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Sanda Win, MBBS, PhD

Assistant Professor of Research Medicine

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Overview

Dr. Win’s major areas of research interest are signal transduction in drug-induced hepatotoxicity, regulation of mitochondrial bioenergetic signaling in hepatotoxicity, metabolic dysfunction-associated steatotic liver disease (MASLD), and alcoholic hepatitis, oxidative stress, and identification of therapeutic targets to prevent drug-induced hepatotoxicity and metabolic dysfunction-associated steatotic liver disease (MASLD) (previous term: nonalcoholic fatty liver disease, NAFLD). Her current research includes cellular mechanisms of hepatotoxicity.

Dr. Win earned her medical degree from University of Yangon Institute of Medicine. She then went on to perform her Medicine and Surgery Internship and Residency at University of Yangon General Hospital, followed by her PhD in Immunology & Molecular Biology from Okayama University Graduate School of Medicine and Dentistry.

Awards

  • American Association for the Study of Liver Disease: Presidential Poster of Distinction, 2020
  • Baxter Foundation: Donald E. and Delia B. Baxter Foundation Faculty Fellowship Award, 2018
  • NIH: Research Center for Liver Diseases, Keck School of Medicine of USC Research Pilot Award, 2016
  • American Association for the Study of Liver Disease: Presidential Poster of Distinction, 2014
  • Sagawa Scholarship Foundation, Japan: Award for Doctoral Program, 2001

Publications

  • Oral magnesium prevents acetaminophen-induced acute liver injury by modulating microbial metabolismCell Host Microbe. 2024 Jan 10; 32(1):48-62. e9. . View in PubMed
  • Antioxid Redox Signal. 2023 06; 38(16-18):1071-1081. . View in PubMed
  • Mechanism and Therapeutic Targets of c-Jun-N-Terminal Kinases Activation in Nonalcoholic Fatty Liver Disease Biomedicines. 2022 Aug 20; 10(8). . View in PubMed
  • Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis Hepatology. 2021 12; 74(6):3127-3145. . View in PubMed
  • Acetaminophen Hepatotoxicity: Strong Offense and Weakened Defense Hepatology. 2020 05; 71(5):1530-1532. . View in PubMed
  • Intestinal Epithelial Chemokine (C-C Motif) Ligand 7 Overexpression Enhances Acetaminophen-Induced Hepatotoxicity in Mice Am J Pathol. 2020 01; 190(1):57-67. . View in PubMed
  • Gut Microbiota and Liver Injury (I)-Acute Liver Injury Adv Exp Med Biol. 2020; 1238:23-37. . View in PubMed
  • Sex Differences in Nonalcoholic Fatty Liver Disease: State of the Art and Identification of Research Gaps Hepatology. 2019 10; 70(4):1457-1469. . View in PubMed
  • Endoplasmic Reticulum Stress-Induced Upregulation of STARD1 Promotes Acetaminophen-Induced Acute Liver Failure Gastroenterology. 2019 08; 157(2):552-568. . View in PubMed
  • Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury J Clin Invest. 2019 12 02; 129(12):5278-5293. . View in PubMed
  • The Regulation of JNK Signaling Pathways in Cell Death through the Interplay with Mitochondrial SAB and Upstream Post-Translational Effects Int J Mol Sci. 2018 Nov 20; 19(11). . View in PubMed
  • Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice J Hepatol. 2018 07; 69(1):51-59. . View in PubMed
  • New insights into the role and mechanism of c-Jun-N-terminal kinase signaling in the pathobiology of liver diseases Hepatology. 2018 05; 67(5):2013-2024. . View in PubMed
  • Response to: ‘Professional identity in clinician-scientists: brokers between care and science’ Med Educ. 2017 12; 51(12):1294. . View in PubMed
  • Protective role of p53 in acetaminophen hepatotoxicity Free Radic Biol Med. 2017 05; 106:111-117. . View in PubMed
  • Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury Proc Natl Acad Sci U S A. 2017 04 04; 114(14):E2862-E2871. . View in PubMed
  • The role of MAP2 kinases and p38 kinase in acute murine liver injury models Cell Death Dis. 2017 06 29; 8(6):e2903. . View in PubMed
  • Antcin H Protects Against Acute Liver Injury Through Disruption of the Interaction of c-Jun-N-Terminal Kinase with Mitochondria Antioxid Redox Signal. 2017 02 10; 26(5):207-220. . View in PubMed
  • c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src Hepatology. 2016 06; 63(6):1987-2003. . View in PubMed
  • Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis Hepatology. 2015 Dec; 62(6):1847-57. . View in PubMed
  • Targeting signal transduction pathways which regulate necrosis in acetaminophen hepatotoxicity J Hepatol. 2015 Jul; 63(1):5-7. . View in PubMed
  • Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity J Hepatol. 2015 Jun; 62(6):1367-74. . View in PubMed
  • In vitro assays of mitochondrial function/dysfunction Clin Pharmacol Ther. 2014 Dec; 96(6):665-8. . View in PubMed
  • JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death Cell Death Dis. 2014 Jan 09; 5:e989. . View in PubMed
  • Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria Trends Pharmacol Sci. 2013 Apr; 34(4):243-53. . View in PubMed
  • c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice J Biol Chem. 2011 Oct 07; 286(40):35071-8. . View in PubMed
  • Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and stress response in liver cells J Biol Chem. 2011 Jun 24; 286(25):22047-54. . View in PubMed
  • Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1 J Biol Chem. 2010 Mar 12; 285(11):8244-55. . View in PubMed
  • Cryptic CTL epitope on a murine sarcoma Meth A generated by exon extension as a novel mechanism J Immunol. 2003 May 01; 170(9):4862-8. . View in PubMed
  • Immune responses against allogeneic and syngeneic tumors in aged C57BL/6 mice Microbiol Immunol. 2002; 46(7):513-9. . View in PubMed
  • ELISPOT cloning of tumor antigens recognized by cytotoxic T-lymphocytes from a cDNA expression library Cancer Immun. 2001 Jul 13; 1:8. . View in PubMed

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