Faculty

Andre J Ouellette

Andre J Ouellette

Professor of Pathology
Pathology
NRT 7505 Health Sciences Campus Los Angeles

Rattusin, an intestinal a-defensin-related peptide in rats with a unique cysteine spacing pattern and salt-insensitive antibacterial activities Antimicrob Agents Chemother. 2013 Apr; 57(4):1823-31. . View in PubMed

ImmunologyHD6 defensin nanonets. Science. 2012 Jul 27; 337(6093):420-1. . View in PubMed

Biosynthesis and antimicrobial evaluation of backbone-cyclized a-defensins Biochemistry. 2011 Dec 06; 50(48):10508-19. . View in PubMed

Paneth cell a-defensins in enteric innate immunity Cell Mol Life Sci. 2011 Jul; 68(13):2215-29. . View in PubMed

Paneth cells and innate mucosal immunity Curr Opin Gastroenterol. 2010 Nov; 26(6):547-53. . View in PubMed

A novel role for defensins in intestinal homeostasis: regulation of IL-1beta secretion J Immunol. 2007 Jul 15; 179(2):1245-53. . View in PubMed

Matrix metalloproteinase-7 activation of mouse paneth cell pro-alpha-defensins: SER43 down arrow ILE44 proteolysis enables membrane-disruptive activity J Biol Chem. 2006 Sep 29; 281(39):28932-42. . View in PubMed

Structural and functional characterization of the conserved salt bridge in mammalian paneth cell alpha-defensins: solution structures of mouse CRYPTDIN-4 and (E15D)-CRYPTDIN-4 J Biol Chem. 2006 Sep 22; 281(38):28068-78. . View in PubMed

Paneth cell alpha-defensins: peptide mediators of innate immunity in the small intestine Springer Semin Immunopathol. 2005 Sep; 27(2):133-46. . View in PubMed

Mammalian defensins in the antimicrobial immune response Nat Immunol. 2005 Jun; 6(6):551-7. . View in PubMed

The alternative sigma factor sigma is required for resistance of Salmonella enterica serovar Typhimurium to anti-microbial peptides Mol Microbiol. 2005 May; 56(3):789-99. . View in PubMed

Mouse paneth cell secretory responses to cell surface glycolipids of virulent and attenuated pathogenic bacteria Infect Immun. 2005 Apr; 73(4):2312-20. . View in PubMed

Solution structure of cryptdin-4, a mouse paneth cell alpha-defensin Biochemistry. 2004 Dec 21; 43(50):15759-66. . View in PubMed

Differential effects on human immunodeficiency virus type 1 replication by alpha-defensins with comparable bactericidal activities J Virol. 2004 Nov; 78(21):11622-31. . View in PubMed

Functional analysis of the alpha-defensin disulfide array in mouse cryptdin-4 J Biol Chem. 2004 Oct 15; 279(42):44188-96. . View in PubMed

Abnormal Paneth cell granule dissolution and compromised resistance to bacterial colonization in the intestine of CF mice Am J Physiol Gastrointest Liver Physiol. 2004 Jun; 286(6):G1050-8. . View in PubMed

Paneth cell cryptdins act in vitro as apical paracrine regulators of the innate inflammatory response J Biol Chem. 2004 May 07; 279(19):19902-7. . View in PubMed

Defensin-mediated innate immunity in the small intestine Best Pract Res Clin Gastroenterol. 2004 Apr; 18(2):405-19. . View in PubMed

Structure-activity determinants in paneth cell alpha-defensins: loss-of-function in mouse cryptdin-4 by charge-reversal at arginine residue positions J Biol Chem. 2004 Mar 19; 279(12):11976-83. . View in PubMed

Cognition and anatomy in three variants of primary progressive aphasia Ann Neurol. 2004 Mar; 55(3):335-46. . View in PubMed

Paneth cell alpha-defensins from rhesus macaque small intestine Infect Immun. 2004 Mar; 72(3):1470-8. . View in PubMed

Interactions of mouse Paneth cell alpha-defensins and alpha-defensin precursors with membranesProsegment inhibition of peptide association with biomimetic membranes. J Biol Chem. 2003 Apr 18; 278(16):13838-46. . View in PubMed

Structural determinants of procryptdin recognition and cleavage by matrix metalloproteinase-7 J Biol Chem. 2003 Mar 07; 278(10):7910-9. . View in PubMed

Activation of Paneth cell alpha-defensins in mouse small intestine J Biol Chem. 2002 Feb 15; 277(7):5219-28. . View in PubMed

Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel J Biol Chem. 2002 Feb 01; 277(5):3793-800. . View in PubMed

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