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Paul Marjoram, PhD
Professor Of Research Preventive Medicine
Preventive Medicine
SSB 202V 2001 N. Soto Street Health Sciences Campus Los Angeles
+1 323 442 0111


Social effects for locomotion vary between environments in Drosophila melanogaster females. Evolution. 2017 Jul; 71(7):1765-1775. View in: PubMed

Basic reversal-learning capacity in flies suggests rudiments of complex cognition. PLoS One. 2017; 12(8):e0181749. View in: PubMed

Translating natural genetic variation to gene expression in a computational model of the Drosophila gap gene regulatory network. PLoS One. 2017; 12(9):e0184657. View in: PubMed

Early mutation bursts in colorectal tumors. PLoS One. 2017; 12(3):e0172516. View in: PubMed

GWASeq: targeted re-sequencing follow up to GWAS. BMC Genomics. 2016 Mar 03; 17:176. View in: PubMed

al3c: high-performance software for parameter inference using Approximate Bayesian Computation. Bioinformatics. 2015 Nov 01; 31(21):3549-51. View in: PubMed

Many private mutations originate from the first few divisions of a human colorectal adenoma. J Pathol. 2015 Nov; 237(3):355-62. View in: PubMed

Exact likelihood-free Markov chain Monte Carlo for elliptically contoured distributions. Stat Appl Genet Mol Biol. 2015 Aug; 14(4):317-32. View in: PubMed

A Bayesian Approach to Social Structure Uncovers Cryptic Regulation of Group Dynamics in Drosophila melanogaster. Am Nat. 2015 Jun; 185(6):797-808. View in: PubMed

A Big Bang model of human colorectal tumor growth. Nat Genet. 2015 Mar; 47(3):209-16. View in: PubMed

Simulation-based Bayesian Analysis of Complex Data. Summer Comput Simul Conf (2015). 2015 Dec; 47(10):176-183. View in: PubMed

Ancestral inference in tumors: how much can we know? J Theor Biol. Ancestral inference in tumors: how much can we know? J Theor Biol. 2014 Oct 21; 359:136-45. View in: PubMed

Native American ancestry is associated with severe diabetic retinopathy in Latinos. Invest Ophthalmol Vis Sci. 2014 Aug 21; 55(9):6041-5. View in: PubMed

Post-GWAS: where next? More samples, more SNPs or more biology? Heredity (Edinb). Post-GWAS: where next? Heredity (Edinb). 2014 Jan; 112(1):79-88. View in: PubMed

Approximation Bayesian Computation. OA Genet. 2013 May 01; 1(3):853. View in: PubMed

A genome-wide association study of central corneal thickness in Latinos. Invest Ophthalmol Vis Sci. 2013 Apr 01; 54(4):2435-43. View in: PubMed

A sample selection strategy for next-generation sequencing. Genet Epidemiol. 2012 Nov; 36(7):696-709. View in: PubMed

A filtering strategy identifies FOXQ1 as a potential effector of lamin A dysfunction. Aging (Albany NY). 2012 Aug; 4(8):567-77. View in: PubMed

In this special issue of the Journal of Computational Biology, we take great pleasure in celebrating the landmark birthdays of two leaders in our field. J Comput Biol. 2012 Jun; 19(6):575-6. View in: PubMed

Exact coalescent simulation of new haplotype data from existing reference haplotypes. Bioinformatics. 2012 Mar 15; 28(6):838-44. View in: PubMed

Genotype Imputation for Latinos Using the HapMap and 1000 Genomes Project Reference Panels. Front Genet. 2012; 3:117. View in: PubMed

Inference of population mutation rate and detection of segregating sites from next-generation sequence data. Genetics. 2011 Oct; 189(2):595-605. View in: PubMed

Choice of summary statistic weights in approximate Bayesian computation. Stat Appl Genet Mol Biol. 2011 Sep 27; 10(1). View in: PubMed

The gene expression profile of cardia intestinal metaplasia is similar to that of Barrett's esophagus, not gastric intestinal metaplasia. Dis Esophagus. 2011 Sep; 24(7):516-22. View in: PubMed

Genetic variation in Native Americans, inferred from Latino SNP and resequencing data. Mol Biol Evol. 2011 Aug; 28(8):2231-7. View in: PubMed

Modeling measurement error in tumor characterization studies. BMC Bioinformatics. 2011 Jul 13; 12:284. View in: PubMed

RNA steady-state defects in myotonic dystrophy are linked to nuclear exclusion of SHARP. EMBO Rep. 2011 Jul 01; 12(7):735-42. View in: PubMed

Methods for detecting associations between phenotype and aggregations of rare variants. BMC Proc. 2011; 5 Suppl 9:S51. View in: PubMed

High DNA methylation pattern intratumoral diversity implies weak selection in many human colorectal cancers. PLoS One. 2011; 6(6):e21657. View in: PubMed

Using DNA methylation patterns to infer tumor ancestry. PLoS One. 2010 Aug 09; 5(8):e12002. View in: PubMed

Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines. Nature. 2010 Jun 03; 465(7298):627-31. View in: PubMed

Copy number variation in the Framingham Heart Study. BMC Proc. 2009 Dec 15; 3 Suppl 7:S133. View in: PubMed

Variation in genetic admixture and population structure among Latinos: the Los Angeles Latino eye study (LALES). BMC Genet. 2009 Nov 10; 10:71. View in: PubMed

Critical role of nuclear calcium/calmodulin-dependent protein kinase IIdeltaB in cardiomyocyte survival in cardiomyopathy. J Biol Chem. 2009 Sep 11; 284(37):24857-68. View in: PubMed

Many colorectal cancers are "flat" clonal expansions. Cell Cycle. 2009 Jul 15; 8(14):2187-93. View in: PubMed

Inferring clonal expansion and cancer stem cell dynamics from DNA methylation patterns in colorectal cancers. Proc Natl Acad Sci U S A. 2009 Mar 24; 106(12):4828-33. View in: PubMed

Fast and flexible simulation of DNA sequence data. Genome Res. 2009 Jan; 19(1):136-42. View in: PubMed

Population genetic inference from resequencing data. Genetics. 2009 Jan; 181(1):187-97. View in: PubMed

Exploring population genetic models with recombination using efficient forward-time simulations. Genetics. 2008 Apr; 178(4):2417-27. View in: PubMed

Modeling DNA methylation in a population of cancer cells. Stat Appl Genet Mol Biol. 2008; 7(1):Article 18. View in: PubMed

Approximately sufficient statistics and bayesian computation. Stat Appl Genet Mol Biol. 2008; 7(1):Article26. View in: PubMed

Direct and acute cardiotoxicity of ultrafine particles in young adult and old rat hearts. Basic Res Cardiol. 2007 Nov; 102(6):467-75. View in: PubMed

Towards the molecular characterization of disease: comparison of molecular and histological analysis of esophageal epithelia. J Gastrointest Surg. 2007 Sep; 11(9):1095-104. View in: PubMed

An Arabidopsis example of association mapping in structured samples. PLoS Genet. 2007 Jan 19; 3(1):e4. View in: PubMed

Cladistic analysis of genotype data-application to GAW15 Problem 3. BMC Proc. 2007; 1 Suppl 1:S125. View in: PubMed

Genome-wide association mapping using mixed-models: application to GAW15 Problem 3. BMC Proc. 2007; 1 Suppl 1:S164. View in: PubMed

Estimating recombination rates from single-nucleotide polymorphisms using summary statistics. Genetics. 2006 Nov; 174(3):1517-28. View in: PubMed

Modern computational approaches for analysing molecular genetic variation data. Nat Rev Genet. 2006 Oct; 7(10):759-70. View in: PubMed

Inferring population parameters from single-feature polymorphism data. Genetics. 2006 Aug; 173(4):2257-67. View in: PubMed

Cluster analysis for DNA methylation profiles having a detection threshold. BMC Bioinformatics. 2006 Jul 26; 7:361. View in: PubMed

Association mapping with single-feature polymorphisms. Genetics. 2006 Jun; 173(2):1125-33. View in: PubMed

Relative influences of crossing over and gene conversion on the pattern of linkage disequilibrium in Arabidopsis thaliana. Genetics. 2006 Apr; 172(4):2441-8. View in: PubMed

Fast "coalescent" simulation. BMC Genet. 2006 Mar 15; 7:16. View in: PubMed

Fine mapping--19th century style. BMC Genet. 2005 Dec 30; 6 Suppl 1:S63. View in: PubMed

Light causes phosphorylation of nonactivated visual pigments in intact mouse rod photoreceptor cells. J Biol Chem. 2005 Dec 16; 280(50):41184-91. View in: PubMed

Genome-wide association mapping in Arabidopsis identifies previously known flowering time and pathogen resistance genes. PLoS Genet. 2005 Nov; 1(5):e60. View in: PubMed

The molecular signature of normal squamous esophageal epithelium identifies the presence of a field effect and can discriminate between patients with Barrett's esophagus and patients with Barrett's-associated adenocarcinoma. Cancer Epidemiol Biomarkers Prev. 2005 Sep; 14(9):2113-7. View in: PubMed

Statistical tests of the coalescent model based on the haplotype frequency distribution and the number of segregating sites. Genetics. 2005 Mar; 169(3):1763-77. View in: PubMed

Haplotype structure and phenotypic associations in the chromosomal regions surrounding two Arabidopsis thaliana flowering time loci. Genetics. 2004 Nov; 168(3):1627-38. View in: PubMed

Nicotine-responsive genes in cultured embryonic mouse lung buds: interaction of nicotine and superoxide dismutase. Pharmacol Res. 2004 Sep; 50(3):341-50. View in: PubMed

Estimating the rate of gene conversion on human chromosome 21. Am J Hum Genet. 2004 Sep; 75(3):386-97. View in: PubMed

A survey of current Bayesian gene mapping methods. Hum Genomics. 2004 Aug; 1(5):371-4. View in: PubMed

A multigene expression panel for the molecular diagnosis of Barrett's esophagus and Barrett's adenocarcinoma of the esophagus. Oncogene. 2004 Jun 10; 23(27):4780-8. View in: PubMed

Markov chain Monte Carlo without likelihoods. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15324-8. View in: PubMed

Age-related changes of cardiac gene expression following myocardial ischemia/reperfusion. Arch Biochem Biophys. 2003 Dec 15; 420(2):268-78. View in: PubMed

Fine-scale mapping of disease genes with multiple mutations via spatial clustering techniques. Am J Hum Genet. 2003 Dec; 73(6):1368-84. View in: PubMed

Application of Bayesian spatial statistical methods to analysis of haplotypes effects and gene mapping. Genet Epidemiol. 2003 Sep; 25(2):95-105. View in: PubMed

Brief episode of ischemia activates protective genetic program in rat heart: a gene chip study. Cardiovasc Res. 2003 Aug 01; 59(2):450-9. View in: PubMed

Gene expression profiling--a new approach in the study of myocardial ischemia. Cardiovasc Pathol. 2003 Jul-Aug; 12(4):180-5. View in: PubMed

Bayesian spatial modeling of haplotype associations. Hum Hered. 2003; 56(1-3):32-40. View in: PubMed

On a test of Depaulis and Veuille. Mol Biol Evol. 2001 Jun; 18(6):1132-3; author reply 1136-8. View in: PubMed

The effects of rate variation on ancestral inference in the coalescent. Genetics. 2000 Nov; 156(3):1427-36. View in: PubMed

The age of a unique event polymorphism. Genetics. 2000 Sep; 156(1):401-9. View in: PubMed

Analysis of germline mutation spectra at the Huntington's disease locus supports a mitotic mutation mechanism. Hum Mol Genet. 1999 Feb; 8(2):173-83. View in: PubMed

Ancestral inference from samples of DNA sequences with recombination. J Comput Biol. 1996; 3(4):479-502. View in: PubMed

Pairwise comparisons of mitochondrial DNA sequences in subdivided populations and implications for early human evolution. Genetics. 1994 Feb; 136(2):673-83. View in: PubMed

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