Faculty

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John C. Wood, MD, PhD
Professor of Pediatrics and Radiology
Pediatrics
CHL Mail Stop 34 Off Campus Los Angeles
+1 323 361 2535

Overview

Dr. John Wood graduated in from UC. Davis (Electrical Engineering) in 1984 and received his MD/PhD (Bioengineering) from the University of Michigan in 1994. He performed his residency and fellowship in Pediatric Cardiology at Yale and joined Children’s Hospital Los Angeles/USC Keck School of Medicine in 1999. Dr. Wood is the director of cardiovascular MRI and specializes in the MRI assessment of congenital heart disease as well as noninvasive assessment of iron burden by MRI.

Dr. Wood has been studying the cardiovascular consequences of hemoglobinopathies for almost a decade. He is one of the pioneer’s of MRI-based cardiac and liver iron measurements but is also studying oral chelation strategies in animals and humans. He was the principle investigator for the NIH-sponsored Early Detection of Iron Cardiomyopathy Trial whose goal is to identify earlier markers of cardiac dysfunction. Dr. Wood also has funded projects examining pancreatic and pituitary iron burden by MRI and their functional correlates. Recently, Dr. Wood received a ARRA Challenge grant to study the role of iron overload and other factors in sickle cell vasculopathy and is exploring the links between abnormal red cell mechanics and vascular dynamics in the hemoglobinopathies.

Awards

RSNA Scholar

Alfred F. Towsley Award for Pediatrics

Alpha Omega Alpha

Medical Scientist Training Program Fellowship

Tau Beta Pi (National Engineering Honor Society)

Tau Beta Pi (National Engineering Honor Socaety)

Publications

The use of MRI to monitor iron overload in SCD. Blood Cells Mol Dis. 2017 Sep 06. View in: PubMed

Measuring Stroke Volume: Impedance Cardiography vs Phase-Contrast Magnetic Resonance Imaging. Am J Crit Care. 2017 Sep; 26(5):408-415. View in: PubMed

Graph Lasso-Based Test for Evaluating Functional Brain Connectivity in Sickle Cell Disease. Brain Connect. 2017 Sep; 7(7):443-453. View in: PubMed

Graph Lasso-based test for evaluating functional brain connectivity in sickle cell disease. Brain Connect. 2017 Jul 26. View in: PubMed

Individuals with sickle cell disease have a significantly greater vasoconstriction response to thermal pain than controls and have significant vasoconstriction in response to anticipation of pain. Am J Hematol. 2017 Jul 13. View in: PubMed

Ultra-short echo time images quantify high liver iron. Magn Reson Med. 2017 Jun 22. View in: PubMed

Empirical model of human blood transverse relaxation at 3?T improves MRI T2 oximetry. Magn Reson Med. 2017 Jun; 77(6):2364-2371. View in: PubMed

How we manage iron overload in sickle cell patients. Br J Haematol. 2017 Jun; 177(5):703-716. View in: PubMed

How we manage iron overload in sickle cell patients. Br J Haematol. 2017 Mar 14. View in: PubMed

Prediction of cardiac complications for thalassemia major in the widespread cardiac magnetic resonance era: a prospective multicentre study by a multi-parametric approach. Eur Heart J Cardiovasc Imaging. 2017 Feb 14. View in: PubMed

Biophysical markers of the peripheral vasoconstriction response to pain in sickle cell disease. PLoS One. 2017; 12(5):e0178353. View in: PubMed

Hemoglobin and mean platelet volume predicts diffuse T1-MRI white matter volume decrease in sickle cell disease patients. Neuroimage Clin. 2017; 15:239-246. View in: PubMed

Persistent Microvascular Obstruction After Myocardial Infarction Culminates in the Confluence of Ferric Iron Oxide Crystals, Proinflammatory Burden, and Adverse Remodeling. Circ Cardiovasc Imaging. 2016 Nov; 9(11). View in: PubMed

Comparison between different software programs and post-processing techniques for the MRI quantification of liver iron concentration in thalassemia patients. Radiol Med. 2016 Oct; 121(10):751-62. View in: PubMed

Determinants of resting cerebral blood flow in sickle cell disease. Am J Hematol. 2016 Sep; 91(9):912-7. View in: PubMed

The heart in sickle cell disease, a model for heart failure with preserved ejection fraction. Proc Natl Acad Sci U S A. 2016 Aug 30; 113(35):9670-2. View in: PubMed

Empirical model of human blood transverse relaxation at 3?T improves MRI T2 oximetry. Empirical model of human blood transverse relaxation at 3? T improves MRI T2 oximetry. Magn Reson Med. 2016 Jul 6. View in: PubMed

Elevated Low-Shear Blood Viscosity is Associated with Decreased Pulmonary Blood Flow in Children with Univentricular Heart Defects. Pediatr Cardiol. 2016 Apr; 37(4):789-801. View in: PubMed

Management of iron overload in hemoglobinopathies: what is the appropriate target iron level? Ann N Y Acad Sci. Management of iron overload in hemoglobinopathies: what is the appropriate target iron level? Ann N Y Acad Sci. 2016 Mar; 1368(1):95-106. View in: PubMed

Organ iron accumulation in chronically transfused children with sickle cell anaemia: baseline results from the TWiTCH trial. Br J Haematol. 2016 Jan; 172(1):122-30. View in: PubMed

Relaxivity-iron calibration in hepatic iron overload: Predictions of a Monte Carlo model. Magn Reson Med. 2015 Sep; 74(3):879-83. View in: PubMed

Liver iron concentration measurements by MRI in chronically transfused children with sickle cell anemia: baseline results from the TWiTCH trial. Am J Hematol. 2015 Sep; 90(9):806-10. View in: PubMed

Chronic transfusion therapy improves but does not normalize systemic and pulmonary vasculopathy in sickle cell disease. Blood. 2015 Aug 06; 126(6):703-10. View in: PubMed

Chronic transfusion therapy improves but does not normalize systemic and pulmonary vasculopathy in sickle cell disease. Blood. 2015 Aug 6; 126(6):703-10. View in: PubMed

Autonomic responses to cold face stimulation in sickle cell disease: a time-varying model analysis. Physiol Rep. 2015 Jul 14; 3(7). View in: PubMed

Estimating tissue iron burden: current status and future prospects. Br J Haematol. 2015 Jul; 170(1):15-28. View in: PubMed

Liver MRI is more precise than liver biopsy for assessing total body iron balance: a comparison of MRI relaxometry with simulated liver biopsy results. Magn Reson Imaging. 2015 Jul; 33(6):761-7. View in: PubMed

Effect of inversion recovery fat suppression on hepatic R2* quantitation in transfusional siderosis. AJR Am J Roentgenol. 2015 Mar; 204(3):625-9. View in: PubMed

Pulmonary hypertension in well-transfused thalassemia major patients. Blood Cells Mol Dis. 2015 Feb; 54(2):189-94. View in: PubMed

A significant proportion of thalassemia major patients have adrenal insufficiency detectable on provocative testing. J Pediatr Hematol Oncol. 2015 Jan; 37(1):54-9. View in: PubMed

Guidelines for quantifying iron overload. Hematology Am Soc Hematol Educ Program. 2014 Dec 5; 2014(1):210-5. View in: PubMed

Guidelines for quantifying iron overload. Hematology Am Soc Hematol Educ Program. 2014 Dec 05; 2014(1):210-5. View in: PubMed

mRNA regulation of cardiac iron transporters and ferritin subunits in a mouse model of iron overload. Exp Hematol. 2014 Dec; 42(12):1059-67. View in: PubMed

Mechanisms of plasma non-transferrin bound iron generation: insights from comparing transfused diamond blackfan anaemia with sickle cell and thalassaemia patients. Br J Haematol. 2014 Dec; 167(5):692-6. View in: PubMed

Characterization of transfusion-derived iron deposition in childhood cancer survivors. Cancer Epidemiol Biomarkers Prev. 2014 Sep; 23(9):1913-9. View in: PubMed

Calibration of myocardial T2 and T1 against iron concentration. J Cardiovasc Magn Reson. 2014 Aug 12; 16:62. View in: PubMed

Cardiac R2* values are independent of the image analysis approach employed. Magn Reson Med. 2014 Aug; 72(2):485-91. View in: PubMed

Use of magnetic resonance imaging to monitor iron overload. Hematol Oncol Clin North Am. 2014 Aug; 28(4):747-64, vii. View in: PubMed

Cardiac iron overload in sickle-cell disease. Am J Hematol. 2014 Jul; 89(7):678-83. View in: PubMed

Dose titration of deferasirox iron chelation therapy by magnetic resonance imaging for chronic iron storage disease in three adult red bald-headed uakari (Cacajao calvus rubicundus). J Zoo Wildl Med. 2014 Jun; 45(2):339-49. View in: PubMed

R2 and R2* are equally effective in evaluating chronic response to iron chelation. Am J Hematol. 2014 May; 89(5):505-8. View in: PubMed

Robust estimation of pulse wave transit time using group delay. J Magn Reson Imaging. 2014 Mar; 39(3):550-8. View in: PubMed

Sex differences and steroid modulation of cardiac iron in a mouse model of iron overload. Transl Res. 2014 Feb; 163(2):151-9. View in: PubMed

Deformability analysis of sickle blood using ektacytometry. Biorheology. 2014; 51(2-3):159-70. View in: PubMed

Calibration of myocardial T2 and T1 against iron concentration. J Cardiovasc Magn Reson. 2014; 16(1):62. View in: PubMed

Deformability analysis of sickle blood using ektacytometry. Biorheology. 2014 Jan 1; 51(2):159-70. View in: PubMed

Tissue iron evaluation in chronically transfused children shows significant levels of iron loading at a very young age. Am J Hematol. 2013 Nov; 88(11):E283-5. View in: PubMed

Fast approximation to pixelwise relaxivity maps: validation in iron overloaded subjects. Magn Reson Imaging. 2013 Sep; 31(7):1074-80. View in: PubMed

The use of appropriate calibration curves corrects for systematic differences in liver R2* values measured using different software packages. Br J Haematol. 2013 Jun; 161(6):888-91. View in: PubMed

Patients with sickle cell anemia on simple chronic transfusion protocol show sex differences for hemodynamic and hematologic responses to transfusion. Transfusion. 2013 May; 53(5):1059-68. View in: PubMed

Comparison of biventricular dimensions and function between pediatric sickle-cell disease and thalassemia major patients without cardiac iron. Am J Hematol. 2013 Mar; 88(3):213-8. View in: PubMed

Exercise performance in thalassemia major: correlation with cardiac iron burden. Am J Hematol. 2013 Mar; 88(3):193-7. View in: PubMed

Low-shear red blood cell oxygen transport effectiveness is adversely affected by transfusion and further worsened by deoxygenation in sickle cell disease patients on chronic transfusion therapy. Transfusion. 2013 Feb; 53(2):297-305. View in: PubMed

Ascorbate status modulates reticuloendothelial iron stores and response to deferasirox iron chelation in ascorbate-deficient rats. Exp Hematol. 2012 Oct; 40(10):820-7. View in: PubMed

Pancreatic iron stores assessed by magnetic resonance imaging (MRI) in beta thalassemic patients. Eur J Radiol. 2012 Jul; 81(7):1465-70. View in: PubMed

Systemic endothelial dysfunction in children with idiopathic pulmonary arterial hypertension correlates with disease severity. J Heart Lung Transplant. 2012 Jun; 31(6):642-7. View in: PubMed

A phase 2 study of the safety, tolerability, and pharmacodynamics of FBS0701, a novel oral iron chelator, in transfusional iron overload. Blood. 2012 Apr 05; 119(14):3263-8. View in: PubMed

A phase 2 study of the safety, tolerability, and pharmacodynamics of FBS0701, a novel oral iron chelator, in transfusional iron overload. Blood. 2012 Apr 5; 119(14):3263-8. View in: PubMed

Iron overload in non-transfusion-dependent thalassemia: a clinical perspective. Blood Rev. 2012 Apr; 26 Suppl 1:S16-9. View in: PubMed

Pancreatic iron and glucose dysregulation in thalassemia major. Am J Hematol. 2012 Feb; 87(2):155-60. View in: PubMed

Inter-site validations of the Pixel-Wise method for cardiac T2* analysis in transfusion-dependent Thai thalassemia patients. J Med Assoc Thai. 2012 Feb; 95 Suppl 2:S165-72. View in: PubMed

Electrocardiographic consequences of cardiac iron overload in thalassemia major. Am J Hematol. 2012 Feb; 87(2):139-44. View in: PubMed

Pituitary iron and volume predict hypogonadism in transfusional iron overload. Am J Hematol. 2012 Feb; 87(2):167-71. View in: PubMed

Intersite validations of the pixel-wise method for liver R2* analysis in transfusion-dependent thalassemia patients: a more accessible and affordable diagnostic technology. Hematol Oncol Stem Cell Ther. 2012; 5(2):91-5. View in: PubMed

Elevated liver iron concentration is a marker of increased morbidity in patients with ß thalassemia intermedia. Haematologica. 2011 Nov; 96(11):1605-12. View in: PubMed

Pulmonary function in thalassaemia major and its correlation with body iron stores. Br J Haematol. 2011 Oct; 155(1):102-5. View in: PubMed

Peripheral vasoconstriction and abnormal parasympathetic response to sighs and transient hypoxia in sickle cell disease. Am J Respir Crit Care Med. 2011 Aug 15; 184(4):474-81. View in: PubMed

Relationship between labile plasma iron, liver iron concentration and cardiac response in a deferasirox monotherapy trial. Haematologica. 2011 Jul; 96(7):1055-8. View in: PubMed

Quantitative computed tomography assessment of transfusional iron overload. Br J Haematol. 2011 Jun; 153(6):780-5. View in: PubMed

Iron overload in Brazilian thalassemic patients. Einstein (Sao Paulo). 2011 Jun; 9(2):165-72. View in: PubMed

Comparison of the region-based and pixel-wise methods for cardiac T2* analysis in 50 transfusion-dependent Thai thalassemia patients. J Comput Assist Tomogr. 2011 May-Jun; 35(3):375-81. View in: PubMed

On T2* magnetic resonance and cardiac iron. Circulation. 2011 Apr 12; 123(14):1519-28. View in: PubMed

Relaxivity-iron calibration in hepatic iron overload: probing underlying biophysical mechanisms using a Monte Carlo model. Magn Reson Med. 2011 Mar; 65(3):837-47. View in: PubMed

Interdependence of cardiac iron and calcium in a murine model of iron overload. Transl Res. 2011 Feb; 157(2):92-9. View in: PubMed

Iron chelation in thalassemia: time to reconsider our comfort zones. Expert Rev Hematol. 2011 Feb; 4(1):17-26. View in: PubMed

Polystyrene microsphere-ferritin conjugates: a robust phantom for correlation of relaxivity and size distribution. Magn Reson Med. 2011 Feb; 65(2):522-30. View in: PubMed

Revisiting the relationship between vitamin D deficiency, cardiac iron and cardiac function in thalassemia major. Eur J Haematol. 2011 Feb; 86(2):176-7. View in: PubMed

Pancreatic iron loading in chronically transfused sickle cell disease is lower than in thalassaemia major. Br J Haematol. 2011 Jan; 152(2):229-33. View in: PubMed

Impact of iron assessment by MRI. Hematology Am Soc Hematol Educ Program. 2011; 2011:443-50. View in: PubMed

Combining two orally active iron chelators for thalassemia. Ann Hematol. 2010 Nov; 89(11):1177-8. View in: PubMed

Follow-up report on the 2-year cardiac data from a deferasirox monotherapy trial. Am J Hematol. 2010 Oct; 85(10):818-9. View in: PubMed

Predicting pituitary iron and endocrine dysfunction. Ann N Y Acad Sci. 2010 Aug; 1202:123-8. View in: PubMed

Cardiovascular MRI in thalassemia major. Ann N Y Acad Sci. 2010 Aug; 1202:173-9. View in: PubMed

The effect of deferasirox on cardiac iron in thalassemia major: impact of total body iron stores. Blood. 2010 Jul 29; 116(4):537-43. View in: PubMed

Absence of cardiac siderosis despite hepatic iron overload in Italian patients with thalassemia intermedia: an MRI T2* study. Ann Hematol. 2010 Jun; 89(6):585-9. View in: PubMed

Iron overload indices rise linearly with transfusion rate in patients with sickle cell disease. Blood. 2010 Apr 08; 115(14):2980-1; author reply 2981-2. View in: PubMed

Iron overload indices rise linearly with transfusion rate in patients with sickle cell disease. Blood. 2010 Apr 8; 115(14):2980-1; author reply 2981-2. View in: PubMed

Magnetic resonance evaluation of hepatic and myocardial iron deposition in transfusion-independent thalassemia intermedia compared to regularly transfused thalassemia major patients. Am J Hematol. 2010 Apr; 85(4):288-90. View in: PubMed

Time-varying analysis of autonomic control in response to spontaneous sighs in sickle cell anemia. Conf Proc IEEE Eng Med Biol Soc. 2010; 2010:1626-9. View in: PubMed

Absence of cardiac siderosis by MRI T2* despite transfusion burden, hepatic and serum iron overload in Lebanese patients with sickle cell disease. Eur J Haematol. 2009 Dec 01; 83(6):565-71. View in: PubMed

Absence of cardiac siderosis by MRI T2* despite transfusion burden, hepatic and serum iron overload in Lebanese patients with sickle cell disease. Eur J Haematol. 2009 Dec 1; 83(6):565-71. View in: PubMed

History and current impact of cardiac magnetic resonance imaging on the management of iron overload. Circulation. 2009 Nov 17; 120(20):1937-9. View in: PubMed

Pancreatic iron loading predicts cardiac iron loading in thalassemia major. Blood. 2009 Nov 5; 114(19):4021-6. View in: PubMed

Pancreatic iron loading predicts cardiac iron loading in thalassemia major. Blood. 2009 Nov 05; 114(19):4021-6. View in: PubMed

Patterns of hepatic iron distribution in patients with chronically transfused thalassemia and sickle cell disease. Am J Hematol. 2009 Aug; 84(8):480-3. View in: PubMed

Nutritional deficiencies in iron overloaded patients with hemoglobinopathies. Am J Hematol. 2009 Jun; 84(6):344-8. View in: PubMed

Spleen R2 and R2* in iron-overloaded patients with sickle cell disease and thalassemia major. J Magn Reson Imaging. 2009 Feb; 29(2):357-64. View in: PubMed

Cardiac complications in thalassemia major. Hemoglobin. 2009; 33 Suppl 1:S81-6. View in: PubMed

Cardiac medications are not associated with clinically important preoperative electrolyte disturbances in children presenting for cardiac surgery. Anesth Analg. 2008 Dec; 107(6):1840-7. View in: PubMed

Cardiac iron across different transfusion-dependent diseases. Blood Rev. 2008 Dec; 22 Suppl 2:S14-21. View in: PubMed

Longitudinal analysis of heart and liver iron in thalassemia major. Blood. 2008 Oct 01; 112(7):2973-8. View in: PubMed

Longitudinal analysis of heart and liver iron in thalassemia major. Blood. 2008 Oct 1; 112(7):2973-8. View in: PubMed

Magnetic resonance detection of kidney iron deposition in sickle cell disease: a marker of chronic hemolysis. J Magn Reson Imaging. 2008 Sep; 28(3):698-704. View in: PubMed

Influence of iron chelation on R1 and R2 calibration curves in gerbil liver and heart. Magn Reson Med. 2008 Jul; 60(1):82-9. View in: PubMed

Vitamin D deficiency, cardiac iron and cardiac function in thalassaemia major. Br J Haematol. 2008 Jun; 141(6):891-4. View in: PubMed

Onset of cardiac iron loading in pediatric patients with thalassemia major. Haematologica. 2008 Jun; 93(6):917-20. View in: PubMed

Reproducibility of carotid intima-media thickness measurements in young adults. Radiology. 2008 May; 247(2):465-71. View in: PubMed

Atrial dysfunction as a marker of iron cardiotoxicity in thalassemia major. Haematologica. 2008 Feb; 93(2):311-2. View in: PubMed

Safety and efficacy of combined chelation therapy with deferasirox and deferoxamine in a gerbil model of iron overload. Acta Haematol. 2008; 120(2):123-8. View in: PubMed

Magnetic resonance imaging assessment of excess iron in thalassemia, sickle cell disease and other iron overload diseases. Hemoglobin. 2008; 32(1-2):85-96. View in: PubMed

Diagnosis and management of transfusion iron overload: the role of imaging. Am J Hematol. 2007 Dec; 82(12 Suppl):1132-5. View in: PubMed

Comparison of twice-daily vs once-daily deferasirox dosing in a gerbil model of iron cardiomyopathy. Exp Hematol. 2007 Jul; 35(7):1069-73. View in: PubMed

Magnetic resonance imaging measurement of iron overload. Curr Opin Hematol. 2007 May; 14(3):183-90. View in: PubMed

R2* imaging of transfusional iron burden at 3T and comparison with 1. 5T. J Magn Reson Imaging. 2007 Mar; 25(3):540-7. View in: PubMed

Antioxidant-mediated effects in a gerbil model of iron overload. Acta Haematol. 2007; 118(4):193-9. View in: PubMed

Myelin deficiencies visualized in vivo: visually evoked potentials and T2-weighted magnetic resonance images of shiverer mutant and wild-type mice. J Neurosci Res. 2006 Dec; 84(8):1716-26. View in: PubMed

Deferasirox and deferiprone remove cardiac iron in the iron-overloaded gerbil. Transl Res. 2006 Nov; 148(5):272-80. View in: PubMed

MRI detects myocardial iron in the human heart. Magn Reson Med. 2006 Sep; 56(3):681-6. View in: PubMed

Improved R2* measurements in myocardial iron overload. J Magn Reson Imaging. 2006 Jan; 23(1):9-16. View in: PubMed

Anatomical assessment of congenital heart disease. J Cardiovasc Magn Reson. 2006; 8(4):595-606. View in: PubMed

Mechanisms of tissue-iron relaxivity: nuclear magnetic resonance studies of human liver biopsy specimens. Magn Reson Med. 2005 Nov; 54(5):1185-93. View in: PubMed

MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. Blood. 2005 Aug 15; 106(4):1460-5. View in: PubMed

Cardiac iron determines cardiac T2*, T2, and T1 in the gerbil model of iron cardiomyopathy. Circulation. 2005 Jul 26; 112(4):535-43. View in: PubMed

Physiology and pathophysiology of iron cardiomyopathy in thalassemia. Ann N Y Acad Sci. 2005; 1054:386-95. View in: PubMed

Total anomalous pulmonary venous return involving drainage above, below, and to the heart: a mixed bag. J Am Soc Echocardiogr. 2004 Oct; 17(10):1084-5. View in: PubMed

MR imaging of newborns by using an MR-compatible incubator with integrated radiofrequency coils: initial experience. Radiology. 2004 May; 231(2):594-601. View in: PubMed

Stenting of the mainstem bronchus in children: a word of caution. Ann Thorac Surg. 2004 Apr; 77(4):1420-2. View in: PubMed

Myocardial iron loading in transfusion-dependent thalassemia and sickle cell disease. Blood. 2004 Mar 01; 103(5):1934-6. View in: PubMed

Myocardial iron loading in transfusion-dependent thalassemia and sickle cell disease. Blood. 2004 Mar 1; 103(5):1934-6. View in: PubMed

Mimicking liver iron overload using liposomal ferritin preparations. Magn Reson Med. 2004 Mar; 51(3):607-11. View in: PubMed

Superiority of 3D wavelet-packet denoising in MR microscopy. Magn Reson Imaging. 2003 Oct; 21(8):913-21. View in: PubMed

Characterization of interpolation effects in cine anatomic and phase-velocity images. J Magn Reson Imaging. 2003 Aug; 18(2):266-71. View in: PubMed

Cardiac abnormalities in children with sickle cell anemia. Am J Hematol. 2002 Aug; 70(4):306-12. View in: PubMed

Homograft conduit failure in infants is not due to somatic outgrowth. J Thorac Cardiovasc Surg. 2002 Jul; 124(1):88-96. View in: PubMed

Diagnosis of very long chain acyl-dehydrogenase deficiency from an infant's newborn screening card. Pediatrics. 2001 Jul; 108(1):E19. View in: PubMed

Pulmonary thrombosis, homocysteinemia, and reperfusion edema in an adolescent. Catheter Cardiovasc Interv. 2000 May; 50(1):59-62. View in: PubMed

Vascular aneurysm producing divided right atrium in a patient with pulmonary atresia and intact ventricular septum. Cardiol Young. 2000 May; 10(3):281-5. View in: PubMed

Predictors of cerebral blood flow in patients with and without anemia. J Appl Physiol (1985). 2016 Apr 15; 120(8):976-81. View in: PubMed

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