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Muller Fabbri, MD
Assistant Professor of Pediatrics
CHL MailStop57 Off Campus Los Angeles
+1 323 361 8920


PRAS40 Connects Microenvironmental Stress Signaling to Exosome-Mediated Secretion. Mol Cell Biol. 2017 Oct 01; 37(19). View in: PubMed

Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells. J Biol Chem. 2017 Aug 25; 292(34):14279. View in: PubMed

Cancer-derived exosomic microRNAs shape the immune system within the tumor microenvironment: State of the art. Semin Cell Dev Biol. 2017 Jul; 67:23-28. View in: PubMed

Exosomal MicroRNAs in Breast Cancer towards Diagnostic and Therapeutic Applications. Cancers (Basel). 2017 Jun 24; 9(7). View in: PubMed

Serum miR-29a Is Upregulated in Acute Graft-versus-Host Disease and Activates Dendritic Cells through TLR Binding. J Immunol. 2017 Mar 15; 198(6):2500-2512. View in: PubMed

Large-scale isolation and cytotoxicity of extracellular vesicles derived from activated human natural killer cells. J Extracell Vesicles. 2017; 6(1):1294368. View in: PubMed

Contribution of neuroblastoma-derived exosomes to the production of pro-tumorigenic signals by bone marrow mesenchymal stromal cells. J Extracell Vesicles. 2017; 6(1):1332941. View in: PubMed

Cellular and viral microRNAs in sepsis: mechanisms of action and clinical applications. Cell Death Differ. 2016 Dec; 23(12):1906-1918. View in: PubMed

Combining Anti-Mir-155 with Chemotherapy for the Treatment of Lung Cancers. Clin Cancer Res. 2016 Nov 30. View in: PubMed

The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis. Gut. 2016 Jun; 65(6):977-989. View in: PubMed

Essential role of miRNAs in orchestrating the biology of the tumor microenvironment. Mol Cancer. 2016 May 26; 15(1):42. View in: PubMed

Exosome-mediated transfer of microRNAs within the tumor microenvironment and neuroblastoma resistance to chemotherapy. J Natl Cancer Inst. 2015 Jul; 107(7). View in: PubMed

B-cell precursor acute lymphoblastic leukemia and stromal cells communicate through Galectin-3. Oncotarget. 2015 May 10; 6(13):11378-94. View in: PubMed

Exosomic microRNAs in the Tumor Microenvironment. Front Med (Lausanne). 2015; 2:47. View in: PubMed

microRNAs in the tumor microenvironment: solving the riddle for a better diagnostics. Expert Rev Mol Diagn. 2014 Jun; 14(5):565-74. View in: PubMed

MicroRNAs and dendritic cell-based vaccination in melanoma patients. Melanoma Res. 2014 Jun; 24(3):181-9. View in: PubMed

MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer. Cancer Cell. 2014 Apr 14; 25(4):469-83. View in: PubMed

MicroRNAs and other non-coding RNAs as targets for anticancer drug development. Nat Rev Drug Discov. 2013 Nov; 12(11):847-65. View in: PubMed

Reciprocal effects of Toll-like receptors and miRNAs on biological processes in human health and disease: a systematic review. Immunotherapy. 2013 Oct; 5(10):1127-42. View in: PubMed

MicroRNAs as lung cancer biomarkers and key players in lung carcinogenesis. Clin Biochem. 2013 Jul; 46(10-11):918-25. View in: PubMed

Toll-like receptor 3 (TLR3) activation induces microRNA-dependent reexpression of functional RARß and tumor regression. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9812-7. View in: PubMed

MicroRNAs and cancer: towards a personalized medicine. Curr Mol Med. 2013 Jun; 13(5):751-6. View in: PubMed

Insights into the epigenetic mechanisms controlling pancreatic carcinogenesis. Cancer Lett. 2013 Jan 28; 328(2):212-21. View in: PubMed

Heat shock protein 70 regulates Tcl1 expression in leukemia and lymphomas. Blood. 2013 Jan 10; 121(2):351-9. View in: PubMed

Epigenetic regulation of miRNAs in cancer. Adv Exp Med Biol. 2013; 754:137-48. View in: PubMed

Epigenetic therapy in lung cancer. Front Oncol. 2013; 3:135. View in: PubMed

A mathematical model for microRNA in lung cancer. PLoS One. 2013; 8(1):e53663. View in: PubMed

TLRs as miRNA receptors. Cancer Res. 2012 Dec 15; 72(24):6333-7. View in: PubMed

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):E2110-6. View in: PubMed

Strand-specific miR-28-5p and miR-28-3p have distinct effects in colorectal cancer cells. Gastroenterology. 2012 Apr; 142(4):886-896. e9. View in: PubMed

Clinical implications of microRNAs in lung cancer. Semin Oncol. 2011 Dec; 38(6):776-80. View in: PubMed

Role of microRNAs in lymphoid biology and disease. Curr Opin Hematol. 2011 Jul; 18(4):266-72. View in: PubMed

MicroRNA-125a-5p is an independent prognostic factor in gastric cancer and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab. Clin Cancer Res. 2011 May 01; 17(9):2725-33. View in: PubMed

Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia. JAMA. 2011 Jan 05; 305(1):59-67. View in: PubMed

MicroRNAs as New Characters in the Plot between Epigenetics and Prostate Cancer. Front Genet. 2011; 2:62. View in: PubMed

MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2). Proc Natl Acad Sci U S A. 2010 Dec 07; 107(49):21098-103. View in: PubMed

MicroRNAs in cancer: personalizing diagnosis and therapy. Ann N Y Acad Sci. 2010 Oct; 1210:25-33. View in: PubMed

microRNA fingerprinting of CLL patients with chromosome 17p deletion identify a miR-21 score that stratifies early survival. Blood. 2010 Aug 12; 116(6):945-52. View in: PubMed

Epigenetic alteration of microRNAs in DNMT3B-mutated patients of ICF syndrome. Epigenetics. 2010 Jul 01; 5(5):427-43. View in: PubMed

Comprehensive miRNA profiling of surgically staged endometrial cancer. Am J Obstet Gynecol. 2010 Jun; 202(6):656. e1-8. View in: PubMed

Beyond genomics: interpreting the 93% of the human genome that does not encode proteins. Curr Opin Drug Discov Devel. 2010 May; 13(3):350-8. View in: PubMed

miRNAs as molecular biomarkers of cancer. Expert Rev Mol Diagn. 2010 May; 10(4):435-44. View in: PubMed

Reprogramming of miRNA networks in cancer and leukemia. Genome Res. 2010 May; 20(5):589-99. View in: PubMed

Modulation of mismatch repair and genomic stability by miR-155. Proc Natl Acad Sci U S A. 2010 Apr 13; 107(15):6982-7. View in: PubMed

Epigenetics and miRNAs in human cancer. Adv Genet. 2010; 70:87-99. View in: PubMed

High-throughput profiling in the hematopoietic system. Methods Mol Biol. 2010; 667:79-91. View in: PubMed

MicroRNA 29b functions in acute myeloid leukemia. Blood. 2009 Dec 17; 114(26):5331-41. View in: PubMed

Epigenetics, miRNAs, and human cancer: a new chapter in human gene regulation. Mamm Genome. 2009 Sep-Oct; 20(9-10):573-80. View in: PubMed

Pathogenetic and clinical relevance of microRNAs in colorectal cancer. Cancer Genomics Proteomics. 2009 Jul-Aug; 6(4):195-204. View in: PubMed

MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1. Blood. 2009 Jun 18; 113(25):6411-8. View in: PubMed

MicroRNAs and genomic variations: from Proteus tricks to Prometheus gift. Carcinogenesis. 2009 Jun; 30(6):912-7. View in: PubMed

MicroRNAs in the ontogeny of leukemias and lymphomas. Leuk Lymphoma. 2009 Feb; 50(2):160-70. View in: PubMed

MicroRNAs and cancer epigenetics. Curr Opin Investig Drugs. 2008 Jun; 9(6):583-90. View in: PubMed

Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells. J Biol Chem. 2008 May 16; 283(20):13736-44. View in: PubMed

MiR-15a and miR-16-1 cluster functions in human leukemia. Proc Natl Acad Sci U S A. 2008 Apr 01; 105(13):5166-71. View in: PubMed

MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia. Blood. 2008 Mar 15; 111(6):3183-9. View in: PubMed

MicroRNAs. Cancer J. 2008 Jan-Feb; 14(1):1-6. View in: PubMed

Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock. J Immunol. 2007 Oct 15; 179(8):5082-9. View in: PubMed

MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci U S A. 2007 Oct 02; 104(40):15805-10. View in: PubMed

Altered extracellular matrix transcript expression and protein modulation in primary Duchenne muscular dystrophy myotubes. Matrix Biol. 2007 Oct; 26(8):615-24. View in: PubMed

Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas. Cancer Cell. 2007 Sep; 12(3):215-29. View in: PubMed

Regulatory mechanisms of microRNAs involvement in cancer. Expert Opin Biol Ther. 2007 Jul; 7(7):1009-19. View in: PubMed

WWOX expression in different histologic types and subtypes of non-small cell lung cancer. Clin Cancer Res. 2007 Feb 01; 13(3):884-91. View in: PubMed

Inhibition of breast cancer cell growth in vitro and in vivo: effect of restoration of Wwox expression. Clin Cancer Res. 2007 Jan 01; 13(1):268-74. View in: PubMed

MicroRNA expression and function in cancer. Trends Mol Med. 2006 Dec; 12(12):580-7. View in: PubMed

A role for the WWOX gene in prostate cancer. Cancer Res. 2006 Jul 01; 66(13):6477-81. View in: PubMed

MicroRNAs and leukemias: how strong is the connection? Leuk Res. MicroRNAs and leukemias: how strong is the connection? Leuk Res. 2006 Jun; 30(6):653-5. View in: PubMed

A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med. 2005 Oct 27; 353(17):1793-801. View in: PubMed

miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A. 2005 Sep 27; 102(39):13944-9. View in: PubMed

MicroRNA gene expression deregulation in human breast cancer. Cancer Res. 2005 Aug 15; 65(16):7065-70. View in: PubMed

WWOX gene restoration prevents lung cancer growth in vitro and in vivo. Proc Natl Acad Sci U S A. 2005 10 25; 102(43):15611-6. View in: PubMed

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