Faculty

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Wange Lu, PhD
Associate Professor of Stem Cell & Regenerative Medicine
Stem Cell Biology & Regenerative Medicine
BCC 413 1425 San Pablo Street Health Sciences Campus Los Angeles
+1 323 442 1618

Overview

Wange Lu Lab Website

Wange Lu obtained his PhD from Harvard Medical School in 1998. His PhD research focused on signal transduction in cancer cells. He then moved on to do a postdoctoral fellowship with David Baltimore, a Nobel laureate, at the California Institute of Technology. In the Baltimore lab, he began to study neuroscience. Particularly, he identified a novel non-canonical Wnt signal transduction pathway in neurons, where it plays a very important role in axon guidance and neurite outgrowth. In 2006, he moved to across town to the Keck School of Medicine of USC to set up his own lab. He extended his research to mechanisms of neural stem cell self-renewal and differentiation, iPS cell induction and neurological diseases.

Publications

. Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis Nat Commun. 2018 01 26; 9(1):401. View in: PubMed

. Smek1/2 is a nuclear chaperone and cofactor for cleaved Wnt receptor Ryk, regulating cortical neurogenesis Proc Natl Acad Sci U S A. 2017 Dec 12; 114(50):E10717-E10725. View in: PubMed

. Smek promotes corticogenesis through regulating Mbd3's stability and Mbd3/NuRD complex recruitment to genes associated with neurogenesis PLoS Biol. 2017 May; 15(5):e2001220. View in: PubMed

. 4C-seq revealed long-range interactions of a functional enhancer at the 8q24 prostate cancer risk locus Sci Rep. 2016 Mar 03; 6:22462. View in: PubMed

. MMP-9 facilitates selective proteolysis of the histone H3 tail at genes necessary for proficient osteoclastogenesis Genes Dev. 2016 Jan 15; 30(2):208-19. View in: PubMed

. Linker histone H12 establishes chromatin compaction and gene silencing through recognition of H3K27me3. Sci Rep. 2015 Nov 19; 5:16714. View in: PubMed

. Derivation of induced pluripotent stem cells from orangutan skin fibroblasts BMC Res Notes. 2015 Oct 16; 8:577. View in: PubMed

. Analysis of a transgenic Oct4 enhancer reveals high fidelity long-range chromosomal interactions Sci Rep. 2015 Oct 05; 5:14558. View in: PubMed

. Induced pluripotent stem cell models of Zellweger spectrum disorder show impaired peroxisome assembly and cell type-specific lipid abnormalities Stem Cell Res Ther. 2015 Aug 29; 6:158. View in: PubMed

. Defective entry into mitosis 1 (Dim1) negatively regulates osteoclastogenesis by inhibiting the expression of nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (NFATc1) J Biol Chem. 2014 Aug 29; 289(35):24366-73. View in: PubMed

. Regulation of induced pluripotent stem (iPS) cell induction by Wnt/ß-catenin signaling J Biol Chem. 2014 Mar 28; 289(13):9221-32. View in: PubMed

. Comprehensive functional annotation of 77 prostate cancer risk loci PLoS Genet. 2014 Jan; 10(1):e1004102. View in: PubMed

. Protein phosphatase 4 and Smek complex negatively regulate Par3 and promote neuronal differentiation of neural stem/progenitor cells Cell Rep. 2013 Nov 14; 5(3):593-600. View in: PubMed

. Genome organization by Klf4 regulates transcription in pluripotent stem cells Cell Cycle. 2013 Nov 01; 12(21):3351-2. View in: PubMed

. The functional genetic link of NLGN4X knockdown and neurodevelopment in neural stem cells Hum Mol Genet. 2013 Sep 15; 22(18):3749-60. View in: PubMed

. Biological implications and regulatory mechanisms of long-range chromosomal interactions J Biol Chem. 2013 Aug 02; 288(31):22369-77. View in: PubMed

. Klf4 organizes long-range chromosomal interactions with the oct4 locus in reprogramming and pluripotency Cell Stem Cell. 2013 Jul 03; 13(1):36-47. View in: PubMed

. Comparative analysis of 4C-Seq data generated from enzyme-based and sonication-based methods BMC Genomics. 2013 May 24; 14:345. View in: PubMed

. Development and specification of GABAergic cortical interneurons Cell Biosci. 2013 Apr 23; 3(1):19. View in: PubMed

. Functional impacts of NRXN1 knockdown on neurodevelopment in stem cell models PLoS One. 2013; 8(3):e59685. View in: PubMed

. The interactomes of POU5F1 and SOX2 enhancers in human embryonic stem cells Sci Rep. 2013; 3:1588. View in: PubMed

. Uncovering the link between malfunctions in Drosophila neuroblast asymmetric cell division and tumorigenesis Cell Biosci. 2012 Nov 14; 2(1):38. View in: PubMed

. Selective requirement of H2B N-Terminal tail for p14ARF-induced chromatin silencing Nucleic Acids Res. 2011 Nov; 39(21):9167-80. View in: PubMed

. Smek promotes histone deacetylation to suppress transcription of Wnt target gene brachyury in pluripotent embryonic stem cells Cell Res. 2011 Jun; 21(6):911-21. View in: PubMed

. The Wnt receptor Ryk controls specification of GABAergic neurons versus oligodendrocytes during telencephalon development Development. 2011 Feb; 138(3):409-19. View in: PubMed

. Identification of preferential target sites for human DNA methyltransferases Nucleic Acids Res. 2011 Jan; 39(1):104-18. View in: PubMed

. Comparison of reprogramming efficiency between transduction of reprogramming factors, cell-cell fusion, and cytoplast fusion Stem Cells. 2010 Aug; 28(8):1338-48. View in: PubMed

. Kruppel-like factor 4 (Klf4) prevents embryonic stem (ES) cell differentiation by regulating Nanog gene expression J Biol Chem. 2010 Mar 19; 285(12):9180-9. View in: PubMed

. A real-time pluripotency reporter for human stem cells Stem Cells Dev. 2010 Jan; 19(1):47-52. View in: PubMed

. Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming Stem Cells. 2009 Dec; 27(12):2969-78. View in: PubMed

. Cdc37 regulates Ryk signaling by stabilizing the cleaved Ryk intracellular domain J Biol Chem. 2009 May 08; 284(19):12940-8. View in: PubMed

. Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis Dev Cell. 2008 Nov; 15(5):773-80. View in: PubMed

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