{"id":1134,"date":"2016-08-08T15:45:40","date_gmt":"2016-08-08T22:45:40","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-researcher-senta-georgia-wins-cirm-discovery-inception-award\/"},"modified":"2023-11-19T12:14:15","modified_gmt":"2023-11-19T20:14:15","slug":"usc-stem-cell-researcher-senta-georgia-wins-cirm-discovery-inception-award","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/usc-stem-cell-researcher-senta-georgia-wins-cirm-discovery-inception-award\/","title":{"rendered":"USC Stem Cell researcher Senta Georgia wins CIRM Discovery Inception award"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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\n\n \n Press Release<\/span>\n\n\n\n<\/div>\n \n \n
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USC Stem Cell researcher Senta Georgia wins CIRM Discovery Inception award<\/h1>\n\n\n<\/div>\n \n \n
\n Cristy Lytal<\/span>\n \n August 08, 2016<\/span>\n <\/div>\n \n \n
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Senta Georgia<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\r\n\r\n\n\n \n \n\n\n\n\n\n\n\n
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Senta Georgia<\/a> \u2014 principal investigator at Children\u2019s Hospital Los Angeles (CHLA), and assistant professor of pediatrics, and stem cell biology and regenerative medicine at USC \u2014 has a creative idea for helping children with a genetic form of diabetes and malabsorptive diarrhea called enteric anendocrinosis. And through its Discovery Inception program, the California Institute for Regenerative Medicine (CIRM) has put forth $180,000 to turn her idea into meaningful progress towards new stem cell-based treatments.
\n<\/span>\u201cWe asked scientists to pitch us their best new ideas, things they want to test but that are hard to get funding for,\u201d said C. Randal Mills, president and CEO of CIRM, the California agency charged with dispensing $3 billion in voter-approved dollars to stem cell researchers throughout the state. \u201cWe know not all of these will pan out, but those that do succeed have the potential to advance our understanding of stem cells and hopefully lead to treatments in the future.\u201d
\nPatients with enteric anendocrinosis are born lacking gastrointestinal cells that produce hormones. During childhood, they also lose insulin-producing pancreatic cells known as beta cells and become severely diabetic.
\nTo better understand this disease, Georgia and her colleagues will focus their studies on a young CHLA patient who has enteric anendocrinosis due to a mutation in a gene called NEUROGENIN3 (NEUROG3).
\n\u201cSimilar to other patients with enteric anendocrinosis, this child developed diabetes at the age of four,\u201d said Georgia. \u201cThis suggests that NEUROG3 is not required for an embryo to develop beta cells initially, but is required for beta cells to function and survive after birth. This contradicts previous studies of how NEUROG3 works in mouse models and underscores the importance of understanding the way genes affect disease in the human context.\u201d
\nIn order to study this patient\u2019s beta cells in a minimally invasive way, the researchers will rely on sophisticated stem cell technology. Using the Chang Stem Cell Engineering Facility, the researchers will reprogram the patient\u2019s skin cells into induced pluripotent stem cells (iPSCs). Georgia\u2019s team will use these iPSCs to generate beta cells with the patient\u2019s unique genetics, including the NEUROG3 mutation.
\nThey will then apply genome editing to correct the NEUROG 3 mutation in hopes that it will improve the beta cells\u2019 survival and function. If these edited beta cells continue to thrive when transplanted into a diabetic mouse, this will be the first step towards developing a cell replacement therapy for this patient.
\nAccording to Georgia, \u201cwe hope that this study can create a precedent for how to generate new insulin cells for patients with genetic forms of diabetes. We hope that CHLA\/USC can become a leader in providing new cellular therapies for patients with genetic diabetes in the future.\u201d<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":84,"featured_media":1135,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[65,20,436],"class_list":["post-1134","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-department-of-pediatrics","tag-research","tag-usc-stem-cell"],"acf":[],"yoast_head":"\nUSC Stem Cell researcher Senta Georgia wins CIRM Discovery Inception award<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" 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