Faculty

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Victoria Kristence Cortessis, PhD
Associate Professor Of Clinical Preventive Medicine
Preventive Medicine
NTT 4449 1441 Eastlake Avenue Health Sciences Campus Los Angeles
+1 323 865 0544

Overview

Dr. Cortessis’ professional activities are dedicated mainly to research and teaching. Her primary scientific identity is as an epidemiologist, but her work integrates approaches from anthropology, epidemiology, human genetics and molecular biology. In her most long-standing research programs, she investigates complex etiology of urogenital malignancies and congenital disorders by implementing hypothesis-driven research at USC and by collaborating with international consortia to accelerate forms of agnostic discovery that require extraordinarily large data resources. She has recently expanded her work to address cervical cancer disparities, a topic in which her expertise in cancer etiology intersects an enduring interest in the health of underserved communities. Her teaching at undergraduate, masters and doctoral levels focuses on epidemiologic methods and epidemiologic approaches to understanding chronic disease; she also brings the perspective of population science to interdisciplinary instruction in clinical-translational research.

Publications

Comprehensive meta-analysis reveals association between multiple imprinting disorders and conception by assisted reproductive technology. J Assist Reprod Genet. 2018 Apr 25. View in: PubMed

The use of a low-literacy version of the Medicaid sterilization consent form to assess sterilization-related knowledge in Spanish-speaking women: results from a randomized controlled trial. Contraception. 2018 Mar 23. View in: PubMed

Intrauterine Device Use and Cervical Cancer Risk: A Systematic Review and Meta-analysis. Obstet Gynecol. 2017 Dec; 130(6):1226-1236. View in: PubMed

Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer. Cell. 2017 Oct 19; 171(3):540-556. e25. View in: PubMed

Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor. Nat Genet. 2017 Jul; 49(7):1141-1147. View in: PubMed

Does the type of progestin influence the production of clotting factors? Contraception. Does the type of progestin influence the production of clotting factors? Contraception. 2017 02; 95(2):113-116. View in: PubMed

Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data. PLoS Genet. 2016 Dec; 12(12):e1006493. View in: PubMed

Identification of a novel susceptibility locus at 13q34 and refinement of the 20p12. 2 region as a multi-signal locus associated with bladder cancer risk in individuals of European ancestry. Hum Mol Genet. 2016 Mar 15; 25(6):1203-14. View in: PubMed

Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types. J Natl Cancer Inst. 2015 Dec; 107(12):djv279. View in: PubMed

The Influence of Screening for Precancerous Lesions on Family-Based Genetic Association Tests: An Example of Colorectal Polyps and Cancer. Am J Epidemiol. 2015 Oct 15; 182(8):714-22. View in: PubMed

Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15. 33. Hum Mol Genet. 2014 Dec 15; 23(24):6616-33. View in: PubMed

Validation of Surveillance, Epidemiology, and End Results TNM staging for testicular germ cell tumor. Urol Oncol. 2014 Nov; 32(8):1341-6. View in: PubMed

The 19q12 bladder cancer GWAS signal: association with cyclin E function and aggressive disease. Cancer Res. 2014 Oct 15; 74(20):5808-18. View in: PubMed

Genome-wide interaction study of smoking and bladder cancer risk. Carcinogenesis. 2014 Aug; 35(8):1737-44. View in: PubMed

Comprehensive analyses of DNA repair pathways, smoking and bladder cancer risk in Los Angeles and Shanghai. Int J Cancer. 2014 Jul 15; 135(2):335-47. View in: PubMed

A meta-analysis of Hodgkin lymphoma reveals 19p13. 3 TCF3 as a novel susceptibility locus. Nat Commun. 2014 Jun 12; 5:3856. View in: PubMed

Three authors reply. Am J Epidemiol. 2014 Apr 15; 179(8):1037. View in: PubMed

Genome-wide association study identifies multiple loci associated with bladder cancer risk. Hum Mol Genet. 2014 Mar 01; 23(5):1387-98. View in: PubMed

Dietary sources of N-nitroso compounds and bladder cancer risk: findings from the Los Angeles bladder cancer study. Int J Cancer. 2014 Jan 01; 134(1):125-35. View in: PubMed

Null association between histology of first and second primary malignancies in men with bilateral testicular germ cell tumors. Am J Epidemiol. 2013 Oct 15; 178(8):1240-5. View in: PubMed

Testicular germ cell tumor susceptibility associated with the UCK2 locus on chromosome 1q23. Hum Mol Genet. 2013 Jul 01; 22(13):2748-53. View in: PubMed

Meta-analysis identifies four new loci associated with testicular germ cell tumor. Nat Genet. 2013 Jun; 45(6):680-5. View in: PubMed

Elevated 4-aminobiphenyl and 2,6-dimethylaniline hemoglobin adducts and increased risk of bladder cancer among lifelong nonsmokers--The Shanghai Bladder Cancer Study. Cancer Epidemiol Biomarkers Prev. 2013 May; 22(5):937-45. View in: PubMed

Potential impact of age at first marijuana use on the development of nonseminomatous testicular germ cell tumors. Cancer. 2013 Mar 15; 119(6):1284-5. View in: PubMed

Combination of molecular alterations and smoking intensity predicts bladder cancer outcome: a report from the Los Angeles Cancer Surveillance Program. Cancer. 2013 Feb 15; 119(4):756-65. View in: PubMed

Reducing the Excess Burden of Cervical Cancer Among Latinas: Translating Science into Health Promotion Initiatives. Calif J Health Promot. 2013; 11(1):45-57. View in: PubMed

Commentary: rapid steps forward in environmental epigenetics: implications for epidemiologic investigation of chronic disease. Int J Epidemiol. 2012 Dec; 41(6):1761-3. View in: PubMed

Population-based case-control study of recreational drug use and testis cancer risk confirms an association between marijuana use and nonseminoma risk. Cancer. 2012 Nov 01; 118(21):5374-83. View in: PubMed

Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships. Hum Genet. 2012 Oct; 131(10):1565-89. View in: PubMed

Shorter androgen receptor CAG repeat lengths associated with cryptorchidism risk among Hispanic white boys. J Clin Endocrinol Metab. 2012 Mar; 97(3):E393-9. View in: PubMed

Cigarette smoking and subtypes of bladder cancer. Int J Cancer. 2012 Feb 15; 130(4):896-901. View in: PubMed

A review of cancer in U. S. Hispanic populations. Cancer Prev Res (Phila). 2012 Feb; 5(2):150-63. View in: PubMed

A genome-wide meta-analysis of nodular sclerosing Hodgkin lymphoma identifies risk loci at 6p21. 32. Blood. 2012 Jan 12; 119(2):469-75. View in: PubMed

Cryptorchidism and testicular germ cell tumors: comprehensive meta-analysis reveals that association between these conditions diminished over time and is modified by clinical characteristics. Front Endocrinol (Lausanne). 2012; 3:182. View in: PubMed

Repeated assessment by high-throughput assay demonstrates that sperm DNA methylation levels are highly reproducible. Fertil Steril. 2011 Dec; 96(6):1325-30. View in: PubMed

Heterogenous effect of androgen receptor CAG tract length on testicular germ cell tumor risk: shorter repeats associated with seminoma but not other histologic types. Carcinogenesis. 2011 Aug; 32(8):1238-43. View in: PubMed

Lower risk in parous women suggests that hormonal factors are important in bladder cancer etiology. Cancer Epidemiol Biomarkers Prev. 2011 Jun; 20(6):1156-70. View in: PubMed

Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study. Carcinogenesis. 2011 Feb; 32(2):197-202. View in: PubMed

Risk of urinary bladder cancer is associated with 8q24 variant rs9642880[T] in multiple racial/ethnic groups: results from the Los Angeles-Shanghai case-control study. Cancer Epidemiol Biomarkers Prev. 2010 Dec; 19(12):3150-6. View in: PubMed

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Nat Genet. 2010 Nov; 42(11):978-84. View in: PubMed

Hypertension, diuretics and antihypertensives in relation to bladder cancer. Carcinogenesis. 2010 Nov; 31(11):1964-71. View in: PubMed

Sequence variant on 3q28 and urinary bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study. Cancer Epidemiol Biomarkers Prev. 2009 Nov; 18(11):3057-61. View in: PubMed

Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer. Cancer Res. 2009 Sep 01; 69(17):6857-64. View in: PubMed

Urinary tract infections and reduced risk of bladder cancer in Los Angeles. Br J Cancer. 2009 Mar 10; 100(5):834-9. View in: PubMed

Effect of cervicitis on visual inspection with acetic acid. J Low Genit Tract Dis. 2008 Oct; 12(4):282-6. View in: PubMed

Water intake and bladder cancer risk in Los Angeles County. Int J Cancer. 2008 Oct 01; 123(7):1649-56. View in: PubMed

RUNX3 methylation reveals that bladder tumors are older in patients with a history of smoking. Cancer Res. 2008 Aug 01; 68(15):6208-14. View in: PubMed

Re: Prepubertal orchiopexy for cryptorchidism may be associated with lower risk of testicular cancer. J Urol. 2008 Aug; 180(2):783-4; author reply 784-5. View in: PubMed

Analysis of the DND1 gene in men with sporadic and familial testicular germ cell tumors. Genes Chromosomes Cancer. 2008 Mar; 47(3):247-52. View in: PubMed

Widespread epigenetic abnormalities suggest a broad DNA methylation erasure defect in abnormal human sperm. PLoS One. 2007 Dec 12; 2(12):e1289. View in: PubMed

Male infertility and variation in CAG repeat length in the androgen receptor gene: a meta-analysis. J Clin Endocrinol Metab. 2007 Nov; 92(11):4319-26. View in: PubMed

Alcohol consumption and risk of bladder cancer in Los Angeles County. Int J Cancer. 2007 Aug 15; 121(4):839-45. View in: PubMed

Genome-wide linkage screen for testicular germ cell tumour susceptibility loci. Hum Mol Genet. 2006 Feb 01; 15(3):443-51. View in: PubMed

The Y deletion gr/gr and susceptibility to testicular germ cell tumor. Am J Hum Genet. 2005 Dec; 77(6):1034-43. View in: PubMed

Meat intake, cooking-related mutagens and risk of colorectal adenoma in a sigmoidoscopy-based case-control study. Carcinogenesis. 2005 Mar; 26(3):637-42. View in: PubMed

A molecular/epidemiologic analysis of expression of cyclooxygenases 1 and 2, use of nonsteroidal antiinflammatory drugs, and risk of colorectal adenoma. Clin Colorectal Cancer. 2005 Mar; 4(6):390-5. View in: PubMed

Mutation analysis of INSL3 and GREAT/LGR8 genes in familial cryptorchidism. Urology. 2004 Nov; 64(5):1032-6. View in: PubMed

Toxicokinetic genetics: an approach to gene-environment and gene-gene interactions in complex metabolic pathways. IARC Sci Publ. 2004; (157):127-50. View in: PubMed

A case-control study of cyclin D1 CCND1 870A-->G polymorphism and bladder cancer. Carcinogenesis. 2003 Oct; 24(10):1645-50. View in: PubMed

Bayesian modeling of complex metabolic pathways. Hum Hered. 2003; 56(1-3):83-93. View in: PubMed

A case-control study of microsomal epoxide hydrolase, smoking, meat consumption, glutathione S-transferase M3, and risk of colorectal adenomas. Cancer Res. 2001 Mar 15; 61(6):2381-5. View in: PubMed

Linkage analysis of DRD2, a marker linked to the ataxia-telangiectasia gene, in 64 families with premenopausal bilateral breast cancer. Cancer Res. 1993 Nov 01; 53(21):5083-6. View in: PubMed

A linkage analysis of D17S74 (CMM86) in thirty-five families with premenopausal bilateral breast cancer. Cancer Res. 1993 Jan 15; 53(2):212-4. View in: PubMed

A Gibbs sampling approach to linkage analysis. Hum Hered. 1992; 42(1):63-76. View in: PubMed

Ornithine aminotransferase (OAT): recombination between an X-linked OAT sequence (7. 5 kb) and the Norrie disease locus. Genomics. 1990 Jan; 6(1):123-8. View in: PubMed

Comparison of the affected-pedigree-member and lod-score methods. Prog Clin Biol Res. 1989; 329:135-40. View in: PubMed

Correcting for variable age of onset in the estimation of familial relative risk when there is a secular trend in incidence of disease. Hum Hered. 1986; 36(4):227-32. View in: PubMed

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