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Shou-Jiang Gao, PhD
Professor of Molecular Microbiology & Immunology
Molecular Microbiology and Immunology
NRT 5501 1450 Biggy Street Health Sciences Campus Los Angeles
+1 323 442 8028


A Critical Role of Glutamine and Asparagine ?-Nitrogen in Nucleotide Biosynthesis in Cancer Cells Hijacked by an Oncogenic Virus. MBio. 2017 Aug 15; 8(4). View in: PubMed

SIRT1 and AMPK pathways are essential for the proliferation and survival of primary effusion lymphoma cells. J Pathol. 2017 Jul; 242(3):309-321. View in: PubMed

KSHV microRNAs: Tricks of the Devil. Trends Microbiol. 2017 Mar 02. View in: PubMed

Tenovin-6 inhibits proliferation and survival of diffuse large B-cell lymphoma cells by blocking autophagy. Oncotarget. 2017 Feb 28; 8(9):14912-14924. View in: PubMed

Tenovin-6 impairs autophagy by inhibiting autophagic flux. Cell Death Dis. 2017 Feb 09; 8(2):e2608. View in: PubMed

HIV-1 Vpr Inhibits Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication by Inducing MicroRNA miR-942-5p and Activating NF-?B Signaling. HIV-1 Vpr Inhibits Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication by Inducing MicroRNA miR-942-5p and Activating NF-? B Signaling. J Virol. 2016 Oct 01; 90(19):8739-53. View in: PubMed

Zika virus update II: Recent development of animal models-Proofs of association with human pathogenesis. J Med Virol. 2016 Oct; 88(10):1657-8. View in: PubMed

LANA-Mediated Recruitment of Host Polycomb Repressive Complexes onto the KSHV Genome during De Novo Infection. PLoS Pathog. 2016 Sep; 12(9):e1005878. View in: PubMed

High Glucose Induces Reactivation of Latent Kaposi's Sarcoma-Associated Herpesvirus. J Virol. 2016 Aug 17. View in: PubMed

Zika virus: An update on epidemiology, pathology, molecular biology, and animal model. J Med Virol. 2016 Aug; 88(8):1291-6. View in: PubMed

Suppression of Kaposi's Sarcoma-Associated Herpesvirus Infection and Replication by 5'-AMP-Activated Protein Kinase. J Virol. 2016 Jul 15; 90(14):6515-25. View in: PubMed

A KSHV microRNA enhances viral latency and induces angiogenesis by targeting GRK2 to activate the CXCR2/AKT pathway. Oncotarget. 2016 May 31; 7(22):32286-305. View in: PubMed

An Oncogenic Virus Promotes Cell Survival and Cellular Transformation by Suppressing Glycolysis. PLoS Pathog. 2016 May; 12(5):e1005648. View in: PubMed

The SH3BGR/STAT3 Pathway Regulates Cell Migration and Angiogenesis Induced by a Gammaherpesvirus MicroRNA. PLoS Pathog. 2016 Apr; 12(4):e1005605. View in: PubMed

SmMYC2a and SmMYC2b played similar but irreplaceable roles in regulating the biosynthesis of tanshinones and phenolic acids in Salvia miltiorrhiza. Sci Rep. 2016 Mar 07; 6:22852. View in: PubMed

Human Mesenchymal Stem Cells of Diverse Origins Support Persistent Infection with Kaposi's Sarcoma-Associated Herpesvirus and Manifest Distinct Angiogenic, Invasive, and Transforming Phenotypes. MBio. 2016 Jan 26; 7(1):e02109-15. View in: PubMed

SIRT1-mediated downregulation of p27Kip1 is essential for overcoming contact inhibition of Kaposi's sarcoma-associated herpesvirus transformed cells. Oncotarget. 2016 11 15; 7(46):75698-75711. View in: PubMed

Posttranslational Modification of HOIP Blocks Toll-Like Receptor 4-Mediated Linear-Ubiquitin-Chain Formation. MBio. 2015 Nov 17; 6(6):e01777-15. View in: PubMed

MiRNA-891a-5p mediates HIV-1 Tat and KSHV Orf-K1 synergistic induction of angiogenesis by activating NF-?B signaling. MiRNA-891a-5p mediates HIV-1 Tat and KSHV Orf-K1 synergistic induction of angiogenesis by activating NF-? B signaling. Nucleic Acids Res. 2015 Oct 30; 43(19):9362-78. View in: PubMed

Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 4 (vIRF4) Perturbs the G1-S Cell Cycle Progression via Deregulation of the cyclin D1 Gene. J Virol. 2015 Oct 21; 90(2):1139-43. View in: PubMed

Combined transcriptome and metabolite profiling reveals that IiPLR1 plays an important role in lariciresinol accumulation in Isatis indigotica. J Exp Bot. 2015 Oct; 66(20):6259-71. View in: PubMed

TRICHOME AND ARTEMISININ REGULATOR 1 Is Required for Trichome Development and Artemisinin Biosynthesis in Artemisia annua. Mol Plant. 2015 Sep; 8(9):1396-411. View in: PubMed

A KSHV microRNA Directly Targets G Protein-Coupled Receptor Kinase 2 to Promote the Migration and Invasion of Endothelial Cells by Inducing CXCR2 and Activating AKT Signaling. PLoS Pathog. 2015 Sep; 11(9):e1005171. View in: PubMed

Screening of the Human Kinome Identifies MSK1/2-CREB1 as an Essential Pathway Mediating Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication during Primary Infection. J Virol. 2015 Sep; 89(18):9262-80. View in: PubMed

Association of Kaposi's Sarcoma-Associated Herpesvirus ORF31 with ORF34 and ORF24 Is Critical for Late Gene Expression. J Virol. 2015 Jun; 89(11):6148-54. View in: PubMed

Recombinant Murine Gamma Herpesvirus 68 Carrying KSHV G Protein-Coupled Receptor Induces Angiogenic Lesions in Mice. PLoS Pathog. 2015 Jun; 11(6):e1005001. View in: PubMed

X-3, a mangiferin derivative, stimulates AMP-activated protein kinase and reduces hyperglycemia and obesity in db/db mice. Mol Cell Endocrinol. 2015 Apr 15; 405:63-73. View in: PubMed

Gene-to-metabolite network for biosynthesis of lignans in MeJA-elicited Isatis indigotica hairy root cultures. Front Plant Sci. 2015; 6:952. View in: PubMed

Quantitative Proteomic Approach for MicroRNA Target Prediction Based on 18O/16O Labeling. Cancer Inform. 2015; 14(Suppl 5):163-173. View in: PubMed

Exploitation of the complement system by oncogenic Kaposi's sarcoma-associated herpesvirus for cell survival and persistent infection. PLoS Pathog. 2014 Sep; 10(9):e1004412. View in: PubMed

HIV-1 Nef and KSHV oncogene K1 synergistically promote angiogenesis by inducing cellular miR-718 to regulate the PTEN/AKT/mTOR signaling pathway. Nucleic Acids Res. 2014 Sep; 42(15):9862-79. View in: PubMed

Viral miRNA targeting of bicistronic and polycistronic transcripts. Curr Opin Virol. 2014 Aug; 7:66-72. View in: PubMed

Kaposi's sarcoma-associated herpesvirus K3 and K5 ubiquitin E3 ligases have stage-specific immune evasion roles during lytic replication. J Virol. 2014 Aug; 88(16):9335-49. View in: PubMed

Oncogenic herpesvirus KSHV Hijacks BMP-Smad1-Id signaling to promote tumorigenesis. PLoS Pathog. 2014 Jul; 10(7):e1004253. View in: PubMed

Activation of Kaposi's sarcoma-associated herpesvirus (KSHV) by inhibitors of class III histone deacetylases: identification of sirtuin 1 as a regulator of the KSHV life cycle. J Virol. 2014 Jun; 88(11):6355-67. View in: PubMed

Inhibition of Kaposi's sarcoma-associated herpesvirus lytic replication by HIV-1 Nef and cellular microRNA hsa-miR-1258. J Virol. 2014 May; 88(9):4987-5000. View in: PubMed

A novel role of SIRT1 in gammaherpesvirus latency and replication. Cell Cycle. 2014; 13(21):3328-30. View in: PubMed

Viral cyclin promotes KSHV-induced cellular transformation and tumorigenesis by overriding contact inhibition. Cell Cycle. 2014; 13(5):845-58. View in: PubMed

Genomewide mapping and screening of Kaposi's sarcoma-associated herpesvirus (KSHV) 3' untranslated regions identify bicistronic and polycistronic viral transcripts as frequent targets of KSHV microRNAs. J Virol. 2014 Jan; 88(1):377-92. View in: PubMed

Biosynthesis of the active compounds of Isatis indigotica based on transcriptome sequencing and metabolites profiling. BMC Genomics. 2013 Dec 05; 14:857. View in: PubMed

The product of Kaposi's sarcoma-associated herpesvirus immediate early gene K4. 2 regulates immunoglobulin secretion and calcium homeostasis by interacting with and inhibiting pERP1. J Virol. 2013 Nov; 87(22):12069-79. View in: PubMed

Kaposi's sarcoma-associated herpesvirus induces rapid release of angiopoietin-2 from endothelial cells. J Virol. 2013 Jun; 87(11):6326-35. View in: PubMed

Accurate LC peak boundary detection for ¹6O/¹8O labeled LC-MS data. PLoS One. 2013; 8(10):e72951. View in: PubMed

KSHV microRNAs mediate cellular transformation and tumorigenesis by redundantly targeting cell growth and survival pathways. PLoS Pathog. 2013; 9(12):e1003857. View in: PubMed

Exploitation of Cellular Cytoskeletons and Signaling Pathways for Cell Entry by Kaposi's Sarcoma-Associated Herpesvirus and the Closely Related Rhesus Rhadinovirus. Pathogens. 2012 Dec; 1(2):102-27. View in: PubMed

A Kaposi's sarcoma-associated herpesvirus microRNA and its variants target the transforming growth factor ß pathway to promote cell survival. J Virol. 2012 Nov; 86(21):11698-711. View in: PubMed

Construction and manipulation of a new Kaposi's sarcoma-associated herpesvirus bacterial artificial chromosome clone. J Virol. 2012 Sep; 86(18):9708-20. View in: PubMed

Cancer angiogenesis induced by Kaposi sarcoma-associated herpesvirus is mediated by EZH2. Cancer Res. 2012 Jul 15; 72(14):3582-92. View in: PubMed

Gender differences in Kaposi's sarcoma-associated herpesvirus infection in a population with schistosomiasis in rural China. Jpn J Infect Dis. 2012 Jul; 65(4):350-3. View in: PubMed

A cluster of transcripts encoded by KSHV ORF30-33 gene locus. Virus Genes. 2012 Apr; 44(2):225-36. View in: PubMed

Direct and efficient cellular transformation of primary rat mesenchymal precursor cells by KSHV. J Clin Invest. 2012 Mar; 122(3):1076-81. View in: PubMed

Microtubule- and dynein-dependent nuclear trafficking of rhesus rhadinovirus in rhesus fibroblasts. J Virol. 2012 Jan; 86(1):599-604. View in: PubMed

The ubiquitin/proteasome system mediates entry and endosomal trafficking of Kaposi's sarcoma-associated herpesvirus in endothelial cells. PLoS Pathog. 2012; 8(5):e1002703. View in: PubMed

A novel role of hydrogen peroxide in Kaposi sarcoma-associated herpesvirus reactivation. Cell Cycle. 2011 Oct 01; 10(19):3237-8. View in: PubMed

Reactive oxygen species hydrogen peroxide mediates Kaposi's sarcoma-associated herpesvirus reactivation from latency. PLoS Pathog. 2011 May; 7(5):e1002054. View in: PubMed

Recent advances in cloning herpesviral genomes as infectious bacterial artificial chromosomes. Cell Cycle. 2011 Feb 01; 10(3):434-40. View in: PubMed

Mechanisms of Kaposi's Sarcoma-Associated Herpesvirus Latency and Reactivation. Adv Virol. 2011; 2011. View in: PubMed

Risk factors influencing antibody responses to Kaposi's sarcoma-associated herpesvirus latent and lytic antigens in patients under antiretroviral therapy. J Acquir Immune Defic Syndr. 2011 Jan 01; 56(1):83-90. View in: PubMed

A Bayesian approach for identifying miRNA targets by combining sequence prediction and gene expression profiling. BMC Genomics. 2010 Dec 01; 11 Suppl 3:S12. View in: PubMed

Robust inference of the context specific structure and temporal dynamics of gene regulatory network. BMC Genomics. 2010 Dec 01; 11 Suppl 3:S11. View in: PubMed

Rhesus rhadinovirus infection of rhesus fibroblasts occurs through clathrin-mediated endocytosis. J Virol. 2010 Nov; 84(22):11709-17. View in: PubMed

Improving performance of mammalian microRNA target prediction. BMC Bioinformatics. 2010 Sep 22; 11:476. View in: PubMed

Regulation of herpesvirus lifecycle by viral microRNAs. Virulence. 2010 Sep-Oct; 1(5):433-5. View in: PubMed

MicroRNAs control herpesviral dormancy. Cell Cycle. 2010 Apr 01; 9(7):1225-6. View in: PubMed

Autoexcision of bacterial artificial chromosome facilitated by terminal repeat-mediated homologous recombination: a novel approach for generating traceless genetic mutants of herpesviruses. J Virol. 2010 Mar; 84(6):2871-80. View in: PubMed

Regulation of NF-kappaB inhibitor IkappaBalpha and viral replication by a KSHV microRNA. Nat Cell Biol. 2010 Feb; 12(2):193-9. View in: PubMed

FLIP-mediated autophagy regulation in cell death control. Nat Cell Biol. 2009 Nov; 11(11):1355-62. View in: PubMed

Seroprevalence of Kaposi's sarcoma-associated herpesvirus and risk factors in Xinjiang, China. J Med Virol. 2009 Aug; 81(8):1422-31. View in: PubMed

Actin dynamics regulate multiple endosomal steps during Kaposi's sarcoma-associated herpesvirus entry and trafficking in endothelial cells. PLoS Pathog. 2009 Jul; 5(7):e1000512. View in: PubMed

Enrichment constrained time-dependent clustering analysis for finding meaningful temporal transcription modules. Bioinformatics. 2009 Jun 15; 25(12):1521-7. View in: PubMed

Genome-wide identification of binding sites for Kaposi's sarcoma-associated herpesvirus lytic switch protein, RTA. Virology. 2009 Apr 10; 386(2):290-302. View in: PubMed

A sequence-independent in vitro transposon-based strategy for efficient cloning of genomes of large DNA viruses as bacterial artificial chromosomes. Nucleic Acids Res. 2009 Jan; 37(1):e2. View in: PubMed

A Bayesian Approach for Identifying miRNA Targets by Combining Sequence Prediction and Expression Profiling. Proc Int Joint Conf Bioinforma Syst Biol Intell Comput. 2009 Jan 01; 2009:185-189. View in: PubMed

Kaposi's sarcoma-associated herpesvirus disrupts adherens junctions and increases endothelial permeability by inducing degradation of VE-cadherin. J Virol. 2008 Dec; 82(23):11902-12. View in: PubMed

Angiogenesis, Kaposi's Sarcoma and Kaposi's Sarcoma-Associated Herpesvirus. Virol Sin. 2008 Dec 01; 23(6):449-458. View in: PubMed

Genetic disruption of KSHV major latent nuclear antigen LANA enhances viral lytic transcriptional program. Virology. 2008 Sep 30; 379(2):234-44. View in: PubMed

A MACHINE LEARNING APPROACH FOR miRNA TARGET PREDICTION. IEEE Int Workshop Genomic Signal Process Stat. 2008 Jun 08; 2008:1-3. View in: PubMed

Kaposi's sarcoma-associated herpesvirus latent gene vFLIP inhibits viral lytic replication through NF-kappaB-mediated suppression of the AP-1 pathway: a novel mechanism of virus control of latency. J Virol. 2008 May; 82(9):4235-49. View in: PubMed

Reactivation of Kaposi's sarcoma-associated herpesvirus from latency requires MEK/ERK, JNK and p38 multiple mitogen-activated protein kinase pathways. Virology. 2008 Feb 05; 371(1):139-54. View in: PubMed

An Iterative Time Windowed Signature Algorithm for Time Dependent Transcription Module Discovery. IEEE Int Workshop Genomic Signal Process Stat. 2008; 2008:1-4. View in: PubMed

Kaposi's sarcoma-associated herpesvirus infection promotes invasion of primary human umbilical vein endothelial cells by inducing matrix metalloproteinases. J Virol. 2007 Jul; 81(13):7001-10. View in: PubMed

Kaposi's sarcoma-associated herpesvirus promotes angiogenesis by inducing angiopoietin-2 expression via AP-1 and Ets1. J Virol. 2007 Apr; 81(8):3980-91. View in: PubMed

In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: a cell and animal model of virally induced Kaposi's sarcoma. Cancer Cell. 2007 Mar; 11(3):245-58. View in: PubMed

Targeted disruption of Kaposi's sarcoma-associated herpesvirus ORF57 in the viral genome is detrimental for the expression of ORF59, K8alpha, and K8. 1 and the production of infectious virus. J Virol. 2007 Feb; 81(3):1062-71. View in: PubMed

Molecular biology of KSHV in relation to AIDS-associated oncogenesis. Cancer Treat Res. 2007; 133:69-127. View in: PubMed

Recurrent genomic imbalances in primary effusion lymphomas. Cancer Genet Cytogenet. 2006 Dec; 171(2):119-21. View in: PubMed

Functional characterization of Kaposi's sarcoma-associated herpesvirus ORF45 by bacterial artificial chromosome-based mutagenesis. J Virol. 2006 Dec; 80(24):12187-96. View in: PubMed

Modulation of Kaposi's sarcoma-associated herpesvirus infection and replication by MEK/ERK, JNK, and p38 multiple mitogen-activated protein kinase pathways during primary infection. J Virol. 2006 Jun; 80(11):5371-82. View in: PubMed

Early and sustained expression of latent and host modulating genes in coordinated transcriptional program of KSHV productive primary infection of human primary endothelial cells. Virology. 2005 Dec 05; 343(1):47-64. View in: PubMed

Kaposi's sarcoma-associated herpesvirus induction of AP-1 and interleukin 6 during primary infection mediated by multiple mitogen-activated protein kinase pathways. J Virol. 2005 Dec; 79(24):15027-37. View in: PubMed

Envelope glycoprotein gB of Kaposi's sarcoma-associated herpesvirus is essential for egress from infected cells. J Virol. 2005 Sep; 79(17):10952-67. View in: PubMed

Detection of KSHV in transbronchial biopsies in patients with Kaposi sarcoma. Appl Immunohistochem Mol Morphol. 2005 Mar; 13(1):61-5. View in: PubMed

Lytic replication-defective Kaposi's sarcoma-associated herpesvirus: potential role in infection and malignant transformation. J Virol. 2004 Oct; 78(20):11108-20. View in: PubMed

Disruption of Kaposi's sarcoma-associated herpesvirus latent nuclear antigen leads to abortive episome persistence. J Virol. 2004 Oct; 78(20):11121-9. View in: PubMed

Kaposi's sarcoma-associated herpesvirus induction of chromosome instability in primary human endothelial cells. Cancer Res. 2004 Jun 15; 64(12):4064-8. View in: PubMed

Kaposi's sarcoma-associated herpesvirus glycoprotein K8. 1 is dispensable for virus entry. J Virol. 2004 Jun; 78(12):6389-98. View in: PubMed

The association of neoplasms and HIV infection in the correctional setting. Int J STD AIDS. 2004 May; 15(5):348-51. View in: PubMed

Productive lytic replication of a recombinant Kaposi's sarcoma-associated herpesvirus in efficient primary infection of primary human endothelial cells. J Virol. 2003 Sep; 77(18):9738-49. View in: PubMed

Identification of a novel cellular transcriptional repressor interacting with the latent nuclear antigen of Kaposi's sarcoma-associated herpesvirus. J Virol. 2003 Sep; 77(18):9758-68. View in: PubMed

Auto-activation of the transforming viral interferon regulatory factor encoded by Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8). J Gen Virol. 2003 Feb; 84(Pt 2):329-36. View in: PubMed

High prevalence of human herpesvirus 8 (HHV-8) infection in south Texas children. J Med Virol. 2002 Aug; 67(4):542-8. View in: PubMed

Characterization of an Epstein-Barr virus-related gammaherpesvirus from common marmoset (Callithrix jacchus). J Gen Virol. 2002 Jul; 83(Pt 7):1621-33. View in: PubMed

Efficient infection by a recombinant Kaposi's sarcoma-associated herpesvirus cloned in a bacterial artificial chromosome: application for genetic analysis. J Virol. 2002 Jun; 76(12):6185-96. View in: PubMed

Transcriptional regulation of Kaposi's sarcoma-associated herpesvirus-encoded oncogene viral interferon regulatory factor by a novel transcriptional silencer, Tis. J Biol Chem. 2002 Apr 05; 277(14):12023-31. View in: PubMed

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