Faculty

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Stephen B Gruber, MD, PhD, MPH
Professor of Medicine and Preventive Medicine
Jane & Kris Popovich Chair in Cancer Research
Medicine
NTT 4436 Health Sciences Campus Los Angeles
+1 323 865 0816

Overview

Stephen B. Gruber, M.D., Ph.D., M.P.H., Director of the USC Norris Comprehensive Cancer Center, is a Professor of Medicine at the Keck School of Medicine of the University of Southern California, and the H. Leslie Hoffman and Elaine S. Hoffman Chair in Cancer Research.

Dr. Gruber is a board certified medical oncologist, cancer geneticist and epidemiologist whose research focuses on genetic and environmental contributions to cancer. His particular research interests include the genetic epidemiology of cancer, with emphasis on colorectal cancer; the molecular pathogenesis of cancer, integrated with genetic epidemiology; methods in genetic and molecular epidemiology; and clinical cancer genetics and translational research in cancer prevention. The goal of his research is to find new ways to prevent cancer and to improve treatment and care for cancer patients.

Dr. Gruber obtained his Bachelor’s Degree from the University of Pennsylvania in 1984 and subsequently a Master of Public Health Degree from Yale University in 1986. After completing his Doctorate Degree in Epidemiology at Yale in 1988, Dr. Gruber enrolled in the University of Pennsylvania Medical School and obtained his Medical Degree in 1992, where he also completed his internship and residency. He completed fellowships in medical oncology at Johns Hopkins Hospital and in clinical medical genetics at the University of Michigan.

He has received a variety of honors and awards and is the author of 158 peer-reviewed publications, many in very high quality journals attesting to his standing in the field of cancer genetics, particularly as it relates to colorectal cancer. In addition to serving on editorial boards for several professional journals, Dr. Gruber is active in national organizations. Since 2005, he has been chair of the Colorectal Family Registries Advisory Panel for the National Cancer Institute and for the past three years chaired the Cancer Genetics Education Committee of the American Society of Clinical Oncology.

Awards

Association of American Cancer Institute: Board of Directors, 2015

Collaborative Group of the Americas on Inherited Colorectal Cancer : Lifetime Achievement Award, 2013

USC: H. Leslie and Elaine S. Hoffman Cancer Research Chair, 2012

University of Michigan: League of Research Excellence, 2011

American Society of Clinical Investigation: Elected Member, 2003

Jerome Conn Award for Excellence in Research

Penn Pearls Teaching Award

Alfred Stengel Memorial Prize

Penn Medical Scholar

National Institute of Health: Cancer Training Grant, 1986-1988

Publications

Inherited variation in circadian rhythm genes and risks of prostate cancer and three other cancer sites in combined cancer consortia. Int J Cancer. 2017 Nov 01; 141(9):1794-1802. View in: PubMed

Implementation of HPV vaccination guidelines in a diverse population in Los Angeles: Results from an environmental scan of local HPV resources and needs. Vaccine. 2017 Sep 05; 35(37):4930-4935. View in: PubMed

Quantifying the Genetic Correlation between Multiple Cancer Types. Cancer Epidemiol Biomarkers Prev. 2017 Sep; 26(9):1427-1435. View in: PubMed

Associations of MC1R genotype and patient phenotypes with BRAF and NRAS mutations in melanoma. J Invest Dermatol. 2017 Aug 22. View in: PubMed

Association of Incident Amelanotic Melanoma With Phenotypic Characteristics, MC1R Status, and Prior Amelanotic Melanoma. JAMA Dermatol. 2017 Jul 26. View in: PubMed

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer. Nat Genet. 2017 May; 49(5):680-691. View in: PubMed

Spectrum of mismatch repair gene mutations and clinical presentation of Hispanic individuals with Lynch syndrome. Cancer Genet. 2017 Apr; 212-213:1-7. View in: PubMed

Microsatellite Instability Is Common in Colorectal Cancer in Native Nigerians. Anticancer Res. 2017 05; 37(5):2649-2654. View in: PubMed

The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers. Cancer Epidemiol Biomarkers Prev. 2017 Jan; 26(1):126-135. View in: PubMed

T-Cell Transfer Therapy Targeting Mutant KRAS. N Engl J Med. 2017 02 16; 376(7):e11. View in: PubMed

Telomere structure and maintenance gene variants and risk of five cancer types. Int J Cancer. 2016 Dec 15; 139(12):2655-2670. View in: PubMed

Variants in autophagy-related genes and clinical characteristics in melanoma: a population-based study. Cancer Med. 2016 Nov; 5(11):3336-3345. View in: PubMed

Nevus count associations with pigmentary phenotype, histopathological melanoma characteristics and survival from melanoma. Int J Cancer. 2016 Sep 15; 139(6):1217-22. View in: PubMed

Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations. Cancer Res. 2016 Sep 01; 76(17):5103-14. View in: PubMed

Association between Adult Height and Risk of Colorectal, Lung, and Prostate Cancer: Results from Meta-analyses of Prospective Studies and Mendelian Randomization Analyses. PLoS Med. 2016 Sep; 13(9):e1002118. View in: PubMed

Tumor-Infiltrating Lymphocytes, Crohn's-Like Lymphoid Reaction, and Survival From Colorectal Cancer. J Natl Cancer Inst. 2016 Aug; 108(8). View in: PubMed

Association of Interferon Regulatory Factor-4 Polymorphism rs12203592 With Divergent Melanoma Pathways. J Natl Cancer Inst. 2016 Jul; 108(7). View in: PubMed

Mendelian randomization study of adiposity-related traits and risk of breast, ovarian, prostate, lung and colorectal cancer. Int J Epidemiol. 2016 Jun; 45(3):896-908. View in: PubMed

Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. Gastroenterology. 2016 Jun; 150(7):1633-1645. View in: PubMed

Increased yield of actionable mutations using multi-gene panels to assess hereditary cancer susceptibility in an ethnically diverse clinical cohort. Cancer Genet. 2016 Apr; 209(4):130-7. View in: PubMed

A novel BAP1 mutation is associated with melanocytic neoplasms and thyroid cancer. Cancer Genet. 2016 Mar; 209(3):75-81. View in: PubMed

Tests for Gene-Environment Interactions and Joint Effects With Exposure Misclassification. Am J Epidemiol. 2016 Feb 01; 183(3):237-47. View in: PubMed

Coffee Consumption and the Risk of Colorectal Cancer. Cancer Epidemiol Biomarkers Prev. 2016 04; 25(4):634-9. View in: PubMed

A Germline Variant on Chromosome 4q31. 1 Associates with Susceptibility to Developing Colon Cancer Metastasis. PLoS One. 2016; 11(1):e0146435. View in: PubMed

A Cross-Cancer Genetic Association Analysis of the DNA Repair and DNA Damage Signaling Pathways for Lung, Ovary, Prostate, Breast, and Colorectal Cancer. Cancer Epidemiol Biomarkers Prev. 2016 Jan; 25(1):193-200. View in: PubMed

Cross Cancer Genomic Investigation of Inflammation Pathway for Five Common Cancers: Lung, Ovary, Prostate, Breast, and Colorectal Cancer. J Natl Cancer Inst. 2015 Nov; 107(11). View in: PubMed

Corrigendum: genome-wide association study of colorectal cancer identifies six new susceptibility loci. Nat Commun. 2015 Oct 26; 6:8739. View in: PubMed

Genetic determinants of telomere length and risk of common cancers: a Mendelian randomization study. Hum Mol Genet. 2015 Sep 15; 24(18):5356-66. View in: PubMed

Inherited variation at MC1R and ASIP and association with melanoma-specific survival. Int J Cancer. 2015 Jun 01; 136(11):2659-67. View in: PubMed

Inherited genetic variants associated with occurrence of multiple primary melanoma. Cancer Epidemiol Biomarkers Prev. 2015 Jun; 24(6):992-7. View in: PubMed

Association Between NRAS and BRAF Mutational Status and Melanoma-Specific Survival Among Patients With Higher-Risk Primary Melanoma. JAMA Oncol. 2015 Jun; 1(3):359-68. View in: PubMed

A homozygous PMS2 founder mutation with an attenuated constitutional mismatch repair deficiency phenotype. J Med Genet. 2015 May; 52(5):348-52. View in: PubMed

The impact of exposure-biased sampling designs on detection of gene-environment interactions in case-control studies with potential exposure misclassification. Eur J Epidemiol. 2015 May; 30(5):413-23. View in: PubMed

Hereditary colorectal cancer syndromes: American Society of Clinical Oncology Clinical Practice Guideline endorsement of the familial risk-colorectal cancer: European Society for Medical Oncology Clinical Practice Guidelines. J Clin Oncol. 2015 Jan 10; 33(2):209-17. View in: PubMed

Inherited variation at MC1R and histological characteristics of primary melanoma. PLoS One. 2015; 10(3):e0119920. View in: PubMed

MicroRNA polymorphisms and risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2015 Jan; 24(1):65-72. View in: PubMed

Screening for germline mismatch repair mutations following diagnosis of sebaceous neoplasm. JAMA Dermatol. 2014 Dec; 150(12):1315-21. View in: PubMed

Comparison of clinicopathologic features and survival of histopathologically amelanotic and pigmented melanomas: a population-based study. JAMA Dermatol. 2014 Dec; 150(12):1306-314. View in: PubMed

A novel colorectal cancer risk locus at 4q32. 2 identified from an international genome-wide association study. Carcinogenesis. 2014 Nov; 35(11):2512-9. View in: PubMed

Sun exposure and melanoma survival: a GEM study. Cancer Epidemiol Biomarkers Prev. 2014 Oct; 23(10):2145-52. View in: PubMed

Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A. Nat Commun. 2014 Aug 08; 5:4613. View in: PubMed

The clinical phenotype of SDHC-associated hereditary paraganglioma syndrome (PGL3). J Clin Endocrinol Metab. 2014 Aug; 99(8):E1482-6. View in: PubMed

Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. Nat Genet. 2014 Jun; 46(6):533-42. View in: PubMed

An oncocytic adrenal tumour in a patient with Birt-Hogg-Dubé syndrome. Clin Endocrinol (Oxf). 2014 Jun; 80(6):925-7. View in: PubMed

MITF E318K's effect on melanoma risk independent of, but modified by, other risk factors. Pigment Cell Melanoma Res. 2014 May; 27(3):485-8. View in: PubMed

Cumulative exposure to medical radiation for children requiring surgery for congenital heart disease. J Pediatr. 2014 Apr; 164(4):789-794. e10. View in: PubMed

Tumor-infiltrating lymphocyte grade in primary melanomas is independently associated with melanoma-specific survival in the population-based genes, environment and melanoma study. J Clin Oncol. 2013 Nov 20; 31(33):4252-9. View in: PubMed

Transcriptome profiling identifies HMGA2 as a biomarker of melanoma progression and prognosis. J Invest Dermatol. 2013 Nov; 133(11):2585-2592. View in: PubMed

Interaction of fatty acid genotype and diet on changes in colonic fatty acids in a Mediterranean diet intervention study. Cancer Prev Res (Phila). 2013 Nov; 6(11):1212-21. View in: PubMed

Distinct molecular features of colorectal cancer in Ghana. Cancer Epidemiol. 2013 Oct; 37(5):556-61. View in: PubMed

Adrenocortical carcinoma is a lynch syndrome-associated cancer. J Clin Oncol. 2013 Aug 20; 31(24):3012-8. View in: PubMed

Survival for patients with single and multiple primary melanomas: the genes, environment, and melanoma study. JAMA Dermatol. 2013 Aug; 149(8):921-7. View in: PubMed

Elevated risk of prostate cancer among men with Lynch syndrome. J Clin Oncol. 2013 May 10; 31(14):1713-8. View in: PubMed

Inflammatory bowel disease and familial adenomatous polyposis. J Crohns Colitis. 2013 Apr; 7(3):e103-7. View in: PubMed

Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Gastroenterology. 2013 Apr; 144(4):799-807. e24. View in: PubMed

BAYESIAN SEMIPARAMETRIC ANALYSIS FOR TWO-PHASE STUDIES OF GENE-ENVIRONMENT INTERACTION. Ann Appl Stat. 2013 Mar; 7(1):543-569. View in: PubMed

Contemporary outcomes of surgical ventricular septal defect closure. J Thorac Cardiovasc Surg. 2013 Mar; 145(3):641-7. View in: PubMed

Prevalence of germline TP53 mutations in a prospective series of unselected patients with adrenocortical carcinoma. J Clin Endocrinol Metab. 2013 Jan; 98(1):E119-25. View in: PubMed

Impact of genetic testing on endometrial cancer risk-reducing practices in women at risk for Lynch syndrome. Gynecol Oncol. 2012 Dec; 127(3):544-51. View in: PubMed

MLH1 methylation screening is effective in identifying epimutation carriers. Eur J Hum Genet. 2012 Dec; 20(12):1256-64. View in: PubMed

Common MUTYH mutations and colorectal cancer risk in multiethnic populations. Fam Cancer. 2012 Sep; 11(3):329-35. View in: PubMed

MLH1 promoter hypermethylation in the analytical algorithm of Lynch syndrome: a cost-effectiveness study. Eur J Hum Genet. 2012 Jul; 20(7):762-8. View in: PubMed

Risk of non-melanoma cancers in first-degree relatives of CDKN2A mutation carriers. J Natl Cancer Inst. 2012 Jun 20; 104(12):953-6. View in: PubMed

Breast cancer phenotype in women with TP53 germline mutations: a Li-Fraumeni syndrome consortium effort. Breast Cancer Res Treat. 2012 Jun; 133(3):1125-30. View in: PubMed

An American founder mutation in MLH1. Int J Cancer. 2012 May 01; 130(9):2088-95. View in: PubMed

Clinicopathologic features of incident and subsequent tumors in patients with multiple primary cutaneous melanomas. Ann Surg Oncol. 2012 Mar; 19(3):1024-33. View in: PubMed

Familial renal cancer as an indicator of hereditary leiomyomatosis and renal cell cancer syndrome. Fam Cancer. 2012 Mar; 11(1):115-21. View in: PubMed

Testing gene-environment interaction in large-scale case-control association studies: possible choices and comparisons. Am J Epidemiol. 2012 Feb 01; 175(3):177-90. View in: PubMed

Meta-analysis of new genome-wide association studies of colorectal cancer risk. Hum Genet. 2012 Feb; 131(2):217-34. View in: PubMed

Vitamin D receptor polymorphisms in patients with cutaneous melanoma. Int J Cancer. 2012 Jan 15; 130(2):405-18. View in: PubMed

Genome-wide search for gene-gene interactions in colorectal cancer. PLoS One. 2012; 7(12):e52535. View in: PubMed

A pilot study of microsatellite instability and endometrial cancer survival in white and African American women. Int J Gynecol Pathol. 2012 Jan; 31(1):66-72. View in: PubMed

Bayesian modeling for genetic anticipation in presence of mutational heterogeneity: a case study in Lynch syndrome. Biometrics. 2011 Dec; 67(4):1627-37. View in: PubMed

Gene expression differences between colon and rectum tumors. Clin Cancer Res. 2011 Dec 01; 17(23):7303-12. View in: PubMed

Micromanaging the classification of colon cancer: the role of the microRNAome. Clin Cancer Res. 2011 Dec 01; 17(23):7207-9. View in: PubMed

Interaction of CDKN2A and sun exposure in the etiology of melanoma in the general population. J Invest Dermatol. 2011 Dec; 131(12):2500-3. View in: PubMed

Personalized oncology through integrative high-throughput sequencing: a pilot study. Sci Transl Med. 2011 Nov 30; 3(111):111ra121. View in: PubMed

Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer. PLoS Biol. 2011 Nov; 9(11):e1001199. View in: PubMed

Clinical implications of UGT1A1*28 genotype testing in colorectal cancer patients. Cancer. 2011 Jul 15; 117(14):3156-62. View in: PubMed

Missing exposure data in stereotype regression model: application to matched case-control study with disease subclassification. Biometrics. 2011 Jun; 67(2):546-58. View in: PubMed

High risk of colorectal and endometrial cancer in Ashkenazi families with the MSH2 A636P founder mutation. Gastroenterology. 2011 Jun; 140(7):1919-26. View in: PubMed

Risk of colorectal cancer in self-reported inflammatory bowel disease and modification of risk by statin and NSAID use. Cancer. 2011 Apr 15; 117(8):1640-8. View in: PubMed

AXIN2-associated autosomal dominant ectodermal dysplasia and neoplastic syndrome. Am J Med Genet A. 2011 Apr; 155A(4):898-902. View in: PubMed

MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite unstable colorectal cancers. Cancer Res. 2011 Apr 01; 71(7):2632-42. View in: PubMed

Use of bisphosphonates and reduced risk of colorectal cancer. J Clin Oncol. 2011 Mar 20; 29(9):1146-50. View in: PubMed

Hereditary prostate cancer as a feature of Lynch syndrome. Fam Cancer. 2011 Mar; 10(1):37-42. View in: PubMed

Disclosing individual CDKN2A research results to melanoma survivors: interest, impact, and demands on researchers. Cancer Epidemiol Biomarkers Prev. 2011 Mar; 20(3):522-9. View in: PubMed

Health benefits and cost-effectiveness of primary genetic screening for Lynch syndrome in the general population. Cancer Prev Res (Phila). 2011 Jan; 4(1):9-22. View in: PubMed

Higher micronutrient intake is associated with human papillomavirus-positive head and neck cancer: a case-only analysis. Nutr Cancer. 2011; 63(5):734-42. View in: PubMed

Nonsteroidal anti-inflammatory drugs and risk of melanoma. J Skin Cancer. 2011; 2011:598571. View in: PubMed

Spectrum and prevalence of FP/TMEM127 gene mutations in pheochromocytomas and paragangliomas. JAMA. 2010 Dec 15; 304(23):2611-9. View in: PubMed

Evaluation of established breast cancer risk factors as modifiers of BRCA1 or BRCA2: a multi-center case-only analysis. Breast Cancer Res Treat. 2010 Nov; 124(2):441-51. View in: PubMed

A review of statistical methods for testing genetic anticipation: looking for an answer in Lynch syndrome. Genet Epidemiol. 2010 Nov; 34(7):756-68. View in: PubMed

Head circumference in the clinical detection of PTEN hamartoma tumor syndrome in a clinic population at high-risk of breast cancer. Breast Cancer Res Treat. 2010 Nov; 124(2):459-65. View in: PubMed

MLH1 founder mutations with moderate penetrance in Spanish Lynch syndrome families. Cancer Res. 2010 Oct 01; 70(19):7379-91. View in: PubMed

Returning individual research results: development of a cancer genetics education and risk communication protocol. J Empir Res Hum Res Ethics. 2010 Sep; 5(3):17-30. View in: PubMed

Case-control studies of gene-environment interaction: Bayesian design and analysis. Biometrics. 2010 Sep; 66(3):934-48. View in: PubMed

Allele-specific expression of APC in adenomatous polyposis families. Gastroenterology. 2010 Aug; 139(2):439-47, 447. e1. View in: PubMed

Prevalence and predictors of appropriate colorectal cancer surveillance in Lynch syndrome. Am J Gastroenterol. 2010 Aug; 105(8):1851-60. View in: PubMed

Common variation in ISL1 confers genetic susceptibility for human congenital heart disease. PLoS One. 2010 May 26; 5(5):e10855. View in: PubMed

How old is this mutation? - a study of three Ashkenazi Jewish founder mutations. BMC Genet. 2010 May 14; 11:39. View in: PubMed

Genetic/familial high-risk assessment: breast and ovarian. J Natl Compr Canc Netw. 2010 May; 8(5):562-94. View in: PubMed

Human papillomavirus is not associated with colorectal cancer in a large international study. Cancer Causes Control. 2010 May; 21(5):737-43. View in: PubMed

Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer. Cancer Prev Res (Phila). 2010 May; 3(5):597-603. View in: PubMed

A case-control study of levothyroxine and the risk of colorectal cancer. J Natl Cancer Inst. 2010 Apr 21; 102(8):568-72. View in: PubMed

Smoking, gender, and ethnicity predict somatic BRAF mutations in colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2010 Mar; 19(3):838-43. View in: PubMed

Microsatellite instability in colorectal cancer-the stable evidence. Nat Rev Clin Oncol. 2010 Mar; 7(3):153-62. View in: PubMed

NCCN clinical practice guidelines in oncology. Colorectal cancer screening. J Natl Compr Canc Netw. 2010 Jan; 8(1):8-61. View in: PubMed

Calculation of risk of colorectal and endometrial cancer among patients with Lynch syndrome. Gastroenterology. 2009 Nov; 137(5):1621-7. View in: PubMed

Risk of pancreatic cancer in families with Lynch syndrome. JAMA. 2009 Oct 28; 302(16):1790-5. View in: PubMed

Use of hormone replacement therapy and the risk of colorectal cancer. J Clin Oncol. 2009 Sep 20; 27(27):4542-7. View in: PubMed

Colorectal cancer risk perception on the basis of genetic test results in individuals at risk for Lynch syndrome. J Clin Oncol. 2009 Aug 20; 27(24):3981-6. View in: PubMed

Emerging molecular technologies for identifying the risk of second cancers. Cancer Prev Res (Phila). 2009 Jul; 2(7):605-7. View in: PubMed

Pediatric duodenal cancer and biallelic mismatch repair gene mutations. Pediatr Blood Cancer. 2009 Jul; 53(1):116-20. View in: PubMed

Familial medullary thyroid carcinoma associated with cutaneous lichen amyloidosis. Thyroid. 2009 Jun; 19(6):651-5. View in: PubMed

Diagnosis and management of hereditary paraganglioma syndrome due to the F933>X67 SDHD mutation. Head Neck. 2009 May; 31(5):689-94. View in: PubMed

Pretreatment health behaviors predict survival among patients with head and neck squamous cell carcinoma. J Clin Oncol. 2009 Apr 20; 27(12):1969-75. View in: PubMed

Gene expression patterns in mismatch repair-deficient colorectal cancers highlight the potential therapeutic role of inhibitors of the phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway. Clin Cancer Res. 2009 Apr 15; 15(8):2829-39. View in: PubMed

FOXP3 germline polymorphisms are not associated with risk of breast cancer. Cancer Genet Cytogenet. 2009 Apr 01; 190(1):40-2. View in: PubMed

Breast cancer characteristics at diagnosis and survival among Arab-American women compared to European- and African-American women. Breast Cancer Res Treat. 2009 Mar; 114(2):339-46. View in: PubMed

Anticipation in lynch syndrome: still waiting for the answer. J Clin Oncol. 2009 Jan 20; 27(3):326-7. View in: PubMed

Pathologic predictors of microsatellite instability in colorectal cancer. Am J Surg Pathol. 2009 Jan; 33(1):126-33. View in: PubMed

Recreational physical activity modifies the association between a common GH1 polymorphism and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev. 2008 Dec; 17(12):3314-8. View in: PubMed

Adenoma-infiltrating lymphocytes (AILs) are a potential marker of hereditary nonpolyposis colorectal cancer. Am J Surg Pathol. 2008 Nov; 32(11):1661-6. View in: PubMed

Tests for gene-environment interaction from case-control data: a novel study of type I error, power and designs. Genet Epidemiol. 2008 Nov; 32(7):615-26. View in: PubMed

PTPRJ haplotypes and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev. 2008 Oct; 17(10):2782-5. View in: PubMed

Gynecologic malignancies in Ashkenazi families with the MSH2 A636P founder mutation. Am J Obstet Gynecol. 2008 Aug; 199(2):148. e1-3. View in: PubMed

Accounting for error due to misclassification of exposures in case-control studies of gene-environment interaction. Stat Med. 2008 Jul 10; 27(15):2756-83. View in: PubMed

Mutation screening of fumarate hydratase by multiplex ligation-dependent probe amplification: detection of exonic deletion in a patient with leiomyomatosis and renal cell cancer. Cancer Genet Cytogenet. 2008 Jun; 183(2):83-8. View in: PubMed

Accurate classification of MLH1/MSH2 missense variants with multivariate analysis of protein polymorphisms-mismatch repair (MAPP-MMR). Hum Mutat. 2008 Jun; 29(6):852-60. View in: PubMed

Quality of life scores predict survival among patients with head and neck cancer. J Clin Oncol. 2008 Jun 01; 26(16):2754-60. View in: PubMed

Inference of the haplotype effect in a matched case-control study using unphased genotype data. Int J Biostat. 2008 May 08; 4(1):Article 6. View in: PubMed

FGFR2 is a breast cancer susceptibility gene in Jewish and Arab Israeli populations. Cancer Epidemiol Biomarkers Prev. 2008 May; 17(5):1060-5. View in: PubMed

Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nat Genet. 2008 May; 40(5):631-7. View in: PubMed

Sharing genetic test results in Lynch syndrome: communication with close and distant relatives. Clin Gastroenterol Hepatol. 2008 Mar; 6(3):333-8. View in: PubMed

Genetic and genomic analysis modeling of germline c-MYC overexpression and cancer susceptibility. BMC Genomics. 2008 Jan 11; 9:12. View in: PubMed

First description of parathyroid disease in multiple endocrine neoplasia 2A syndrome. Endocr Pathol. 2008; 19(4):289-93. View in: PubMed

Health behaviors of head and neck cancer patients the first year after diagnosis. Head Neck. 2008 Jan; 30(1):93-102. View in: PubMed

Network modeling links breast cancer susceptibility and centrosome dysfunction. Nat Genet. 2007 Nov; 39(11):1338-49. View in: PubMed

Dietary intake of carotenoid isomers in Israel. Int J Vitam Nutr Res. 2007 Nov; 77(6):398-405. View in: PubMed

Genetic variation in 8q24 associated with risk of colorectal cancer. Cancer Biol Ther. 2007 Jul; 6(7):1143-7. View in: PubMed

Clinical implications of founder and recurrent CDH1 mutations in hereditary diffuse gastric cancer. JAMA. 2007 Jun 06; 297(21):2410-1. View in: PubMed

CDKN2A germline mutations in individuals with cutaneous malignant melanoma. J Invest Dermatol. 2007 May; 127(5):1234-43. View in: PubMed

The 2006 K/DOQI guidelines for peritoneal dialysis adequacy are not adequate. Blood Purif. 2007; 25(1):103-5. View in: PubMed

Population stratification in epidemiologic studies of founder populations. Cancer Biomark. 2007; 3(3):123-8. View in: PubMed

APC E1317Q is not associated with Colorectal Cancer in a population-based case-control study in Northern Israel. Cancer Epidemiol Biomarkers Prev. 2006 Nov; 15(11):2325-7. View in: PubMed

ASCO/SSO review of current role of risk-reducing surgery in common hereditary cancer syndromes. J Clin Oncol. 2006 Oct 01; 24(28):4642-60. View in: PubMed

Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway. Nat Cell Biol. 2006 Oct; 8(10):1053-63. View in: PubMed

BRAF and NRAS mutations in spitzoid melanocytic lesions. Mod Pathol. 2006 Oct; 19(10):1324-32. View in: PubMed

ASCO/SSO review of current role of risk-reducing surgery in common hereditary cancer syndromes. Ann Surg Oncol. 2006 Oct; 13(10):1296-321. View in: PubMed

Prediction of germline mutations and cancer risk in the Lynch syndrome. JAMA. 2006 Sep 27; 296(12):1479-87. View in: PubMed

Population-based study of natural variation in the melanocortin-1 receptor gene and melanoma. Cancer Res. 2006 Sep 15; 66(18):9330-7. View in: PubMed

Incidence of initial local therapy among men with lower-risk prostate cancer in the United States. J Natl Cancer Inst. 2006 Aug 16; 98(16):1134-41. View in: PubMed

Early results of single-stage biventricular repair of severe aortic hypoplasia or atresia with ventricular septal defect and normal left ventricle. J Thorac Cardiovasc Surg. 2006 Aug; 132(2):260-3. View in: PubMed

BRAF and NRAS mutations in melanoma and melanocytic nevi. Melanoma Res. 2006 Aug; 16(4):267-73. View in: PubMed

The prevalence of CDKN2A germ-line mutations and relative risk for cutaneous malignant melanoma: an international population-based study. Cancer Epidemiol Biomarkers Prev. 2006 Aug; 15(8):1520-5. View in: PubMed

A design for cancer case-control studies using only incident cases: experience with the GEM study of melanoma. Int J Epidemiol. 2006 Jun; 35(3):756-64. View in: PubMed

Frequency and spectrum of cancers in the Peutz-Jeghers syndrome. Clin Cancer Res. 2006 May 15; 12(10):3209-15. View in: PubMed

Colorectal Cancer Screening Clinical Practice Guidelines. J Natl Compr Canc Netw. 2006 Apr; 4(4):384-420. View in: PubMed

Multiple forms of genetic instability within a 2-Mb chromosomal segment of 3q26. 3-q27 are associated with development of esophageal adenocarcinoma. Genes Chromosomes Cancer. 2006 Apr; 45(4):319-31. View in: PubMed

APC I1307K and the risk of prostate cancer. Cancer Epidemiol Biomarkers Prev. 2006 Mar; 15(3):468-73. View in: PubMed

Genetics of colorectal cancer. Oncology (Williston Park). 2006 Mar; 20(3):269-76; discussion 285-6, 288-9. View in: PubMed

Polymorphisms in nucleotide excision repair genes and risk of multiple primary melanoma: the Genes Environment and Melanoma Study. Carcinogenesis. 2006 Mar; 27(3):610-8. View in: PubMed

Vulvar melanoma in a 10-year-old girl in association with lichen sclerosus. J Am Acad Dermatol. 2006 Feb; 54(2 Suppl):S52-3. View in: PubMed

New developments in Lynch syndrome (hereditary nonpolyposis colorectal cancer) and mismatch repair gene testing. Gastroenterology. 2006 Feb; 130(2):577-87. View in: PubMed

Colorectal polyps in carriers of the APC I1307K polymorphism. Dis Colon Rectum. 2005 Dec; 48(12):2317-21. View in: PubMed

Statins and cancer prevention. Nat Rev Cancer. 2005 Dec; 5(12):930-42. View in: PubMed

History and molecular genetics of Lynch syndrome in family G: a century later. JAMA. 2005 Nov 02; 294(17):2195-202. View in: PubMed

The value of small observations in the era of big science. Cancer Epidemiol Biomarkers Prev. 2005 Nov; 14(11 Pt 1):2472-3. View in: PubMed

Lifetime risk of melanoma in CDKN2A mutation carriers in a population-based sample. J Natl Cancer Inst. 2005 Oct 19; 97(20):1507-15. View in: PubMed

Low allele frequency of MLH1 D132H in American colorectal and endometrial cancer patients. Dis Colon Rectum. 2005 Sep; 48(9):1723-7. View in: PubMed

Identifying susceptibility genes for prostate cancer--a family-based association study of polymorphisms in CYP17, CYP19, CYP11A1, and LH-beta. Cancer Epidemiol Biomarkers Prev. 2005 Aug; 14(8):2035-9. View in: PubMed

CDX2 polymorphisms, RNA expression, and risk of colorectal cancer. Cancer Res. 2005 Jul 01; 65(13):5488-92. View in: PubMed

Statins and the risk of colorectal cancer. N Engl J Med. 2005 May 26; 352(21):2184-92. View in: PubMed

CDX2-regulated expression of iron transport protein hephaestin in intestinal and colonic epithelium. Gastroenterology. 2005 Apr; 128(4):946-61. View in: PubMed

Comparison of seven methods for producing Affymetrix expression scores based on False Discovery Rates in disease profiling data. BMC Bioinformatics. 2005 Feb 10; 6:26. View in: PubMed

Hyperglycemia, obesity, and cancer risks on the horizon. JAMA. 2005 Jan 12; 293(2):235-6. View in: PubMed

Endometrial cancer: socioeconomic status and racial/ethnic differences in stage at diagnosis, treatment, and survival. Am J Public Health. 2004 Dec; 94(12):2104-11. View in: PubMed

Familial aggregation of melanoma risks in a large population-based sample of melanoma cases. Cancer Causes Control. 2004 Nov; 15(9):957-65. View in: PubMed

Truncating BRCA1 mutations are uncommon in a cohort of hereditary prostate cancer families with evidence of linkage to 17q markers. Clin Cancer Res. 2004 Sep 15; 10(18 Pt 1):5975-80. View in: PubMed

The MLH1 D132H variant is associated with susceptibility to sporadic colorectal cancer. Nat Genet. 2004 Jul; 36(7):694-9. View in: PubMed

Relative frequency and morphology of cancers in STK11 mutation carriers. Gastroenterology. 2004 Jun; 126(7):1788-94. View in: PubMed

EGF gene polymorphism and the risk of incident primary melanoma. Cancer Res. 2004 Apr 15; 64(8):2668-72. View in: PubMed

Risk perception and concern among brothers of men with prostate carcinoma. Cancer. 2004 Apr 01; 100(7):1537-44. View in: PubMed

Vulvar melanoma: a report of 20 cases and review of the literature. J Am Acad Dermatol. 2004 Apr; 50(4):554-62. View in: PubMed

Merkel cell carcinoma and the controversial role of adjuvant radiation therapy: clinical choices in the absence of statistical evidence. J Am Acad Dermatol. 2004 Mar; 50(3):435-7; discussion 437-8. View in: PubMed

Use of complementary and alternative medicine in men with family history of prostate cancer: a pilot study. Urology. 2004 Feb; 63(2):282-7. View in: PubMed

BRCA1 and BRCA2 founder mutations and the risk of colorectal cancer. J Natl Cancer Inst. 2004 Jan 07; 96(1):15-21. View in: PubMed

Vulvar melanoma: review of diagnosis, staging, and therapy. J Low Genit Tract Dis. 2004 Jan; 8(1):58-69. View in: PubMed

Staging workup, sentinel node biopsy, and follow-up tests for melanoma: update of current concepts. Arch Dermatol. 2004 Jan; 140(1):107-13. View in: PubMed

Genetic anthropology of the colorectal cancer-susceptibility allele APC I1307K: evidence of genetic drift within the Ashkenazim. Am J Hum Genet. 2003 Dec; 73(6):1250-60. View in: PubMed

Accurate molecular classification of human cancers based on gene expression using a simple classifier with a pathological tree-based framework. Am J Pathol. 2003 Nov; 163(5):1985-95. View in: PubMed

Prostate cancer early detection practices among men with a family history of disease. Urology. 2003 Sep; 62(3):470-5. View in: PubMed

Cyclooxygenase 2 expression and molecular alterations in Peutz-Jeghers hamartomas and carcinomas. Clin Cancer Res. 2003 Aug 01; 9(8):3065-72. View in: PubMed

Phenotype of microsatellite unstable colorectal carcinomas: Well-differentiated and focally mucinous tumors and the absence of dirty necrosis correlate with microsatellite instability. Am J Surg Pathol. 2003 May; 27(5):563-70. View in: PubMed

R726L androgen receptor mutation is uncommon in prostate cancer families in the united states. Prostate. 2003 Mar 01; 54(4):306-9. View in: PubMed

The genetics of hereditary non-polyposis colorectal cancer. J Natl Compr Canc Netw. 2003 Jan; 1(1):137-44. View in: PubMed

BLM heterozygosity and the risk of colorectal cancer. Science. 2002 Sep 20; 297(5589):2013. View in: PubMed

Cancer risks in BRCA1 carriers: time for the next generation of studies. J Natl Cancer Inst. 2002 Sep 18; 94(18):1344-5. View in: PubMed

Small changes in expression affect predisposition to tumorigenesis. Nat Genet. 2002 Jan; 30(1):25-6. View in: PubMed

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