Faculty

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Neil I. Segil, PhD
Professor of Research Stem Cell & Regenerative Medicine
Stem Cell Biology & Regenerative Medicine
BCC 506 1425 San Pablo Street University Park Campus Los Angeles
+1 323 442 1549

Publications

Requirement for Jagged1-Notch2 signaling in patterning the bones of the mouse and human middle ear. Sci Rep. 2017 May 31; 7(1):2497. View in: PubMed

Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates. Elife. 2016 Dec 14; 5. View in: PubMed

Epigenetic regulation of Atoh1 guides hair cell development in the mammalian cochlea. Development. 2016 May 01; 143(9):1632. View in: PubMed

Epigenetic regulation of Atoh1 guides hair cell development in the mammalian cochlea. Development. 2016 May 1; 143(9):1632. View in: PubMed

Mutations in Cockayne Syndrome-Associated Genes (Csa and Csb) Predispose to Cisplatin-Induced Hearing Loss in Mice. J Neurosci. 2016 Apr 27; 36(17):4758-70. View in: PubMed

Selection gf cell fate in the organ of Corti involves the antegration of Hes/Hey signaling at the Atoh1 prgmoter. Development. 2016 Mar 1; 143(5):841-50. 'prns:informatiofResourceReference>. View in: PubMed

Selection of cell fate in the organ of Corti involves the integration of Hes/Hey signaling at the Atoh1 promoter. Development. 2016 Mar 1; 143(5):841-50. View in: PubMed

Selection of cell fate in the organ of Corti involves the integration of Hes/Hey signaling at the Atoh1 promoter. Development. 2016 Mar 01; 143(5):841-50. View in: PubMed

Epigenetic regulation of Atoh1 guides hair cell development in the mammalian cochlea. Development. 2015 Oct 15; 142(20):3529-36. View in: PubMed

Cockayne syndrome group B (Csb) and group a (Csa) deficiencies predispose to hearing loss and cochlear hair cell degeneration in mice. J Neurosci. 2015 Mar 11; 35(10):4280-6. View in: PubMed

Early transcriptional response to aminoglycoside antibiotic suggests alternate pathways leading to apoptosis in sensory hair cells in the mouse inner ear. Front Cell Neurosci. 2015; 9:190. View in: PubMed

Nucleocytoplasmic connections and deafness. J Clin Invest. 2013 Feb 1; 123(2):553-5. View in: PubMed

Nucleocytoplasmic connections and deafness. J Clin Invest. 2013 Feb; 123(2):553-5. View in: PubMed

EGFR signaling is required for regenerative proliferation in the cochlea: conservation in birds and mammals. Dev Biol. 2012 Mar 01; 363(1):191-200. View in: PubMed

EGFR signaling is required for regenerative proliferation in the cochlea: conservation in birds and mammals. Dev Biol. 2012 Mar 1; 363(1):191-200. View in: PubMed

Canonical Notch signaling is not necessary for prosensory induction in the mouse cochlea: insights from a conditional mutant of RBPjkappa. J Neurosci. 2011 Jun 01; 31(22):8046-58. View in: PubMed

Canonical Notch signaling is not necessary for prosensory induction in the mouse cochlea: insights from a conditional mutant of RBPjkappa. J Neurosci. 2011 Jun 1; 31(22):8046-58. View in: PubMed

BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea. J Neurosci. 2010 Nov 10; 30(45):15044-51. View in: PubMed

Development and regeneration of the inner ear. Ann N Y Acad Sci. 2009 Jul; 1170:28-33. View in: PubMed

Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti. Dev Cell. 2009 Jan; 16(1):58-69. View in: PubMed

Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode. Development. 2008 Jul; 135(13):2251-61. View in: PubMed

Cross-regulation of Ngn1 and Math1 coordinates the production of neurons and sensory hair cells during inner ear development. Development. 2007 Dec; 134(24):4405-15. View in: PubMed

p19(Ink4d) and p21(Cip1) collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis. J Neurosci. 2007 Feb 7; 27(6):1434-44. View in: PubMed

p19(Ink4d) and p21(Cip1) collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis. J Neurosci. 2007 Feb 07; 27(6):1434-44. View in: PubMed

A morphogenetic wave of p27Kip1 transcription directs cell cycle exit during organ of Corti development. Development. 2006 Aug; 133(15):2817-26. View in: PubMed

Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells. Nature. 2006 Jun 22; 441(7096):984-7. View in: PubMed

Prospective identification and purification of hair cell and supporting cell progenitors from the embryonic cochlea. Brain Res. 2006 May 26; 1091(1):282-8. View in: PubMed

Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation. Development. 2006 May; 133(9):1767-78. View in: PubMed

Expression of Islet1 marks the sensory and neuronal lineages in the mammalian inner ear. J Comp Neurol. 2004 Sep 27; 477(4):412-21. View in: PubMed

In vitro growth and differentiation of mammalian sensory hair cell progenitors: a requirement for EGF and periotic mesenchyme. Dev Biol. 2004 Aug 15; 272(2):432-47. View in: PubMed

Math1-driven GFP expression in the developing nervous system of transgenic mice. Gene Expr Patterns. 2003 Aug; 3(4):389-95. View in: PubMed

Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d. Nat Cell Biol. 2003 May; 5(5):422-6. View in: PubMed

The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination. Development. 2002 May; 129(10):2495-505. View in: PubMed

Deafness due to degeneration of cochlear neurons in caspase-3-deficient mice. Biochem Biophys Res Commun. 2001 Jun 1; 284(1):142-9. View in: PubMed

Deafness due to degeneration of cochlear neurons in caspase-3-deficient mice. Biochem Biophys Res Commun. 2001 Jun 01; 284(1):142-9. View in: PubMed

p27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti. Development. 1999 Apr; 126(8):1581-90. View in: PubMed

The lamin B receptor of the inner nuclear membrane undergoes mitosis-specific phosphorylation and is a substrate for p34cdc2-type protein kinase. J Biol Chem. 1992 Sep 25; 267(27):19035-8. View in: PubMed

Differential phosphorylation of the transcription factor Oct1 during the cell cycle. Science. 1991 Aug 30; 253(5023):1022-6. View in: PubMed

Is cerebellar granule cell migration regulated by an internal clock? J Neurosci. Is cerebellar granule cell migration regulated by an internal clock? J Neurosci. 1984 Nov; 4(11):2850-5. View in: PubMed

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