Giselle M Petzinger

Giselle M Petzinger

Associate Professor of Neurology (Clinical Scholar)
HCC 3000 Health Sciences Campus Los Angeles

Exercise alters cortico-basal ganglia network metabolic connectivity: a mesoscopic level analysis informed by anatomic parcellation defined in the mouse brain connectome Brain Struct Funct. 2023 Nov; 228(8):1865-1884. . View in PubMed

Increased perivascular space volume in white matter and basal ganglia is associated with cognition in Parkinson's Disease Brain Imaging Behav. 2023 Oct 19. . View in PubMed

Physical activity intensity is associated with cognition and functional connectivity in Parkinson's disease Parkinsonism Relat Disord. 2022 Nov; 104:7-14. . View in PubMed

Promoting Physical Activity in a Spanish-Speaking Latina Population of Low Socioeconomic Status With Chronic Neurological Disorders: Proof-of-Concept Study JMIR Form Res. 2022 Apr 20; 6(4):e34312. . View in PubMed

Knockdown of Astrocytic Monocarboxylate Transporter 4 in the Motor Cortex Leads to Loss of Dendritic Spines and a Deficit in Motor Learning Mol Neurobiol. 2022 Feb; 59(2):1002-1017. . View in PubMed

Magnetic resonance spectroscopy shows associations between neurometabolite levels and perivascular space volume in Parkinson's disease: a pilot and feasibility study Neuroreport. 2022 05 04; 33(7):291-296. . View in PubMed

A mind in motion: Exercise improves cognitive flexibility, impulsivity and alters dopamine receptor gene expression in a Parkinsonian rat model Curr Res Neurobiol. 2022; 3:100039. . View in PubMed

Thalamic volume mediates associations between cardiorespiratory fitness (VO2max) and cognition in Parkinson's disease Parkinsonism Relat Disord. 2021 05; 86:19-26. . View in PubMed

Exogenous l-lactate promotes astrocyte plasticity but is not sufficient for enhancing striatal synaptogenesis or motor behavior in mice J Neurosci Res. 2021 05; 99(5):1433-1447. . View in PubMed

Global and Regional Changes in Perivascular Space in Idiopathic and Familial Parkinson's Disease Mov Disord. 2021 05; 36(5):1126-1136. . View in PubMed

Cognition and motor learning in a Parkinson's disease cohort: importance of recall in episodic memory Neuroreport. 2021 10 06; 32(14):1153-1160. . View in PubMed

The Effects of Cardiorespiratory and Motor Skill Fitness on Intrinsic Functional Connectivity of Neural Networks in Individuals with Parkinson's Disease Brain Plast. 2021; 7(2):77-95. . View in PubMed

Treadmill exercise rescues mitochondrial function and motor behavior in the CAG140 knock-in mouse model of Huntington's disease Chem Biol Interact. 2020 Jan 05; 315:108907. . View in PubMed

Mild cognitive impairment, psychiatric symptoms, and executive functioning in patients with Parkinson's disease Int J Geriatr Psychiatry. 2020 04; 35(4):396-404. . View in PubMed

Cognitive flexibility deficits in rats with dorsomedial striatal 6-hydroxydopamine lesions tested using a three-choice serial reaction time task with reversal learning Neuroreport. 2020 10 14; 31(15):1055-1064. . View in PubMed

Exercise induces region-specific remodeling of astrocyte morphology and reactive astrocyte gene expression patterns in male mice J Neurosci Res. 2019 09; 97(9):1081-1094. . View in PubMed

Intensive treadmill exercise increases expression of hypoxia-inducible factor 1a and its downstream transcript targets: a potential role in neuroplasticity Neuroreport. 2019 06 12; 30(9):619-627. . View in PubMed

Worse cognitive performance predicts increased anxiety and depressive symptoms in patients with Parkinson's disease: A bidirectional analysis Neuropsychology. 2019 Jan; 33(1):35-46. . View in PubMed

Basal ganglia and beyond: The interplay between motor and cognitive aspects in Parkinson's disease rehabilitation Neurosci Biobehav Rev. 2018 07; 90:294-308. . View in PubMed

Treadmill exercise modifies dopamine receptor expression in the prefrontal cortex of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of Parkinson's disease Neuroreport. 2017 Oct 18; 28(15):987-995. . View in PubMed

Treadmill exercise delays the onset of non-motor behaviors and striatal pathology in the CAG140 knock-in mouse model of Huntington's disease Neurobiol Dis. 2017 Sep; 105:15-32. . View in PubMed

The Oxygen Paradox, the French Paradox, and age-related diseases Geroscience. 2017 12; 39(5-6):499-550. . View in PubMed

Noradrenergic mechanisms of arousal's bidirectional effects on episodic memory Neurobiol Learn Mem. 2017 Jan; 137:1-14. . View in PubMed

Engaging cognitive circuits to promote motor recovery in degenerative disordersexercise as a learning modality. J Hum Kinet. 2016 Sep 01; 52:35-51. . View in PubMed

Context-Dependent Learning in People With Parkinson's Disease J Mot Behav. 2016 May-Jun; 48(3):240-8. . View in PubMed

Personality traits and the risk for Parkinson disease: a prospective study Eur J Epidemiol. 2016 Feb; 31(2):169-75. . View in PubMed

Evidence of functional brain reorganization on the basis of blood flow changes in the CAG140 knock-in mouse model of Huntington's disease Neuroreport. 2016 06 15; 27(9):632-9. . View in PubMed

The Effects of Exercise on Dopamine Neurotransmission in Parkinson's Disease: Targeting Neuroplasticity to Modulate Basal Ganglia Circuitry Brain Plast. 2015; 1(1):29-39. . View in PubMed

Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease Neurobiol Dis. 2014 Mar; 63:201-9. . View in PubMed

A kinder, gentler dopamine… highlighting dopamine's role in behavioral flexibility Front Neurosci. 2014; 8:4. . View in PubMed

Exercise modifies a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor expression in striatopallidal neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse J Neurosci Res. 2013 Nov; 91(11):1492-507. . View in PubMed

Treadmill exercise elevates striatal dopamine D2 receptor binding potential in patients with early Parkinson's disease Neuroreport. 2013 Jul 10; 24(10):509-14. . View in PubMed

Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease Lancet Neurol. 2013 Jul; 12(7):716-26. . View in PubMed

The Enemy within: Propagation of Aberrant Corticostriatal Learning to Cortical Function in Parkinson's Disease Front Neurol. 2013; 4:134. . View in PubMed

Brief mitochondrial inhibition causes lasting changes in motor behavior and corticostriatal synaptic physiology in the Fischer 344 rat Neuroscience. 2012 Jul 26; 215:149-59. . View in PubMed

Accuracy and sensitivity of Parkinsonian disorder diagnoses in two Swedish national health registers Neuroepidemiology. 2012; 38(3):186-93. . View in PubMed

How might physical activity benefit patients with Parkinson disease? Nat Rev Neurol. 2011 Jul 12; 7(9):528-34.. View in PubMed

Acute and long-term response of dopamine nigrostriatal synapses to a single, low-dose episode of 3-nitropropionic acid-mediated chemical hypoxia Synapse. 2011 Apr; 65(4):339-50. . View in PubMed

The role of exercise in facilitating basal ganglia function in Parkinson's disease Neurodegener Dis Manag. 2011 Apr 01; 1(2):157-170. . View in PubMed

MPTP Neurotoxicity and Testosterone Induce Dendritic Remodeling of Striatal Medium Spiny Neurons in the C57Bl/6 Mouse Parkinsons Dis. 2011; 2011:138471. . View in PubMed

Exercise elevates dopamine D2 receptor in a mouse model of Parkinson's disease: in vivo imaging with [¹8F]fallypride Mov Disord. 2010 Dec 15; 25(16):2777-84. . View in PubMed

Exercise effects on motor and affective behavior and catecholamine neurochemistry in the MPTP-lesioned mouse Behav Brain Res. 2010 Dec 01; 213(2):253-62. . View in PubMed

Sex differences in motor behavior in the MPTP mouse model of Parkinson's disease Pharmacol Biochem Behav. 2010 Jun; 95(4):466-72. . View in PubMed

Altered AMPA receptor expression with treadmill exercise in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury J Neurosci Res. 2010 Feb 15; 88(3):650-68. . View in PubMed

Enhancing neuroplasticity in the basal ganglia: the role of exercise in Parkinson's disease Mov Disord. 2010; 25 Suppl 1:S141-5. . View in PubMed

The relationships between the unified Parkinson's disease rating scale and lower extremity functional performance in persons with early-stage Parkinson's disease Neurorehabil Neural Repair. 2009 Sep; 23(7):657-61. . View in PubMed

Complete ascertainment of Parkinson disease in the Swedish Twin Registry Neurobiol Aging. 2008 Dec; 29(12):1765-73. . View in PubMed

Memory, mood, dopamine, and serotonin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury Neurobiol Dis. 2008 Nov; 32(2):319-27. . View in PubMed

Decreased striatal dopamine release underlies increased expression of long-term synaptic potentiation at corticostriatal synapses 24 h after 3-nitropropionic-acid-induced chemical hypoxia J Neurosci. 2008 Sep 17; 28(38):9585-97. . View in PubMed

The effect of exercise training in improving motor performance and corticomotor excitability in people with early Parkinson's disease Arch Phys Med Rehabil. 2008 Jul; 89(7):1221-9. . View in PubMed

Asymmetric corticomotor excitability correlations in early Parkinson's disease Mov Disord. 2007 Aug 15; 22(11):1587-93. . View in PubMed

Effects of treadmill exercise on dopaminergic transmission in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury J Neurosci. 2007 May 16; 27(20):5291-300. . View in PubMed

Behavioral motor recovery in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned squirrel monkey (Saimiri sciureus): changes in striatal dopamine and expression of tyrosine hydroxylase and dopamine transporter proteins J Neurosci Res. 2006 Feb 01; 83(2):332-47. . View in PubMed

High and low responders to novelty show differential effects in striatal glutamate Synapse. 2005 Dec 01; 58(3):200-7. . View in PubMed

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned model of parkinson's disease, with emphasis on mice and nonhuman primates Comp Med. 2004 Oct; 54(5):497-513. . View in PubMed

Exercise-induced behavioral recovery and neuroplasticity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse basal ganglia J Neurosci Res. 2004 Aug 01; 77(3):378-90. . View in PubMed

Tyrosine hydroxylase and dopamine transporter expression following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration of the mouse nigrostriatal pathway J Neurosci Res. 2004 May 15; 76(4):539-50. . View in PubMed

Human neural stem cell transplantation in the MPTP-lesioned mouse Brain Res. 2003 May 09; 971(2):168-77. . View in PubMed

Absence of elevated anti-alpha-synuclein and anti-EBV latent membrane protein antibodies in PD Neurology. 2002 May 14; 58(9):1435-6. . View in PubMed

Reliability and validity of a new global dyskinesia rating scale in the MPTP-lesioned non-human primate Mov Disord. 2001 Mar; 16(2):202-7. . View in PubMed

The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a technical review of its utility and safety J Neurochem. 2001 Mar; 76(5):1265-74. . View in PubMed

Relationship among nigrostriatal denervation, parkinsonism, and dyskinesias in the MPTP primate model Mov Disord. 2000 May; 15(3):459-66. . View in PubMed

Combined assessment of tau and neuronal thread protein in Alzheimer's disease CSF Neurology. 2000 Apr 11; 54(7):1498-504. . View in PubMed

Investigating levodopa-induced dyskinesias in the parkinsonian primate Ann Neurol. 2000 Apr; 47(4 Suppl 1):S79-89. . View in PubMed

Experimental models of Parkinson's disease: insights from many models Lab Anim Sci. 1999 Aug; 49(4):363-71. . View in PubMed

Isolation and identification of process impurities in trimethoprim drug substance by high-performance liquid chromatography, atmospheric pressure chemical ionization liquid chromatography/mass spectrometry and nuclear magnetic resonance spectroscopy J Pharm Biomed Anal. 1999 Mar; 19(3-4):373-89. . View in PubMed

The native form of alpha-synuclein is not found in the cerebrospinal fluid of patients with Parkinson's disease or normal controls Neurosci Lett. 1998 Aug 28; 253(1):13-6. . View in PubMed

A case of tetrabenazine-induced neuroleptic malignant syndrome after prolonged treatment Mov Disord. 1997 Mar; 12(2):246-8. . View in PubMed

Use of intrathecal baclofen in the treatment of patients with dystonia Arch Neurol. 1996 Dec; 53(12):1241-6. . View in PubMed

GC/MS comparison of the West Indian aphrodisiac "Love Stone" to the Chinese medication "chan su": bufotenine and related bufadienolides J Forensic Sci. 1996 Nov; 41(6):1068-73. . View in PubMed

Fentanyl-induced dyskinesias Mov Disord. 1995 Sep; 10(5):679-80. . View in PubMed

Gas chromatographic/mass spectrometric analyses of unknown analytical response in imported Fava beans: 4-chloro-6-methoxyindole J AOAC Int. 1995 May-Jun; 78(3):888-92. . View in PubMed

Purge-and-trap gas chromatographic-mass spectrometric determination of benzene in denture adhesives J AOAC Int. 1995 Mar-Apr; 78(2):413-8. . View in PubMed

Potential misidentification of trichlorophenylethanol in imported peppers Rapid Commun Mass Spectrom. 1990 Feb; 4(2):58-60. . View in PubMed

Thermospray mass spectrometry of thiazidesA novel elimination and rearrangement resulting from a molecular adduct ion. Rapid Commun Mass Spectrom. 1988 Feb; 2(2):25-7. . View in PubMed

Identification of fluchloralin in imported dried fruit Bull Environ Contam Toxicol. 1985 Sep; 35(3):285-90. . View in PubMed

Negative ion chemical ionization mass spectrometric method for confirmation of identity of aflatoxin B1: collaborative study J Assoc Off Anal Chem. 1985 Jul-Aug; 68(4):636-40. . View in PubMed

Confirmation of ethylene dibromide in fruits and grains by mass spectrometry Anal Chem. 1984 Oct; 56(12):2138-41. . View in PubMed

GC-MS identification of prothiophos in imported preserved cabbage Bull Environ Contam Toxicol. 1983 Jul; 31(1):116-9. . View in PubMed

Application of mass spectrometry in the regulatory analysis of pesticides and industrial chemicals in food and feed commodities Biomed Mass Spectrom. 1983 May; 10(5):301-15. . View in PubMed

GC-MS identification and analytical behavior of procymidone in imported foods Bull Environ Contam Toxicol. 1982 Nov; 29(5):611-4. . View in PubMed

GC-MS identification and analytical behavior of pirimiphos-methyl in imported foods Bull Environ Contam Toxicol. 1981 Oct; 27(4):524-8. . View in PubMed

Colorimetric determination of disulfiram in tablets: collaborative study J Assoc Off Anal Chem. 1981 May; 64(3):554-6. . View in PubMed

Identification of the herbicide 2,4,6-trichlorophenyl p4-nitrophenyl ether in imported rainbow trout Bull Environ Contam Toxicol. 1979 Sep; 23(1-2):165-9. . View in PubMed

Dr. Petzinger is a board certified neurologist specializing in the care of patients with Parkinson’s disease. She divides her time between clinical care of patients and laboratory research. The primary focus of Dr. Petzinger’s research is to better understand how to promote brain repair following injury and to translate these findings into new therapeutic treatments. Dr. Petzinger has been involved in numerous federally funded research grants. Currently, she is the principal investigator on the US Army Research Grant entitled Behaviorial and Pharmacolgical Enhancement of Neuroplasticity in Basal Ganglia of the MPTP-Lesioned Mouse and Non-Human Primate.
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