Meredith N. Braskie

Meredith N. Braskie

Assistant Professor of Neurology;INI Director of Education
ISI, 4676 Admiralty Way, Ste. 200 Health Sciences Campus Marina Del Rey

: Bosco S. Tjan Mentorship Award, 2023

: Search, 2011

: Turken Award for Alzheimer’s Disease Research, 2011

: Turken Award for Alzheimer’s Disease Research, 2011

: Ruth L. Kirschstein National Research Service Award, 2009-2010

: Ruth L. Kirschstein National Research Service Award , 2009-2010

: Achievement Rewards for College Scientists (ARCS) fellowship, 2004-2006

: Ruth L Kirschstein National Research Service Award, 2003-2006

: Ruth L Kirschstein National Research Service Award , 2003-2006

White matter hyperintensity volume modifies the association between CSF vascular inflammatory biomarkers and regional FDG-PET along the Alzheimer's disease continuum Neurobiol Aging. 2023 Dec; 132:1-12. . View in PubMed

Associations of ApoE4 status and DHA supplementation on plasma and CSF lipid profiles and entorhinal cortex thickness J Lipid Res. 2023 Jun; 64(6):100354. . View in PubMed

Correction: Mitochondrial DNA variation in Alzheimer's disease reveals a unique microprotein called SHMOOSE Mol Psychiatry. 2023 Apr; 28(4):1827. . View in PubMed

Mitochondrial DNA variation in Alzheimer's disease reveals a unique microprotein called SHMOOSE Mol Psychiatry. 2023 04; 28(4):1813-1826. . View in PubMed

Baseline Findings of PreventE4: A Double-Blind Placebo Controlled Clinical Trial Testing High Dose DHA in APOE4 Carriers before the Onset of Dementia J Prev Alzheimers Dis. 2023; 10(4):810-820. . View in PubMed

Brain energy failure in dementia syndromes: Opportunities and challenges for glucagon-like peptide-1 receptor agonists Alzheimers Dement. 2022 03; 18(3):478-497. . View in PubMed

Characterizing plasma NfL in a community-dwelling multi-ethnic cohort: Results from the HABLE study Alzheimers Dement. 2022 02; 18(2):240-250. . View in PubMed

A blood screening tool for detecting mild cognitive impairment and Alzheimer's disease among community-dwelling Mexican Americans and non-Hispanic Whites: A method for increasing representation of diverse populations in clinical research Alzheimers Dement. 2022 01; 18(1):77-87. . View in PubMed

Testing a convolutional neural network-based hippocampal segmentation method in a stroke population Hum Brain Mapp. 2022 01; 43(1):234-243. . View in PubMed

Proteomic Profiles of Neurodegeneration Among Mexican Americans and Non-Hispanic Whites in the HABS-HD Study J Alzheimers Dis. 2022; 86(3):1243-1254. . View in PubMed

Vascular risk profile and white matter hyperintensity volume among Mexican Americans and non-Hispanic Whites: The HABLE study Alzheimers Dement (Amst). 2022; 14(1):e12263. . View in PubMed

Neurodegeneration from the AT(N) framework is different among Mexican Americans compared to non-Hispanic Whites: A Health & Aging Brain among Latino Elders (HABLE) Study Alzheimers Dement (Amst). 2022; 14(1):e12267. . View in PubMed

Characterization of Mild Cognitive Impairment and Dementia among Community-Dwelling Mexican Americans and Non-Hispanic Whites J Alzheimers Dis. 2022; 90(2):905-915. . View in PubMed

Racial/Ethnic Disparities in Alzheimer's Disease Risk: Role of Exposure to Ambient Fine Particles J Gerontol A Biol Sci Med Sci. 2022 05 05; 77(5):977-985. . View in PubMed

Regional relationships between CSF VEGF levels and Alzheimer's disease brain biomarkers and cognition Neurobiol Aging. 2021 09; 105:241-251. . View in PubMed

The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics Alzheimers Dement (Amst). 2021; 13(1):e12202. . View in PubMed

MRI biomarkers of small vessel disease and cognition: A cross-sectional study of a cognitively normal Mexican American cohort Alzheimers Dement (Amst). 2021; 13(1):e12236. . View in PubMed

Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial EBioMedicine. 2020 Sep; 59:102883. . View in PubMed

White matter hyperintensities and their relationship to cognition: Effects of segmentation algorithm Neuroimage. 2020 02 01; 206:116327. . View in PubMed

Effect of APOE Genotype on Plasma Docosahexaenoic Acid (DHA), Eicosapentaenoic Acid, Arachidonic Acid, and Hippocampal Volume in the Alzheimer's Disease Cooperative Study-Sponsored DHA Clinical Trial J Alzheimers Dis. 2020; 74(3):975-990. . View in PubMed

White matter hypointensities and hyperintensities have equivalent correlations with age and CSF ß-amyloid in the nondemented elderly Brain Behav. 2019 12; 9(12):e01457. . View in PubMed

Sulcal morphology in Alzheimer's disease: an effective marker of diagnosis and cognition Neurobiol Aging. 2019 12; 84:41-49. . View in PubMed

Systemic inflammation as a predictor of brain aging: Contributions of physical activity, metabolic risk, and genetic risk Neuroimage. 2018 05 15; 172:118-129. . View in PubMed

Association of Docosahexaenoic Acid Supplementation With Alzheimer Disease Stage in Apolipoprotein E e4 Carriers: A Review JAMA Neurol. 2017 Mar 01; 74(3):339-347. . View in PubMed

Resting-state networks associated with cognitive processing show more age-related decline than those associated with emotional processing Neurobiol Aging. 2017 06; 54:152-162. . View in PubMed


Independent value added by diffusion MRI for prediction of cognitive function in older adults Neuroimage Clin. 2017; 14:166-173. . View in PubMed

Relationship of a common OXTR gene variant to brain structure and default mode network function in healthy humans Neuroimage. 2017 02 15; 147:500-506. . View in PubMed

Brain Structure and Function Associated with Younger Adults in Growth Hormone Receptor-Deficient Humans J Neurosci. 2017 02 15; 37(7):1696-1707. . View in PubMed

Cerebral amyloid is associated with greater white-matter hyperintensity accrual in cognitively normal older adults Neurobiol Aging. 2016 12; 48:48-52. . View in PubMed

Widespread white matter and conduction defects in PSEN1-related spastic paraparesis Neurobiol Aging. 2016 11; 47:201-209. . View in PubMed

Cerebral Amyloid and Hypertension are Independently Associated with White Matter Lesions in Elderly Front Aging Neurosci. 2015; 7:221. . View in PubMed

Obesity gene NEGR1 associated with white matter integrity in healthy young adults Neuroimage. 2014 Nov 15; 102 Pt 2:548-57. . View in PubMed

Physical activity, inflammation, and volume of the aging brain Neuroscience. 2014 Jul 25; 273:199-209. . View in PubMed

A focus on structural brain imaging in the Alzheimer's disease neuroimaging initiative Biol Psychiatry. 2014 Apr 01; 75(7):527-33. . View in PubMed

Memory performance and fMRI signal in presymptomatic familial Alzheimer's disease Hum Brain Mapp. 2013 Dec; 34(12):3308-19. . View in PubMed

Relation between variants in the neurotrophin receptor gene, NTRK3, and white matter integrity in healthy young adults Neuroimage. 2013 Nov 15; 82:146-53. . View in PubMed

Understanding cognitive deficits in Alzheimer's disease based on neuroimaging findings Trends Cogn Sci. 2013 Oct; 17(10):510-6. . View in PubMed

Regional brain volume differences in symptomatic and presymptomatic carriers of familial Alzheimer's disease mutations J Neurol Neurosurg Psychiatry. 2013 Feb; 84(2):154-62. . View in PubMed

Recent advances in imaging Alzheimer's disease J Alzheimers Dis. 2013; 33 Suppl 1:S313-27. . View in PubMed

How a common variant in the growth factor receptor gene, NTRK1, affects white matter Bioarchitecture. 2012 Sep-Oct; 2(5):181-4. . View in PubMed

Predicting white matter integrity from multiple common genetic variants Neuropsychopharmacology. 2012 Aug; 37(9):2012-9. . View in PubMed

Prediction of cognitive decline based on hemispheric cortical surface maps of FDDNP PET Neuroimage. 2012 Jul 16; 61(4):749-60. . View in PubMed

Relationship of a variant in the NTRK1 gene to white matter microstructure in young adults J Neurosci. 2012 Apr 25; 32(17):5964-72. . View in PubMed

Dopamine and frontostriatal networks in cognitive agingNeurobiol Aging. 2012 Mar; 33(3):623. e15-24. . View in PubMed

Increased fMRI signal with age in familial Alzheimer's disease mutation carriersNeurobiol Aging. 2012 Feb; 33(2):424. e11-21. . View in PubMed

Correlations of striatal dopamine synthesis with default network deactivations during working memory in younger adults Hum Brain Mapp. 2011 Jun; 32(6):947-61. . View in PubMed

Common Alzheimer's disease risk variant within the CLU gene affects white matter microstructure in young adults J Neurosci. 2011 May 04; 31(18):6764-70. . View in PubMed

Effects of risk genes on BOLD activation in presymptomatic carriers of familial Alzheimer's disease mutations during a novelty encoding task Cereb Cortex. 2011 Apr; 21(4):877-83. . View in PubMed

Neuroimaging measures as endophenotypes in Alzheimer's disease Int J Alzheimers Dis. 2011 Mar 31; 2011:490140. . View in PubMed

Cortical and hippocampal atrophy in patients with autosomal dominant familial Alzheimer's disease Dement Geriatr Cogn Disord. 2011; 32(2):118-25. . View in PubMed

Plaque and tangle imaging and cognition in normal aging and Alzheimer's disease Neurobiol Aging. 2010 Oct; 31(10):1669-78. . View in PubMed

Vascular health risks and fMRI activation during a memory task in older adults Neurobiol Aging. 2010 Sep; 31(9):1532-42. . View in PubMed

Overeating Behavior and Striatal Dopamine with 6-[F]-Fluoro-L-m-Tyrosine PET J Obes. 2010; 2010. . View in PubMed

FDDNP binding using MR derived cortical surface maps Neuroimage. 2010 Jan 01; 49(1):240-8. . View in PubMed

Entorhinal cortex structure and functional MRI response during an associative verbal memory task Hum Brain Mapp. 2009 Dec; 30(12):3981-92. . View in PubMed

Relationship of striatal dopamine synthesis capacity to age and cognition J Neurosci. 2008 Dec 24; 28(52):14320-8. . View in PubMed

Reduced cortical thickness in hippocampal subregions among cognitively normal apolipoprotein E e4 carriers Neuroimage. 2008 Jul 15; 41(4):1177-83. . View in PubMed

The Braskie lab seeks to gain a better understanding of risk factors for Alzheimer's disease (AD), in particular, vascular and metabolic risk and inflammation. We do this by relating measures of multimodal imaging (structural and functional MRI, diffusion tensor imaging, and amyloid and tau PET) both to relevant blood and cerebrospinal fluid measures and to other medical and demographic data. We collaborate widely, including with wet labs that are researching similar topics.
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