Mark Floyd Lew, MD

Dr. Lew has an international reputation for the treatment of patients with Parkinson’s disease, dystonia, and other movement disorders. He is a board certified neurologist and a fellow of the American Academy of Neurology. Dr. Lew is the director of the Division of Movement Disorders and serves as the vice chairman of the Department of Neurology. He has lectured extensively in the United States and abroad on clinical research related to new therapies for Parkinson’s disease and dystonia. Dr. Lew also collaborates closely with local and national advocacy organizations (e.g., the Hollyrod Foundation and the National Parkinson’s Foundation) to increase public awareness and to support research and care.

• Common mitochondrial deletions in RNA-Seq: evaluation of bulk, single-cell, and spatial transcriptomic datasets Commun Biol. 2024 Feb 17; 7(1):200. . View in PubMed
• BoNT clinical trial update: Sialorrhea Toxicon. 2023 Apr; 226:107087. . View in PubMed
• Should “on-demand” treatments for Parkinson’s disease OFF episodes be used earlier? Clin Park Relat Disord. 2022; 7:100161.. View in PubMed
• Correction: Sustained functional benefits after a single set of injections with abobotulinumtoxinA using a 2-mL injection volume in adults with cervical dystonia: 12-week results from a randomized, double-blind, placebo-controlled phase 3b study PLoS One. 2021; 16(4):e0250475. . View in PubMed
• Sustained functional benefits after a single set of injections with abobotulinumtoxinA using a 2-mL injection volume in adults with cervical dystonia: 12-week results from a randomized, double-blind, placebo-controlled phase 3b study PLoS One. 2021; 16(2):e0245827. . View in PubMed
• AbobotulinumtoxinA provides flexibility for the treatment of cervical dystonia with 500 U/1 mL and 500 U/2 mL dilutions Clin Park Relat Disord. 2021; 5:100115. . View in PubMed
• Tears – more to them than meets the eye: why tears are a good source of biomarkers in Parkinson’s disease Biomark Med. 2020 02; 14(2):151-163. . View in PubMed
• Safety and Efficacy of RimabotulinumtoxinB for Treatment of Sialorrhea in Adults: A Randomized Clinical Trial JAMA Neurol. 2020 04 01; 77(4):461-469. . View in PubMed
• Prospective Home-use Study on Non-invasive Neuromodulation Therapy for Essential Tremor Tremor Other Hyperkinet Mov (N Y). 2020 08 14; 10:29. . View in PubMed
• Levels of oligomeric a-Synuclein in reflex tears distinguish Parkinson’s disease patients from healthy controls Biomark Med. 2019 12; 13(17):1447-1457. . View in PubMed
• Oligomeric a-synuclein is increased in basal tears of Parkinson’s patients Biomark Med. 2019 08; 13(11):941-952. . View in PubMed
• Safety and efficacy of CVT-301 (levodopa inhalation powder) on motor function during off periods in patients with Parkinson’s disease: a randomised, double-blind, placebo-controlled phase 3 trial Lancet Neurol. 2019 02; 18(2):145-154. . View in PubMed
• Use of botulinum toxin in Parkinson’s disease Parkinsonism Relat Disord. 2019 02; 59:57-64. . View in PubMed
• Targeting neurons in the gastrointestinal tract to treat Parkinson’s disease Clin Park Relat Disord. 2019; 1:2-7. . View in PubMed
• Long-term safety and efficacy of levodopa-carbidopa intestinal gel in advanced Parkinson’s disease Mov Disord. 2018 Jul; 33(6):928-936. . View in PubMed
• A 500 U/2 mL dilution of abobotulinumtoxinA vsplacebo: randomized study in cervical dystonia. Int J Neurosci. 2018 Jul; 128(7):619-626. . View in PubMed
• The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic orthostatic hypotension and associated supine hypertension J Neurol. 2017 Aug; 264(8):1567-1582. . View in PubMed
• Multicenter observational study of abobotulinumtoxinA neurotoxin in cervical dystonia: The ANCHOR-CD registry J Neurol Sci. 2017 May 15; 376:84-90. . View in PubMed
• Initiating droxidopa for neurogenic orthostatic hypotension in a patient with Parkinson disease Clin Auton Res. 2017 07; 27(Suppl 1):13-14. . View in PubMed
• Managing supine hypertension in a patient with non-diabetic autonomic neuropathy receiving droxidopa for neurogenic orthostatic hypotension Clin Auton Res. 2017 07; 27(Suppl 1):35-37. . View in PubMed
• Adding droxidopa to fludrocortisone or midodrine in a patient with neurogenic orthostatic hypotension and Parkinson disease Clin Auton Res. 2017 07; 27(Suppl 1):29-31. . View in PubMed
• Differential diagnosis of suspected neurogenic orthostatic hypotension in a patient with Parkinson disease Clin Auton Res. 2017 07; 27(Suppl 1):5-7. . View in PubMed
• A randomized trial of a low-dose Rasagiline and Pramipexole combination (P2B001) in early Parkinson’s disease Mov Disord. 2017 05; 32(5):783-789. . View in PubMed
• Clinical utility of DaTscan™ imaging in the evaluation of patients with parkinsonism: a US perspective Expert Rev Neurother. 2017 03; 17(3):219-225. . View in PubMed
• Apomorphine Subcutaneous Injection for the Management of Morning Akinesia in Parkinson’s Disease Mov Disord Clin Pract. 2017 Jan-Feb; 4(1):78-83. . View in PubMed
• RimabotulinumtoxinB in sialorrhea: systematic review of clinical trials J Clin Mov Disord. 2017; 4:9. . View in PubMed
• Poster 290 Efficacy and Safety of a 2 mL Dilution of AbobotulinumtoxinA Compared with Placebo in Adult Patients with Cervical Dystonia PM R. 2016 Sep; 8(9S):S254-S255. . View in PubMed
• Integrated safety of levodopa-carbidopa intestinal gel from prospective clinical trials Mov Disord. 2016 Apr; 31(4):538-46. . View in PubMed
• A Phase 2A Trial of the Novel mGluR5-Negative Allosteric Modulator Dipraglurant for Levodopa-Induced Dyskinesia in Parkinson’s Disease Mov Disord. 2016 09; 31(9):1373-80. . View in PubMed
• Initiation and dose optimization for levodopa-carbidopa intestinal gel: Insights from phase 3 clinical trials Parkinsonism Relat Disord. 2015 Jul; 21(7):742-8. . View in PubMed
• Levodopa-carbidopa intestinal gel in advanced Parkinson’s disease: final 12-month, open-label results Mov Disord. 2015 Apr; 30(4):500-9. . View in PubMed
• Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a randomized clinical trial JAMA. 2015 Feb 10; 313(6):584-93. . View in PubMed
• Tozadenant (SYN115) in patients with Parkinson’s disease who have motor fluctuations on levodopa: a phase 2b, double-blind, randomised trial Lancet Neurol. 2014 Aug; 13(8):767-76. . View in PubMed
• A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit JAMA Neurol. 2014 May; 71(5):543-52. . View in PubMed
• Rasagiline treatment effects on parkinsonian tremor Int J Neurosci. 2013 Dec; 123(12):859-65. . View in PubMed
• Immunogenicity and long-term efficacy of botulinum toxin type B in the treatment of cervical dystonia: report of 4 prospective, multicenter trials Clin Neuropharmacol. 2012 Sep-Oct; 35(5):215-23. . View in PubMed
• Accuracy and sensitivity of Parkinsonian disorder diagnoses in two Swedish national health registers Neuroepidemiology. 2012; 38(3):186-93. . View in PubMed
• Immediate versus delayed switch from levodopa/carbidopa to levodopa/carbidopa/entacapone: effects on motor function and quality of life in patients with Parkinson’s disease with end-of-dose wearing off Int J Neurosci. 2011 Nov; 121(11):605-13. . View in PubMed
• Long-term, open-label study of once-daily ropinirole prolonged release in early Parkinson’s disease Int J Neurosci. 2011 May; 121(5):246-53. . View in PubMed
• The evidence for disease modification in Parkinson’s disease Int J Neurosci. 2011; 121 Suppl 2:18-26. . View in PubMed
• Polycythemia and chorea Handb Clin Neurol. 2011; 100:271-6. . View in PubMed
• Long-term efficacy and safety of botulinum toxin type A (Dysport) in cervical dystonia Parkinsonism Relat Disord. 2010 Jun; 16(5):316-23. . View in PubMed
• Long-term efficacy of rasagiline in early Parkinson’s disease Int J Neurosci. 2010 Jun; 120(6):404-8. . View in PubMed
• RimabotulinumtoxinB effects on pain associated with cervical dystonia: results of placebo and comparator-controlled studies Int J Neurosci. 2010 Apr; 120(4):298-300. . View in PubMed
• Increased melanoma risk in Parkinson disease: a prospective clinicopathological study Arch Neurol. 2010 Mar; 67(3):347-52. . View in PubMed
• Orally disintegrating selegiline in Parkinson patients with dopamine agonist-related adverse effects Clin Neuropharmacol. 2010 Jan-Feb; 33(1):5-10. . View in PubMed
• Long-term outcome of early versus delayed rasagiline treatment in early Parkinson’s disease Mov Disord. 2009 Mar 15; 24(4):564-73. . View in PubMed
• Complete ascertainment of Parkinson disease in the Swedish Twin Registry Neurobiol Aging. 2008 Dec; 29(12):1765-73. . View in PubMed
• The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson’s disease: the GenePD study BMC Med. 2008 Nov 05; 6:32. . View in PubMed
• Huntington CAG repeat size does not modify onset age in familial Parkinson’s disease: the GenePD study Mov Disord. 2008 Aug 15; 23(11):1596-601. . View in PubMed
• Replication of association between ELAVL4 and Parkinson disease: the GenePD study Hum Genet. 2008 Aug; 124(1):95-9. . View in PubMed
• Haplotypes and gene expression implicate the MAPT region for Parkinson disease: the GenePD Study Neurology. 2008 Jul 01; 71(1):28-34. . View in PubMed
• Role of botulinum toxin in the treatment of cervical dystonia Neurol Clin. 2008 May; 26 Suppl 1:43-53. . View in PubMed
• Overview of Parkinson’s disease Pharmacotherapy. 2007 Dec; 27(12 Pt 2):155S-160S. . View in PubMed
• Results from a 2-year centralized tolcapone liver enzyme monitoring program Clin Neuropharmacol. 2007 Sep-Oct; 30(5):281-6. . View in PubMed
• Safety and efficacy of newly formulated selegiline orally disintegrating tablets as an adjunct to levodopa in the management of ‘off’ episodes in patients with Parkinson’s disease Curr Med Res Opin. 2007 Apr; 23(4):741-50. . View in PubMed
• Calcification of the Basal Ganglia Handb Clin Neurol. 2007; 84:479-86. . View in PubMed
• Herbicide exposure modifies GSTP1 haplotype association to Parkinson onset age: the GenePD Study Neurology. 2006 Dec 26; 67(12):2206-10. . View in PubMed
• Influence of heterozygosity for parkin mutation on onset age in familial Parkinson disease: the GenePD study Arch Neurol. 2006 Jun; 63(6):826-32. . View in PubMed
• BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study Neurology. 2005 Dec 13; 65(11):1823-5. . View in PubMed
• Selegiline orally disintegrating tablets for the treatment of Parkinson’s disease Expert Rev Neurother. 2005 Nov; 5(6):705-12. . View in PubMed
• Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ-1 (T497C) genes in familial Parkinson’s disease from the GenePD study Mov Disord. 2005 Sep; 20(9):1188-91. . View in PubMed
• Efficacy and safety of botulinum type A toxin (Dysport) in cervical dystonia: results of the first US randomized, double-blind, placebo-controlled study Mov Disord. 2005 Jul; 20(7):783-91. . View in PubMed
• Behavioral changes as side effects of medication treatment for Parkinson’s disease Adv Neurol. 2005; 96:114-29. . View in PubMed
• Duration of effectiveness of botulinum toxin type B in the treatment of cervical dystonia Adv Neurol. 2004; 94:211-5. . View in PubMed
• A haplotype at the PARK3 locus influences onset age for Parkinson’s disease: the GenePD study Neurology. 2003 Dec 09; 61(11):1557-61. . View in PubMed
• Gait and Balance Dysfunction in Adults Curr Treat Options Neurol. 2003 Mar; 5(2):177-185. . View in PubMed
• Review of the FDA-approved uses of botulinum toxins, including data suggesting efficacy in pain reduction Clin J Pain. 2002 Nov-Dec; 18(6 Suppl):S142-6. . View in PubMed
• PARK3 influences age at onset in Parkinson disease: a genome scan in the GenePD study Am J Hum Genet. 2002 May; 70(5):1089-95. . View in PubMed
• Epidemiologic study of 203 sibling pairs with Parkinson’s disease: the GenePD study Neurology. 2002 Jan 08; 58(1):79-84. . View in PubMed
• Botulinum toxin type B: An effective treatment for alleviating pain associated with cervical dystonia J Back Musculoskelet Rehabil. 2002 Jan 01; 16(1):3-9. . View in PubMed
• Botulinum toxin type B (Myobloc, NeuroBloc): a new choice in cervical dystonia Expert Rev Neurother. 2001 Nov; 1(2):143-52. . View in PubMed
• A randomized, controlled trial of remacemide for motor fluctuations in Parkinson’s disease Neurology. 2001 Feb 27; 56(4):455-62. . View in PubMed
• Current and emerging treatments for cervical dystonia CNS Spectr. 2000 Jun; 5(6 Suppl 5):S1-8. . View in PubMed
• The safety and efficacy of botulinum toxin type B in the treatment of patients with cervical dystonia: summary of three controlled clinical trials Neurology. 2000; 55(12 Suppl 5):S29-35. . View in PubMed
• Safety and efficacy of NeuroBloc (botulinum toxin type B) in type A-resistant cervical dystonia Neurology. 1999 Oct 22; 53(7):1431-8. . View in PubMed
• Safety and efficacy of NeuroBloc (botulinum toxin type B) in type A-responsive cervical dystonia Neurology. 1999 Oct 22; 53(7):1439-46. . View in PubMed
• Randomized, placebo-controlled study of tolcapone in patients with fluctuating Parkinson disease treated with levodopa-carbidopaTolcapone Fluctuator Study Group III. Arch Neurol. 1998 Aug; 55(8):1089-95. . View in PubMed
• Botulinum toxin type B: a double-blind, placebo-controlled, safety and efficacy study in cervical dystonia Neurology. 1997 Sep; 49(3):701-7. . View in PubMed
• Ventroposterior medial pallidotomy in patients with advanced Parkinson’s disease Neurosurgery. 1995 Jun; 36(6):1112-6; discussion 1116-7. . View in PubMed
• Pallidotomy increases activity of motor association cortex in Parkinson’s disease: a positron emission tomographic study Ann Neurol. 1995 Jun; 37(6):776-83. . View in PubMed
• Adductor laryngeal breathing dystonia in a patient with lubag (X-linked dystonia-Parkinsonism syndrome) Mov Disord. 1994 May; 9(3):318-20. . View in PubMed
• Clozapine treatment of parkinsonism with psychosis J Am Geriatr Soc. 1993 Jun; 41(6):669-71. . View in PubMed
• Consciousness, coma, and the vegetative state: physical basis and definitional character Issues Law Med. 1991; 6(4):361-71. . View in PubMed

• Hamm-Alvarez, Sarah