{"id":1060,"date":"2016-07-01T15:08:06","date_gmt":"2016-07-01T22:08:06","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/sunscreen-gene-may-help-protect-against-skin-cancer\/"},"modified":"2023-11-19T12:13:21","modified_gmt":"2023-11-19T20:13:21","slug":"sunscreen-gene-may-help-protect-against-skin-cancer","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/sunscreen-gene-may-help-protect-against-skin-cancer\/","title":{"rendered":"\u2018Sunscreen\u2019 gene may help protect against skin cancer"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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\n\n \n Press Release<\/span>\n\n\n\n<\/div>\n \n \n
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\u2018Sunscreen\u2019 gene may help protect against skin cancer<\/h1>\n\n\n<\/div>\n \n \n
\n \u00a0Zen Vuong<\/span>\n \n July 01, 2016<\/span>\n <\/div>\n \n \n
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USC researchers found that that melanoma patients with deficient or mutant copies of a \u201csunscreen" gene are less protected from harmful ultraviolet rays that could cause skin cancer.<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\r\n\r\n\n\n \n \n\n\n\n\n\n\n\n
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A new study has identified a \u201csunscreen\u201d gene that may help stave off skin cancer.
\nThe team, led by researchers from the Keck School of Medicine of USC,\u00a0found that the \u201cUV radiation Resistance Associated Gene\u201d is a tumor suppressor for skin cancer, which is the most common form of cancer in the United States. Melanoma is the deadliest skin cancer. In fact, melanoma rates have doubled over the last three decades, according to the Centers for Disease Control and Prevention.
\n\u201cIf we understand how this UV-resistant gene functions and the processes by which cells repair themselves after ultraviolet damage, then we could find targets for drugs to revert a misguided mechanism back to normal conditions,\u201d said Chengyu Liang, the study\u2019s senior author and an associate professor of molecular microbiology and immunology at the Keck School.
\nThe study was published in\u00a0Molecular Cell<\/em>\u00a0on May 19. More than 90 percent of melanoma skin cancers develop because of cell damage from exposure to UV radiation. Melanoma kills about 10,130 people annually, according to the American Cancer Society.
\n\u201cPeople who have the mutated UV-resistant gene or low levels of the UV-resistant gene may be at higher risk of melanoma or other skin cancers, especially if they go sunbathing or tanning frequently,\u201d Liang said. \u201cOur study suggests that the UV-resistant gene may serve as a biomarker for skin cancer prevention.\u201d
\nThe researchers used data from 340 melanoma patients who participated in The Cancer Genome Atlas. The study also included two experimental groups with either reduced levels of the UV-resistant gene or a mutant copy of that gene in melanoma cells and 50 fly eyes. The control groups were melanoma cells or fly eyes with normal copies of the UV-resistant gene.
\nThe scientists gave a UV shot to cells carrying the normal UV-resistant gene and cells carrying defective copies of it. After 24 hours, cells carrying normal versions of the gene had repaired more than 50 percent of the UV-induced damage. In contrast, the defective samples repaired less than 20 percent of the damaged cells.
\n\u201cThat means when people sunbathe or go tanning, those who have the normal UV-resistant gene can repair most UV-induced DNA burns in a timely manner, whereas those with the defective UV-resistant gene will have more damage left unrepaired,\u201d Liang said. \u201cAfter daily accumulation, if they sunbathe or go tanning often, these people will have increased risk for developing skin cancers such as melanoma.\u201d
\nThe researchers were able to show a correlation with increased cancer risk. Their study did not definitively say diminished levels or mutant copies of the UV-resistant gene were causes for skin cancer development.
\nScientists first discovered the UV-resistant gene nearly two decades ago in relation to a disease called\u00a0Xeroderma Pigmentosum<\/em>, which makes people extremely sensitive to sunlight and puts them at high risk for developing skin cancer. Scientists did not examine the function of the UV-resistant gene in people who are healthy or who have skin cancer.
\nThe USC-led team has now identified what the UV-resistant gene does and how it operates in a general population, said Yongfei Yang, lead author and a research associate at Keck Medicine of USC.
\n\u201cThe UV-resistant gene is a tumor suppressor involved in the UV-repair process of a cell\u2019s DNA and is essential for preventing UV-induced genomic instability,\u201d Yang said. \u201cWhen the UV-resistant gene is lost, the cell cannot efficiently repair UV- and chemical-induced damage.\u201d
\nThe UV-resistant gene is involved in the multistep DNA cell-repair process, researchers found. First a known protein scans for damaged DNA. Once it finds lesions, it tags the UV-resistant gene into action. The UV-resistant gene is like a humanitarian convoy dropping off reinforcements or aid to help damaged areas repair at precisely the right time.
\nThe researchers did not have data from people without skin cancer, so they were unable to compare their observations of melanoma patients with those of skin cancer-free people.
\n\u201cWe found the expression level of the UV-resistant gene is related to melanoma patients\u2019 survival and metastasis stages,\u201d Yang said. \u201cLower levels of the UV-resistant gene means a lower survival rate and advanced metastases stages.\u201d
\nUV exposure, frequent trips to the tanning salon and genetics all play a role in developing skin cancer. Studies have shown, for example, that redheads are more prone to skin cancer because of their genetic background. Liang, Yang and their colleagues have identified a new player in the skin cancer field.
\n\u201cTo our knowledge, the UV-resistant gene does not have any enzymic activity; It\u2019s a supporter or coordinator,\u201d Liang said. \u201cAlthough it may not be the direct doer, without it, the whole structure collapses.\u201d
\nFuture studies will use mouse models to better understand how the UV-resistant gene functions.
\n\u201cThe UV-resistant gene may serve as a good target for drug development,\u201d Yang said. \u201cPerhaps one day a drug could stimulate the repairing functionality of the UV-resistant gene to ensure swift and effective repair of UV-damaged skin cells. That would be a good treatment for people who are at high risk of developing skin cancer.\u201d
\nScientists at Children\u2019s Hospital Los Angeles, the Korea Advanced Institute of Science and Technology and the Chinese Academy of Sciences in Beijing also contributed to the study. The Margaret Early Trustee Foundation, American Cancer Society, National Institutes of Health grants and GRL Program from the National Research Foundation of Korea funded the research.<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":60,"featured_media":1061,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[596,20],"class_list":["post-1060","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-department-of-immunology-and-immune-therapeutics","tag-research"],"acf":[],"yoast_head":"\n\u2018Sunscreen\u2019 gene may help protect against skin cancer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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cancer.","series_order":"","_links":{"self":[{"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/posts\/1060","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/users\/60"}],"replies":[{"embeddable":true,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/comments?post=1060"}],"version-history":[{"count":0,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/posts\/1060\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/media\/1061"}],"wp:attachment":[{"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/media?parent=1060"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/categories?post=1060"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/tags?post=1060"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}