Faculty

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Wange Lu, PhD
Associate Professor of Stem Cell & Regenerative Medicine
Stem Cell Biology & Regenerative Medicine
BCC 413 1425 San Pablo Street Health Sciences Campus Los Angeles
+1 323 442 1618

Overview

Wange Lu Lab Website

Wange Lu obtained his PhD from Harvard Medical School in 1998. His PhD research focused on signal transduction in cancer cells. He then moved on to do a postdoctoral fellowship with David Baltimore, a Nobel laureate, at the California Institute of Technology. In the Baltimore lab, he began to study neuroscience. Particularly, he identified a novel non-canonical Wnt signal transduction pathway in neurons, where it plays a very important role in axon guidance and neurite outgrowth. In 2006, he moved to across town to the Keck School of Medicine of USC to set up his own lab. He extended his research to mechanisms of neural stem cell self-renewal and differentiation, iPS cell induction and neurological diseases.

Publications

Smek promotes corticogenesis through regulating Mbd3's stability and Mbd3/NuRD complex recruitment to genes associated with neurogenesis. PLoS Biol. 2017 May; 15(5):e2001220. View in: PubMed

4C-seq revealed long-range interactions of a functional enhancer at the 8q24 prostate cancer risk locus. Sci Rep. 2016 Mar 03; 6:22462. View in: PubMed

MMP-9 facilitates selective proteolysis of the histone H3 tail at genes necessary for proficient osteoclastogenesis. Genes Dev. 2016 Jan 15; 30(2):208-19. View in: PubMed

Linker histone H1. 2 establishes chromatin compaction and gene silencing through recognition of H3K27me3. Sci Rep. 2015 Nov 19; 5:16714. View in: PubMed

Derivation of induced pluripotent stem cells from orangutan skin fibroblasts. BMC Res Notes. 2015 Oct 16; 8:577. View in: PubMed

Analysis of a transgenic Oct4 enhancer reveals high fidelity long-range chromosomal interactions. Sci Rep. 2015 Oct 05; 5:14558. View in: PubMed

Induced pluripotent stem cell models of Zellweger spectrum disorder show impaired peroxisome assembly and cell type-specific lipid abnormalities. Stem Cell Res Ther. 2015 Aug 29; 6:158. View in: PubMed

Defective entry into mitosis 1 (Dim1) negatively regulates osteoclastogenesis by inhibiting the expression of nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (NFATc1). J Biol Chem. 2014 Aug 29; 289(35):24366-73. View in: PubMed

Regulation of induced pluripotent stem (iPS) cell induction by Wnt/ß-catenin signaling. J Biol Chem. 2014 Mar 28; 289(13):9221-32. View in: PubMed

Comprehensive functional annotation of 77 prostate cancer risk loci. PLoS Genet. 2014 Jan; 10(1):e1004102. View in: PubMed

Protein phosphatase 4 and Smek complex negatively regulate Par3 and promote neuronal differentiation of neural stem/progenitor cells. Cell Rep. 2013 Nov 14; 5(3):593-600. View in: PubMed

Genome organization by Klf4 regulates transcription in pluripotent stem cells. Cell Cycle. 2013 Nov 01; 12(21):3351-2. View in: PubMed

The functional genetic link of NLGN4X knockdown and neurodevelopment in neural stem cells. Hum Mol Genet. 2013 Sep 15; 22(18):3749-60. View in: PubMed

Biological implications and regulatory mechanisms of long-range chromosomal interactions. J Biol Chem. 2013 Aug 02; 288(31):22369-77. View in: PubMed

Klf4 organizes long-range chromosomal interactions with the oct4 locus in reprogramming and pluripotency. Cell Stem Cell. 2013 Jul 03; 13(1):36-47. View in: PubMed

Comparative analysis of 4C-Seq data generated from enzyme-based and sonication-based methods. BMC Genomics. 2013 May 24; 14:345. View in: PubMed

Development and specification of GABAergic cortical interneurons. Cell Biosci. 2013 Apr 23; 3(1):19. View in: PubMed

The interactomes of POU5F1 and SOX2 enhancers in human embryonic stem cells. Sci Rep. 2013; 3:1588. View in: PubMed

Functional impacts of NRXN1 knockdown on neurodevelopment in stem cell models. PLoS One. 2013; 8(3):e59685. View in: PubMed

Uncovering the link between malfunctions in Drosophila neuroblast asymmetric cell division and tumorigenesis. Cell Biosci. 2012 Nov 14; 2(1):38. View in: PubMed

Selective requirement of H2B N-Terminal tail for p14ARF-induced chromatin silencing. Nucleic Acids Res. 2011 Nov; 39(21):9167-80. View in: PubMed

Smek promotes histone deacetylation to suppress transcription of Wnt target gene brachyury in pluripotent embryonic stem cells. Cell Res. 2011 Jun; 21(6):911-21. View in: PubMed

The Wnt receptor Ryk controls specification of GABAergic neurons versus oligodendrocytes during telencephalon development. Development. 2011 Feb; 138(3):409-19. View in: PubMed

Identification of preferential target sites for human DNA methyltransferases. Nucleic Acids Res. 2011 Jan; 39(1):104-18. View in: PubMed

Comparison of reprogramming efficiency between transduction of reprogramming factors, cell-cell fusion, and cytoplast fusion. Stem Cells. 2010 Aug; 28(8):1338-48. View in: PubMed

Kruppel-like factor 4 (Klf4) prevents embryonic stem (ES) cell differentiation by regulating Nanog gene expression. J Biol Chem. 2010 Mar 19; 285(12):9180-9. View in: PubMed

A real-time pluripotency reporter for human stem cells. Stem Cells Dev. 2010 Jan; 19(1):47-52. View in: PubMed

Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming. Stem Cells. 2009 Dec; 27(12):2969-78. View in: PubMed

Cdc37 regulates Ryk signaling by stabilizing the cleaved Ryk intracellular domain. J Biol Chem. 2009 May 08; 284(19):12940-8. View in: PubMed

Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis. Dev Cell. 2008 Nov; 15(5):773-80. View in: PubMed

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