Bibliography Section

Developing methods for functional brain mapping in freely moving, awake animals

  1. Novel single-pass extraction perfusion tracer:
    Holschneider DP, Yang J, Sadler TR, Galifianakis NB, Bozorgzadeh MH, Bading JR, Conti PS, Maarek J-MI, “Changes in Regional Brain Perfusion During Functional Brain Activation:   Comparison of [64Cu]-PTSM with [14C]-Iodoantipyrine”, Brain Research, 1234:32-43, 2008
  2. Implantable, miniature, infusion pump for the administration of radiotracers by remote activation in freely moving animals.
    Holschneider DP, Maarek J, Harimoto J, Yang, J, Scremin OU, “An Implantable Bolus Infusion Pump For Use In Freely Moving, Nontethered Rats”, American Journal of Physiology, Heart & Circ Physiol, 283(4):H1713-19, 2002Givrad TK, Maarek J-M I, Moore WH, Holschneider DP, “Powering an Implantable Minipump with a Multi-layered Printed Circuit Coil for Drug Infusion Applications in Rodents”, Annals of Biomed. Engineering, 38(3):707-13, 2010

Adapting analytic methods for whole brain autoradiographic data sets

  1. Statistical Parametric Mapping:
    Nguyen PT, Holschneider DP, Maarek J-MI, Yang J, Mandelkern MA, “Statistical Parametric Mapping Applied to an Autoradiographic Study of Cerebral Activation During Treadmill Walking in Rats”, Neuroimage, 23:252-259, 2004
  2. Cortical flat maps:
    Peng Y-H, Heintz R, Wang Z, Guo Y, Myers KG, Scremin OU, Maarek J-M I, Holschneider DP “Exercise training reinstates cortico-cortical sensorimotor functional connectivity following striatal lesioning: Development and application of a subregional-level analytic toolbox for perfusion autoradiographs of the rat brain”, Frontiers in Physics. Interdisc. Section, doi: 10.3389/fphy.2014.00072 2014
  3. Functional connectivity:
    Wang Z, Pang RD, Hernandez M, Ocampo MA, Holschneider DP, “Anxiolytic-like effect of pregabalin on unconditioned fear in the rat: An autoradiographic brain perfusion mapping and functional connectivity study”, Neuroimage, 59(4):4168-88, 2012.Holschneider DP, Wang Z, Pang RP, “Functional connectivity-based parcellation and connectome of cortical midline structures in the mouse: a perfusion autoradiography study”, Frontiers in Neuroinformatics, 8:61. Doi: 10.3389/fninf.2014.00061, 2014
  4. Structurally-linked functional connectivity:
    Wang Z, Ocampo MA, Pang RD, Bota M, Bradesi S, Mayer EA, Holschneider DP “Alterations in Prefrontal-Limbic Functional Activation and Connectivity in Chronic Stress-Induced Visceral Hyperalgesia”, PLoS ONE, 8(3):e59138, 2013.

Studies in visceral pain

Wang Z, Guo Y, Bradesi S, Labus JS, Maarek J-M I., Lee K, Winchester WJ, Mayer EA, Holschneider DP, “Sex Differences In Functional Brain Activation During Noxious Visceral Stimulation In Rats”, Pain, 145(1-2):120-8, 2009.

Wang Z, Bradesi S, Charles J, Pang RD, Maarek J-MI, Mayer EA, Holschneider DP,  “Functional brain activation during retrieval of visceral pain-conditioned passive avoidance in the rat”, Pain, 152(12):2746-56, 2011.

Holschneider DP, Guo Y, Mayer EA, Wang Z, “Early life stress elicits visceral hyperalgesia and functional

reorganization of pain circuits in adult rats”, Neurobiology of Stress, 3:8-22, 2015,

Wang Z, Guo Y, Mayer EA, Holschneider DP, “Sex differences in the functional connectivity of insular cortex during colorectal distension” Brain Research, 1717:15-26, 2019.  PMID: 30974090

Functional brain remodeling with cholinergic intervention in brain trauma rehabilitation:

Scremin OU, Norman KM, Roch M, Holschneider DP, Scremin AM, “Acetylcholinesterase Inhibition Interacts with Training to Reverse Spatial Learning Deficits of Cortical Impact Injury”, J. Neurotrauma, 29(15):2457-64, 2012.

Holschneider DP, Guo Y, Roch M, Norman KM, Scremin OU, “Acetylcholinesterase inhibition and locomotor function after motor-sensory cortex impact injury”, J. Neurotrauma, 28(9):1909-19, 2011.

Holschneider DP, Guo Y, Wang Z, Roch M, Scremin OU, “Remote brain networks changes after unilateral cortical impact injury and their modulation by acetylcholinesterase inhibition” J. Neurotrauma, 30(11):907-19, 2013,

Holschneider DP, Guo Y, Wang Z, Vidal M, Scremin OU, “Positive allosteric modulation of cholinergic receptors improves spatial learning following cortical contusion injury in mice”, J. Neurotrauma, 36(14):2233-2245, 2019.

Functional brain reorganization with exercise

Yang Y, Sadler TS, Maarek J-MI, Givrad TK, Holschneider DP “Changes in Brain Functional Activation During Resting and Locomotor States After Unilateral Striatonigral Damage in Rats” Neuroimage, 36:755-73, 2007.

Wang Z, Myers KG, Guo Y, Ocampo MA, Jakowec MW, Holschneider DP, “Functional reorganization of motor and limbic circuits after forced exercise training in a rat model of bilateral Parkinsonism”, PLoS ONE, 8(11), 2013, doi: 10.1371/journal.pone.0080058,.

Wang Z, Guo Y, Myers KG, Heintz R, Peng Y-H, Maarek J-MI, Holschneider DP “Exercise alters resting state functional connectivity of motor circuits in Parkinsonian rats,” Neurobiology of Aging, 36(1):536-44, 2015.

Wang Z, Guo Y, Myers KG, Heintz R, Holschneider DP, “Recruitment of the prefrontal cortex and cerebellum in Parkinsonian rats following skilled aerobic exercise”, Neurobiology of Disease, 77:71-87, 2015.

Guo Y, Wang Z, Prathap S, Holschneider DP

“Recruitment of Prefrontal-Striatal Circuit in Response to Skilled Motor Challenge”, NeuroReport, 28(18):1187-1194, 2017.

Functional imaging of stress and anxiety

Holschneider DP, Yang J, Sadler TR, Nguyen PT, Givrad TK, Maarek J-M I, “Mapping Cerebral Blood Flow Changes During Auditory-Cued Conditioned Fear in the Nontethered, Nonrestrained Rat”, Neuroimage,  29(4):1344-1358, 2006.

Pang RD, Klosinski L, Wang Z, Guo Y, Herman DH, Celikel T, Dong HW, Holschneider DP, “Mapping Functional Brain Activation in Mice Lacking the Serotonin Transporter”, PLoS ONE, 2011, 6(8):e23869.

Sadler T, Nguyen P, Yang J, Givrad TK, Mayer EA, Maarek JM, Hinton DR, Holschneider DP, “Regional Cerebral Blood Flow Changes During Conditioned Fear In Adult Rats Exposed to Prenatal Stress”, Brain Research, 1385:163-74, 2011.

Wang Z, Pang RD, Hernandez M, Ocampo MA, Holschneider DP, “Anxiolytic-like effect of pregabalin on unconditioned fear in the rat: An autoradiographic brain perfusion mapping and functional connectivity study”, Neuroimage, 59(4):4168-88, 2012,

Wang Z, Chang HH, Gao Y, Zhang R, Guo Y, Holschneider DP, Rodriguez LR, “Effects of

water avoidance stress on peripheral and central responses during bladder filling in the rat: A multidisciplinary approach to the study of urologic chronic pelvic pain syndrome (MAPP) research network study”, PLoS ONE, 12(9): e0182976., doi: 10.1371/journal.pone.0182976, 2017.