{"id":1075,"date":"2016-10-17T00:00:12","date_gmt":"2016-10-17T07:00:12","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/staying-on-target\/"},"modified":"2023-11-19T12:13:31","modified_gmt":"2023-11-19T20:13:31","slug":"staying-on-target","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/staying-on-target\/","title":{"rendered":"Staying on Target: USC Norris researchers target cancer cells"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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\n\n \n Press Release<\/span>\n\n\n\n<\/div>\n \n \n
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Staying on Target: USC Norris researchers target cancer cells<\/h1>\n\n\n<\/div>\n \n \n
\n Melissa Masatani<\/span>\n \n October 17, 2016<\/span>\n <\/div>\n \n \n
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\"ClinicalResearch\"
\nWhen USC Norris Comprehensive Cancer Center member Ann Mohrbacher, MD<\/a>, began her career in immunology, the idea that physicians one day could fight cancer using the body\u2019s own immune system was still science fiction. Research at the time was focused on lupus, an autoimmune disease, rather than cancerous diseases like lymphomas \u2014 until researchers found that the immune system also can be directed to control cancer cells.
\n\u201cI was one of the early investigators with Rituximab, the very first designed immunotherapy for cancer,\u201d says Mohrbacher, medical director of the Autologous Bone Marrow Transplant Program in the Blood Diseases Center at USC Norris. \u201cI remember one of my colleagues saying, \u2018Oh my gosh, do you really think we\u2019re going to treat cancer with an antibody?\u2019\u201d
\nMohrbacher, an associate professor of clinical medicine in the Jane Anne Nohl Division of Hematology and Center for the Study of Blood Diseases, says that once the trial showed results, it changed the way researchers looked at cancer research. \u201cThat turned out to be the most amazing drug of two decades and totally broke barriers \u2014 the first immunotherapy to successfully fight cancer,\u201d she says. By using the body\u2019s immune system to target cancer cells, physicians are learning how to treat patients who may not be responding to chemotherapy. Since those early days in research, Mohrbacher has continued her work in immunotherapy alongside colleagues in the Blood Diseases Center at USC Norris, where researchers are bringing leading-edge technology to the treatment and study of diseases of the blood.
\nAnother approach to activating the body\u2019s own immune system to control cancer is by using viruses as a cancer treatment. A study that is being led by Kevin Kelly, MD, PhD<\/a>, an associate professor of medicine in the Jane Anne Nohl Division of Hematology and Center for the Study of Blood Diseases, is examining the use of a form of the human reovisrus (Reolysin), a naturally occurring virus that preferentially targets and destroys cancer cells.
\n\u201cReolysin is being given in combination with standard myeloma treatments,\u201d Kelly says. \u201cThe objective is to determine the safety and effectiveness of the virus in combination with the standard chemotherapy in myeloma. We are studying the myeloma cells of each patient that is enrolled to identify the patients that will respond preferentially to the virus. We also are determining if Reolysin can re-educate the immune system to target and destroy myeloma.\u201d
\nBy re-educating the immune system, physicians may be able to help patients who are no longer responding to standard treatment. \u201cThe trial is based on exciting research in the lab that shows that myeloma cells have high levels of the receptor for the virus,\u201d Kelly says. \u201cWe noticed that myeloma cells had a very high expression of receptors for the virus and in particular myeloma patients who had relapsed after standard treatment had an even higher expression of the Reolysin receptor. The Reolysin receptor may be an Achilles heel in the drug-resistant myeloma cell that we can take advantage of.\u201d
\nThe study is one of several ongoing clinical trials that are looking to the future of cancer research. With lessons learned in clinical trials for combined immunotherapies and viral therapies, physicians may be able to move away from using chemotherapy for longterm remission and focus on using the body\u2019s immune system to deliver cancer-killing drugs. Those clinical trials and the patients participating in them are crucial to advancing the understanding of cancer and improving its treatment.
\n\u201cIn the end, we have to thank the patients who are brave enough to try a new treatment,\u201d notes Mohrbacher. \u201cThe courage of the patients to participate is what finally makes it all move forward.\u201d
\nFor more information about clinical trials at USC Norris Comprehensive Cancer Center, visit clinicaltrials.keckmedicine.org. To support research at USC Norris, please call (323) 865-0700 or email norrisdev@usc.edu<\/a>.<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":49,"featured_media":1076,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[10,226,20],"class_list":["post-1075","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-cancer","tag-department-of-medicine","tag-research"],"acf":[],"yoast_head":"\nStaying on Target: USC Norris researchers target cancer cells<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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