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Michele T. Pato, MD
Clinical Professor of Psychiatry & The Behavioral Sciences (Part Time)
Psychiatry and The Behavioral Sciences
CSC-2200 2250 Alcazar Street Health Sciences Campus Los Angeles
+1 323 442 4000


Michele Pato, MD is Professor and Associate Chair for Education, Della Martin Chair in Psychiatry and Associate Dean for Academic Scholarship at the Keck School of Medicine, Department of Psychiatry at the University of Southern California (USC). She is the Principal Investigator of the Genomic Psychiatry Cohort, developed clinical trials in pharmacologic and cognitive behavioral treatments of psychiatric illnesses, and teaches students and colleagues how to teach research and clinical skills. Dr. Pato is internationally known for her genetic research, OCD clinical research and teaching. She is the Co-Director of the OCD Treatment and Research Program at Keck School of Medicine, USC.


Rare Copy Number Variants in NRXN1 and CNTN6 Increase Risk for Tourette Syndrome. Neuron. 2017 Jun 21; 94(6):1101-1111. e7. View in: PubMed

Association Between Substance Use Disorder and Polygenic Liability to Schizophrenia. Biol Psychiatry. 2017 Jun 06. View in: PubMed

The Role of Regional Conferences in Research Resident Career Development: The California Psychiatry Research Resident Retreat. Acad Psychiatry. 2017 Apr; 41(2):272-277. View in: PubMed

Genetic correlation between smoking behaviors and schizophrenia. Schizophr Res. 2017 Mar 08. View in: PubMed

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects. Nat Genet. 2017 Jan; 49(1):27-35. View in: PubMed

A Randomized Controlled Trial of Team-Based Learning Versus Lectures with Break-Out Groups on Knowledge Retention. Acad Psychiatry. 2016 Oct; 40(5):755-60. View in: PubMed

A reference panel of 64,976 haplotypes for genotype imputation. Nat Genet. 2016 Oct; 48(10):1279-83. View in: PubMed

Parental age effects on odor sensitivity in healthy subjects and schizophrenia patients. Am J Med Genet B Neuropsychiatr Genet. 2016 Jun; 171(4):513-20. View in: PubMed

Nicotine dependence and psychosis in Bipolar disorder and Schizoaffective disorder, Bipolar type. Am J Med Genet B Neuropsychiatr Genet. 2016 Jun; 171(4):521-4. View in: PubMed

Symptoms of psychosis in schizophrenia, schizoaffective disorder, and bipolar disorder: A comparison of African Americans and Caucasians in the Genomic Psychiatry Cohort. Am J Med Genet B Neuropsychiatr Genet. 2016 Jun; 171(4):546-55. View in: PubMed

LINE1 insertions as a genomic risk factor for schizophrenia: Preliminary evidence from an affected family. Am J Med Genet B Neuropsychiatr Genet. 2016 Jun; 171(4):534-45. View in: PubMed

Substance use associated with short sleep duration in patients with schizophrenia or schizoaffective disorder. Am J Med Genet B Neuropsychiatr Genet. 2016 Jun; 171(4):525-33. View in: PubMed

Association of DNA Methylation Differences With Schizophrenia in an Epigenome-Wide Association Study. JAMA Psychiatry. 2016 May 01; 73(5):506-14. View in: PubMed

Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness. Am J Med Genet B Neuropsychiatr Genet. 2016 Mar; 171B(2):276-89. View in: PubMed

Paternal age effect: Replication in schizophrenia with intriguing dissociation between bipolar with and without psychosis. Am J Med Genet B Neuropsychiatr Genet. 2016 06; 171(4):495-505. View in: PubMed

New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis. Int J Epidemiol. 2015 Oct; 44(5):1706-21. View in: PubMed

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores. Am J Hum Genet. 2015 Oct 01; 97(4):576-92. View in: PubMed

Structural forms of the human amylase locus and their relationships to SNPs, haplotypes and obesity. Nat Genet. 2015 Aug; 47(8):921-5. View in: PubMed

Uncovering the hidden risk architecture of the schizophrenias: confirmation in three independent genome-wide association studies. Am J Psychiatry. 2015 Feb 01; 172(2):139-53. View in: PubMed

Family Accommodation Scale for Obsessive-Compulsive Disorder-Interviewer-Rated (FAS-IR), Brazilian Portuguese version: internal consistency, reliability, and exploratory factor analysis. Compr Psychiatry. 2015 Feb; 57:155-9. View in: PubMed

Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD. Am J Psychiatry. 2015 Jan; 172(1):82-93. View in: PubMed

Pindolol augmentation of selective serotonin reuptake inhibitors and clomipramine for the treatment of obsessive-compulsive disorder: A meta-analysis. J Pharmacol Pharmacother. 2015 Jan-Mar; 6(1):36-8. View in: PubMed

A rare functional noncoding variant at the GWAS-implicated MIR137/MIR2682 locus might confer risk to schizophrenia and bipolar disorder. Am J Hum Genet. 2014 Dec 04; 95(6):744-53. View in: PubMed

Copy number variation in obsessive-compulsive disorder and tourette syndrome: a cross-disorder study. J Am Acad Child Adolesc Psychiatry. 2014 Aug; 53(8):910-9. View in: PubMed

In reply. JAMA Psychiatry. 2014 Aug; 71(8):969. View in: PubMed

Patient and family factors associated with family accommodation in obsessive-compulsive disorder. Psychiatry Clin Neurosci. 2014 Aug; 68(8):621-30. View in: PubMed

CNV analysis in a large schizophrenia sample implicates deletions at 16p12. 1 and SLC1A1 and duplications at 1p36. 33 and CGNL1. Hum Mol Genet. 2014 Mar 15; 23(6):1669-76. View in: PubMed

Comorbidity of severe psychotic disorders with measures of substance use. JAMA Psychiatry. 2014 Mar; 71(3):248-54. View in: PubMed

Association study of 83 candidate genes for bipolar disorder in chromosome 6q selected using an evidence-based prioritization algorithm. Am J Med Genet B Neuropsychiatr Genet. 2013 Dec; 162B(8):898-906. View in: PubMed

Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genet. 2013 Oct; 9(10):e1003864. View in: PubMed

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet. 2013 Sep; 45(9):984-94. View in: PubMed

A comprehensive family-based replication study of schizophrenia genes. JAMA Psychiatry. 2013 Jun; 70(6):573-81. View in: PubMed

Journal club for faculty or residents: a model for lifelong learning and maintenance of certification. Int Rev Psychiatry. 2013 Jun; 25(3):276-83. View in: PubMed

The genomic psychiatry cohort: partners in discovery. Am J Med Genet B Neuropsychiatr Genet. 2013 Jun; 162B(4):306-12. View in: PubMed

Teaching evidence-based approaches to suicide risk assessment and prevention that enhance psychiatric training. Compr Psychiatry. 2013 Apr; 54(3):201-8. View in: PubMed

Teaching scholarly activity in psychiatric training: years 6 and 7. Acad Psychiatry. 2013 Mar 01; 37(2):82-6. View in: PubMed

What to learn and how to teach it: five years of pre-meetings for training directors in psychiatry. Acad Psychiatry. 2013 Mar 01; 37(2):76-81. View in: PubMed

Virtual patients as novel teaching tools in psychiatry. Acad Psychiatry. 2012 Sep 01; 36(5):398-400. View in: PubMed

Why I like being an academic psychiatrist. Acad Psychiatry. 2012 Sep 01; 36(5):422-7. View in: PubMed

Genetic overlap of schizophrenia and bipolar disorder in a high-density linkage survey in the Portuguese Island population. Am J Med Genet B Neuropsychiatr Genet. 2012 Jun; 159B(4):383-91. View in: PubMed

Treatment of adults with attention-deficit/hyperactivity disorder. J Am Osteopath Assoc. 2011 Nov; 111(11):610-4. View in: PubMed

Transforming residency training: a case study. Acad Psychiatry. 2011 Mar-Apr; 35(2):149-53. View in: PubMed

Genetic differences between five European populations. Hum Hered. 2010; 70(2):141-9. View in: PubMed

Perfectionism in obsessive-compulsive and eating disorders. Rev Bras Psiquiatr. 2009 Dec; 31(4):322-7. View in: PubMed

Perfectionism and eating attitudes in Portuguese students: a longitudinal study. Eur Eat Disord Rev. 2009 Sep-Oct; 17(5):390-8. View in: PubMed

Objective structured clinical interview training using a virtual human patient. Stud Health Technol Inform. 2008; 132:357-62. View in: PubMed

Perfectionism and eating attitudes in Portuguese university students. Eur Eat Disord Rev. 2007 Jul; 15(4):296-304. View in: PubMed

Teaching interested clinicians how to develop research projects. Acad Psychiatry. 2007 Mar-Apr; 31(2):168-70. View in: PubMed

Genetics of schizophrenia: recent advances. Psychopharmacol Bull. 2007; 40(4):168-77. View in: PubMed

What Do You Need to Know About Leadership? Acad Psychiatry. What Do You Need to Know About Leadership? Acad Psychiatry. 2006 Jul; 30(4):281-2. View in: PubMed

Clinical features associated with treatment response in obsessive-compulsive disorder. Compr Psychiatry. 2006 Jul-Aug; 47(4):276-81. View in: PubMed

Complete maternal uniparental isodisomy of chromosome 4 in a subject with major depressive disorder detected by high density SNP genotyping arrays. Am J Med Genet B Neuropsychiatr Genet. 2006 Jan 05; 141B(1):28-32. View in: PubMed

Genetic and post-mortem mRNA analysis of the 14-3-3 genes that encode phosphoserine/threonine-binding regulatory proteins in schizophrenia and bipolar disorder. Schizophr Res. 2005 Oct 15; 78(2-3):137-46. View in: PubMed

Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q. Am J Hum Genet. 2005 Oct; 77(4):582-95. View in: PubMed

A day in the life of an academic psychiatrist. Michele T. Pato, M. D. Acad Psychiatry. 2005 Sep-Oct; 29(4):378-9. View in: PubMed

Gene expression analysis of peripheral blood leukocytes from discordant sib-pairs with schizophrenia and bipolar disorder reveals points of convergence between genetic and functional genomic approaches. Am J Med Genet B Neuropsychiatr Genet. 2005 Jul 05; 136B(1):12-25. View in: PubMed

Genetic linkage of bipolar disorder to chromosome 6q22 is a consistent finding in Portuguese subpopulations and may generalize to broader populations. Am J Med Genet B Neuropsychiatr Genet. 2005 Apr 05; 134B(1):119-21. View in: PubMed

Association between schizophrenia and the syntaxin 1A gene. Biol Psychiatry. 2004 Jul 01; 56(1):24-9. View in: PubMed

Assessing the impact of population stratification on genetic association studies. Nat Genet. 2004 Apr; 36(4):388-93. View in: PubMed

Nonparametric linkage analysis between schizophrenia and candidate genes of dopaminergic and serotonergic systems. CNS Spectr. 2004 Apr; 9(4):302-8. View in: PubMed

Taking some unnatural steps: "improvements to complex systems do not occur naturally". Acad Psychiatry. 2004; 28(4):351-3. View in: PubMed

From genomics to proteomics: new directions in molecular neuropsychiatry. Acta Neuropsychiatr. 2003 Dec; 15(6):388-97. View in: PubMed

Efficacy of clozapine in the treatment of atypical antipsychotic refractory schizophrenia: a pilot study. J Clin Psychopharmacol. 2003 Feb; 23(1):103-4. View in: PubMed

Treatment non-response in OCD: methodological issues and operational definitions. Int J Neuropsychopharmacol. 2002 Jun; 5(2):181-91. View in: PubMed

Recent findings in the genetics of OCD. J Clin Psychiatry. 2002; 63 Suppl 6:30-3. View in: PubMed

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