. 2017 Sep 08. View in: PubMed

Behavioral protective factors of increased depressive symptoms in community-dwelling older adults: A prospective cohort study. Int J Geriatr Psychiatry. 2017 Aug 25. View in: PubMed

Association of high microvessel avß3 and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126. Oncotarget. 2017 Aug 08; 8(32):52193-52210. View in: PubMed

Psychological predictors of participation in screening for cognitive impairment among community-dwelling older adults. Geriatr Gerontol Int. 2017 Aug; 17(8):1197-1204. View in: PubMed

Effects of Cognitive Leisure Activity on Cognition in Mild Cognitive Impairment: Results of a Randomized Controlled Trial. J Am Med Dir Assoc. 2017 Aug 01; 18(8):686-691. View in: PubMed

Salvage therapy for children with relapsed or refractory Philadelphia chromosome-positive acute lymphoblastic leukemia. Pediatr Blood Cancer. 2017 Aug; 64(8). View in: PubMed

Age-dependent changes in physical performance and body composition in community-dwelling Japanese older adults. J Cachexia Sarcopenia Muscle. 2017 Aug; 8(4):607-614. View in: PubMed

Wet laboratory training using porcine eyes with eyelids. Can J Ophthalmol. 2017 Aug; 52(4):398-402. View in: PubMed

Prevalence of frailty in Japan: A systematic review and meta-analysis. J Epidemiol. 2017 Aug; 27(8):347-353. View in: PubMed

Reduced anterior chamber contamination by frequent surface irrigation with diluted iodine solutions during cataract surgery. Acta Ophthalmol. 2017 Aug; 95(5):e373-e378. View in: PubMed

Predictors of self-reported knee osteoarthritis in community-dwelling older women in Japan: A cross-sectional and longitudinal cohort study. Arch Gerontol Geriatr. 2017 Jul 30; 73:125-132. View in: PubMed

Capsular bag irrigation using 0. 025% povidone-iodine in balanced salt solution PLUS for the treatment of postoperative endophthalmitis. Int Ophthalmol. 2017 Jul 08. View in: PubMed

Cancer-Associated Fibroblasts Share Characteristics and Protumorigenic Activity with Mesenchymal Stromal Cells. Cancer Res. 2017 Jul 07. View in: PubMed

Comparative study of 27-gauge and 25-gauge vitrectomy performed as day surgery. Int Ophthalmol. 2017 Jul 03. View in: PubMed

Comments to: Povidone-iodine 3-minute exposure time is viable in preparation for cataract surgery. Eur J Ophthalmol. 2017 Jul 02; 0. View in: PubMed

Re: Merani et al. : Aqueous chlorhexidine for intravitreal injection antisepsis (Ophthalmology. 2016;123:2588-2594). Ophthalmology. 2017 Jul; 124(7):e57-e58. View in: PubMed

Association of Social Frailty With Both Cognitive and Physical Deficits Among Older People. J Am Med Dir Assoc. 2017 Jul 01; 18(7):603-607. View in: PubMed

Fear of falling and gait parameters in older adults with and without fall history. Geriatr Gerontol Int. 2017 Jun 28. View in: PubMed

Assessing competence at a higher level among older adults: development of the Japan Science and Technology Agency Index of Competence (JST-IC). Aging Clin Exp Res. 2017 Jun 23. View in: PubMed

Effects of a community disability prevention program for frail older adults at 48-month follow up. Geriatr Gerontol Int. 2017 Jun 18. View in: PubMed

Validity of the National Center for Geriatrics and Gerontology-Functional Assessment Tool and Mini-Mental State Examination for detecting the incidence of dementia in older Japanese adults. Geriatr Gerontol Int. 2017 Jun 16. View in: PubMed

Expectation for Physical Activity to Minimize Dementia Risk and Physical Activity Level Among Older Adults. J Aging Phys Act. 2017 Jun 12; 1-28. View in: PubMed

Subjective Memory Complaints are Associated with Incident Dementia in Cognitively Intact Older People, but Not in Those with Cognitive Impairment: A 24-Month Prospective Cohort Study. Am J Geriatr Psychiatry. 2017 Jun; 25(6):607-616. View in: PubMed

Gray matter volume and dual-task gait performance in mild cognitive impairment. Brain Imaging Behav. 2017 Jun; 11(3):887-898. View in: PubMed

Expression of Five Neuroblastoma Genes in Bone Marrow or Blood of Patients with Relapsed/Refractory Neuroblastoma Provides a New Biomarker for Disease and Prognosis. Clin Cancer Res. 2017 May 30. View in: PubMed

Effects of exercise on brain activity during walking in older adults: a randomized controlled trial. J Neuroeng Rehabil. 2017 May 30; 14(1):50. View in: PubMed

Association between body composition parameters and risk of mild cognitive impairment in older Japanese adults. Geriatr Gerontol Int. 2017 May 09. View in: PubMed

Association between sedentary time and kidney function in community-dwelling elderly Japanese people. Geriatr Gerontol Int. 2017 May; 17(5):730-736. View in: PubMed

Association of Social Frailty With Both Cognitive and Physical Deficits Among Older People. J Am Med Dir Assoc. 2017 Apr 11. View in: PubMed

Effects of Cognitive Leisure Activity on Cognition in Mild Cognitive Impairment: Results of a Randomized Controlled Trial. J Am Med Dir Assoc. 2017 Apr 07. View in: PubMed

Postoperative roll cake-like macular fold after retinal detachment surgery. Int Ophthalmol. 2017 Apr 03. View in: PubMed

Recommendations for the standardization of bone marrow disease assessment and reporting in children with neuroblastoma on behalf of the International Neuroblastoma Response Criteria Bone Marrow Working Group. Cancer. 2017 Apr 01; 123(7):1095-1105. View in: PubMed

Predictive Cutoff Values of the Five-Times Sit-to-Stand Test and the Timed "Up & Go" Test for Disability Incidence in Older People Dwelling in the Community. Phys Ther. 2017 Apr 01; 97(4):417-424. View in: PubMed

Brain uptake and safety of Flutemetamol F 18 injection in Japanese subjects with probable Alzheimer's disease, subjects with amnestic mild cognitive impairment and healthy volunteers. Ann Nucl Med. 2017 Apr; 31(3):260-272. View in: PubMed

Severe hypertriglyceridemia during treatment of acute lymphoblastic leukemia associated with type III hyperlipoproteinemia. Pediatr Blood Cancer. 2017 Apr 01. View in: PubMed

Predictive Cutoff Values of the Five-Times Sit-to-Stand Test and the Timed "Up & Go" Test for Disability Incidence in Older People Dwelling in the Community. Phys Ther. 2017 Mar 22. View in: PubMed

Vitamin D receptor gene polymorphisms, smoking, and risk of sporadic Parkinson's disease in Japan. Neurosci Lett. 2017 Mar 16; 643:97-102. View in: PubMed

Reduced anterior chamber contamination by frequent surface irrigation with diluted iodine solutions during cataract surgery. Acta Ophthalmol. 2017 Mar 08. View in: PubMed

The association between anorexia of aging and physical frailty: Results from the national center for geriatrics and gerontology's study of geriatric syndromes. Maturitas. 2017 Mar; 97:32-37. View in: PubMed

Flow cytometric analysis as an additional predictive tool of treatment response in children with chronic-phase chronic myeloid leukemia treated with imatinib. Pediatr Blood Cancer. 2017 Feb 24. View in: PubMed

Impact of poor sleep quality and physical inactivity on cognitive function in community-dwelling older adults. Geriatr Gerontol Int. 2017 Feb 11. View in: PubMed

Brain uptake and safety of Flutemetamol F 18 injection in Japanese subjects with probable Alzheimer's disease, subjects with amnestic mild cognitive impairment and healthy volunteers. Ann Nucl Med. 2017 Feb 08. View in: PubMed

Implantable chemotherapy-loaded silk protein materials for neuroblastoma treatment. Int J Cancer. 2017 Feb 01; 140(3):726-735. View in: PubMed

Prospective associations between sedentary behaviour and incident depressive symptoms in older people: a 15-month longitudinal cohort study. Int J Geriatr Psychiatry. 2017 Feb; 32(2):193-200. View in: PubMed

Randomized double-blind placebo-controlled multicenter trial of Yokukansan for neuropsychiatric symptoms in Alzheimer's disease. Geriatr Gerontol Int. 2017 Feb; 17(2):211-218. View in: PubMed

Salvage therapy for children with relapsed or refractory Philadelphia chromosome-positive acute lymphoblastic leukemia. Pediatr Blood Cancer. 2017 Jan 13. View in: PubMed

Subjective Memory Complaints are Associated with Incident Dementia in Cognitively Intact Older People, but Not in Those with Cognitive Impairment: A 24-Month Prospective Cohort Study. Am J Geriatr Psychiatry. 2017 Jan 04. View in: PubMed

Prevention and Treatment of Postoperative Endophthalmitis Using Povidone-Iodine. Curr Pharm Des. 2017; 23(4):574-585. View in: PubMed

Joint Association of Neighborhood Environment and Fear of Falling on Physical Activity Among Frail Older Adults. J Aging Phys Act. 2017 Jan; 25(1):140-148. View in: PubMed

Relationship Between Frailty and Oral Function in Community-Dwelling Elderly Adults. J Am Geriatr Soc. 2017 Jan; 65(1):66-76. View in: PubMed

Contribution of neuroblastoma-derived exosomes to the production of pro-tumorigenic signals by bone marrow mesenchymal stromal cells. J Extracell Vesicles. 2017; 6(1):1332941. View in: PubMed

Motoric Cognitive Risk Syndrome: Association with Incident Dementia and Disability. J Alzheimers Dis. 2017; 59(1):77-84. View in: PubMed

Aß levels in the jugular vein and high molecular weight Aß oligomer levels in CSF can be used as biomarkers to indicate the anti-amyloid effect of IVIg for Alzheimer's disease. PLoS One. 2017; 12(4):e0174630. View in: PubMed

The Associations among Insulin Resistance, Hyperglycemia, Physical Performance, Diabetes Mellitus, and Cognitive Function in Relatively Healthy Older Adults with Subtle Cognitive Dysfunction. Front Aging Neurosci. 2017; 9:72. View in: PubMed

Recommendations for the standardization of bone marrow disease assessment and reporting in children with neuroblastoma; on behalf of the International Neuroblastoma Response Criteria Bone Marrow Working Group. Cancer. 2016 Dec 16. View in: PubMed

Prevention and treatment of postoperative endophthalmitis using povidone-iodine. Curr Pharm Des. 2016 Dec 04. View in: PubMed

Age-related changes in prefrontal oxygenation during memory encoding and retrieval. Geriatr Gerontol Int. 2016 Dec; 16(12):1296-1304. View in: PubMed

Cancer association as a risk factor for anti-HMGCR antibody-positive myopathy. Neurol Neuroimmunol Neuroinflamm. 2016 Dec; 3(6):e290. View in: PubMed

Prevalence of frailty in Japan: A systematic review and meta-analysis. J Epidemiol. 2016 Nov 15. View in: PubMed

Reactive Oxygen Species Mediates the Synergistic Activity of Fenretinide Combined with the Microtubule Inhibitor ABT-751 against Multidrug-Resistant Recurrent Neuroblastoma Xenografts. Mol Cancer Ther. 2016 Nov; 15(11):2653-2664. View in: PubMed

Implantable chemotherapy-loaded silk protein materials for neuroblastoma treatment. Int J Cancer. 2016 Oct 22. View in: PubMed

Comorbid Mild Cognitive Impairment and Depressive Symptoms Predict Future Dementia in Community Older Adults: A 24-Month Follow-Up Longitudinal Study. J Alzheimers Dis. 2016 Oct 18; 54(4):1473-1482. View in: PubMed

Am80-GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia-associated infection and mortality. EMBO Mol Med. 2016 Oct 13. View in: PubMed

EXPERIMENTAL VISUALIZATION AND QUANTIFICATION OF VITREOUS CONTAMINATION FOLLOWING INTRAVITREAL INJECTIONS. Retina. 2016 Oct; 36(10):1882-7. View in: PubMed

The Association Between Excessive Daytime Sleepiness and Gait Parameters in Community-Dwelling Older Adults. J Aging Health. 2016 Oct 01; 898264316673253. View in: PubMed

Relationship between chronic kidney disease with diabetes or hypertension and frailty in community-dwelling Japanese older adults. Geriatr Gerontol Int. 2016 Sep 27. View in: PubMed

Objectively-measured outdoor time and physical and psychological function among older adults. Geriatr Gerontol Int. 2016 Sep 16. View in: PubMed

Joint Association of Neighborhood Environment and Fear of Falling on Physical Activity Among Frail Older Adults. J Aging Phys Act. 2016 Sep 6; 1-28. View in: PubMed

Effects of group exercise programmes on quality of life in older adults with mild cognitive impairment: preliminary results from a randomized controlled trial. Psychogeriatrics. 2016 Sep; 16(5):327-8. View in: PubMed

Serum Levels of Albumin-ß-Amyloid Complex in Patients with Depression. Am J Geriatr Psychiatry. 2016 Sep; 24(9):764-72. View in: PubMed

Reactive Oxygen Species Mediates the Synergistic Activity of Fenretinide Combined with the Microtubule Inhibitor ABT-751 against Multidrug-Resistant Recurrent Neuroblastoma Xenografts. Mol Cancer Ther. 2016 Aug 16. View in: PubMed

Sleep Duration and Excessive Daytime Sleepiness Are Associated With Incidence of Disability in Community-Dwelling Older Adults. J Am Med Dir Assoc. 2016 Aug 1; 17(8):768. e1-5. View in: PubMed

A Phase I New Approaches to Neuroblastoma Therapy Study of Buthionine Sulfoximine and Melphalan With Autologous Stem Cells for Recurrent/Refractory High-Risk Neuroblastoma. Pediatr Blood Cancer. 2016 Aug; 63(8):1349-56. View in: PubMed

Sleep Duration and Excessive Daytime Sleepiness Are Associated With Incidence of Disability in Community-Dwelling Older Adults. J Am Med Dir Assoc. 2016 Aug 01; 17(8):768. e1-5. View in: PubMed

Anti-TIF1-? antibody and cancer-associated myositis: A clinicohistopathologic study. Neurology. 2016 Jul 19; 87(3):299-308. View in: PubMed

Psychological predictors of participation in screening for cognitive impairment among community-dwelling older adults. Geriatr Gerontol Int. 2016 Jul 18. View in: PubMed

Gray matter volume and dual-task gait performance in mild cognitive impairment. Brain Imaging Behav. 2016 Jul 09. View in: PubMed

The clinical management and outcomes of cervical neuroblastic tumors. J Surg Res. 2016 Jul; 204(1):109-13. View in: PubMed

[Exercise and Physical Activity for Dementia Prevention]. Brain Nerve. 2016 Jul; 68(7):799-808. View in: PubMed

Association between sedentary time and kidney function in community-dwelling elderly Japanese people. Geriatr Gerontol Int. 2016 Jun 14. View in: PubMed

Reduced prefrontal oxygenation in mild cognitive impairment during memory retrieval. Int J Geriatr Psychiatry. 2016 Jun; 31(6):583-91. View in: PubMed

Insulin-Like Growth Factor-1 Related to Disability Among Older Adults. J Gerontol A Biol Sci Med Sci. 2016 Jun; 71(6):797-802. View in: PubMed

Intravitreal Tissue Plasminogen Activator, Ranibizumab, and Gas Injection for Submacular Hemorrhage in Polypoidal Choroidal Vasculopathy. Ophthalmology. 2016 Jun; 123(6):1278-86. View in: PubMed

The 14-3-3 Gene Function of Cryptococcus neoformans Is Required for its Growth and Virulence. J Microbiol Biotechnol. 2016 May 28; 26(5):918-27. View in: PubMed

Self-reported exhaustion associated with physical activity among older adults. Geriatr Gerontol Int. 2016 May; 16(5):625-30. View in: PubMed

Importance of Phox2B Immunohistochemical Stain for Detecting Metastatic Neuroblastoma Cells in Bone Marrow Specimens. Pediatr Dev Pathol. 2016 May-Jun; 19(3):254-5. View in: PubMed

Phase I Study of the Aurora A Kinase Inhibitor Alisertib in Combination With Irinotecan and Temozolomide for Patients With Relapsed or Refractory Neuroblastoma: A NANT (New Approaches to Neuroblastoma Therapy) Trial. J Clin Oncol. 2016 Apr 20; 34(12):1368-75. View in: PubMed

Driving continuity in cognitively impaired older drivers. Geriatr Gerontol Int. 2016 Apr; 16(4):508-14. View in: PubMed

PARK16 polymorphisms, interaction with smoking, and sporadic Parkinson's disease in Japan. J Neurol Sci. 2016 Mar 15; 362:47-52. View in: PubMed

[Significance and progress of DIAN/A4/API]. Nihon Rinsho. 2016 Mar; 74(3):417-22. View in: PubMed

Leukostasis in Children and Adolescents with Chronic Myeloid Leukemia: Japanese Pediatric Leukemia/Lymphoma Study Group. Pediatr Blood Cancer. 2016 Mar; 63(3):406-11. View in: PubMed

Combined Effect of Slow Gait Speed and Depressive Symptoms on Incident Disability in Older Adults. J Am Med Dir Assoc. 2016 Feb; 17(2):123-7. View in: PubMed

Performance on the flanker task predicts driving cessation in older adults. Int J Geriatr Psychiatry. 2016 Feb; 31(2):169-75. View in: PubMed

Combined Effect of Slow Gait Speed and Depressive Symptoms on Incident Disability in Older Adults. J Am Med Dir Assoc. 2016 Feb 1; 17(2):123-7. View in: PubMed

Am80-GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia-associated infection and mortality. EMBO Mol Med. 2016 11; 8(11):1340-1359. View in: PubMed

A Phase I New Approaches to Neuroblastoma Therapy Study of Buthionine Sulfoximine and Melphalan With Autologous Stem Cells for Recurrent/Refractory High-Risk Neuroblastoma. Pediatr Blood Cancer. 2016 08; 63(8):1349-56. View in: PubMed

The effects of the employment of physical therapists and occupational therapists on the gait function of adult day service users after 1 year. Nihon Ronen Igakkai Zasshi. 2016; 53(4):412-418. View in: PubMed

Driving and Incidence of Functional Limitation in Older People: A Prospective Population-Based Study. Gerontology. 2016; 62(6):636-643. View in: PubMed

Characteristics of Hyperautofluorescent Choroidal Vessels Using Fundus Camera Type Short-Wavelength Autofluorescence. Ophthalmologica. 2016; 236(3):175-180. View in: PubMed

Cognitive Impairment and Disability in Older Japanese Adults. PLoS One. 2016; 11(7):e0158720. View in: PubMed

Going outdoors and cognitive function among community-dwelling older adults: Moderating role of physical function. Geriatr Gerontol Int. 2016 Jan; 16(1):65-73. View in: PubMed

Motoric Cognitive Risk Syndrome: Prevalence and Risk Factors in Japanese Seniors. J Am Med Dir Assoc. 2015 Dec; 16(12):1103. e21-5. View in: PubMed

Mild Cognitive Impairment, Slow Gait, and Risk of Disability: A Prospective Study. J Am Med Dir Assoc. 2015 Dec; 16(12):1082-6. View in: PubMed

Effects of Mild Cognitive Impairment on the Development of Fear of Falling in Older Adults: A Prospective Cohort Study. J Am Med Dir Assoc. 2015 Dec; 16(12):1104. e9-13. View in: PubMed

Mild Cognitive Impairment, Slow Gait, and Risk of Disability: A Prospective Study. J Am Med Dir Assoc. 2015 Dec 1; 16(12):1082-6. View in: PubMed

Effects of white matter lesions on trunk stability during dual-task walking among older adults with mild cognitive impairment. Age (Dordr). 2015 Dec; 37(6):120. View in: PubMed

Motoric Cognitive Risk Syndrome: Prevalence and Risk Factors in Japanese Seniors. J Am Med Dir Assoc. 2015 Dec 1; 16(12):1103. e21-5. View in: PubMed

Effects of exercise and horticultural intervention on the brain and mental health in older adults with depressive symptoms and memory problems: study protocol for a randomized controlled trial [UMIN000018547]. Trials. 2015 Nov 04; 16:499. View in: PubMed

Social Frailty in Community-Dwelling Older Adults as a Risk Factor for Disability. J Am Med Dir Assoc. 2015 Nov 01; 16(11):1003. e7-11. View in: PubMed

The 14-3-3 gene function of Cryptococcus neoformans is required for its growth and virulence. J Microbiol Biotechnol. 2015 Oct 6. View in: PubMed

Impact of physical frailty on disability in community-dwelling older adults: a prospective cohort study. BMJ Open. 2015 Sep 02; 5(9):e008462. View in: PubMed

Onset of Disability According to Mild Cognitive Impairment Subtype in Community-Dwelling Older Adults in Japan. J Am Geriatr Soc. 2015 Sep; 63(9):1959-61. View in: PubMed

Set-Shifting Ability Is Associated with Gray Matter Volume in Older People with Mild Cognitive Impairment. Dement Geriatr Cogn Dis Extra. 2015 Sep-Dec; 5(3):395-403. View in: PubMed

RANDOMIZED CONTROLLED STUDY OF INTRAVITREAL BEVACIZUMAB 0. 16 MG INJECTED ONE DAY BEFORE SURGERY FOR PROLIFERATIVE DIABETIC RETINOPATHY. Retina. 2015 Sep; 35(9):1800-7. View in: PubMed

Cognitive function and falling among older adults with mild cognitive impairment and slow gait. Geriatr Gerontol Int. 2015 Aug; 15(8):1073-8. View in: PubMed

Subjective physical and cognitive age among community-dwelling older people aged 75 years and older: differences with chronological age and its associated factors. Aging Ment Health. 2015 Aug; 19(8):756-61. View in: PubMed

Insulin-like Growth Factor 2 Gene Expression Molecularly Differentiates Pleuropulmonary Blastoma and Embryonal Rhabdomyosarcoma. J Pediatr Hematol Oncol. 2015 Aug; 37(6):e356-60. View in: PubMed

Incidence of Disability in Frail Older Persons With or Without Slow Walking Speed. J Am Med Dir Assoc. 2015 Aug 1; 16(8):690-6. View in: PubMed

Incidence of Disability in Frail Older Persons With or Without Slow Walking Speed. J Am Med Dir Assoc. 2015 Aug 01; 16(8):690-6. View in: PubMed

Exosome-mediated transfer of microRNAs within the tumor microenvironment and neuroblastoma resistance to chemotherapy. J Natl Cancer Inst. 2015 Jul; 107(7). View in: PubMed

Phase I Study of Vorinostat as a Radiation Sensitizer with 131I-Metaiodobenzylguanidine (131I-MIBG) for Patients with Relapsed or Refractory Neuroblastoma. Clin Cancer Res. 2015 Jun 15; 21(12):2715-21. View in: PubMed

Vitrectomy using 0. 025% povidone-iodine in balanced salt solution plus for the treatment of postoperative endophthalmitis. Retina. 2015 Jun; 35(6):1087-94. View in: PubMed

[Incidence of Postoperative Retinal Detachment after 25-gauge Vitrectomy for Macular Diseases]. Nippon Ganka Gakkai Zasshi. 2015 Jun; 119(6):402-9. View in: PubMed

[Incidence of Postoperative Retinal Detachment after 25-gauge Vitrectomy for Macular Diseases]. Nihon Ganka Gakkai Zasshi. 2015 Jun; 119(6):402-9. View in: PubMed

Nitrogen K-edge x-ray absorption near edge structure of pyrimidine-containing nucleotides in aqueous solution. J Chem Phys. 2015 May 7; 142(17):175102. View in: PubMed

Nitrogen K-edge x-ray absorption near edge structure of pyrimidine-containing nucleotides in aqueous solution. J Chem Phys. 2015 May 07; 142(17):175102. View in: PubMed

Imatinib use immediately before stem cell transplantation in children with Philadelphia chromosome-positive acute lymphoblastic leukemia: Results from Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) Study Ph(+) ALL04. Cancer Med. 2015 May; 4(5):682-9. View in: PubMed

Cigarette smoking and cognitive health in elderly Japanese. Am J Health Behav. 2015 May; 39(3):294-300. View in: PubMed

Human and mouse tissue-engineered small intestine both demonstrate digestive and absorptive function. Am J Physiol Gastrointest Liver Physiol. 2015 Apr 15; 308(8):G664-77. View in: PubMed

131I-metaiodobenzylguanidine with intensive chemotherapy and autologous stem cell transplantation for high-risk neuroblastoma. A new approaches to neuroblastoma therapy (NANT) phase II study. Biol Blood Marrow Transplant. 2015 Apr; 21(4):673-81. View in: PubMed

The association between kidney function and cognitive decline in community-dwelling, elderly Japanese people. J Am Med Dir Assoc. 2015 Apr; 16(4):349. e1-5. View in: PubMed

Apolipoprotein?E genotype and physical function among older people with mild cognitive impairment. Geriatr Gerontol Int. 2015 Apr; 15(4):422-7. View in: PubMed

The Association Between Kidney Function and Cognitive Decline in Community-Dwelling, Elderly Japanese People. J Am Med Dir Assoc. 2015 Apr 1; 16(4):349. e1-5. View in: PubMed

Moderate-intensity physical activity, hippocampal volume, and memory in older adults with mild cognitive impairment. J Gerontol A Biol Sci Med Sci. 2015 Apr; 70(4):480-6. View in: PubMed

Cognitive functioning and walking speed in older adults as predictors of limitations in self-reported instrumental activity of daily living: prospective findings from the Obu Study of Health Promotion for the Elderly. Int J Environ Res Public Health. 2015 Mar 11; 12(3):3002-13. View in: PubMed

Physical frailty predicts incident depressive symptoms in elderly people: prospective findings from the Obu Study of Health Promotion for the Elderly. J Am Med Dir Assoc. 2015 Mar; 16(3):194-9. View in: PubMed

Association of insulin-like growth factor-1 with mild cognitive impairment and slow gait speed. Neurobiol Aging. 2015 Feb; 36(2):942-7. View in: PubMed

Successful treatment of metastatic rhabdomyosarcoma with radiochemotherapy and allogeneic hematopoietic stem cell transplantation. Jpn J Clin Oncol. 2015 Feb; 45(2):225-8. View in: PubMed

Objectively measured physical activity, brain atrophy, and white matter lesions in older adults with mild cognitive impairment. Exp Gerontol. 2015 Feb; 62:1-6. View in: PubMed

Impact of physical frailty on disability in community-dwelling older adults: a prospective cohort study. BMJ Open. 2015; 5(9):e008462. View in: PubMed

Cognitive functioning and walking speed in older adults as predictors of limitations in self-reported instrumental activity of daily living: prospective findings from the obu study of health promotion for the elderly. Int J Environ Res Public Health. 2015; 12(3):3002-13. View in: PubMed

Subjective physical and cognitive age among community-dwelling older people aged 75 years and older: differences with chronological age and its associated factors. Aging Ment Health. 2015; 19(8):756-61. View in: PubMed

Development of the Japan Science and Technology Agency Index of Competence to Assess Functional Capacity in Older Adults: Conceptual Definitions and Preliminary Items. Gerontol Geriatr Med. 2015 Jan-Dec; 1:2333721415609490. View in: PubMed

Incidence and predictors of sarcopenia onset in community-dwelling elderly Japanese women: 4-year follow-up study. J Am Med Dir Assoc. 2015 Jan 1; 16(1):85. e1-8. View in: PubMed

A second pedigree with amyloid-less familial Alzheimer's disease harboring an identical mutation in the amyloid precursor protein gene (E693delta). Intern Med. 2015; 54(2):205-8. View in: PubMed

Effects of exercise and horticultural intervention on the brain and mental health in older adults with depressive symptoms and memory problems: study protocol for a randomized controlled trial [UMIN000018547]. Trials. 2015; 16(1):499. View in: PubMed

Lifestyle-Related Factors Contributing to Decline in Knee Extension Strength among Elderly Women: A Cross-Sectional and Longitudinal Cohort Study. PLoS One. 2015; 10(7):e0132523. View in: PubMed

Incidence and predictors of sarcopenia onset in community-dwelling elderly Japanese women: 4-year follow-up study. J Am Med Dir Assoc. 2015 Jan; 16(1):85. e1-8. View in: PubMed

Self-reported Exhaustion is Associated with Small Life Space in Older Adults with Mild Cognitive Impairment. J Phys Ther Sci. 2014 Dec; 26(12):1979-83. View in: PubMed

Kiss1 neurons drastically change their firing activity in accordance with the reproductive state: insights from a seasonal breeder. Endocrinology. 2014 Dec; 155(12):4868-80. View in: PubMed

Cerebral infarction in the left hemisphere compared with the right hemisphere increases the risk of aspiration pneumonia. Osaka City Med J. 2014 Dec; 60(2):81-6. View in: PubMed

MYCN-Dependent Expression of Sulfatase-2 Regulates Neuroblastoma Cell Survival. Cancer Res. 2014 Nov 1; 74(21):5999-6009. View in: PubMed

MYCN-dependent expression of sulfatase-2 regulates neuroblastoma cell survival. Cancer Res. 2014 Nov 01; 74(21):5999-6009. View in: PubMed

Age-dependent prognostic effect by Mitosis-Karyorrhexis Index in neuroblastoma: a report from the Children's Oncology Group. Pediatr Dev Pathol. 2014 Nov-Dec; 17(6):441-9. View in: PubMed

Development of an equation for estimating appendicular skeletal muscle mass in Japanese older adults using bioelectrical impedance analysis. Geriatr Gerontol Int. 2014 Oct; 14(4):851-7. View in: PubMed

Depressive symptoms and cognitive performance in older adults. J Psychiatr Res. 2014 Oct; 57:149-56. View in: PubMed

Depressive symptoms in older adults are associated with decreased cerebral oxygenation of the prefrontal cortex during a trail-making test. Arch Gerontol Geriatr. 2014 Sep-Oct; 59(2):422-8. View in: PubMed

Diffusion-weighted imaging thermometry in multiple sclerosis. J Magn Reson Imaging. 2014 Sep; 40(3):649-54. View in: PubMed

Nitrogen K-edge X-ray absorption near edge structure (XANES) spectra of purine-containing nucleotides in aqueous solution. J Chem Phys. 2014 Aug 07; 141(5):055102. View in: PubMed

Nitrogen K-edge X-ray absorption near edge structure (XANES) spectra of purine-containing nucleotides in aqueous solution. J Chem Phys. 2014 Aug 7; 141(5):055102. View in: PubMed

Secondary malignant neoplasms after high-dose chemotherapy and autologous stem cell rescue for high-risk neuroblastoma. Pediatr Blood Cancer. 2014 Aug; 61(8):1350-6. View in: PubMed

Acquisition process of typing skill using hierarchical materials in the Japanese language. Atten Percept Psychophys. 2014 Aug; 76(6):1838-46. View in: PubMed

Association of knee-extension strength with instrumental activities of daily living in community-dwelling older adults. Geriatr Gerontol Int. 2014 Jul; 14(3):674-80. View in: PubMed

Serum levels of albumin-amyloid beta complexes are decreased in Alzheimer's disease. Geriatr Gerontol Int. 2014 Jul; 14(3):716-23. View in: PubMed

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A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia. Ann Neurol. 2008 Mar; 63(3):377-87. View in: PubMed

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An unusual case of neuroblastoma with angiomatoid features. J Pediatr Surg. 2007 Dec; 42(12):e11-3. View in: PubMed

The use of positron emission tomography and [18F]fluorodeoxyglucose for functional imaging of muscular activity during exercise with a stride assistance system. IEEE Trans Neural Syst Rehabil Eng. 2007 Sep; 15(3):442-8. View in: PubMed

A case of composite neuroblastoma composed of histologically and biologically distinct clones. Pediatr Dev Pathol. 2007 May-Jun; 10(3):229-32. View in: PubMed

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E-cadherin cell-cell adhesion in ewing tumor cells mediates suppression of anoikis through activation of the ErbB4 tyrosine kinase. Cancer Res. 2007 Apr 1; 67(7):3094-105. View in: PubMed

E-cadherin cell-cell adhesion in ewing tumor cells mediates suppression of anoikis through activation of the ErbB4 tyrosine kinase. Cancer Res. 2007 Apr 01; 67(7):3094-105. View in: PubMed

[Sighting dominance in patients with macular disease]. Nippon Ganka Gakkai Zasshi. 2007 Apr; 111(4):322-5. View in: PubMed

Clinicopathological findings of retinal angiomatous proliferation. Graefes Arch Clin Exp Ophthalmol. 2007 Feb; 245(2):295-300. View in: PubMed

Pathology of peripheral neuroblastic tumors: significance of prominent nucleoli in undifferentiated/poorly differentiated neuroblastoma. Pathol Oncol Res. 2007; 13(4):269-75. View in: PubMed

Predictors of cessation of regular leisure-time physical activity in community-dwelling elderly people. Gerontology. 2007; 53(5):293-7. View in: PubMed

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Deferasirox and deferiprone remove cardiac iron in the iron-overloaded gerbil. Transl Res. 2006 Nov; 148(5):272-80. View in: PubMed

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Expanded indications for 25-gauge transconjunctival vitrectomy. Jpn J Ophthalmol. 2005 Sep-Oct; 49(5):397-401. View in: PubMed

Surgical excision of type 1 + 2 choroidal neovascularization in age-related macular degeneration. Jpn J Ophthalmol. 2005 Jul-Aug; 49(4):324-6. View in: PubMed

Protocol for the examination of specimens from patients with neuroblastoma and related neuroblastic tumors. Arch Pathol Lab Med. 2005 Jul; 129(7):874-83. View in: PubMed

Effects of internal limiting membrane peeling in vitrectomy on diabetic cystoid macular edema patients. Jpn J Ophthalmol. 2005 Jul-Aug; 49(4):297-300. View in: PubMed

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Surgical excision of neovascularization in retinal angiomatous proliferation. Graefes Arch Clin Exp Ophthalmol. 2005 Jun; 243(6):519-24. View in: PubMed

EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors. Cancer Res. 2005 Jun 1; 65(11):4633-44. View in: PubMed

Endothelial apoptosis induced by inhibition of integrins alphavbeta3 and alphavbeta5 involves ceramide metabolic pathways. Blood. 2005 Jun 1; 105(11):4353-61. View in: PubMed

Neonatal gene therapy of MPS I mice by intravenous injection of a lentiviral vector. Mol Ther. 2005 May; 11(5):776-89. View in: PubMed

In situ neuroblastoma: an important concept related to the natural history of neural crest tumors. Pediatr Dev Pathol. 2005 May-Jun; 8(3):305-6. View in: PubMed

Twenty-gauge Transconjunctival Vitrectomy. Jpn J Ophthalmol. 2005 May-Jun; 49(3):257-60. View in: PubMed

The contribution of bone marrow-derived cells to the tumor vasculature in neuroblastoma is matrix metalloproteinase-9 dependent. Cancer Res. 2005 Apr 15; 65(8):3200-8. View in: PubMed

[Evaluation of osteoporosis by markers of bone metabolism]. Nihon Naika Gakkai Zasshi. 2005 Apr 10; 94(4):675-81. View in: PubMed

Bone marrow mesenchymal stem cells provide an alternate pathway of osteoclast activation and bone destruction by cancer cells. Cancer Res. 2005 Feb 15; 65(4):1129-35. View in: PubMed

Assessment of NMYC amplification: a comparison of FISH, quantitative PCR monoplexing and traditional blotting methods used with formalin-fixed, paraffin-embedded neuroblastomas. Anal Quant Cytol Histol. 2005 Feb; 27(1):5-14. View in: PubMed

Enlarged and prominent nucleoli may be indicative of MYCN amplification: a study of neuroblastoma (Schwannian stroma-poor), undifferentiated/poorly differentiated subtype with high mitosis-karyorrhexis index. Cancer. 2005 Jan 1; 103(1):174-80. View in: PubMed

Enlarged and prominent nucleoli may be indicative of MYCN amplification: a study of neuroblastoma (Schwannian stroma-poor), undifferentiated/poorly differentiated subtype with high mitosis-karyorrhexis index. Cancer. 2005 Jan 01; 103(1):174-80. View in: PubMed

Neuroblastoma in an adult. Urology. 2004 Dec; 64(6):1232. View in: PubMed

A novel presenilin-1 mutation (Leu85Pro) in early-onset Alzheimer disease with spastic paraparesis. Arch Neurol. 2004 Nov; 61(11):1773-6. View in: PubMed

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First case of aplastic anemia in a Japanese child with a homozygous missense mutation in the NBS1 gene (I171V) associated with genomic instability. Hum Genet. 2004 Oct; 115(5):372-6. View in: PubMed

New intervention program for preventing falls among frail elderly people: the effects of perturbed walking exercise using a bilateral separated treadmill. Am J Phys Med Rehabil. 2004 Jul; 83(7):493-9. View in: PubMed

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Correlation between indocyanine green angiographic findings and histopathology of polypoidal choroidal vasculopathy. Jpn J Ophthalmol. 2004 May-Jun; 48(3):249-55. View in: PubMed

Colocolic intussusception associated with pneumatosis cystoides intestinalis after cord blood stem cell transplantation. J Pediatr Gastroenterol Nutr. 2004 May; 38(5):549-51. View in: PubMed

[A randomized controlled trial of a treadmill training with the perturbation to improve the balance performance in the community dwelling elderly subjects]. Nihon Ronen Igakkai Zasshi. 2004 May; 41(3):321-7. View in: PubMed

The matrix metalloproteinase inhibitor prinomastat enhances photodynamic therapy responsiveness in a mouse tumor model. Cancer Res. 2004 Apr 01; 64(7):2328-32. View in: PubMed

The matrix metalloproteinase inhibitor prinomastat enhances photodynamic therapy responsiveness in a mouse tumor model. Cancer Res. 2004 Apr 1; 64(7):2328-32. View in: PubMed

The incidence of hyperglycemia in patients treated with olanzapine. J Clin Psychiatry. 2004 Mar; 65(3):443-4. View in: PubMed

Stromal matrix metalloproteinase-9 regulates the vascular architecture in neuroblastoma by promoting pericyte recruitment. Cancer Res. 2004 Mar 1; 64(5):1675-86. View in: PubMed

Stromal matrix metalloproteinase-9 regulates the vascular architecture in neuroblastoma by promoting pericyte recruitment. Cancer Res. 2004 Mar 01; 64(5):1675-86. View in: PubMed

Position-specific expression of Hox genes along the gastrointestinal tract. Congenit Anom (Kyoto). 2004 Mar; 44(1):18-26. View in: PubMed

Epstein-Barr virus-associated posttransplant lymphoproliferative disorder after a cord blood stem cell transplantation presenting with pulmonary nodules. J Pediatr Hematol Oncol. 2004 Feb; 26(2):124-7. View in: PubMed

Pars plana suture fixation for intraocular lenses dislocated into the vitreous cavity using a closed-eye cow-hitch technique. J Cataract Refract Surg. 2004 Feb; 30(2):302-6. View in: PubMed

Large cell neuroblastoma: a distinct phenotype of neuroblastoma with aggressive clinical behavior. Cancer. 2004 Jan 15; 100(2):390-7. View in: PubMed

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TraJ-dependent Escherichia coli K1 interactions with professional phagocytes are important for early systemic dissemination of infection in the neonatal rat. Infect Immun. 2004 Jan; 72(1):478-88. View in: PubMed

Revision of the International Neuroblastoma Pathology Classification: confirmation of favorable and unfavorable prognostic subsets in ganglioneuroblastoma, nodular. Cancer. 2003 Nov 15; 98(10):2274-81. View in: PubMed

[Surgical removal of juxtafoveal and extrafoveal choroidal neovascularization in age-related macular degeneration]. Nippon Ganka Gakkai Zasshi. 2003 Nov; 107(11):695-701. View in: PubMed

[Surgical removal of juxtafoveal and extrafoveal choroidal neovascularization in age-related macular degeneration]. Nihon Ganka Gakkai Zasshi. 2003 Nov; 107(11):695-701. View in: PubMed

Pediatric tumor cells express erythropoietin and a functional erythropoietin receptor that promotes angiogenesis and tumor cell survival. Lab Invest. 2003 Oct; 83(10):1477-87. View in: PubMed

Citrobacter koseri brain abscess in the neonatal rat: survival and replication within human and rat macrophages. Infect Immun. 2003 Oct; 71(10):5871-80. View in: PubMed

Entry and intracellular replication of Escherichia coli K1 in macrophages require expression of outer membrane protein A. Infect Immun. 2003 Oct; 71(10):5951-61. View in: PubMed

[Surgical removal of choroidal neovascularization in angioid streaks]. Nippon Ganka Gakkai Zasshi. 2003 Aug; 107(8):440-4. View in: PubMed

[Surgical removal of choroidal neovascularization in angioid streaks]. Nihon Ganka Gakkai Zasshi. 2003 Aug; 107(8):440-4. View in: PubMed

Relationship with dynamic balance function during standing and walking. Am J Phys Med Rehabil. 2003 Jul; 82(7):511-6. View in: PubMed

Lytic bone lesions in human neuroblastoma xenograft involve osteoclast recruitment and are inhibited by bisphosphonate. Cancer Res. 2003 Jun 15; 63(12):3026-31. View in: PubMed

Anaplastic large cell lymphoma in Japanese children: retrospective analysis of 34 patients diagnosed at the National Research Institute for Child Health and Development. Br J Haematol. 2003 Apr; 121(1):94-6. View in: PubMed

Detecting functional asymmetries through the dipole moment of magnetoencephalography. J Neurol Sci. 2002 Jun 15; 198(1-2):51-61. View in: PubMed

Antidisialoganglioside/granulocyte macrophage-colony-stimulating factor fusion protein facilitates neutrophil antibody-dependent cellular cytotoxicity and depends on FcgammaRII (CD32) and Mac-1 (CD11b/CD18) for enhanced effector cell adhesion and azurophil granule exocytosis. Blood. 2002 Jun 01; 99(11):4166-73. View in: PubMed

Antidisialoganglioside/granulocyte macrophage-colony-stimulating factor fusion protein facilitates neutrophil antibody-dependent cellular cytotoxicity and depends on FcgammaRII (CD32) and Mac-1 (CD11b/CD18) for enhanced effector cell adhesion and azurophil granule exocytosis. Blood. 2002 Jun 1; 99(11):4166-73. View in: PubMed

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Vitrectomy for diabetic cystoid macular edema. Jpn J Ophthalmol. 2002 May-Jun; 46(3):315-22. View in: PubMed

Aberrations of the hSNF5/INI1 gene are restricted to malignant rhabdoid tumors or atypical teratoid/rhabdoid tumors in pediatric solid tumors. Genes Chromosomes Cancer. 2002 May; 34(1):33-41. View in: PubMed

alpha v-Integrin antagonist EMD 121974 induces apoptosis in brain tumor cells growing on vitronectin and tenascin. Int J Cancer. 2002 Apr 10; 98(5):690-7. View in: PubMed

Morphologic features of neuroblastoma (Schwannian stroma-poor tumors) in clinically favorable and unfavorable groups. Cancer. 2002 Mar 01; 94(5):1574-83. View in: PubMed

Morphologic features of neuroblastoma (Schwannian stroma-poor tumors) in clinically favorable and unfavorable groups. Cancer. 2002 Mar 1; 94(5):1574-83. View in: PubMed

[Relationship between lifestyle activities and physical functions in elderly persons utilizing care facilities]. Nihon Ronen Igakkai Zasshi. 2002 Mar; 39(2):197-203. View in: PubMed

[Preoperative factors influencing visual acuity following vitrectomy for exudative age-related macular degeneration]. Nihon Ganka Gakkai Zasshi. 2002 Jan; 106(1):16-22. View in: PubMed

Shortening the duration of prone positioning after macular hole surgery- comparison between 1-week and 1-day prone positioning. Jpn J Ophthalmol. 2002 Jan-Feb; 46(1):84-8. View in: PubMed

[Preoperative factors influencing visual acuity following vitrectomy for exudative age-related macular degeneration]. Nippon Ganka Gakkai Zasshi. 2002 Jan; 106(1):16-22. View in: PubMed

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