Takeshi Saito

Takeshi Saito

Associate Professor of Medicine
HMR 801A Health Sciences Campus Los Angeles

NIH (NIAID): R21AI139954, 2018-2020

CRDFG: CRDF Global Research Award, 2017-2018

L.K. Whittier Foundation: L.K. Whittier Foundation Award, 2016-2017

American Federation For Medical Research: Western Region American Federation For Medical Research (WAFMR) Outstanding Investigator Award, 2016

NIH (NIDDK): R01DK101773 , 2015-2020

NIH (NIAAA): R21AA022751, 2014-2017

ISHSR: Young Investigator Award International Symposium on Cells of the Hepatic Sinusoid , 2013

Baxter Foundation : Donald E. and Delia B. Baxter Foundation Faculty Fellow Award, 2011

International Meeting on Hepatitis C Virus & Related Viruses: Travel Scholarship for 18th International Meeting on Hepatitis C Virus & Related Viruses, 2011

AASLD and American Liver Foundation: Liver Scholar Award , 2010-2012

AGA: American Gastroenterological Association Foundation’s Research Scholar Award (Declined for LSA), 2010-2012

Japan Society of Hepatology: 2010 Hepatology Research High Citation Award, 2010

Viral Hepatitis Research Foundation of Japan : Viral Hepatitis Research Foundation of Japan Research Fellowship, 2009

ISICR: International Society for Interferon & Cytokine Research Milstein Young Investigator Award, 2008

Cholesterol-binding translocator protein TSPO regulates steatosis and bile acid synthesis in nonalcoholic fatty liver disease iScience. 2021 May 21; 24(5):102457. . View in PubMed

Suppression of hepatitis B virus through therapeutic activation of RIG-I and IRF3 signaling in hepatocytes iScience. 2021 Jan 22; 24(1):101969. . View in PubMed

A Case of Benign Hepatic Cyst with Supra-elevated Cyst Fluid Tumor Markers Dig Dis Sci. 2021 Jan 06. . View in PubMed

Evaluation of low-volume post-dilution online hemodiafiltration with Japanese high-performance hemodiafilters J Artif Organs. 2020 Sep; 23(3):234-239. . View in PubMed

High Prevalence of Chronic Viral Hepatitis and Liver Fibrosis Among Mongols in Southern California Dig Dis Sci. 2020 Aug 08. . View in PubMed

Art of Making Artificial Liver: Depicting Human Liver Biology and Diseases in Mice Semin Liver Dis. 2020 05; 40(2):189-212. . View in PubMed

Development of Capsular Fibrosis Beneath the Liver Surface in Humans and Mice Hepatology. 2020 01; 71(1):291-305. . View in PubMed

Comparative Analyses of the Antiviral Activities of IgG and IgA Antibodies to Influenza A Virus M2 Protein Viruses. 2020 07 20; 12(7). . View in PubMed

A Surrogate Animal Model for Screening of Ebola and Marburg Glycoprotein-Targeting Drugs Using Pseudotyped Vesicular Stomatitis Viruses Viruses. 2020 08 22; 12(9). . View in PubMed

Hepatic IFN-Induced Protein with Tetratricopeptide Repeats Regulation of HCV Infection J Interferon Cytokine Res. 2019 03; 39(3):133-146. . View in PubMed

Special Issue "IFN-Independent ISG Expression and its Role in Antiviral Cell-Intrinsic Innate Immunity" Viruses. 2019 10 24; 11(11). . View in PubMed

Regulation of Hepatitis C Virus Infection by Cellular Retinoic Acid Binding Proteins through the Modulation of Lipid Droplet Abundance J Virol. 2019 04 15; 93(8). . View in PubMed

Elucidation of the mechanism of changes in the antioxidant function with the aging in the liver of the senescence-accelerated mouse P10 (SAMP10) Exp Gerontol. 2018 06; 106:46-53. . View in PubMed

Hepatic angiosarcoma with clinical and histological features of Kasabach-Merritt syndrome World J Gastroenterol. 2017 Apr 07; 23(13):2443-2447. . View in PubMed

Reply Gastroenterology. 2017 07; 153(1):328-329. . View in PubMed

Detection of Occult Hepatitis C Virus Infection in Patients Who Achieved a Sustained Virologic Response to Direct-Acting Antiviral Agents for Recurrent Infection After Liver TransplantationGastroenterology. 2017 02; 152(3):550-553. e8. . View in PubMed

Dual modulation of human hepatic zonation via canonical and non-canonical Wnt pathways Exp Mol Med. 2017 12 15; 49(12):e413. . View in PubMed

Organ system view of the hepatic innate immunity in HCV infection J Med Virol. 2016 12; 88(12):2025-2037. . View in PubMed

Comparison of Demographic and Clinical Characteristics of Hispanic and Asian Chronic Hepatitis B Patients in Southern California J Clin Gastroenterol. 2016 08; 50(7):602-7. . View in PubMed

Retinoid regulation of antiviral innate immunity in hepatocytes Hepatology. 2016 06; 63(6):1783-95. . View in PubMed

An Internally Translated MAVS Variant Exposes Its Amino-terminal TRAF-Binding Motifs to Deregulate Interferon Induction PLoS Pathog. 2015 Jul; 11(7):e1005060. . View in PubMed

Novel antiviral host factor, TNK1, regulates IFN signaling through serine phosphorylation of STAT1 Proc Natl Acad Sci U S A. 2014 Feb 04; 111(5):1909-14. . View in PubMed

Isolated arterioportal fistula presenting with variceal hemorrhage World J Gastroenterol. 2013 May 07; 19(17):2714-7. . View in PubMed

Innate immune tolerance and the role of kupffer cells in differential responses to interferon therapy among patients with HCV genotype 1 infectionGastroenterology. 2013 Feb; 144(2):402-413. e12. . View in PubMed

RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP RNA. 2010 Nov; 16(11):2108-19. . View in PubMed

Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA Nature. 2008 Jul 24; 454(7203):523-7. . View in PubMed

Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity J Exp Med. 2008 Jul 07; 205(7):1523-7. . View in PubMed

Regulation of innate immunity against hepatitis C virus infection Hepatol Res. 2008; 38(2):115-22. . View in PubMed

Principles of intracellular viral recognition Curr Opin Immunol. 2007 Feb; 19(1):17-23. . View in PubMed

Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2 Proc Natl Acad Sci U S A. 2007 Jan 09; 104(2):582-7. . View in PubMed

Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection Proc Natl Acad Sci U S A. 2006 Apr 11; 103(15):6001-6. . View in PubMed

Translational enhancement of HCV RNA genotype 1b by 3'-untranslated and envelope 2 protein-coding sequences Virology. 2006 Feb 20; 345(2):404-15. . View in PubMed

Sequence analysis of PePHD within HCV E2 region and correlation with resistance of interferon therapy in Japanese patients infected with HCV genotypes 2a and 2b Am J Gastroenterol. 2003 Jun; 98(6):1377-83. . View in PubMed

A case of autoimmune pancreatitis responding to steroid therapyEvidence of histologic recovery. Pancreatology. 2002; 2(6):550-6. . View in PubMed

My research interest has been centered on hepatitis C virus (HCV) virology, pathogenesis, and virus-host interaction including immune response. For the past 10 years during my PhD and Post-Doctoral training, I have investigated viral-host interactions that regulate HCV viral replication through the activation of intracellular innate immune response. In recent years, I have focused on understanding how host cell innate immune pathways sense HCV infection and initiate the host response which involves type I interferon and proinflammatory cytokine production to regulate hepatic immunity. After recent transition to an independent junior faculty position at the University of Southern California (USC), Keck School of Medicine, my laboratory continues to investigate virus-host interactions that regulates disease outcome and pathogenesis of HCV infection. I have extensive expertise and skills in virology, cell signaling, cytokine biology, and cell biology.

My role as a physician specializing in the care of viral hepatitis at an academic medical center offers the unique integration of basic science and clinical/translational science into the laboratory research program, allowing us to set our aim as
esearch for the better healthcare. My chief goal is to become an established physician scientist with the skills and knowledge necessary to pursue a lasting career dedicated to translating discoveries in molecular virology into clinical practice or development of novel therapies. USC is supported by two major centers for the study of liver diseases: 1) USC Research Center for Liver Diseases, and 2) Southern California Research Center for ALPD and Cirrhosis. These center directors serve as consultants for the research program and career development. In summary, I have substantial expertise and a track record in the field of innate immunology against viral infection and am efficiently establishing an independent research program in an environment well suited for the study of liver diseases.
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