Michael Jakowec
Exercise alters cortico-basal ganglia network metabolic connectivity: a mesoscopic level analysis informed by anatomic parcellation defined in the mouse brain connectome Brain Struct Funct. 2023 Nov; 228(8):1865-1884. . View in PubMed
Increased perivascular space volume in white matter and basal ganglia is associated with cognition in Parkinson's Disease Brain Imaging Behav. 2023 Oct 19. . View in PubMed
Physical activity intensity is associated with cognition and functional connectivity in Parkinson's disease Parkinsonism Relat Disord. 2022 Nov; 104:7-14. . View in PubMed
Promoting Physical Activity in a Spanish-Speaking Latina Population of Low Socioeconomic Status With Chronic Neurological Disorders: Proof-of-Concept Study JMIR Form Res. 2022 Apr 20; 6(4):e34312. . View in PubMed
Knockdown of Astrocytic Monocarboxylate Transporter 4 in the Motor Cortex Leads to Loss of Dendritic Spines and a Deficit in Motor Learning Mol Neurobiol. 2022 Feb; 59(2):1002-1017. . View in PubMed
A mind in motion: Exercise improves cognitive flexibility, impulsivity and alters dopamine receptor gene expression in a Parkinsonian rat model Curr Res Neurobiol. 2022; 3:100039. . View in PubMed
Magnetic resonance spectroscopy shows associations between neurometabolite levels and perivascular space volume in Parkinson's disease: a pilot and feasibility study Neuroreport. 2022 05 04; 33(7):291-296. . View in PubMed
Exogenous l-lactate promotes astrocyte plasticity but is not sufficient for enhancing striatal synaptogenesis or motor behavior in mice J Neurosci Res. 2021 05; 99(5):1433-1447. . View in PubMed
Thalamic volume mediates associations between cardiorespiratory fitness (VO2max) and cognition in Parkinson's disease Parkinsonism Relat Disord. 2021 05; 86:19-26. . View in PubMed
Global and Regional Changes in Perivascular Space in Idiopathic and Familial Parkinson's Disease Mov Disord. 2021 05; 36(5):1126-1136. . View in PubMed
The Effects of Cardiorespiratory and Motor Skill Fitness on Intrinsic Functional Connectivity of Neural Networks in Individuals with Parkinson's Disease Brain Plast. 2021; 7(2):77-95. . View in PubMed
Cognition and motor learning in a Parkinson's disease cohort: importance of recall in episodic memory Neuroreport. 2021 10 06; 32(14):1153-1160. . View in PubMed
Treadmill exercise rescues mitochondrial function and motor behavior in the CAG140 knock-in mouse model of Huntington's disease Chem Biol Interact. 2020 Jan 05; 315:108907. . View in PubMed
Mild cognitive impairment, psychiatric symptoms, and executive functioning in patients with Parkinson's disease Int J Geriatr Psychiatry. 2020 04; 35(4):396-404. . View in PubMed
Cognitive flexibility deficits in rats with dorsomedial striatal 6-hydroxydopamine lesions tested using a three-choice serial reaction time task with reversal learning Neuroreport. 2020 10 14; 31(15):1055-1064. . View in PubMed
The macrocyclic lactones ivermectin and moxidectin show differential effects on rotational behavior in the 6-hydroxydopamine mouse model of Parkinson's disease Behav Brain Res. 2020 09 01; 393:112804. . View in PubMed
Exercise induces region-specific remodeling of astrocyte morphology and reactive astrocyte gene expression patterns in male mice J Neurosci Res. 2019 09; 97(9):1081-1094. . View in PubMed
Dopamine Receptor Blockade Attenuates Purinergic P2X4 Receptor-Mediated Prepulse Inhibition Deficits and Underlying Molecular Mechanisms Front Cell Neurosci. 2019; 13:331. . View in PubMed
Intensive treadmill exercise increases expression of hypoxia-inducible factor 1a and its downstream transcript targets: a potential role in neuroplasticity Neuroreport. 2019 06 12; 30(9):619-627. . View in PubMed
Preclinical evaluation of avermectins as novel therapeutic agents for alcohol use disorders Psychopharmacology (Berl). 2018 06; 235(6):1697-1709. . View in PubMed
Reduced expression of purinergic P2X4 receptors increases voluntary ethanol intake in C57BL/6J mice Alcohol. 2018 05; 68:63-70. . View in PubMed
Treadmill exercise modifies dopamine receptor expression in the prefrontal cortex of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of Parkinson's disease Neuroreport. 2017 Oct 18; 28(15):987-995. . View in PubMed
Treadmill exercise delays the onset of non-motor behaviors and striatal pathology in the CAG140 knock-in mouse model of Huntington's disease Neurobiol Dis. 2017 Sep; 105:15-32. . View in PubMed
The Oxygen Paradox, the French Paradox, and age-related diseases Geroscience. 2017 12; 39(5-6):499-550. . View in PubMed
Preclinical development of moxidectin as a novel therapeutic for alcohol use disorder Neuropharmacology. 2017 02; 113(Pt A):60-70. . View in PubMed
Engaging cognitive circuits to promote motor recovery in degenerative disordersexercise as a learning modality. J Hum Kinet. 2016 Sep 01; 52:35-51. . View in PubMed
Role of purinergic P2X4 receptors in regulating striatal dopamine homeostasis and dependent behaviors J Neurochem. 2016 10; 139(1):134-48. . View in PubMed
Evidence of functional brain reorganization on the basis of blood flow changes in the CAG140 knock-in mouse model of Huntington's disease Neuroreport. 2016 06 15; 27(9):632-9. . View in PubMed
The Effects of Exercise on Dopamine Neurotransmission in Parkinson's Disease: Targeting Neuroplasticity to Modulate Basal Ganglia Circuitry Brain Plast. 2015; 1(1):29-39. . View in PubMed
Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease Neurobiol Dis. 2014 Mar; 63:201-9. . View in PubMed
P2X4 receptors (P2X4Rs) represent a novel target for the development of drugs to prevent and/or treat alcohol use disorders Front Neurosci. 2014; 8:176. . View in PubMed
Exercise modifies a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor expression in striatopallidal neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse J Neurosci Res. 2013 Nov; 91(11):1492-507. . View in PubMed
Sociocommunicative and sensorimotor impairments in male P2X4-deficient mice Neuropsychopharmacology. 2013 Sep; 38(10):1993-2002. . View in PubMed
Treadmill exercise elevates striatal dopamine D2 receptor binding potential in patients with early Parkinson's disease Neuroreport. 2013 Jul 10; 24(10):509-14. . View in PubMed
Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease Lancet Neurol. 2013 Jul; 12(7):716-26. . View in PubMed
Physiol Behav. 2013 Feb 17; 110-111:6-12. . View in PubMed
Functional reorganization of motor and limbic circuits after exercise training in a rat model of bilateral parkinsonism PLoS One. 2013; 8(11):e80058. . View in PubMed
The Enemy within: Propagation of Aberrant Corticostriatal Learning to Cortical Function in Parkinson's Disease Front Neurol. 2013; 4:134. . View in PubMed
Brief mitochondrial inhibition causes lasting changes in motor behavior and corticostriatal synaptic physiology in the Fischer 344 rat Neuroscience. 2012 Jul 26; 215:149-59. . View in PubMed
Acute and long-term response of dopamine nigrostriatal synapses to a single, low-dose episode of 3-nitropropionic acid-mediated chemical hypoxia Synapse. 2011 Apr; 65(4):339-50. . View in PubMed
The role of exercise in facilitating basal ganglia function in Parkinson's disease Neurodegener Dis Manag. 2011 Apr 01; 1(2):157-170. . View in PubMed
MPTP Neurotoxicity and Testosterone Induce Dendritic Remodeling of Striatal Medium Spiny Neurons in the C57Bl/6 Mouse Parkinsons Dis. 2011; 2011:138471. . View in PubMed
Exercise elevates dopamine D2 receptor in a mouse model of Parkinson's disease: in vivo imaging with [¹8F]fallypride Mov Disord. 2010 Dec 15; 25(16):2777-84. . View in PubMed
Exercise effects on motor and affective behavior and catecholamine neurochemistry in the MPTP-lesioned mouse Behav Brain Res. 2010 Dec 01; 213(2):253-62. . View in PubMed
Sex differences in motor behavior in the MPTP mouse model of Parkinson's disease Pharmacol Biochem Behav. 2010 Jun; 95(4):466-72. . View in PubMed
Altered AMPA receptor expression with treadmill exercise in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury J Neurosci Res. 2010 Feb 15; 88(3):650-68. . View in PubMed
Enhancing neuroplasticity in the basal ganglia: the role of exercise in Parkinson's disease Mov Disord. 2010; 25 Suppl 1:S141-5. . View in PubMed
Memory, mood, dopamine, and serotonin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury Neurobiol Dis. 2008 Nov; 32(2):319-27. . View in PubMed
Decreased striatal dopamine release underlies increased expression of long-term synaptic potentiation at corticostriatal synapses 24 h after 3-nitropropionic-acid-induced chemical hypoxia J Neurosci. 2008 Sep 17; 28(38):9585-97. . View in PubMed
The effect of exercise training in improving motor performance and corticomotor excitability in people with early Parkinson's disease Arch Phys Med Rehabil. 2008 Jul; 89(7):1221-9. . View in PubMed
Effects of treadmill exercise on dopaminergic transmission in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury J Neurosci. 2007 May 16; 27(20):5291-300. . View in PubMed
Association of MBP peptides with Hsp70 in normal appearing human white matter J Neurol Sci. 2006 Nov 15; 249(2):122-34. . View in PubMed
Behavioral motor recovery in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned squirrel monkey (Saimiri sciureus): changes in striatal dopamine and expression of tyrosine hydroxylase and dopamine transporter proteins J Neurosci Res. 2006 Feb 01; 83(2):332-47. . View in PubMed
High and low responders to novelty show differential effects in striatal glutamate Synapse. 2005 Dec 01; 58(3):200-7. . View in PubMed
Differential regulation of the growth-associated proteins GAP-43 and superior cervical ganglion 10 in response to lesions of the cortex and substantia nigra in the adult rat Neuroscience. 2005; 135(4):1231-9. . View in PubMed
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned model of parkinson's disease, with emphasis on mice and nonhuman primates Comp Med. 2004 Oct; 54(5):497-513. . View in PubMed
Exercise-induced behavioral recovery and neuroplasticity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse basal ganglia J Neurosci Res. 2004 Aug 01; 77(3):378-90. . View in PubMed
Tyrosine hydroxylase and dopamine transporter expression following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration of the mouse nigrostriatal pathway J Neurosci Res. 2004 May 15; 76(4):539-50. . View in PubMed
Human neural stem cell transplantation in the MPTP-lesioned mouse Brain Res. 2003 May 09; 971(2):168-77. . View in PubMed
Reliability and validity of a new global dyskinesia rating scale in the MPTP-lesioned non-human primate Mov Disord. 2001 Mar; 16(2):202-7. . View in PubMed
The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a technical review of its utility and safety J Neurochem. 2001 Mar; 76(5):1265-74. . View in PubMed
Localization of nicotinic receptor subunit mRNAs in monkey brain by in situ hybridization J Comp Neurol. 2000 Sep 11; 425(1):58-69. . View in PubMed
Combined assessment of tau and neuronal thread protein in Alzheimer's disease CSF Neurology. 2000 Apr 11; 54(7):1498-504. . View in PubMed
Investigating levodopa-induced dyskinesias in the parkinsonian primate Ann Neurol. 2000 Apr; 47(4 Suppl 1):S79-89. . View in PubMed
Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP J Neurochem. 2000 Feb; 74(2):721-9. . View in PubMed
Experimental models of Parkinson's disease: insights from many models Lab Anim Sci. 1999 Aug; 49(4):363-71. . View in PubMed
The native form of alpha-synuclein is not found in the cerebrospinal fluid of patients with Parkinson's disease or normal controls Neurosci Lett. 1998 Aug 28; 253(1):13-6. . View in PubMed
The postnatal development of AMPA receptor subunits in the basal ganglia of the rat Dev Neurosci. 1998; 20(1):19-33. . View in PubMed
Role of nitric oxide in methamphetamine neurotoxicity: protection by 7-nitroindazole, an inhibitor of neuronal nitric oxide synthase J Neurochem. 1996 Dec; 67(6):2443-50. . View in PubMed
Monoamine oxidase-dependent metabolism of dopamine in the striatum and substantia nigra of L-DOPA-treated monkeys Brain Res. 1996 Oct 28; 738(1):53-9. . View in PubMed
Brain superoxide dismutase, catalase, and glutathione peroxidase activities in amyotrophic lateral sclerosis Ann Neurol. 1996 Feb; 39(2):158-65. . View in PubMed
Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Neurodegeneration. 1995 Sep; 4(3):257-69. . View in PubMed
In situ hybridization analysis of AMPA receptor subunit gene expression in the developing rat spinal cord Neuroscience. 1995 Aug; 67(4):909-20. . View in PubMed
Quantitative and qualitative changes in AMPA receptor expression during spinal cord development Neuroscience. 1995 Aug; 67(4):893-907. . View in PubMed
Mutational analysis of the open reading frames in the transposable element IS1 Genetics. 1988 Sep; 120(1):47-55. . View in PubMed
Expression of proteins essential for IS1 transposition: specific binding of InsA to the ends of IS1 EMBO J. 1987 Oct; 6(10):3163-9. . View in PubMed
Recombinant plasmid conferring proline overproduction and osmotic tolerance Appl Environ Microbiol. 1985 Aug; 50(2):441-6. . View in PubMed
