Faculty

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M. Elizabeth Fini, PhD
Professor of Cell & Neurobiology
Medicine
CSC 135K 2250 Alcazar Street Health Sciences Campus Los Angeles
+1 323 442 7732

Overview

Repair, Regeneration and the Tissue Response to Stress

The Fini Lab is best known for innovative contributions to our understanding of eye diseases. For many years, the research focus was on the Matrix Metalloproteinase (MMP) gene family. MMP genes encode a family of neutral proteinases that serve as central players in development and normal tissue maintenance. They are also important mediators of pathophysiology in a multitude of disorders.

The first MMP publication in 1960 described activity of collagenase, now known as MMP1. A small group of labs advanced the field slowly over the next 25 years using biochemical approaches, identifying several related enzymes. The field expanded dramatically once recombinant DNA technologies entered the biomedical research scene. The search string “Matrix Metalloproteinase” now brings up more than 48,000 papers on PubMed.

As a trainee, Dr. Fini was centrally involved in expansion of the MMP field, cloning genes for collagenase (MMP1) and stromelysin (MMP3). In her first faculty position, she began work on gelatinase A (MMP2) and gelatinase B (MMP9). Her lab cloned the MMP9 gene and pioneered many of the early studies characterizing MMP9 gene transcriptional regulation during development, and under various conditions of stress. The lab has also contributed to our knowledge of biological and disease roles for MMP1 and MMP9, including in corneal repair, remodeling and ulceration, maintenance of the corneal epithelium, glaucoma, eye development, cancer, brain trauma, and angiogenesis. Investigation of these MMP roles led to the lab's broader research focus in the area of repair, regeneration, and the tissue response to stress.

Dr. Fini relocated to USC in 2008. After a five year stint in senior administration, she launched the lab in new directions. Research is now focused on molecules that emerged from broad-based molecular and genomic screens, with practical application to the treatment of dry eye, ocular hypertension, and prostate cancer. The lab is currently supported by NIH R01 EY026479 and R41 EY025890.

Publications

Polydeoxyribonucleotides (PDRNs) From Skin to Musculoskeletal Tissue Regeneration via Adenosine A2A Receptor Involvement. J Cell Physiol. 2017 Sep; 232(9):2299-2307. View in: PubMed

Effects of pulsed electromagnetic fields and platelet rich plasma in preventing osteoclastogenesis in an in vitro model of osteolysis. J Cell Physiol. 2017 Aug 08. View in: PubMed

Uremic Serum Impairs Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stromal Cells. J Cell Physiol. 2017 Aug; 232(8):2201-2209. View in: PubMed

A Human 3D In Vitro Model to Assess the Relationship Between Osteoporosis and Dissemination to Bone of Breast Cancer Tumor Cells. J Cell Physiol. 2017 Jul; 232(7):1826-1834. View in: PubMed

SIRT1-SIRT3 Axis Regulates Cellular Response to Oxidative Stress and Etoposide. J Cell Physiol. 2017 Jul; 232(7):1835-1844. View in: PubMed

Osteogenic commitment and differentiation of human mesenchymal stem cells by low-intensity pulsed ultrasound stimulation. J Cell Physiol. 2017 Jun 16. View in: PubMed

An advanced tri-culture model to evaluate the dynamic interplay among osteoblasts, osteoclasts, and endothelial cells. J Cell Physiol. 2017 Feb 27. View in: PubMed

Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine. Prog Retin Eye Res. 2017 Jan; 56:58-83. View in: PubMed

Uremic Serum Impairs Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stromal Cells. J Cell Physiol. 2016 Dec 14. View in: PubMed

A Human 3D In Vitro Model to Assess the Relationship Between Osteoporosis and Dissemination to Bone of Breast Cancer Tumor Cells. J Cell Physiol. 2016 Dec 07. View in: PubMed

A surgical multi-layer technique for pelvic reconstruction after total exenteration using a combination of pedicled omental flap, human acellular dermal matrix and autologous adipose derived cells. Gynecol Oncol Rep. 2016 Nov; 18:36-39. View in: PubMed

Polydeoxyribonucleotides (PDRNs) From Skin to Musculoskeletal Tissue Regeneration Via Adenosine A2A Receptor Involvement: A Mini-Review. J Cell Physiol. 2016 Oct 28. View in: PubMed

Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine. Prog Retin Eye Res. 2016 Sep 22. View in: PubMed

Novel therapeutic targets in osteoarthritis: Narrative review on knock-out genes involved in disease development in mouse animal models. Cytotherapy. 2016 May; 18(5):593-612. View in: PubMed

Mining Retrospective Data for Virtual Prospective Drug Repurposing: L-DOPA and Age-related Macular Degeneration. Am J Med. 2016 Mar; 129(3):292-8. View in: PubMed

A cell-based screening assay to identify pharmaceutical compounds that enhance the regenerative quality of corneal repair. Wound Repair Regen. 2016 Jan-Feb; 24(1):89-99. View in: PubMed

A cell-based screening assay to identify pharmaceutical compounds that enhance the regenerative quality of corneal repair. Wound Repair Regen. 2016 Jan; 24(1):89-99. View in: PubMed

Electromagnetic fields counteract IL-1ß activity during chondrogenesis of bovine mesenchymal stem cells. J Tissue Eng Regen Med. 2015 Dec; 9(12):E229-38. View in: PubMed

Identification of a Novel Mucin Gene HCG22 Associated With Steroid-Induced Ocular Hypertension. Invest Ophthalmol Vis Sci. 2015 Apr; 56(4):2737-48. View in: PubMed

Identification of a Novel Mucin Gene HCG22 Associated with Steroid-Induced Ocular Hypertension. Invest Ophthalmol Vis Sci. 2015 Mar 26. View in: PubMed

Expression and functional role of orphan receptor GPR158 in prostate cancer growth and progression. PLoS One. 2015; 10(2):e0117758. View in: PubMed

Chondrogenesis in scleral stem/progenitor cells and its association with form-deprived myopia in mice. Mol Vis. 2015; 21:138-47. View in: PubMed

Glaucomatous MYOC mutations activate the IL-1/NF-?B inflammatory stress response and the glaucoma marker SELE in trabecular meshwork cells. Mol Vis. 2015; 21:1071-84. View in: PubMed

Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles. J Mater Chem B Mater Biol Med. 2014 Dec 14; 2(46):8131-8141. View in: PubMed

Mechanisms for PDGF, a serum cytokine, stimulating loss of corneal keratocyte crystallins. Cornea. 2013 Sep; 32(9):1269-75. View in: PubMed

GPR158, an orphan member of G protein-coupled receptor Family C: glucocorticoid-stimulated expression and novel nuclear role. PLoS One. 2013; 8(2):e57843. View in: PubMed

Interaction of clusterin and matrix metalloproteinase-9 and its implication for epithelial homeostasis and inflammation. Am J Pathol. 2012 May; 180(5):2028-39. View in: PubMed

Single-shot dimension measurements of the mouse eye using SD-OCT. Ophthalmic Surg Lasers Imaging. 2012 May-Jun; 43(3):252-6. View in: PubMed

Single-Shot Dimension Measurements of the Mouse Eye Using SD-OCT. Ophthalmic Surg Lasers Imaging. 2012 May 1; 43(3):252-6. View in: PubMed

ß1 integrin-focal adhesion kinase (FAK) signaling modulates retinal ganglion cell (RGC) survival. PLoS One. 2012; 7(10):e48332. View in: PubMed

A novel mechanism of increased infections in contact lens wearers. Invest Ophthalmol Vis Sci. 2011 Nov 25; 52(12):9188-94. View in: PubMed

Identification of multipotent stem/progenitor cells in murine sclera. Invest Ophthalmol Vis Sci. 2011 Jul 25; 52(8):5481-7. View in: PubMed

Identification of multipotent stem/progenitor cells in murine sclera. Invest Ophthalmol Vis Sci. 2011 Jul; 52(8):5481-7. View in: PubMed

Comprehensive gene expression profiling and functional analysis of matrix metalloproteinases and TIMPs, and identification of ADAM-10 gene expression, in a corneal model of epithelial resurfacing. J Cell Physiol. 2011 Jun; 226(6):1461-70. View in: PubMed

A novel mechanism of increased infections in contact lens wearers. Invest Ophthalmol Vis Sci. 2011; 52(12):9188-94. View in: PubMed

Isoform- and dose-sensitive feedback interactions between paired box 6 gene and delta-catenin in cell differentiation and death. Exp Cell Res. 2010 Apr 01; 316(6):1070-81. View in: PubMed

Correlation between epithelial ingrowth and basement membrane remodeling in human corneas after laser-assisted in situ keratomileusis. Arch Ophthalmol. 2010 Apr; 128(4):426-36. View in: PubMed

Isoform- and dose-sensitive feedback interactions between paired box 6 gene and delta-catenin in cell differentiation and death. Exp Cell Res. 2010 Apr 1; 316(6):1070-81. View in: PubMed

Pharmacogenomics for the Retina Specialist. Retina Today. 2010; (Jul/Aug):71-72. View in: PubMed

Encyclopedia of the Eye (Darlene A. Dartt, ed). Corneal epithelium: wound healing junctions, attachment to stroma receptors, matrix metalloproteinases, intracellular communications. 2010; 1:456-462. View in: PubMed

Vertebrate Eye Development. Results and Problems in Cell Differentiation book series. 2010. View in: PubMed

The Corneal Stroma: Shape, Structure, and Biomechanical Properties. Corneal Surgery (Brightbill FS, McDonnell PJ, McGhee CNJ, and Serdarevic O, eds). 2010. View in: PubMed

Cytokines and signaling pathways regulating matrix metalloproteinase-9 (MMP-9) expression in corneal epithelial cells. J Cell Physiol. 2009 Nov; 221(2):402-11. View in: PubMed

Utility of molecular sequence analysis of the ITS rRNA region for identification of Fusarium spp. from ocular sources. Invest Ophthalmol Vis Sci. 2009 May; 50(5):2230-6. View in: PubMed

Molecular identification of t4 and t5 genotypes in isolates from acanthamoeba keratitis patients. J Clin Microbiol. 2009 May; 47(5):1458-62. View in: PubMed

Collagen fibril growth during chicken tendon development: matrix metalloproteinase-2 and its activation. Cell Tissue Res. 2009 Apr; 336(1):79-89. View in: PubMed

Pharmacogenomics of Ophthalmic Beta Blockers. International Journal of Medical and Biological Frontiers. 2009; (14):139-152. View in: PubMed

Glucocorticoid receptor polymorphisms and intraocular pressure response to intravitreal triamcinolone acetonide. Ophthalmic Genet. 2008 Dec; 29(4):166-70. View in: PubMed

Identification of E2F1 as a positive transcriptional regulator for delta-catenin. Biochem Biophys Res Commun. 2008 May 02; 369(2):414-20. View in: PubMed

Identification of E2F1 as a positive transcriptional regulator for delta-catenin. Biochem Biophys Res Commun. 2008 May 2; 369(2):414-20. View in: PubMed

Correlations of long-term matrix metalloproteinase localization in human corneas after successful laser-assisted in situ keratomileusis with minor complications at the flap margin. Arch Ophthalmol. 2008 Feb; 126(2):162-70. View in: PubMed

Pharmacogenomics of Open-Angle Glaucoma. Current Pharmacogenomics and Personalized Medicine, 6: 121-125. 2008. View in: PubMed

Conditional deletion of activating protein 2alpha (AP-2alpha) in the developing retina demonstrates non-cell-autonomous roles for AP-2alpha in optic cup development. Mol Cell Biol. 2007 Nov; 27(21):7497-510. View in: PubMed

Constitutive collagenase-1 synthesis through MAPK pathways is mediated, in part, by endogenous IL-1alpha during fibrotic repair in corneal stroma. J Cell Biochem. 2007 Oct 01; 102(2):453-62. View in: PubMed

Constitutive collagenase-1 synthesis through MAPK pathways is mediated, in part, by endogenous IL-1alpha during fibrotic repair in corneal stroma. J Cell Biochem. 2007 Oct 1; 102(2):453-62. View in: PubMed

Roles of MMP/TIMP in regulating matrix swelling and cell migration during chick corneal development. J Cell Biochem. 2007 Aug 01; 101(5):1222-37. View in: PubMed

Roles of MMP/TIMP in regulating matrix swelling and cell migration during chick corneal development. J Cell Biochem. 2007 Aug 1; 101(5):1222-37. View in: PubMed

Retinoblastoma tumor vessel maturation impacts efficacy of vessel targeting in the LH(BETA)T(AG) mouse model. Invest Ophthalmol Vis Sci. 2007 Jun; 48(6):2476-82. View in: PubMed

Inhibition of human corneal epithelial production of fibrotic mediator TGF-beta2 by basement membrane-like extracellular matrix. Invest Ophthalmol Vis Sci. 2007 Mar; 48(3):1061-71. View in: PubMed

Cell lines and transgenic mice expressing a matrix metalloproteinase-9 promoter-driven reporter gene: potential for assay of ultraviolet light effects and light-inhibiting compounds. Cutan Ocul Toxicol. 2007; 26(4):383-97. View in: PubMed

Selective spatiotemporal induction of matrix metalloproteinase-2 and matrix metalloproteinase-9 transcription after myocardial infarction. Am J Physiol Heart Circ Physiol. 2006 Nov; 291(5):H2216-28. View in: PubMed

Pax6 overexpression suppresses cell proliferation and retards the cell cycle in corneal epithelial cells. Invest Ophthalmol Vis Sci. 2006 Jun; 47(6):2397-407. View in: PubMed

Constitutive signalling pathway activity in trabecular meshwork cells from glaucomatous eyes. Exp Eye Res. 2006 Jun; 82(6):968-73. View in: PubMed

How the cornea heals: cornea-specific repair mechanisms affecting surgical outcomes. Cornea. 2005 Nov; 24(8 Suppl):S2-S11. View in: PubMed

Matrix metalloproteinase gelatinase B (MMP-9) is associated with leaking glaucoma filtering blebs. Exp Eye Res. 2005 Oct; 81(4):429-36. View in: PubMed

Selective reduction of fibrotic markers in repairing corneas of mice deficient in Smad3. J Cell Physiol. 2005 Apr; 203(1):226-32. View in: PubMed

Matrix metalloproteinase-9 knockout confers resistance to corneal epithelial barrier disruption in experimental dry eye. Am J Pathol. 2005 Jan; 166(1):61-71. View in: PubMed

Uncoupling keratocyte loss of corneal crystallin from markers of fibrotic repair. Invest Ophthalmol Vis Sci. 2004 Nov; 45(11):4010-5. View in: PubMed

Activity and expression of Xenopus laevis matrix metalloproteinases: identification of a novel role for the hormone prolactin in regulating collagenolysis in both amphibians and mammals. J Cell Physiol. 2004 Oct; 201(1):155-64. View in: PubMed

Monoclonal antibody (3G5)-defined ganglioside: cell surface marker of corneal keratocytes. Invest Ophthalmol Vis Sci. 2004 Mar; 45(3):807-12. View in: PubMed

Matrix metalloproteinase-9 is required for adequate angiogenic revascularization of ischemic tissues: potential role in capillary branching. Circ Res. 2004 Feb 6; 94(2):262-8. View in: PubMed

Matrix metalloproteinase-9 is required for adequate angiogenic revascularization of ischemic tissues: potential role in capillary branching. Circ Res. 2004 Feb 06; 94(2):262-8. View in: PubMed

Transcription Factors Pax6 and AP-2alpha Interact To Coordinate Corneal Epithelial Repair by Controlling Expression of Matrix Metalloproteinase Gelatinase B. Mol Cell Biol. 2004 Jan; 24(1):245-57. View in: PubMed

Large spot endolaser for retinal photocoagulation and transvitreal thermotherapy. Ophthalmic Surg Lasers Imaging. 2004 Jan-Feb; 35(1):26-30. View in: PubMed

Molecular mechanisms controlling the fibrotic repair phenotype in cornea: implications for surgical outcomes. Invest Ophthalmol Vis Sci. 2003 Oct; 44(10):4237-46. View in: PubMed

Increased SPARC accumulation during corneal repair. Exp Eye Res. 2003 Jul; 77(1):85-92. View in: PubMed

Ultrasound activates the TM ELAM-1/IL-1/NF-kappaB response: a potential mechanism for intraocular pressure reduction after phacoemulsification. Invest Ophthalmol Vis Sci. 2003 May; 44(5):1977-81. View in: PubMed

Positive influence of AP-2alpha transcription factor on cadherin gene expression and differentiation of the ocular surface. Differentiation. 2003 Apr; 71(3):206-16. View in: PubMed

Effect of gamma-synuclein overexpression on matrix metalloproteinases in retinoblastoma Y79 cells. Arch Biochem Biophys. 2003 Feb 01; 410(1):167-76. View in: PubMed

Effect of gamma-synuclein overexpression on matrix metalloproteinases in retinoblastoma Y79 cells. Arch Biochem Biophys. 2003 Feb 1; 410(1):167-76. View in: PubMed

Deficiency in matrix metalloproteinase gelatinase B (MMP-9) protects against retinal ganglion cell death after optic nerve ligation. J Biol Chem. 2002 Dec 6; 277(49):47461-8. View in: PubMed

Deficiency in matrix metalloproteinase gelatinase B (MMP-9) protects against retinal ganglion cell death after optic nerve ligation. J Biol Chem. 2002 Dec 06; 277(49):47461-8. View in: PubMed

Secretion of matrix metalloproteinase-2 and -9 after mechanical trauma injury in rat cortical cultures and involvement of MAP kinase. J Neurotrauma. 2002 May; 19(5):615-25. View in: PubMed

Mitogen-activated protein kinase inhibition in traumatic brain injury: in vitro and in vivo effects. J Cereb Blood Flow Metab. 2002 Apr; 22(4):444-52. View in: PubMed

Matrix metalloproteinases mediate the dismantling of mesenchymal structures in the tadpole tail during thyroid hormone-induced tail resorption. Dev Dyn. 2002 Mar; 223(3):402-13. View in: PubMed

Possible role of the vitamin E solubilizer in topical diclofenac on matrix metalloproteinase expression in corneal melting: an analysis of postoperative keratolysis. Ophthalmology. 2002 Feb; 109(2):343-50. View in: PubMed

Matrix metalloproteinase gelatinase B (MMP-9) coordinates and effects epithelial regeneration. J Biol Chem. 2002 Jan 18; 277(3):2065-72. View in: PubMed

Enzymatic mechanisms in corneal ulceration with specific reference to familial dysautonomia: potential for genetic approaches. Adv Exp Med Biol. 2002; 506(Pt A):629-39. View in: PubMed

MMPs in the eye: emerging roles for matrix metalloproteinases in ocular physiology. Prog Retin Eye Res. 2002 Jan; 21(1):1-14. View in: PubMed

Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia. J Neurosci. 2001 Oct 1; 21(19):7724-32. View in: PubMed

Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia. J Neurosci. 2001 Oct 01; 21(19):7724-32. View in: PubMed

Matrix metalloproteinase 2 gene knockout has no effect on acute brain injury after focal ischemia. Neuroreport. 2001 Sep 17; 12(13):3003-7. View in: PubMed

Induction of the ubiquitin-proteasome pathway during the keratocyte transition to the repair fibroblast phenotype. Invest Ophthalmol Vis Sci. 2001 Jul; 42(8):1698-706. View in: PubMed

Trefoil peptides promote restitution of wounded corneal epithelial cells. Exp Cell Res. 2001 Apr 1; 264(2):337-44. View in: PubMed

Trefoil peptides promote restitution of wounded corneal epithelial cells. Exp Cell Res. 2001 Apr 01; 264(2):337-44. View in: PubMed

Activation of a tissue-specific stress response in the aqueous outflow pathway of the eye defines the glaucoma disease phenotype. Nat Med. 2001 Mar; 7(3):304-9. View in: PubMed

Role for matrix metalloproteinase 9 after focal cerebral ischemia: effects of gene knockout and enzyme inhibition with BB-94. J Cereb Blood Flow Metab. 2000 Dec; 20(12):1681-9. View in: PubMed

Matrix metalloproteinase 9 promoter activity is induced coincident with invasion during tumor progression. Am J Pathol. 2000 Dec; 157(6):1777-83. View in: PubMed

Effects of matrix metalloproteinase-9 gene knock-out on morphological and motor outcomes after traumatic brain injury. J Neurosci. 2000 Sep 15; 20(18):7037-42. View in: PubMed

Pax-6 expression and activity are induced in the reepithelializing cornea and control activity of the transcriptional promoter for matrix metalloproteinase gelatinase B. Dev Biol. 2000 Jun 1; 222(1):41-54. View in: PubMed

Pax-6 expression and activity are induced in the reepithelializing cornea and control activity of the transcriptional promoter for matrix metalloproteinase gelatinase B. Dev Biol. 2000 Jun 01; 222(1):41-54. View in: PubMed

Curcuminoids inhibit the angiogenic response stimulated by fibroblast growth factor-2, including expression of matrix metalloproteinase gelatinase B. J Biol Chem. 2000 Apr 07; 275(14):10405-12. View in: PubMed

Curcuminoids inhibit the angiogenic response stimulated by fibroblast growth factor-2, including expression of matrix metalloproteinase gelatinase B. J Biol Chem. 2000 Apr 7; 275(14):10405-12. View in: PubMed

Failure to activate transcription factor NF-kappaB in corneal stromal cells (keratocytes). Invest Ophthalmol Vis Sci. 1999 Dec; 40(13):3122-31. View in: PubMed

Keratocyte and fibroblast phenotypes in the repairing cornea. Prog Retin Eye Res. 1999 Jul; 18(4):529-51. View in: PubMed

Differential inhibition of collagenase and interleukin-1alpha gene expression in cultured corneal fibroblasts by TGF-beta, dexamethasone, and retinoic acid. Invest Ophthalmol Vis Sci. 1999 Apr; 40(5):887-96. View in: PubMed

Regulation of gelatinase B production in corneal cells is independent of autocrine IL-1alpha. Invest Ophthalmol Vis Sci. 1999 Mar; 40(3):784-9. View in: PubMed

Gelatinase B/lacZ transgenic mice, a model for mapping gelatinase B expression during developmental and injury-related tissue remodeling. J Biol Chem. 1998 Oct 02; 273(40):25903-14. View in: PubMed

Gelatinase B/lacZ transgenic mice, a model for mapping gelatinase B expression during developmental and injury-related tissue remodeling. J Biol Chem. 1998 Oct 2; 273(40):25903-14. View in: PubMed

Proteolytic mechanisms in corneal ulceration and repair. Arch Dermatol Res. 1998 Jul; 290 Suppl:S12-23. View in: PubMed

Collagen type IX and developmentally regulated swelling of the avian primary corneal stroma. Dev Dyn. 1998 May; 212(1):27-37. View in: PubMed

Matrix Metalloproteinases in degradation and remodeling of the corneal epithelial basement membrane. Proceedings of the Kyoto Cornea Club. 1998. View in: PubMed

Regulation of Matrix Metalloproteinase gene expression. In: Parks W. , and Mecham, R. Matrix Metalloproteinases. 1998. View in: PubMed

Role of serum amyloid A as an intermediate in the IL-1 and PMA-stimulated signaling pathways regulating expression of rabbit fibroblast collagenase. Exp Cell Res. 1997 Dec 15; 237(2):275-87. View in: PubMed

Frog PNKT-4B cells express specific extracellular matrix-degrading enzymes and cytokines correlated with an invasive phenotype. J Exp Zool. 1997 Jul 01; 278(4):201-14. View in: PubMed

Frog PNKT-4B cells express specific extracellular matrix-degrading enzymes and cytokines correlated with an invasive phenotype. J Exp Zool. 1997 Jul 1; 278(4):201-14. View in: PubMed

Repair phenotype in corneal fibroblasts is controlled by an interleukin-1 alpha autocrine feedback loop. Invest Ophthalmol Vis Sci. 1997 Jun; 38(7):1367-79. View in: PubMed

Regulation of paracrine cytokine balance controlling collagenase synthesis by corneal cells. Invest Ophthalmol Vis Sci. 1997 Feb; 38(2):546-52. View in: PubMed

In: Krachmer JH, Mannis MJ, and Holland EJ, eds. The Cornea. Volume I: Fundamentals of Cornea and External Disease. Corneal responses to infection. 1997; 129-162. View in: PubMed

Perspectives on eye development. Dev Genet. 1997; 20(3):175-85. View in: PubMed

Role of matrix metalloproteinases in failure to re-epithelialize after corneal injury. Am J Pathol. 1996 Oct; 149(4):1287-302. View in: PubMed

Regionalized growth patterns of young chicken corneas. Invest Ophthalmol Vis Sci. 1996 Sep; 37(10):2060-7. View in: PubMed

Molecular mechanisms initiating the gene expression program for corneal repair. Advances in Cornea Research: Selected Transactions of the World Corneal Congress (Lass J, ed). 1996. View in: PubMed

Competence for collagenase gene expression by tissue fibroblasts requires activation of an interleukin 1 alpha autocrine loop. Proc Natl Acad Sci U S A. 1995 Jul 18; 92(15):6768-72. View in: PubMed

Unique regulation of the matrix metalloproteinase, gelatinase B. Invest Ophthalmol Vis Sci. 1995 Mar; 36(3):622-33. View in: PubMed

A corneal epithelial inhibitor of stromal cell collagenase synthesis identified as TGF-beta 2. Invest Ophthalmol Vis Sci. 1995 Jan; 36(1):151-62. View in: PubMed

The rabbit gene for 92-kDa matrix metalloproteinase. Role of AP1 and AP2 in cell type-specific transcription. J Biol Chem. 1994 Nov 18; 269(46):28620-8. View in: PubMed

Interleukin 1 alpha mediates collagenase synthesis stimulated by phorbol 12-myristate 13-acetate. J Biol Chem. 1994 Apr 15; 269(15):11291-8. View in: PubMed

MMPs and proteinase inhibitors in the human aqueous humor. Invest Ophthalmol Vis Sci. 1993 Dec; 34(13):3541-8. View in: PubMed

Stromal fibroblasts synthesize collagenase and stromelysin during long-term tissue remodeling. J Cell Sci. 1993 Apr; 104 ( Pt 4):1001-11. View in: PubMed

Collagenolytic/gelatinolytic metalloproteinases in normal and keratoconus corneas. Curr Eye Res. 1992 Sep; 11(9):849-62. View in: PubMed

Non-coordinate regulation of metalloproteinase gene expression in cornea. Matrix Suppl. 1992; 1:203-4. View in: PubMed

Collagenolytic/gelatinolytic enzymes in corneal wound healing. Acta Ophthalmol Suppl. 1992; (202):26-33. View in: PubMed

Mechanism of basement membrane dissolution preceding corneal ulceration. Invest Ophthalmol Vis Sci. 1991 Dec; 32(13):3221-37. View in: PubMed

Differential roles for two gelatinolytic enzymes of the matrix metalloproteinase family in the remodelling cornea. Dev Biol. 1991 Oct; 147(2):425-39. View in: PubMed

An inhibitor of the matrix metalloproteinase synthesized by rabbit corneal epithelium. Invest Ophthalmol Vis Sci. 1991 Oct; 32(11):2997-3001. View in: PubMed

Transforming growth factor-beta and interleukin-1 modulate metalloproteinase expression by corneal stromal cells. Invest Ophthalmol Vis Sci. 1991 Aug; 32(9):2441-54. View in: PubMed

The pattern of metalloproteinase expression by corneal fibroblasts is altered by passage in cell culture. J Cell Sci. 1990 Oct; 97 ( Pt 2):373-83. View in: PubMed

Expression of collagenolytic/gelatinolytic metalloproteinases by normal cornea. Invest Ophthalmol Vis Sci. 1990 Sep; 31(9):1779-88. View in: PubMed

Hsr-omega, a novel gene encoded in a Drosophila heat shock puff. The Biological Bulletin. 1990; 179:77-86. View in: PubMed

Unusual behavior of the cytoplasmic transcript of hsr omega: an abundant, stress-inducible RNA that is translated but yields no detectable protein product. J Cell Biol. 1989 Jun; 108(6):2045-57. View in: PubMed

In: Olsen B, Nimmi ME, eds. Collagen: Volume IV, Molecular Biology. Molecular cloning of collagenase and activator/stromelysin: members of a coordinately regulated gene family of metalloproteinases important in the modulation of connective tissue metabolism. 1989; 65-86. View in: PubMed

Hsr-omega: a different sort of heat shock locus. In: Pardue ML, Lindquist S, Ferimisco J, eds. Stress-Induced Proteins. (Proceedings of the UCLA Symposium). 1988; 3-14. View in: PubMed

Cloning of a complementary DNA for rabbit proactivator. A metalloproteinase that activates synovial cell collagenase, shares homology with stromelysin and transin, and is coordinately regulated with collagenase. Arthritis Rheum. 1987 Nov; 30(11):1254-64. View in: PubMed

A gene for rabbit synovial cell collagenase: member of a family of metalloproteinases that degrade the connective tissue matrix. Biochemistry. 1987 Sep 22; 26(19):6156-65. View in: PubMed

Molecular cloning of human synovial cell collagenase and selection of a single gene from genomic DNA. J Clin Invest. 1987 Feb; 79(2):542-6. View in: PubMed

Coordinate regulation of metalloproteinase gene expression in synovial cells. In: Sen A, Thornhill T, eds. Development and Diseases of Cartilage and Bone Matrix. (Proceedings of the UCLA Symposium). 1987; 299-217. View in: PubMed

Characterization of rabbit genes for synovial cell collagenase. Arthritis Rheum. 1986 Nov; 29(11):1301-15. View in: PubMed

Homology between exon-containing portions of rabbit genomic clones for synovial cell collagenase and human foreskin and synovial cell mRNAs. Coll Relat Res. 1986 Jul; 6(3):239-48. View in: PubMed

The relationship of body temperature to the efficacy of chemotherapy against systemic metastases from B16 melanoma. Journal of Surgical Research. 1984; 37:139-144. View in: PubMed

Limb regeneration of the adult newt (Notophthalmus viridescens) in the absence of the spleen. Wilhelm Roux's Archives of Developmental Biology. 1980; (189):77-79. View in: PubMed

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