{"id":7,"date":"2024-07-22T03:26:12","date_gmt":"2024-07-22T03:26:12","guid":{"rendered":"https:\/\/keck.usc.edu\/myeloidcancercures\/?page_id=7"},"modified":"2025-11-05T00:01:54","modified_gmt":"2025-11-05T00:01:54","slug":"clinical-trials","status":"publish","type":"page","link":"https:\/\/keck.usc.edu\/myeloidcancercures\/clinical-trials\/","title":{"rendered":"Clinical Trials"},"content":{"rendered":"\n\n\n\n\n  \n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--hero-primary horizontal-navigation\"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--hero-primary\"\n    \n      >\n\n    \n  \n  <div class=\"inner-wrapper has-horizontal-nav\">\n\n          <div class=\"title-wrapper\">\n\n                  <div class=\"eyebrow-container\">\n                              \n<div class=\"f--field f--eyebrow\">\n\n    \n  <a href=\"https:\/\/keck.usc.edu\/myeloidcancercures\/\" >Gehr Family Center For Health Systems Science And Innovation<\/a>\n\n\n\n<\/div>\n                      <\/div>\n        \n                      \n<div class=\"f--field f--page-title has-stripe\">\n\n    \n      <h1>Clinical Trials<\/h1>\n\n\n<\/div>\n        \n              <\/div>\n    \n              \n<div class=\"f--field f--link eyebrow-link\">\n\n    \n    \n  \n\n<a\n  class=\"link \"\n  href=\"https:\/\/keck.usc.edu\/myeloidcancercures\/our-team\/\"\n    >\n        Connect and Collaborate\n    <\/a>\n\n\n<\/div>\n    \n    \n      \n              <div class=\"horizontal-nav\">\n                      <div class=\"horizontal-menu-container\">\n              <button class=\"expand-menu\">\n                                  In This Section\n                                <svg class=\"menu\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" x=\"0px\"\n                  y=\"0px\" viewBox=\"0 0 35 35\" enable-background=\"new 0 0 35 35\" xml:space=\"preserve\">\n                  <path fill-rule=\"evenodd\" clip-rule=\"evenodd\" fill=\"#000\" d=\"M4,23h3v3H4V23z M4,16h3v3H4V16z M10,23\n                  h21v3H10V23z M10,16h21v3H10V16z M10,9h21v3H10V9z M4,9h3v3H4V9z\"\/>\n                <\/svg>\n\n                <svg class=\"close\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" x=\"0px\" y=\"0px\"\n                  viewBox=\"0 0 35 35\" enable-background=\"new 0 0 35 35\" xml:space=\"preserve\">\n                  <polygon fill=\"#000\" fill-rule=\"evenodd\" clip-rule=\"evenodd\" points=\"26,10.4 24.6,9 17.5,16.1 10.4,9 9,10.4 16.1,17.5\n                  9,24.6 10.4,26 17.5,18.9 24.6,26 26,24.6 18.9,17.5 \"\/>\n                <\/svg>\n              <\/button>\n\n              <nav\n  class=\"mc--menu mc--\"\n  >\n  <ul class=\"m--menu m--\">\n    \n    \n      <li class=\" menu-item menu-item-type-post_type menu-item-object-page menu-item-home menu-item-6\">\n      <a href=\"https:\/\/keck.usc.edu\/myeloidcancercures\/\" >Myeloid Cancer Cures<\/a>\n  \n  \n<\/li>\n\n    \n      <li class=\" menu-item menu-item-type-post_type menu-item-object-page menu-item-15\">\n      <a href=\"https:\/\/keck.usc.edu\/myeloidcancercures\/clinical-trials\/\" >Clinical Trials<\/a>\n  \n  \n<\/li>\n\n    \n      <li class=\" menu-item menu-item-type-post_type menu-item-object-page menu-item-16\">\n      <a href=\"https:\/\/keck.usc.edu\/myeloidcancercures\/patient-care\/\" >Patient Care<\/a>\n  \n  \n<\/li>\n\n    \n      <li class=\" menu-item menu-item-type-post_type menu-item-object-page menu-item-17\">\n      <a href=\"https:\/\/keck.usc.edu\/myeloidcancercures\/grants\/\" >Grants<\/a>\n  \n  \n<\/li>\n\n    \n      <li class=\" menu-item menu-item-type-post_type menu-item-object-page menu-item-82\">\n      <a href=\"https:\/\/keck.usc.edu\/myeloidcancercures\/our-team\/\" >Our Team<\/a>\n  \n  \n<\/li>\n\n    \n      <\/ul><!-- m--menu -->\n<\/nav>\n\n            <\/div>\n                  <\/div>\n        <\/div>\n\n\n  <\/div><\/div>\n\n\n\n\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--featured-block image-left white\"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--featured-block\"\n    \n      >\n\n    \n  <div class=\"text-image-container\">\n    <div class=\"text-container\">\n\n      \n                  \n<div class=\"f--field f--section-title has-stripe\">\n\n    \n      <h2>\n          Access to innovative therapies\n      <\/h2>\n\n\n<\/div>\n      \n                  \n<div class=\"f--field f--description description-medium\">\n\n    \n  <p>The aims of our research are to discover cures for myeloid malignancies and to uncover methods for preventing the development of acute myeloid leukemia. Our unique program has allowed us to rapidly achieve breakthroughs in both basic research science and clinical trials in which patients can benefit from the latest innovations.<\/p>\n\n\n\n<\/div>\n      \n      \n    <\/div>\n\n          <div class=\"image-container\">\n            \n<div class=\"f--field f--image\">\n\n    \n    \n    \n    \n    \n    \n              \n      <img\n                            data-src=\"https:\/\/keck.usc.edu\/myeloidcancercures\/wp-content\/uploads\/sites\/177\/2025\/10\/Marquee-1.jpg\"\n                    data-sizes=\"(min-width:1024px) 50vw, (min-width:768px) 100vw, 100vw\"          class=\"lazyload\"\n        \n                alt=\"Clinical Trials\"\n\n                \n        \n                \n                                      \/>\n\n    \n    \n  \n  \n\n<\/div>\n      <\/div>\n    \n  <\/div>\n\n\n  <\/div><\/div>\n\n\n\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text white\"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p><strong>Myelodysplastic Syndrome:<\/strong><\/p>\n<ol>\n<li>A Multi-phase, Dose-Escalation followed by an Open-label, Randomized, Crossover Study of Oral ASTX030 (Cedazuridine and Azacitidine Given in Combination) Versus Subcutaneous Azacitidine in Subjects with Myelodysplastic Syndromes (MDS), Chronic Myelomonocytic Leukemia (CMML).<\/li>\n<\/ol>\n<p><a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fclinicaltrials.gov%2Fct2%2Fshow%2FNCT04256317&amp;data=05%7C02%7CKarren.Cuadra%40med.usc.edu%7Cb534d0d9480849b44dd008de18a42f31%7Ca63249ac3e0b4a249e0cc90ab9891e30%7C1%7C0%7C638975290610833905%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&amp;sdata=rAM5dFDHW4RM%2BIB1L00iAEHApzwmY6Zv%2BM7QYQb2TL8%3D&amp;reserved=0\" target=\"_blank\" rel=\"noopener\">clinicaltrials.gov NCT No: NCT04256317\u00a0<\/a><\/p>\n<p><strong>Myeloproliferative Neoplasm:<\/strong><\/p>\n<ol>\n<li>Assessment of Cognitive Function in Patients with Myeloproliferative Neoplasms<\/li>\n<li>A Phase 1\/2, Open-label, Dose-escalation, Safety, Pharmacokinetic, and Pharmacodynamic Study of Oral TP-3654 in Patients with Intermediate or High-risk Primary or Secondary Myelofibrosis.<\/li>\n<\/ol>\n<p><a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fclinicaltrials.gov%2Fct2%2Fshow%2FNCT04176198&amp;data=05%7C02%7CKarren.Cuadra%40med.usc.edu%7Cb534d0d9480849b44dd008de18a42f31%7Ca63249ac3e0b4a249e0cc90ab9891e30%7C1%7C0%7C638975290610870156%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&amp;sdata=ejCpopJ4zYF4F17DhGn9zpY4UGDPtmRoMFntEgf4vY0%3D&amp;reserved=0\" target=\"_blank\" rel=\"noopener\">clinicaltrials.gov NCT No: NCT04176198\u00a0<\/a><\/p>\n<p><strong>Myelodysplastic Syndrome \/ Myeloproliferative Neoplasm<\/strong><\/p>\n<ol>\n<li>A Phase 2, Double-blind, Randomized Study to Compare the Effect of Curcumin Versus Placebo on Inflammatory Cytokines, Symptoms,\u00a0and Disease Parameters in Clonal Cytopenia of Undetermined Significance (CCUS), Low-Risk Myelodysplastic Syndrome (LR-MDS), Myeloproliferative Neoplasms (MPNs), Clonal Monocytosis of Undetermined Significance (CMUS), and Chronic Myelomonocytic Leukemia (CMML-1)<\/li>\n<\/ol>\n<p><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06063486\" target=\"_blank\" rel=\"noopener\">https:\/\/clinicaltrials.gov\/study\/NCT06063486<\/a><\/p>\n<p><strong>Idiopathic Erythrocytosis<\/strong><\/p>\n<ol>\n<li>Prospective Study of Clinicopathologic Features and Mutation Frequency in Patients With Unexplained Erythrocytosis<\/li>\n<\/ol>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":5,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":true,"footnotes":""},"class_list":["post-7","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.2 (Yoast SEO v28.6) - 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