Faculty

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Sita Reddy, PhD
Associate Professor of Biochemistry & Molecular Medicine
Medicine
HMR 702 2011 Zonal Avenue Health Sciences Campus Los Angeles
+1 323 442 2457

Publications

Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins. Cell. 2012 Aug 17; 150(4):710-24. View in: PubMed

A filtering strategy identifies FOXQ1 as a potential effector of lamin A dysfunction. Aging (Albany NY). 2012 Aug; 4(8):567-77. View in: PubMed

Lamin A, farnesylation and aging. Exp Cell Res. 2012 Jan 1; 318(1):1-7. View in: PubMed

Lamin A, farnesylation and aging. Exp Cell Res. 2012 Jan 01; 318(1):1-7. View in: PubMed

RNA splicing is responsive to MBNL1 dose. PLoS One. 2012; 7(11):e48825. View in: PubMed

Expanded CUG repeats Dysregulate RNA splicing by altering the stoichiometry of the muscleblind 1 complex. J Biol Chem. 2011 Nov 04; 286(44):38427-38. View in: PubMed

Expanded CUG repeats Dysregulate RNA splicing by altering the stoichiometry of the muscleblind 1 complex. J Biol Chem. 2011 Nov 4; 286(44):38427-38. View in: PubMed

RNA steady-state defects in myotonic dystrophy are linked to nuclear exclusion of SHARP. EMBO Rep. 2011 Jul; 12(7):735-42. View in: PubMed

RNA steady-state defects in myotonic dystrophy are linked to nuclear exclusion of SHARP. EMBO Rep. 2011 Jul 01; 12(7):735-42. View in: PubMed

Cell cycle-regulated association between the Werner syndrome protein and its molecular partners. Cell Cycle. 2011 Jun 15; 10(12):2038-40. View in: PubMed

Depletion of Ku70/80 reduces the levels of extrachromosomal telomeric circles and inhibits proliferation of ALT cells. Aging (Albany NY). 2011 Apr; 3(4):395-406. View in: PubMed

Accumulation of distinct prelamin A variants in human diploid fibroblasts differentially affects cell homeostasis. Exp Cell Res. 2011 Feb 01; 317(3):319-29. View in: PubMed

Accumulation of distinct prelamin A variants in human diploid fibroblasts differentially affects cell homeostasis. Exp Cell Res. 2011 Feb 1; 317(3):319-29. View in: PubMed

Processing of human telomeres by the Werner syndrome protein. Cell Cycle. 2010 Aug 15; 9(16):3137-8. View in: PubMed

Muscleblind-like 1 (Mbnl1) promotes insulin receptor exon 11 inclusion via binding to a downstream evolutionarily conserved intronic enhancer. J Biol Chem. 2010 Aug 13; 285(33):25426-37. View in: PubMed

Muscleblind1, but not Dmpk or Six5, contributes to a complex phenotype of muscular and motivational deficits in mouse models of myotonic dystrophy. PLoS One. 2010 Mar 25; 5(3):e9857. View in: PubMed

Muscleblind1, but not Dmpk or Six5, contributes to a complex phenotype of muscular and motivational deficits in mouse models of myotonic dystrophy. PLoS One. 2010; 5(3):e9857. View in: PubMed

Altered nuclear functions in progeroid syndromes: a paradigm for aging research. ScientificWorldJournal. 2009 Dec 16; 9:1449-62. View in: PubMed

Sequence-specific processing of telomeric 3' overhangs by the Werner syndrome protein exonuclease activity. Aging (Albany NY). 2009 Mar 17; 1(3):289-302. View in: PubMed

Sequence-specific processing of telomeric 3' overhangs by the Werner syndrome protein exonuclease activity. Aging (Albany NY). 2009 Mar; 1(3):289-302. View in: PubMed

Altered nuclear functions in progeroid syndromes: a paradigm for aging research. ScientificWorldJournal. 2009; 9:1449-62. View in: PubMed

Perturbation of wild-type lamin A metabolism results in a progeroid phenotype. Aging Cell. 2008 Jun; 7(3):355-67. View in: PubMed

WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening. Mol Cell Biol. 2008 Mar; 28(6):1892-904. View in: PubMed

Cytoplasmic CUG RNA foci are insufficient to elicit key DM1 features. PLoS One. 2008; 3(12):e3968. View in: PubMed

Role of myotonic dystrophy protein kinase (DMPK) in glucose homeostasis and muscle insulin action. PLoS One. 2007 Nov 07; 2(11):e1134. View in: PubMed

Role of myotonic dystrophy protein kinase (DMPK) in glucose homeostasis and muscle insulin action. PLoS One. 2007; 2(11):e1134. View in: PubMed

Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing. EMBO J. 2006 Sep 20; 25(18):4271-83. View in: PubMed

CK2-mediated stimulation of Pol I transcription by stabilization of UBF-SL1 interaction. Nucleic Acids Res. 2006; 34(17):4752-66. View in: PubMed

Decreased expression of DMPK: correlation with CTG repeat expansion and fibre type composition in myotonic dystrophy type 1. Neurol Sci. 2005 Oct; 26(4):235-42. View in: PubMed

Myotonia and muscle contractile properties in mice with SIX5 deficiency. Muscle Nerve. 2005 Apr; 31(4):503-5. View in: PubMed

Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum. J Biol Chem. 2005 Mar 04; 280(9):8016-21. View in: PubMed

Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum. J Biol Chem. 2005 Mar 4; 280(9):8016-21. View in: PubMed

MBNL1 is the primary determinant of focus formation and aberrant insulin receptor splicing in DM1. J Biol Chem. 2005 Feb 18; 280(7):5773-80. View in: PubMed

In situ hybridization analysis of Dmpk mRNA in adult mouse tissues. Neuromuscul Disord. 2004 Sep; 14(8-9):497-506. View in: PubMed

Six5 is required for spermatogenic cell survival and spermiogenesis. Hum Mol Genet. 2004 Jul 15; 13(14):1421-31. View in: PubMed

Abnormal Na channel gating in murine cardiac myocytes deficient in myotonic dystrophy protein kinase. Physiol Genomics. 2003 Jan 15; 12(2):147-57. View in: PubMed

Characterization of cardiac conduction system abnormalities in mice with targeted disruption of Six5 gene. J Interv Card Electrophysiol. 2002 Oct; 7(2):127-35. View in: PubMed

Effects of age and gene dose on skeletal muscle sodium channel gating in mice deficient in myotonic dystrophy protein kinase. Muscle Nerve. 2002 Jun; 25(6):850-7. View in: PubMed

Skeletal muscle Na currents in mice heterozygous for Six5 deficiency. Physiol Genomics. 2001 Aug 28; 6(3):153-8. View in: PubMed

RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1. J Biol Chem. 2001 Mar 16; 276(11):7820-6. View in: PubMed

Skeletal muscle sodium channel gating in mice deficient in myotonic dystrophy protein kinase. Hum Mol Genet. 2000 Sep 22; 9(15):2313-20. View in: PubMed

Progressive atrioventricular conduction block in a mouse myotonic dystrophy model. J Interv Card Electrophysiol. 2000 Jun; 4(2):351-8. View in: PubMed

Heterozygous loss of Six5 in mice is sufficient to cause ocular cataracts. Nat Genet. 2000 May; 25(1):110-4. View in: PubMed

Localization of the sites of conduction abnormalities in a mouse model of myotonic dystrophy. J Cardiovasc Electrophysiol. 1999 Sep; 10(9):1214-20. View in: PubMed

DMPK dosage alterations result in atrioventricular conduction abnormalities in a mouse myotonic dystrophy model. J Clin Invest. 1999 Feb; 103(4):R1-7. View in: PubMed

CTG repeats show bimodal amplification in E. coli. Cell. 1998 Nov 13; 95(4):531-40. View in: PubMed

Altered phosphorylation and intracellular distribution of a (CUG)n triplet repeat RNA-binding protein in patients with myotonic dystrophy and in myotonin protein kinase knockout mice. Proc Natl Acad Sci U S A. 1997 Nov 25; 94(24):13221-6. View in: PubMed

Mice lacking the myotonic dystrophy protein kinase develop a late onset progressive myopathy. Nat Genet. 1996 Jul; 13(3):325-35. View in: PubMed

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