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Ramakrishnan Gopalakrishan
Research Associate
NRT 1450 Biggy St. Health Sciences Campus Los Angeles
+1 323 442 5771


American Society of Hematology: Abstract achievement award, 2014

Society for Free Radical Research: Travel Award, 2008

Indian Council of Medical Research: Senior Research Fellowship, 2007


Immunomodulatory drugs target IKZF1-IRF4-MYC axis in primary effusion lymphoma in a cereblon-dependent manner and display synergistic cytotoxicity with BRD4 inhibitors. Oncogene. 2016 Apr 07; 35(14):1797-810. View in: PubMed

The Anticancer Role of Capsaicin in Experimentallyinduced Lung Carcinogenesis. J Pharmacopuncture. 2015 Jun; 18(2):19-25. View in: PubMed

The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192. Sci Signal. 2014 Dec 09; 7(355):ra118. View in: PubMed

NEMO is essential for Kaposi's sarcoma-associated herpesvirus-encoded vFLIP K13-induced gene expression and protection against death receptor-induced cell death, and its N-terminal 251 residues are sufficient for this process. J Virol. 2014 Jun; 88(11):6345-54. View in: PubMed

Targeting Myc in KSHV-associated primary effusion lymphoma with BET bromodomain inhibitors. Oncogene. 2014 May 29; 33(22):2928-37. View in: PubMed

Factor VIIa binding to endothelial cell protein C receptor protects vascular barrier integrity in vivo. J Thromb Haemost. 2014 May; 12(5):690-700. View in: PubMed

Capsaicin provokes apoptosis and restricts benzo(a)pyrene induced lung tumorigenesis in Swiss albino mice. Int Immunopharmacol. 2013 Oct; 17(2):254-9. View in: PubMed

A purine scaffold HSP90 inhibitor BIIB021 has selective activity against KSHV-associated primary effusion lymphoma and blocks vFLIP K13-induced NF-?B. A purine scaffold HSP90 inhibitor BIIB021 has selective activity against KSHV-associated primary effusion lymphoma and blocks vFLIP K13-induced NF-? B. Clin Cancer Res. 2013 Sep 15; 19(18):5016-26. View in: PubMed

Dietary supplementation of silymarin is associated with decreased cell proliferation, increased apoptosis, and activation of detoxification system in hepatocellular carcinoma. Mol Cell Biochem. 2013 May; 377(1-2):163-76. View in: PubMed

Capsaicin inhibits benzo(a)pyrene-induced lung carcinogenesis in an in vivo mouse model. Inflamm Res. 2012 Nov; 61(11):1169-75. View in: PubMed

Influence of endothelial cell protein C receptor on plasma clearance of factor VIIa. J Thromb Haemost. 2012 May; 10(5):971-3. View in: PubMed

Factor VIIa binding to endothelial cell protein C receptor: differences between mouse and human systems. Thromb Haemost. 2012 May; 107(5):951-61. View in: PubMed

Kaposi's sarcoma associated herpesvirus encoded viral FLICE inhibitory protein K13 activates NF-?B pathway independent of TRAF6, TAK1 and LUBAC. PLoS One. 2012; 7(5):e36601. View in: PubMed

Factor X binding to endothelial cell protein C receptor: comparison with factor VIIa and activated protein C. Blood. 2011 Sep 01; 118(9):2635-6. View in: PubMed

Constitutive NF-kappaB activation confers interleukin 6 (IL6) independence and resistance to dexamethasone and Janus kinase inhibitor INCB018424 in murine plasmacytoma cells. J Biol Chem. 2011 Aug 12; 286(32):27988-97. View in: PubMed

A20 is induced by Kaposi sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 and blocks K13-induced nuclear factor-kappaB in a negative feedback manner. J Biol Chem. 2011 Jun 17; 286(24):21555-64. View in: PubMed

Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection. Blood. 2011 Mar 17; 117(11):3199-208. View in: PubMed

Hesperidin attenuates mitochondrial dysfunction during benzo(a)pyrene-induced lung carcinogenesis in mice. Fundam Clin Pharmacol. 2011 Feb; 25(1):91-8. View in: PubMed

Modulatory effect of hesperidin on benzo(a)pyrene induced experimental lung carcinogenesis with reference to COX-2, MMP-2 and MMP-9. Eur J Pharmacol. 2010 Dec 15; 649(1-3):320-7. View in: PubMed

rFVIIa transported from the blood stream into tissues is functionally active. J Thromb Haemost. 2010 Oct; 8(10):2318-21. View in: PubMed

Bio-distribution of pharmacologically administered recombinant factor VIIa (rFVIIa). J Thromb Haemost. 2010 Feb; 8(2):301-10. View in: PubMed

Capsaicin alleviates the imbalance in xenobiotic metabolizing enzymes and tumor markers during experimental lung tumorigenesis. Mol Cell Biochem. 2009 Nov; 331(1-2):135-43. View in: PubMed

Endothelial cell protein C receptor cellular localization and trafficking: potential functional implications. Blood. 2009 Aug 27; 114(9):1974-86. View in: PubMed

Antioxidant and anticancer efficacy of hesperidin in benzo(a)pyrene induced lung carcinogenesis in mice. Invest New Drugs. 2009 Jun; 27(3):214-22. View in: PubMed

Silymarin attenuated mast cell recruitment thereby decreased the expressions of matrix metalloproteinases-2 and 9 in rat liver carcinogenesis. Invest New Drugs. 2009 Jun; 27(3):233-40. View in: PubMed

Chemopreventive task of capsaicin against benzo(a)pyrene-induced lung cancer in Swiss albino mice. Basic Clin Pharmacol Toxicol. 2009 May; 104(5):360-5. View in: PubMed

Silymarin inhibited proliferation and induced apoptosis in hepatic cancer cells. Cell Prolif. 2009 Apr; 42(2):229-40. View in: PubMed

Ameliorating effect of capsaicin on alterations in lipid metabolism during mice lung carcinoma. Arch Pharm Res. 2009 Feb; 32(2):229-34. View in: PubMed

Lysosomal abnormalities during benzo(a)pyrene-induced experimental lung carcinogenesis--defensive role of capsaicin. Fundam Clin Pharmacol. 2009 Feb; 23(1):97-103. View in: PubMed

Effect of capsaicin on glucose metabolism studied in experimental lung carcinogenesis. Nat Prod Res. 2009; 23(8):763-74. View in: PubMed

Antiproliferative potential of gallic acid against diethylnitrosamine-induced rat hepatocellular carcinoma. Mol Cell Biochem. 2008 Dec; 319(1-2):51-9. View in: PubMed

Stabilization of pulmonary mitochondrial enzyme system by capsaicin during benzo(a)pyrene induced experimental lung cancer. Biomed Pharmacother. 2008 Jul-Aug; 62(6):390-4. View in: PubMed

Beneficial influence of capsaicin on lipid peroxidation, membrane-bound enzymes and glycoprotein profile during experimental lung carcinogenesis. J Pharm Pharmacol. 2008 Jun; 60(6):803-8. View in: PubMed

Silymarin downregulates COX-2 expression and attenuates hyperlipidemia during NDEA-induced rat hepatocellular carcinoma. Mol Cell Biochem. 2008 Jun; 313(1-2):53-61. View in: PubMed

Capsaicin modulates pulmonary antioxidant defense system during benzo(a)pyrene-induced lung cancer in Swiss albino mice. Phytother Res. 2008 Apr; 22(4):529-33. View in: PubMed

The effects of quercetin on antioxidant status and tumor markers in the lung and serum of mice treated with benzo(a)pyrene. Biol Pharm Bull. 2007 Dec; 30(12):2268-73. View in: PubMed

Effect of silymarin on N-nitrosodiethylamine induced hepatocarcinogenesis in rats. Exp Oncol. 2007 Mar; 29(1):39-44. View in: PubMed

Depsipeptide a histone deacetlyase inhibitor down regulates levels of matrix metalloproteinases 2 and 9 mRNA and protein expressions in lung cancer cells (A549). Chem Biol Interact. 2007 Feb 20; 165(3):220-9. View in: PubMed

Suppression of N-nitrosodiethylamine induced hepatocarcinogenesis by silymarin in rats. Chem Biol Interact. 2006 Jun 10; 161(2):104-14. View in: PubMed

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