{"id":1271,"date":"2016-09-09T16:17:36","date_gmt":"2016-09-09T23:17:36","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/paralyzed-man-regains-use-of-arms-and-hands-after-experimental-stem-cell-therapy\/"},"modified":"2023-11-19T12:15:24","modified_gmt":"2023-11-19T20:15:24","slug":"paralyzed-man-regains-use-of-arms-and-hands-after-experimental-stem-cell-therapy","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/paralyzed-man-regains-use-of-arms-and-hands-after-experimental-stem-cell-therapy\/","title":{"rendered":"Experimental stem cell therapy helps paralyzed man regain use of arms and hands"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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\n\n \n Press Release<\/span>\n\n\n\n<\/div>\n \n \n
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Experimental stem cell therapy helps paralyzed man regain use of arms and hands<\/h1>\n\n\n<\/div>\n \n \n
\n Meg Aldrich<\/span>\n \n September 09, 2016<\/span>\n <\/div>\n \n \n
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Kris Boesen works to strengthen his upper body. (Photo\/Greg Iger)<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\r\n\r\n\n\n \n \n\n\n\n\n\n\n\n
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On March 6, just shy of his 21st birthday, Kristopher (Kris) Boesen of Bakersfield suffered a traumatic injury to his cervical spine when his car fishtailed on a wet road, hit a tree and slammed into a telephone pole.
\nHis parents were warned there was a good chance their son would be permanently paralyzed from the neck down. However, they also learned that he could possibly qualify for a clinical study that might help.
\nEnter the Keck Medical Center of USC, which announced that a team of doctors became the first in California to inject its patient with an experimental treatment made from stem cells as part of a multi-center clinical trial.
\nLeading the surgical team and working in collaboration with Rancho Los Amigos National Rehabilitation Center and Keck Medicine of USC, Charles Liu, MD, PhD<\/a>, director of the USC Neurorestoration Center, injected an experimental dose of 10 million AST-OPC1 cells directly into Kris\u2019 cervical spinal cord in early April.
\n\u201cTypically, spinal cord injury patients undergo surgery that stabilizes the spine but generally does very little to restore motor or sensory function,\u201d explains Liu. \u201cWith this study, we are testing a procedure that may improve neurological function, which could mean the difference between being permanently paralyzed and being able to use one\u2019s arms and hands. Restoring that level of function could significantly improve the daily lives of patients with severe spinal injuries.\u201d
\nTwo weeks after surgery, Kris began to show signs of improvement.\u00a0 Three months later, he\u2019s able to feed himself, use his cell phone, write his name, operate a motorized wheelchair and hug his friends and family. Improved sensation and movement in both arms and hands also makes it easier for Kris to care for himself, and to envision a life lived more independently.
\n\u201cAs of 90 days post-treatment, Kris has gained significant improvement in his motor function, up to two spinal cord levels,\u201d said Dr. Liu.\u00a0 \u201cIn Kris\u2019 case, two spinal cord levels means the difference between using your hands to brush your teeth, operate a computer or do other things you wouldn\u2019t otherwise be able to do, so having this level of functional independence cannot be overstated.\u201d
\nDoctors are careful not to predict Kris\u2019 future progress.
\n\u201cAll I\u2019ve wanted from the beginning was a fighting chance,\u201d said Kris, who has a passion for fixing up and driving sports cars and was studying to become a life insurance broker at the time of the accident. \u201cBut if there\u2019s a chance for me to walk again, then heck yeah! I want to do anything possible to do that.\u201d<\/p>\n

Qualifying for the Study<\/h3>\n

Because the window for performing the surgery was tight, everything needed to go according to schedule in order for Kris to qualify.
\nOnce Kris made the decision to pursue enrollment in the study, dozens of doctors, nurses, rehabilitation specialists and others sprang into action. Because he would need to provide voice confirmation of his desire to participate in the study, Kris had to be able to breathe without a ventilator. Weaning a patient from assisted breathing generally is a three-week process. He did it in five days with the help of a respiratory care team. He signed the paperwork and began a week of assessments, scans and other pre-surgery tests.
\nIn early April, a surgical team from Keck Hospital of USC carefully injected 10 million AST-OPC1 cells directly into Kris\u2019 cervical spine.\u00a0 Nearly six weeks later, Kris was discharged and returned to Bakersfield to continue his rehabilitation. Doctors reviewed his progress at seven days, 30 days, 60 days and 90 days post-injection, and Kris can look forward to detailed assessments after 180 days, 270 days and one year.
\nRodney and Annette Boesen say they are amazed at the level of collaboration and cooperation that enabled their son to participate in the study. \u201cSo many things had to happen, and there were so many things that could have put up a roadblock,\u201d marvels Rodney. \u201cThe people at Keck Medical Center of USC and elsewhere moved heaven and earth to get things done. There was never a moment through all of this when we didn\u2019t think our son was getting world class care.\u201d<\/p>\n

About the Study<\/h3>\n

The pioneering surgery is the latest example of how the emerging fields of neurorestoration and regenerative medicine may have the potential to improve the lives of thousands of patients who have suffered a severe spinal cord injury.
\nThe stem cell procedure Kris received is part of a Phase 1\/2a clinical trial that is evaluating the safety and efficacy of escalating doses of AST-OPC1 cells developed by Fremont, California-based Asterias Biotherapeutics. AST-OPC1 cells are made from embryonic stem cells by carefully converting them into oligodendrocyte progenitor cells (OPCs), which are cells found in the brain and spinal cord that support the healthy functioning of nerve cells.\u00a0 In previous laboratory studies, AST-OPC1 was shown to produce neurotrophic factors, stimulate vascularization and induce remyelination of denuded axons. All are critical factors in the survival, regrowth and conduction of nerve impulses through axons at the injury site, according to Edward D. Wirth III, MD, PhD, chief medical director of Asterias and lead investigator of the study, dubbed \u201cSCiStar.\u201d
\n\u201cAt the 10 million cell level, we\u2019re now in a dose range that is the human equivalent of where we were when we saw efficacy in pre-clinical studies,\u201d says Wirth. \u201cWhile we continue to evaluate safety first and foremost, we are also now looking at how well treatment might help restore movement in these patients.\u201d
\nTo qualify for the clinical trial, enrollees must be between the age of 18 and 69, and their condition must be stable enough to receive an injection of AST-OPC1 between the fourteenth and thirtieth days following injury.
\nKeck is one of six sites in the U.S. authorized to enroll subjects and administer the clinical trial dosage.
\nThe first early data results from a group of patients in this study will become available on September 14, 2016.<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":47,"featured_media":1272,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[80,108,17],"class_list":["post-1271","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-neurology","tag-neurosurgery","tag-stem-cell"],"acf":[],"yoast_head":"\nExperimental stem cell therapy helps paralyzed man regain use of arms and hands<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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