Faculty

Back to Index
Mark Lee Barr, MD
Associate Professor of Surgery
Surgery
1520 San Pablo St. Health Sciences Campus Los Angeles
+1 323 442 5849

Overview

Dr. Mark L. Barr obtained his medical degree from Mount Sinai School of Medicine in New York and completed 10 years of postgraduate residency at New York University and Columbia University, including a 2-year NIH-sponsored research fellowship in transplantation immunology. Dr. Barr is former President and current Chair of the Scientific Grants and Awards Committee of the International Society for Heart and Lung Transplantation (ISHLT) and is the Immediate Past Chair of the Thoracic Committee of the American Society of Transplant Surgeons (ASTS). He has served on the Board of Directors of both the ASTS and the American Society of Transplantation, and as the Program Chair for the Annual Scientific Meeting of Both the ISHLT and the American Transplant Congress. Dr. Barr actively serves on multiple governmental transplant-related oversight subcommittees under the auspices of the Health Resources and Services Administration (HRSA) of the US Department of Health and Human Services (DHHS), including the Scientific Technical Advisory Committee of the Scientific Registry of Transplant Recipients. He is the incoming Chair of the Thoracic Committee for the United Network of Organ Sharing (UNOS). Dr. Barr has authored more than 150 peer-reviewed publications and book chapters in the fields of cardiothoracic surgery and heart and lung transplantation. He is a Deputy Editor of the American Journal of Transplantation. In addition, Dr. Barr is a standing reviewer for the Annals of Thoracic Surgery, the Journal of Heart and Lung Transplantation, the Journal of Thoracic and Cardiovascular Surgery, Lancet, and Transplantation. He maintains an active research program, funded by both federal and regional grant support, studying transplant immunology and Pulmonary physiology. He has served as a study section member for the NIAID, NHLBI, and NCRR of the National Institutes of Health.

Publications

Outcomes after mitral valve repair: A single-center 16-year experience. J Thorac Cardiovasc Surg. 2017 Sep; 154(3):822-830. e2. View in: PubMed

. View in: PubMed

Assessment of segmental myocardial blood flow and myocardial perfusion reserve by adenosine-stress myocardial arterial spin labeling perfusion imaging. J Magn Reson Imaging. 2017 Aug; 46(2):413-420. View in: PubMed

The Utility of Nurse-Managed Extracorporeal Life Support in an Adult Cardiac Intensive Care Unit. Ann Thorac Surg. 2017 Aug; 104(2):510-514. View in: PubMed

Double-gated myocardial ASL perfusion imaging is robust to heart rate variation. Magn Reson Med. 2017 May; 77(5):1975-1980. View in: PubMed

A comparison of aortic valve replacement via an anterior right minithoracotomy with standard sternotomy: a propensity score analysis of 492 patients. Eur J Cardiothorac Surg. 2016 Feb; 49(2):456-63. View in: PubMed

Changes in donor heart allocation in the United States without fundamental changes in the system: rearranging deck chairs and elephants in the room. Am J Transplant. 2015 Jan; 15(1):7-9. View in: PubMed

Outcomes after pregnancy in living lobar lung transplantation. Transplantation. 2014 Oct 15; 98(7):692-4. View in: PubMed

Morbidity and mortality of live lung donation: results from the RELIVE study. Am J Transplant. 2014 Aug; 14(8):1846-52. View in: PubMed

Pediatric lung allocation: the rest of the story. Am J Transplant. 2014 Jan; 14(1):11-2. View in: PubMed

Call it BOS, call it CLAD--the need for prospective clinical trials and elucidating the mechanism of extracorporeal photopheresis. Am J Transplant. 2013 Apr; 13(4):833-4. View in: PubMed

Identifying the barriers and facilitators to participation in physical activity for children with Down syndrome. J Intellect Disabil Res. 2011 Nov; 55(11):1020-33. View in: PubMed

Oscillatory shear stress induces mitochondrial superoxide production: implication of NADPH oxidase and c-Jun NH2-terminal kinase signaling. Antioxid Redox Signal. 2011 Sep 1; 15(5):1379-88. View in: PubMed

Oscillatory shear stress induces mitochondrial superoxide production: implication of NADPH oxidase and c-Jun NH2-terminal kinase signaling. Antioxid Redox Signal. 2011 Sep 01; 15(5):1379-88. View in: PubMed

Electrochemical impedance spectroscopy to assess vascular oxidative stress. Ann Biomed Eng. 2011 Jan; 39(1):287-96. View in: PubMed

Lung transplantation in the United States, 1999-2008. Am J Transplant. 2010 Apr; 10(4 Pt 2):1047-68. View in: PubMed

Lung transplantation for cystic fibrosis. Proc Am Thorac Soc. 2009 Dec; 6(8):619-33. View in: PubMed

CT-guided tube pericardiostomy: a safe and effective technique in the management of postsurgical pericardial effusion. AJR Am J Roentgenol. 2009 Oct; 193(4):W314-20. View in: PubMed

Genetic modulation of CD44 expression by intragraft fibroblasts. J Biochem. 2008 Nov; 144(5):571-80. View in: PubMed

Outcomes after lung retransplantation in the modern era. Am J Respir Crit Care Med. 2008 Jan 01; 177(1):114-20. View in: PubMed

Outcomes after lung retransplantation in the modern era. Am J Respir Crit Care Med. 2008 Jan 1; 177(1):114-20. View in: PubMed

Hemodynamics influences vascular peroxynitrite formation: Implication for low-density lipoprotein apo-B-100 nitration. Free Radic Biol Med. 2007 Feb 15; 42(4):519-29. View in: PubMed

Rat chemokine CXCL11: structure, tissue distribution, function and expression in cardiac transplantation models. Mol Cell Biochem. 2007 Feb; 296(1-2):1-9. View in: PubMed

Repeat organ transplantation in the United States, 1996-2005. Am J Transplant. 2007; 7(5 Pt 2):1424-33. View in: PubMed

Pediatric transplantation in the United States, 1996-2005. Am J Transplant. 2007; 7(5 Pt 2):1339-58. View in: PubMed

Multicenter retrospective analysis of cardiovascular risk factors affecting long-term outcome of de novo cardiac transplant recipients. J Heart Lung Transplant. 2006 Sep; 25(9):1063-9. View in: PubMed

A report of the Vancouver Forum on the care of the live organ donor: lung, liver, pancreas, and intestine data and medical guidelines. Transplantation. 2006 May 27; 81(10):1373-85. View in: PubMed

The role of the hyaluronan receptor CD44 in mesenchymal stem cell migration in the extracellular matrix. Stem Cells. 2006 Apr; 24(4):928-35. View in: PubMed

Report of a National Conference on Donation after cardiac death. Am J Transplant. 2006 Feb; 6(2):281-91. View in: PubMed

Transfer of regulatory T cells generated ex vivo modifies graft rejection through induction of tolerogenic CD4+CD25+ cells in the recipient. Int Immunol. 2006 Feb; 18(2):279-89. View in: PubMed

Contribution of mesenchymal progenitor cells to tissue repair in rat cardiac allografts undergoing chronic rejection. J Heart Lung Transplant. 2005 Dec; 24(12):2160-9. View in: PubMed

Transforming growth factor-beta/interleukin-2-induced regulatory CD4+ T cells prolong cardiac allograft survival in rats. J Heart Lung Transplant. 2005 Dec; 24(12):2153-9. View in: PubMed

Pleural space problems after living lobar transplantation. J Heart Lung Transplant. 2005 Dec; 24(12):2086-90. View in: PubMed

Living donor lobar lung transplantation: current status and future directions. Transplant Proc. 2005 Nov; 37(9):3983-6. View in: PubMed

The ethics of living donor lung transplantation. Thorac Surg Clin. 2005 Nov; 15(4):519-25. View in: PubMed

Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part IV: recipient-related risk factors and markers. J Heart Lung Transplant. 2005 Oct; 24(10):1468-82. View in: PubMed

Thoracic organ transplantation in the United States, 1994-2003. Am J Transplant. 2005 Apr; 5(4 Pt 2):934-49. View in: PubMed

Long-term pulmonary function after living-donor lobar lung transplantation in adults. Ann Thorac Surg. 2005 Feb; 79(2):418-25. View in: PubMed

Living lobar lung transplantation. Respir Care Clin N Am. 2004 Dec; 10(4):563-79. View in: PubMed

A decade of living lobar lung transplantation: perioperative complications after 253 donor lobectomies. Am J Transplant. 2004 Aug; 4(8):1283-8. View in: PubMed

Surrogate markers and risk factors for chronic lung allograft dysfunction. Am J Transplant. 2004 Jul; 4(7):1171-8. View in: PubMed

Neochordal repair of the posterior mitral leaflet. J Thorac Cardiovasc Surg. 2004 Feb; 127(2):440-7. View in: PubMed

Thoracic organ transplantation. Am J Transplant. 2004; 4 Suppl 9:93-105. View in: PubMed

A decade of living lobar lung transplantation: recipient outcomes. J Thorac Cardiovasc Surg. 2004 Jan; 127(1):114-22. View in: PubMed

Potential role for antiangiogenic proteins in the myocardial infarction repair process. J Surg Res. 2004 Jan; 116(1):156-64. View in: PubMed

Determinants of quality of life changes among long-term cardiac transplant survivors: results from longitudinal data. J Heart Lung Transplant. 2003 Oct; 22(10):1157-67. View in: PubMed

Evidence for recipient derived fibroblast recruitment and activation during the development of chronic cardiac allograft rejection. Transplantation. 2003 Aug 15; 76(3):609-14. View in: PubMed

Depopulated vena caval homograft: a new venous conduit. J Thorac Cardiovasc Surg. 2003 Aug; 126(2):498-503. View in: PubMed

Living lobar transplantation. Chest Surg Clin N Am. 2003 Aug; 13(3):505-24. View in: PubMed

Photopheresis for the prevention and treatment of transplant rejection. J Cutan Med Surg. 2003 Jul-Aug; 7(4 Suppl):18-9. View in: PubMed

The PORTEL registry: overview and selected findings. Prog Transplant. 2003 Jun; Suppl:3-13; quiz 16-7. View in: PubMed

Migration of mesenchymal stem cells to heart allografts during chronic rejection. Transplantation. 2003 Mar 15; 75(5):679-85. View in: PubMed

Thoracic transplantation. Am J Transplant. 2003; 3 Suppl 4:91-102. View in: PubMed

Does lung growth occur when mature lobes are transplanted into children? Pediatr Transplant. Does lung growth occur when mature lobes are transplanted into children? Pediatr Transplant. 2002 Dec; 6(6):500-4. View in: PubMed

Hyperinflation resulting in hemodynamic collapse following living donor lobar transplantation. Anesthesiology. 2002 Nov; 97(5):1315-7. View in: PubMed

Vascular endothelial cell apoptosis induced by anti-donor non-MHC antibodies: a possible injury pathway contributing to chronic allograft rejection. J Heart Lung Transplant. 2002 Nov; 21(11):1174-87. View in: PubMed

Life satisfaction and adverse effects in renal transplant recipients: a longitudinal analysis. Clin Transplant. 2002 Apr; 16(2):113-21. View in: PubMed

Dyspnea lusoria: compression of the pulmonary artery by a Kommerell's diverticulum. Ann Thorac Surg. 2002 Jan; 73(1):312-3. View in: PubMed

The effect of pleural adhesions on pediatric cystic fibrosis patients undergoing lung transplantation. Am Surg. 2001 Dec; 67(12):1136-9. View in: PubMed

Current status of heart and lung transplantation. Transplant Proc. 2001 Nov-Dec; 33(7-8):3564-5. View in: PubMed

Living donor lung transplantation: selection, technique, and outcome. Transplant Proc. 2001 Nov-Dec; 33(7-8):3527-32. View in: PubMed

Life satisfaction in renal transplant recipients: preliminary results from the transplant learning center. Am J Kidney Dis. 2001 Sep; 38(3):580-7. View in: PubMed

Regional topical hypothermia of the beating heart: preservation of function and tissue. Ann Thorac Surg. 2001 Sep; 72(3):804-9. View in: PubMed

Suggested guidelines for the use of tacrolimus in cardiac transplant recipients. J Heart Lung Transplant. 2001 Jul; 20(7):734-8. View in: PubMed

A novel paracorporeal method for isolated rodent lung reperfusion. Transplantation. 2001 May 15; 71(9):1244-8. View in: PubMed

Bronchiolitis obliterans is not the primary cause of death in pediatric living donor lobar lung transplant recipients. J Heart Lung Transplant. 2001 May; 20(5):491-6. View in: PubMed

Building a clinical cardiothoracic surgical program: a multi-institutional model. J Thorac Cardiovasc Surg. 2001 Apr; 121(4 Suppl):S8-11. View in: PubMed

Mechanical cardiac support 2000: current applications and future trial design: June 15-16, 2000 Bethesda, Maryland. Circulation. 2001 Jan 16; 103(2):337-42. View in: PubMed

Mechanical cardiac support 2000: current applications and future trial design. June 15-16, 2000 Bethesda, Maryland. J Am Coll Cardiol. 2001 Jan; 37(1):340-70. View in: PubMed

Consensus statement on the live organ donor. JAMA. 2000 Dec 13; 284(22):2919-26. View in: PubMed

Modulation of pulmonary NA+ pump gene expression during cold storage and reperfusion. Transplantation. 2000 Oct 15; 70(7):1016-20. View in: PubMed

Platelet activating factor acetylhydrolase decreases lung reperfusion injury. Ann Thorac Surg 2000 Aug; 70(2!:423-8. View in: PubMed

Platelet activating factor acetylhydrolase decreases lung reperfusion injury. Ann Thorac Surg. 2000 Aug; 70(2):423-8. View in: PubMed

Prophylactic photopheresis and chronic rejection: effects on graft intimal hyperplasia in cardiac transplantation. Clin Transplant. 2000 Apr; 14(2):162-6. View in: PubMed

Comparison of outcomes between living donor and cadaveric lung transplantation in children. Ann Thorac Surg. 1999 Dec; 68(6):2279-83; discussion 2283-4. View in: PubMed

Addition of a water-soluble alpha-tocopherol analogue to University of Wisconsin solution improves endothelial viability and decreases lung reperfusion injury. J Surg Res. 1999 Sep; 86(1):145-9. View in: PubMed

Sirolimus (rapamycin) potentiates cyclosporine in prevention of acute lung rejection. J Thorac Cardiovasc Surg. 1999 Apr; 117(4):714-8. View in: PubMed

A randomized, multicenter comparison of tacrolimus and cyclosporine immunosuppressive regimens in cardiac transplantation: decreased hyperlipidemia and hypertension with tacrolimus. J Heart Lung Transplant. 1999 Apr; 18(4):336-45. View in: PubMed

A comparison of the new preservation solution Celsior to Euro-Collins and University of Wisconsin solutions in lung reperfusion injury. Transplantation. 1999 Jan 15; 67(1):152-5. View in: PubMed

Photopheresis for the prevention of rejection in cardiac transplantation. Photopheresis Transplantation Study Group. N Engl J Med. 1998 Dec 10; 339(24):1744-51. View in: PubMed

Living donor lobar lung transplantation: the pediatric experience. Pediatr Transplant. 1998 Aug; 2(3):185-90. View in: PubMed

Recipient and donor outcomes in living related and unrelated lobar transplantation. Transplant Proc. 1998 Aug; 30(5):2261-3. View in: PubMed

Photopheresis in transplantation: future research and directions. Transplant Proc. 1998 Aug; 30(5):2248-50. View in: PubMed

Addition of aprotinin to organ preservation solutions decreases lung reperfusion injury. Ann Thorac Surg. 1998 Jul; 66(1):225-30. View in: PubMed

Addition of a mast cell stabilizing compound to organ preservation solutions decreases lung reperfusion injury. J Thorac Cardiovasc Surg. 1998 Mar; 115(3):631-6; discussion 636-7. View in: PubMed

Experience with living-donor lobar transplantation for indications other than cystic fibrosis. J Thorac Cardiovasc Surg. 1997 Dec; 114(6):917-21; discussion 921-2. View in: PubMed

Living donor lobar lung transplants and HLA matching: a preliminary report. Transplant Proc. 1997 Feb-Mar; 29(1-2):1418-9. View in: PubMed

A new organ preservation solution, Celsior, is superior to Euro-Collins and University of Wisconsin solutions in decreasing lung reperfusion injury. Transplant Proc. 1997 Feb-Mar; 29(1-2):1357-8. View in: PubMed

Living-donor lobar lung transplantation experience: intermediate results. J Thorac Cardiovasc Surg. 1996 Nov; 112(5):1284-90; discussion 1290-1. View in: PubMed

Bilateral lobar transplantation utilizing living related donors. Artif Organs. 1996 Oct; 20(10):1110-1. View in: PubMed

Immunomodulation in transplantation with photopheresis. Artif Organs. 1996 Aug; 20(8):971-3. View in: PubMed

Safe application of diagnostic laparoscopy during biventricular assistance. Ann Thorac Surg. 1996 Feb; 61(2):735-7. View in: PubMed

Prophylactic photopheresis and effect on graft atherosclerosis in cardiac transplantation. Transplant Proc. 1995 Jun; 27(3):1993-4. View in: PubMed

Living-related lobar transplantation: recipient outcome and early rejection patterns. Transplant Proc. 1995 Jun; 27(3):1995-6. View in: PubMed

Surgical management of cardiac pheochromocytoma. Resection versus transplantation. Ann Surg. 1995 Apr; 221(4):415-9. View in: PubMed

Increased early mortality in women undergoing cardiac transplantation. Circulation. 1995 Feb 15; 91(4):1029-35. View in: PubMed

Living-related lobar transplantation: recipient outcome and early rejection patterns. Transplaft Proc. 1995 Juf; 27(3):1995-6. 4/prns:informatignResourceReferefce>. View in: PubMed

Lobar transplantation. Indications, technique, and outcome. J Thorac Cardiovasc Surg. 1994 Sep; 108(3):403-10; discussion 410-1. View in: PubMed

Influence of HLA mismatch on rejection after heart transplantation: a multiinstitutional study. The Cardiac Transplant Research Database Group. J Heart Lung Transplant. 1994 Jul-Aug; 13(4):583-95; discussion 595-6. View in: PubMed

Living-related donor lobectomy for bilateral lobar transplantation in patients with cystic fibrosis. Ann Thorac Surg. 1994 Jun; 57(6):1423-7; discussion 1428. View in: PubMed

Myocardial perfusion scintigraphy in heart transplant recipients with and without allograft atherosclerosis: a comparison of thallium-201 and technetium 99m sestamibi. J Heart Lung Transplant. 1994 Mar-Apr; 13(2):173-80. View in: PubMed

Posttransplantation lymphoproliferative disorders treated with cyclophosphamide-doxorubicin-vincristine-prednisone chemotherapy. Cancer. 1993 Nov 01; 72(9):2782-5. View in: PubMed

Pediatric lung transplantation. Semin Pediatr Surg. 1993 Nov; 2(4):279-88. View in: PubMed

Posttransplantation lymphoproliferative disorders treated with cyclophosphamide-doxorubicin-vincristine-prednisone chemotherapy. Cancer. 1993 Nov 1; 72(9):2782-5. View in: PubMed

Clinical experience with cardiac retransplantation. J Thorac Cardiovasc Surg. 1993 Oct; 106(4):622-9; discussion 629-31. View in: PubMed

Management of lymphoproliferative disorders after cardiac transplantation. Ann Thorac Surg. 1993 Sep; 56(3):527-38. View in: PubMed

Effect of anti-HLA antibodies on the long-term survival of heart and kidney allografts. Transplant Proc. 1993 Feb; 25(1 Pt 1):262-4. View in: PubMed

Effect of recipient gender and race on heart and kidney allograft survival. Transplant Proc. 1992 Dec; 24(6):2670-1. View in: PubMed

Effect of anti-HLA and anti-idiotypic antibodies on the long-term survival of heart and kidney allografts. Transplant Proc. 1992 Dec; 24(6):2494-5. View in: PubMed

Effect of complete cardiac denervation on atrial natriuretic factor release in baboons. J Surg Res. 1992 Jul; 53(1):43-7. View in: PubMed

Photochemotherapy in human heart transplant recipients at high risk for fatal rejection. J Heart Lung Transplant. 1992 Jul-Aug; 11(4 Pt 1):746-50. View in: PubMed

Relation of HLA antibodies and graft atherosclerosis in human cardiac allograft recipients. J Heart Lung Transplant. 1992 May-Jun; 11(3 Pt 2):S120-3. View in: PubMed

Predictors of survival after repeat heart transplantation. The Registry of the International Society for Heart and Lung Transplantation, and Contributing Investigators. J Heart Lung Transplant. 1992 May-Jun; 11(3 Pt 2):S142-58. View in: PubMed

Alternative splicing of the mRNA encoding the human cholesteryl ester transfer protein. Biochemistry. 1992 Mar 3; 31(8):2352-8. View in: PubMed

Alternative splicing of the mRNA encoding the human cholesteryl ester transfer protein. Biochemistry. 1992 Mar 03; 31(8):2352-8. View in: PubMed

University of Wisconsin solution versus crystalloid cardioplegia for human donor heart preservation. A randomized blinded prospective clinical trial. J Thorac Cardiovasc Surg. 1992 Feb; 103(2):194-8; discussion 198-9. View in: PubMed

Beta-adrenergic receptor sensitivity and guanine nucleotide regulatory proteins in transplanted human hearts and autotransplanted baboons. Transplantation. 1991 Dec; 52(6):960-6. View in: PubMed

University of Wisconsin solution for human donor heart preservation: initial clinical experience. Ann Thorac Surg. 1991 Dec; 52(6):1213-6. View in: PubMed

Improved heart preservation with University of Wisconsin solution: experimental and preliminary human experience. Circulation. 1991 Nov; 84(5 Suppl):III324-8. View in: PubMed

Anti-CD3 monoclonal antibody induction therapy. Immunological equivalency with triple-drug therapy in heart transplantation. Circulation. 1990 Nov; 82(5 Suppl):IV291-4. View in: PubMed

Humoral immune responses after cardiac transplantation: correlation with fatal rejection and graft atherosclerosis. Surgery. 1989 Aug; 106(2):203-7; discussion 207-8. View in: PubMed

LTC4, thromboxane B2 and 6-keto PGF1 in syngeneic and allogenic heterotopic cardiac transplant in rats. Transplant Proc. 1989 Feb; 21(1 Pt 1):442. View in: PubMed

Acute reoxygenation injury in the isolated rat heart: role of resident cardiac mast cells. Circ Res. 1988 Dec; 63(6):1044-52. View in: PubMed

Powered bySC CTSI