Faculty

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Rayudu Gopalakrishna, PhD
Associate Professor of Integrative Anatomical Sciences
Integrative Anatomical Sciences
BMT 306 A 1333 San Pablo Street Health Sciences Campus Los Angeles
+1 323 442 1770

Awards

Keck School of Medicine of USC: Outstanding Teaching Award (Year II med), 2014

Keck School of Medicine of USC: Outstanding Teaching Award (Year I med), 2014

Keck School of Medicine of USC: Outstanding Teaching Award (Year I med), 2011

Alpha Omega Alpha: Membership, 2010

Keck School of Medicine of USC: Outstanding Teaching Award (Year II med), 2008

Keck School of Medicine of USC: Master Teacher, 2008

Keck School of Medicine of USC: Outstanding Teaching Award (Year I med), 2006

Keck School of Medicine of USC: Outstanding teaching Award (year II med), 2004

Keck School of Medicine of USC: Outstanding Teaching Award (year I med), 2003

Keck School of Medicine of USC: Outstanding Teaching Award (year II med), 2000

Keck School of Medicine of USC: Outstanding Teaching Award (year II med)), 1996

Keck School of Medicine of USC: Excellence in Teaching Certificate, 1995

National Cancer Institute, NIH: FIRST Award, 1988-1993

Publications

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Counteraction of Nogo-A and axonal growth inhibitors by green tea polyphenols and other natural products. Neural Regen Res. 2016 Apr; 11(4):545-6. View in: PubMed

Polyphenols from green tea prevent antineuritogenic action of Nogo-A via 67-kDa laminin receptor and hydrogen peroxide. J Neurochem. 2015 Jan; 132(1):70-84. View in: PubMed

Green tea catechins potentiate the neuritogenic action of brain-derived neurotrophic factor: role of 67-kDa laminin receptor and hydrogen peroxide. Biochem Biophys Res Commun. 2014 Feb 28; 445(1):218-24. View in: PubMed

Methods for studying oxidative regulation of protein kinase C. Methods Enzymol. 2013; 528:79-98. View in: PubMed

Green tea polyphenols precondition against cell death induced by oxygen-glucose deprivation via stimulation of laminin receptor, generation of reactive oxygen species, and activation of protein kinase Ce. J Biol Chem. 2012 Oct 05; 287(41):34694-708. View in: PubMed

Green Tea Polyphenols Precondition against Cell Death Induced by Oxygen-Glucose Deprivation via Stimulation of Laminin Receptor, Generation of Reactive Oxygen Species, and Activation of Protein Kinase C{epsilon}. J Biol Chem. 2012 Oct 5; 287(41):34694-708. View in: PubMed

Green tea polyphenols potentiate the action of nerve growth factor to induce neuritogenesis: possible role of reactive oxygen species. J Neurosci Res. 2010 Dec; 88(16):3644-55. View in: PubMed

Negation of the cancer-preventive actions of selenium by over-expression of protein kinase Cepsilon and selenoprotein thioredoxin reductase. Carcinogenesis. 2009 Sep; 30(9):1553-61. View in: PubMed

Locally generated methylseleninic acid induces specific inactivation of protein kinase C isoenzymes: relevance to selenium-induced apoptosis in prostate cancer cells. J Biol Chem. 2008 Dec 12; 283(50):34519-31. View in: PubMed

A direct redox regulation of protein kinase C isoenzymes mediates oxidant-induced neuritogenesis in PC12 cells. J Biol Chem. 2008 May 23; 283(21):14430-44. View in: PubMed

The synthetic estrogen 4-estren-3 alpha,17 beta-diol (estren) induces estrogen-like neuroprotection. Neurobiol Dis. 2005 Jun-Jul; 19(1-2):331-9. View in: PubMed

Estrogen activates protein kinase C in neurons: role in neuroprotection. J Neurochem. 2003 Mar; 84(6):1340-8. View in: PubMed

Estrogen activates protein kinase C in neurons: role in neuroprotection. J Neurochee. 2003 Mar; 84(6):1340-8. View in: PubMed

Antioxidant regulation of protein kinase C in cancer prevention. J Nutr. 2002 Dec; 132(12):3819S-3823S. View in: PubMed

Protein kinase C as a molecular target for cancer prevention by selenocompounds. Nutr Cancer. 2001; 40(1):55-63. View in: PubMed

Protein kinase C signaling and oxidative stress. Free Radic Biol Med. 2000 May 01; 28(9):1349-61. View in: PubMed

Protein kinase C signaling and oxidative stress. Free Radic Biol Med. 2000 May 1; 28(9):1349-61. View in: PubMed

Tumor promoter benzoyl peroxide induces sulfhydryl oxidation in protein kinase C: its reversibility is related to the cellular resistance to peroxide-induced cytotoxicity. Arch Biochem Biophys. 1999 Mar 15; 363(2):246-58. View in: PubMed

Differential distribution of protein phosphatase 2A in human breast carcinoma cell lines and its relation to estrogen receptor status. Cancer Lett. 1999 Mar 1; 136(2):143-51. View in: PubMed

Differential distribution of protein phosphatase 2A in human breast carcinoma cell lines and its relation to estrogen receptor status. Cancer Lett. 1999 Mar 01; 136(2):143-51. View in: PubMed

Role of protein kinase C in basal and hydrogen peroxide-stimulated NF-kappa B activation in the murine macrophage J774A. 1 cell line. Arch Biochem Biophys. 1998 Feb 01; 350(1):79-86. View in: PubMed

Role of protein kinase C in basal and hydrogen peroxide-stimulated NF-kappa B activation in the murine macrophage J774A. 1 cell line. Arch Biochem Biophys. 1998 Feb 1; 350(1):79-86. View in: PubMed

Selenocompounds induce a redox modulation of protein kinase C in the cell, compartmentally independent from cytosolic glutathione: its role in inhibition of tumor promotion. Arch Biochem Biophys. 1997 Dec 01; 348(1):37-48. View in: PubMed

Cancer-preventive selenocompounds induce a specific redox modification of cysteine-rich regions in Ca(2+)-dependent isoenzymes of protein kinase C. Arch Biochem Biophys. 1997 Dec 01; 348(1):25-36. View in: PubMed

Cancer-preventive selenocompounds induce a specific redox modification of cysteine-rich regions in Ca(2+)-dependent isoenzymes of protein kinase C. Arch Biochem Biophys. 1997 Dec 1; 348(1):25-36. View in: PubMed

Selenocompounds induce a redox modulation of protein kinase C in the cell, compartmentally independent from cytosolic glutathione: its role in inhibition of tumor promotion. Arch Biochem Biophys. 1997 Dec 1; 348(1):37-48. View in: PubMed

Hypericin inhibits choroidal endothelial cell proliferation and cord formation in vitro. Curr Eye Res. 1997 Oct; 16(10):967-72. View in: PubMed

Inhibition of cellular growth and induction of apoptosis in pituitary adenoma cell lines by the protein kinase C inhibitor hypericin: potential therapeutic application. J Neurosurg. 1996 Aug; 85(2):329-34. View in: PubMed

Tamoxifen modulates protein kinase C via oxidative stress in estrogen receptor-negative breast cancer cells. J Biol Chem. 1996 Jun 7; 271(23):13504-14. View in: PubMed

Tamoxifen modulates protein kinase C via oxidative stress in estrogen receptor-negative breast cancer cells. J Biol Chem. 1996 Jun 07; 271(23):13504-14. View in: PubMed

Enhancement of radiosensitivity in human malignant glioma cells by hypericin in vitro. Clin Cancer Res. 1996 May; 2(5):843-6. View in: PubMed

Induction of intercellular adhesion molecule-1 by tumor necrosis factor-alpha through the 55-kDa receptor is dependent on protein kinase C in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 1996 Mar; 37(4):597-606. View in: PubMed

Protein kinase C and growth regulation of pituitary adenomas. Acta Neurochir Suppl. 1996; 65:22-6. View in: PubMed

Effect of linoleic acid hydroperoxide on endothelial cell calcium homeostasis and phospholipid hydrolysis. Arch Biochem Biophys. 1995 Oct 20; 323(1):97-107. View in: PubMed

Modifications of cysteine-rich regions in protein kinase C induced by oxidant tumor promoters and enzyme-specific inhibitors. Methods Enzymol. 1995; 252:132-46. View in: PubMed

Tobacco smoke tumor promoters, catechol and hydroquinone, induce oxidative regulation of protein kinase C and influence invasion and metastasis of lung carcinoma cells. Proc Natl Acad Sci U S A. 1994 Dec 06; 91(25):12233-7. View in: PubMed

Tobacco smoke tumor promoters, catechol and hydroquinone, induce oxidative regulation of protein kinase C and influence invasion and metastasis of lung carcinoma cells. Proc Natl Acad Sci U S A. 1994 Dec 6; 91(25):12233-7. View in: PubMed

Transforming growth factor-beta regulates human retinal pigment epithelial cell phagocytosis by influencing a protein kinase C-dependent pathway. Graefes Arch Clin Exp Ophthalmol. 1994 Nov; 232(11):695-701. View in: PubMed

Hypericin: a potential antiglioma therapy. Neurosurgery. 1994 Oct; 35(4):705-9; discussion 709-10. View in: PubMed

Nitric oxide and nitric oxide-generating agents induce a reversible inactivation of protein kinase C activity and phorbol ester binding. J Biol Chem. 1993 Dec 25; 268(36):27180-5. View in: PubMed

Multiwell filtration assay for rapid determination of protein phosphatase activity. Anal Biochem. 1993 Jul; 212(1):296-9. View in: PubMed

Retinoids inhibit the oxidative modification of protein kinase C induced by oxidant tumor promoters. Arch Biochem Biophys. 1993 Jan; 300(1):526-30. View in: PubMed

Nonphorbol tumor promoters okadaic acid and calyculin-A induce membrane translocation of protein kinase C. Biochem Biophys Res Commun. 1992 Dec 15; 189(2):950-7. View in: PubMed

Irreversible oxidative inactivation of protein kinase C by photosensitive inhibitor calphostin C. FEBS Lett. 1992 Dec 14; 314(2):149-54. View in: PubMed

Rapid filtration assays for protein kinase C activity and phorbol ester binding using multiwell plates with fitted filtration discs. Anal Biochem. 1992 Oct; 206(1):24-35. View in: PubMed

Reversible oxidative activation and inactivation of protein kinase C by the mitogen/tumor promoter periodate. Arch Biochem Biophys. 1991 Mar; 285(2):382-7. View in: PubMed

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