{"id":1315,"date":"2017-02-14T17:12:04","date_gmt":"2017-02-15T01:12:04","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/your-health-depends-on-more-than-your-dna\/"},"modified":"2023-11-19T12:15:56","modified_gmt":"2023-11-19T20:15:56","slug":"your-health-depends-on-more-than-your-dna","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/your-health-depends-on-more-than-your-dna\/","title":{"rendered":"Your Health Depends on More Than Your DNA"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
\n\n \n
\n \n
\n\n \n Press Release<\/span>\n\n\n\n<\/div>\n \n \n
\n\n \n

Your Health Depends on More Than Your DNA<\/h1>\n\n\n<\/div>\n \n \n
\n Koren Wetmore<\/span>\n \n February 14, 2017<\/span>\n <\/div>\n \n \n
\n\n \n
<\/path><\/svg><\/span><\/a><\/path><\/svg><\/span><\/a><\/path><\/svg><\/span><\/a><\/path><\/path><\/path><\/svg><\/span><\/a><\/path><\/svg><\/span><\/a><\/path><\/path><\/g><\/svg><\/span><\/a><\/svg><\/span><\/a><\/div>
<\/div><\/div>\n\n\n<\/div>\n \n <\/div>\n\n \n
\n\n \n \n \n
\n \n \n \n \n \n\n \n
Illustrations by Chris Gash<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\r\n\r\n\n\n \n \n\n\n\n\n\n\n\n
\n\n \n
\n \n
\n\n \n

Nature and nurture both matter in the move to personalized medicine.<\/h3>\n

In some not-too-distant\u00a0future, your health risks and medical problems may be investigated and pieced together like crime scenes. Your health care provider will collect key evidence: urine, blood and DNA samples. You\u2019ll be questioned about where you live, work and travel, and what you eat, drink and do.
\nYour relatives, too, will be investigated\u2014not personally, of course, but their medical histories and genetic data will be scoured for additional clues.
\nThe information will be given to the detectives in this future scenario: software programs equipped with smart algorithms. What will it mean for you?
\nA shift to this kind of data-driven, individualized health care is a lofty aim. It promises a more complete picture of what promotes health versus disease in any given person.
\nUSC researchers are moving closer to that. Through studies that compare health outcomes across ethnicities and races and between genders, they\u2019re piecing together the factors that raise or lower disease risk.
\nTheir findings will help future clinicians interpret each patient\u2019s information to practice truly \u201cpersonalized\u201d medicine. Some patients are already seeing the benefits today.<\/p>\n

Getting Personal<\/h3>\n

When you look at their DNA, any two random people will appear more than 99 percent identical. But they can differ at about 3 million positions along the DNA sequence. Understanding these differences and how they interact with factors such as diet, environment and behavior is what will make medicine personal.
\n\u201cA disease may not be caused by a single gene mutation, but rather by a combination of genetics, behavior, socioeconomic situation, and other underlying issues we\u2019re just beginning to understand,\u201d says USC Roski Eye Institute Director\u00a0Rohit Varma<\/a>, who studies how eye disease affects different ethnic and racial groups.
\nIn a recent study, Varma\u2019s team found that Latinos with significant Native American roots who have Type 2 diabetes face an 87 percent higher risk of vision-threatening diabetic retinopathy than the general population. He suspects that their Native American ancestry represents a genetic variant that, combined with lifestyle factors, raises the risk. Consider the Pima Indians, who have high rates of diabetes. In contemporary life, many in this community of former hunters and explorers have become more sedentary and eat a diet full of fast food. These lifestyle changes have contributed to diabetes risk with all of its complications, Varma says.
\nAnother study led by Varma\u2019s team showed that African-Americans have more than double the risk for diabetic macular edema, which can lead to blindness. With such a high risk, it\u2019s vital to detect macular edema early in this population to successfully treat it, Varma says, but disparities in African-Americans\u2019 access to medical care often keep patients from getting the necessary vision screenings and preventive treatment.
\n\u201cWe have good drugs to treat this, so if someone comes in and gets regular eye care, that person should not lose their vision,\u201d he says. \u201cBut even though many people have insurance, they are unable to see a physician because they can\u2019t afford their copayments.\u201d<\/p>\n

Battles of the Sexes<\/h3>\n

Men and women also can have different risks of disease tied to factors like diet and behavior, as well as their own genes and anatomy. Recent USC research points out that learning more about the interplay between gender, ethnicity and diet may help doctors find more effective disease screening, prevention and treatment for patients.
\nIn\u00a0a study<\/a>\u00a0of nearly 7,500 adult women, USC researchers noted links between breast cancer, race and ethnicity, and diet. They found that Latinas who ate 20 grams of processed meat per day (equal to a strip of bacon) had a 42 percent higher risk of breast cancer than Latinas who ate little to no processed meat. In contrast, for Caucasian women in the study, eating tuna posed more of a breast cancer risk. In fact, a thimble-sized serving of tuna per day was enough to raise their breast cancer risk by 25 percent. No one is sure yet why.
\nHormones, too, can affect health risks differently between men and women. While many people know that estrogen exposure over a lifetime can increase a woman\u2019s breast cancer risk, fewer probably know that the same hormone reduces kidney cancer risk. (Yes, men have estrogen too\u2014just at lower levels than women do.)
\nUrologist\u00a0Inderbir Gill<\/a>, chair and professor in the Catherine and Joseph Aresty Department of Urology<\/a>, explains that estrogen levels drop in women as they age, but estrogen levels rise in men as they get older. And that rise in estrogen seems to impact senior men when it comes to kidney cancer.
\n\u201cIf a younger woman has a kidney tumor, it is likely benign, whereas in younger men, it likely is cancer. As [men] grow older, we see the opposite,\u201d says Gill, executive director of the\u00a0USC Institute of Urology.<\/a>\u00a0\u201cIt has to do with the influence of the hormones progesterone and estrogen, which seem to inhibit the growth of this cancer.\u201d
\nHeart disease offers insight into gender\u2019s effects, too. Differences in anatomy and behavior affect outcomes for men and women with cardiovascular issues.
\n\u201cWomen have smaller coronary arteries than men, and tend to have more extensive coronary artery disease, which makes treatment more complicated,\u201d says\u00a0Vivian Mo<\/a>, director of the\u00a0Women\u2019s Cardiovascular Center of USC.
\nAnd unlike men who arrive at the local hospital with classic chest pain when they\u2019re having a heart attack, women often ignore their symptoms, which can be as vague as throat tightness and nausea. \u201cBy the time they reach the ER, they may have already sustained a fair amount of heart muscle damage, which can lead to future episodes of congestive heart failure,\u201d Mo says.
\nAlthough early diagnosis and screening for risk factors such as diabetes and high blood pressure could help, women tend to delay their care and put others\u2019 needs first. After a recent screening event at the Women\u2019s Cardiovascular Center, only 10 percent of women exhibiting key risk factors for heart disease followed up with a physician for preventive care.
\n\u201cEven though heart disease claims more lives than the top five cancers combined, women are more aware of breast cancer and will seek out screening and treatment for that,\u201d Mo says.<\/p>\n

Tailoring Treatment<\/h3>\n

Researchers believe that collecting information from vast numbers of patients will turn up important clues to how cancer starts and how it can better be treated. Patients at the\u00a0USC Norris Comprehensive Cancer Center<\/a>\u00a0already benefit from data collection focusing on cancer risk factors and incidence across ethnicities and genders. Doctors can apply findings both to cancer treatment and genetic screening for cancer risk.
\n\u201cWe develop customized treatments for each patient that reflect the full complexity of who they are\u2014not just ancestry or gender, but also their medical history, social situation and risk factors, as well as the best evidence from our clinical trials research,\u201d says Stephen Gruber<\/a>, director of the USC Norris Comprehensive Cancer Center. \u201cWe can integrate all of those things into computer models that calculate the risks and benefits of specific diagnostic and therapeutic approaches. We also can tailor our prevention strategies by understanding a patient\u2019s cancer risk and what interventions we can use to modify those risks.\u201d
\nIn some ways, the cancer center was built on this idea. Gruber credits the center\u2019s position as a leader in understanding disparities and treatment options to two pioneering Keck School of Medicine of USC initiatives: the\u00a0Los Angeles Cancer Surveillance Program\u00a0founded in 1972 and the\u00a0Multiethnic Cohort study\u00a0founded in 1993. The Cancer Surveillance Program records data on every cancer case reported in Los Angeles County, which boasts an ethnically diverse population of about 10 million people. The Multiethnic Cohort study is a long-term, population-based study of more than 215,000 people of African-American, Japanese, Latino, Native Hawaiian and Caucasian origin that examines the relationships between cancer and factors such as genetics, diet and nutrition.
\nResearchers nationwide use data from both programs to analyze incidence patterns and potential causes of cancer.
\n\u201cIf you want to understand the pattern of cancer in all of us, we are the sole source,\u201d says Cancer Surveillance Program Director\u00a0Dennis Deapen<\/a>. \u201cThe Los Angeles area\u2019s diverse population enables us to produce ethnicity data that you won\u2019t find in most of the country.\u201d
\nDrawing on more than 1.3 million cancer cases, the program also helps point out therapies that are more effective for specific kinds of patients over the years.
\n\u201cPatients and physicians have to make decisions at a given point in time and go with it,\u201d Deapen says. \u201cWe\u2019re the people who can look at the data 10 years later and say, \u2018For this kind of cancer patient, this treatment worked a whole lot better than that one.\u2019\u201d<\/p>\n

Decoding Disease<\/h3>\n

Sometimes researchers start with genes and then study how they interact with other factors to get a clearer picture of individual health risks and preventive measures.
\nKeck School of Medicine genetic epidemiologist\u00a0Chris Haiman<\/a>\u00a0co-leads a study to look for gene variations that might explain the uneven risks for conditions such as heart disease and cancer among different groups. Through the study of some 50,000 DNA samples from people of African, Latino and Asian ancestries, the scientists are investigating everything from waist-to-hip measurements (body shape) to the effects of inflammation\u2014and then linking these factors to variations in genes.
\n\u201cOur hope and expectation is to identify all of the genetic variants involved in disease,\u201d Haiman says.
\nIf Haiman and his colleagues are successful, you might someday take a genetic test that screens for all known diseases rather than just answer questions about family history to determine your risks. Those results will then be considered alongside information about your diet, where you live and work, and even how much exercise and sleep you get. This combined picture will empower you and your doctor to discuss the lifestyle changes and treatment options to keep you healthy.
\n\u201cAre we there yet? No, we\u2019re not,\u201d Haiman says. \u201cBut that\u2019s the goal.\u201d<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":124,"featured_media":1316,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[10,226,627,81,638],"class_list":["post-1315","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-cancer","tag-department-of-medicine","tag-department-of-ophthalmology","tag-department-of-population-and-public-health-sciences","tag-department-of-urology"],"acf":[],"yoast_head":"\nYour Health Depends on More Than Your DNA<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/keck.usc.edu\/news\/your-health-depends-on-more-than-your-dna\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Your Health Depends on More Than Your DNA\" \/>\n<meta property=\"og:url\" content=\"https:\/\/keck.usc.edu\/news\/your-health-depends-on-more-than-your-dna\/\" \/>\n<meta property=\"og:site_name\" content=\"Newsroom\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/KECKschoolUSC\/\" \/>\n<meta property=\"article:published_time\" content=\"2017-02-15T01:12:04+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-11-19T20:15:56+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/UNIQUE-1_web.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"600\" \/>\n\t<meta property=\"og:image:height\" content=\"447\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Koren Wetmore\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@KeckSchool_USC\" \/>\n<meta name=\"twitter:site\" content=\"@KeckSchool_USC\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/your-health-depends-on-more-than-your-dna\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/your-health-depends-on-more-than-your-dna\\\/\"},\"author\":{\"name\":\"Koren Wetmore\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#\\\/schema\\\/person\\\/6d7ec11b986a30e736709864bc4fe84f\"},\"headline\":\"Your Health Depends on More Than Your DNA\",\"datePublished\":\"2017-02-15T01:12:04+00:00\",\"dateModified\":\"2023-11-19T20:15:56+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/your-health-depends-on-more-than-your-dna\\\/\"},\"wordCount\":8,\"publisher\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/your-health-depends-on-more-than-your-dna\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/68\\\/2023\\\/11\\\/UNIQUE-1_web.jpg\",\"keywords\":[\"Cancer\",\"Department of Medicine\",\"Department of Ophthalmology\",\"Department of Population and Public Health Sciences\",\"Department of Urology\"],\"articleSection\":[\"Press Release\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/your-health-depends-on-more-than-your-dna\\\/\",\"url\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/your-health-depends-on-more-than-your-dna\\\/\",\"name\":\"Your Health Depends on More Than Your DNA\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/your-health-depends-on-more-than-your-dna\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/your-health-depends-on-more-than-your-dna\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/68\\\/2023\\\/11\\\/UNIQUE-1_web.jpg\",\"datePublished\":\"2017-02-15T01:12:04+00:00\",\"dateModified\":\"2023-11-19T20:15:56+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/your-health-depends-on-more-than-your-dna\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/keck.usc.edu\\\/news\\\/your-health-depends-on-more-than-your-dna\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/your-health-depends-on-more-than-your-dna\\\/#primaryimage\",\"url\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/68\\\/2023\\\/11\\\/UNIQUE-1_web.jpg\",\"contentUrl\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/68\\\/2023\\\/11\\\/UNIQUE-1_web.jpg\",\"width\":600,\"height\":447,\"caption\":\"Illustrations by Chris Gash\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/your-health-depends-on-more-than-your-dna\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Your Health Depends on More Than Your DNA\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#website\",\"url\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/\",\"name\":\"Newsroom\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#organization\",\"name\":\"Keck School of Medicine of USC\",\"alternateName\":\"Keck School of Medicine\",\"url\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/68\\\/2023\\\/11\\\/keck-school-of-medicine-logo-696-square.jpg\",\"contentUrl\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/68\\\/2023\\\/11\\\/keck-school-of-medicine-logo-696-square.jpg\",\"width\":696,\"height\":696,\"caption\":\"Keck School of Medicine of USC\"},\"image\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/KECKschoolUSC\\\/\",\"https:\\\/\\\/x.com\\\/KeckSchool_USC\",\"https:\\\/\\\/www.linkedin.com\\\/school\\\/keckschoolusc\\\/\",\"https:\\\/\\\/www.instagram.com\\\/KeckSchoolUSC\\\/\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UCpL1E1W5ZTfkc5iihwLSFEA\",\"https:\\\/\\\/www.tiktok.com\\\/@keckschoolusc\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#\\\/schema\\\/person\\\/6d7ec11b986a30e736709864bc4fe84f\",\"name\":\"Koren Wetmore\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/ec946351ef02ae600d5dd599f48b63ed6f23771c749c176c3b2cd31796963681?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/ec946351ef02ae600d5dd599f48b63ed6f23771c749c176c3b2cd31796963681?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/ec946351ef02ae600d5dd599f48b63ed6f23771c749c176c3b2cd31796963681?s=96&d=mm&r=g\",\"caption\":\"Koren Wetmore\"},\"url\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/author\\\/koren_wetmore\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Your Health Depends on More Than Your DNA","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/keck.usc.edu\/news\/your-health-depends-on-more-than-your-dna\/","og_locale":"en_US","og_type":"article","og_title":"Your Health Depends on More Than Your DNA","og_url":"https:\/\/keck.usc.edu\/news\/your-health-depends-on-more-than-your-dna\/","og_site_name":"Newsroom","article_publisher":"https:\/\/www.facebook.com\/KECKschoolUSC\/","article_published_time":"2017-02-15T01:12:04+00:00","article_modified_time":"2023-11-19T20:15:56+00:00","og_image":[{"width":600,"height":447,"url":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/UNIQUE-1_web.jpg","type":"image\/jpeg"}],"author":"Koren Wetmore","twitter_card":"summary_large_image","twitter_creator":"@KeckSchool_USC","twitter_site":"@KeckSchool_USC","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/keck.usc.edu\/news\/your-health-depends-on-more-than-your-dna\/#article","isPartOf":{"@id":"https:\/\/keck.usc.edu\/news\/your-health-depends-on-more-than-your-dna\/"},"author":{"name":"Koren Wetmore","@id":"https:\/\/keck.usc.edu\/news\/#\/schema\/person\/6d7ec11b986a30e736709864bc4fe84f"},"headline":"Your Health Depends on More Than Your DNA","datePublished":"2017-02-15T01:12:04+00:00","dateModified":"2023-11-19T20:15:56+00:00","mainEntityOfPage":{"@id":"https:\/\/keck.usc.edu\/news\/your-health-depends-on-more-than-your-dna\/"},"wordCount":8,"publisher":{"@id":"https:\/\/keck.usc.edu\/news\/#organization"},"image":{"@id":"https:\/\/keck.usc.edu\/news\/your-health-depends-on-more-than-your-dna\/#primaryimage"},"thumbnailUrl":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/UNIQUE-1_web.jpg","keywords":["Cancer","Department of Medicine","Department of Ophthalmology","Department of Population and Public Health Sciences","Department of Urology"],"articleSection":["Press Release"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/keck.usc.edu\/news\/your-health-depends-on-more-than-your-dna\/","url":"https:\/\/keck.usc.edu\/news\/your-health-depends-on-more-than-your-dna\/","name":"Your Health Depends on More Than Your DNA","isPartOf":{"@id":"https:\/\/keck.usc.edu\/news\/#website"},"primaryImageOfPage":{"@id":"https:\/\/keck.usc.edu\/news\/your-health-depends-on-more-than-your-dna\/#primaryimage"},"image":{"@id":"https:\/\/keck.usc.edu\/news\/your-health-depends-on-more-than-your-dna\/#primaryimage"},"thumbnailUrl":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/UNIQUE-1_web.jpg","datePublished":"2017-02-15T01:12:04+00:00","dateModified":"2023-11-19T20:15:56+00:00","breadcrumb":{"@id":"https:\/\/keck.usc.edu\/news\/your-health-depends-on-more-than-your-dna\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/keck.usc.edu\/news\/your-health-depends-on-more-than-your-dna\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/keck.usc.edu\/news\/your-health-depends-on-more-than-your-dna\/#primaryimage","url":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/UNIQUE-1_web.jpg","contentUrl":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/UNIQUE-1_web.jpg","width":600,"height":447,"caption":"Illustrations by Chris Gash"},{"@type":"BreadcrumbList","@id":"https:\/\/keck.usc.edu\/news\/your-health-depends-on-more-than-your-dna\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/keck.usc.edu\/news\/"},{"@type":"ListItem","position":2,"name":"Your Health Depends on More Than Your DNA"}]},{"@type":"WebSite","@id":"https:\/\/keck.usc.edu\/news\/#website","url":"https:\/\/keck.usc.edu\/news\/","name":"Newsroom","description":"","publisher":{"@id":"https:\/\/keck.usc.edu\/news\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/keck.usc.edu\/news\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/keck.usc.edu\/news\/#organization","name":"Keck School of Medicine of USC","alternateName":"Keck School of Medicine","url":"https:\/\/keck.usc.edu\/news\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/keck.usc.edu\/news\/#\/schema\/logo\/image\/","url":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/keck-school-of-medicine-logo-696-square.jpg","contentUrl":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/keck-school-of-medicine-logo-696-square.jpg","width":696,"height":696,"caption":"Keck School of Medicine of USC"},"image":{"@id":"https:\/\/keck.usc.edu\/news\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/KECKschoolUSC\/","https:\/\/x.com\/KeckSchool_USC","https:\/\/www.linkedin.com\/school\/keckschoolusc\/","https:\/\/www.instagram.com\/KeckSchoolUSC\/","https:\/\/www.youtube.com\/channel\/UCpL1E1W5ZTfkc5iihwLSFEA","https:\/\/www.tiktok.com\/@keckschoolusc"]},{"@type":"Person","@id":"https:\/\/keck.usc.edu\/news\/#\/schema\/person\/6d7ec11b986a30e736709864bc4fe84f","name":"Koren Wetmore","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/ec946351ef02ae600d5dd599f48b63ed6f23771c749c176c3b2cd31796963681?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/ec946351ef02ae600d5dd599f48b63ed6f23771c749c176c3b2cd31796963681?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/ec946351ef02ae600d5dd599f48b63ed6f23771c749c176c3b2cd31796963681?s=96&d=mm&r=g","caption":"Koren Wetmore"},"url":"https:\/\/keck.usc.edu\/news\/author\/koren_wetmore\/"}]}},"author_meta":{"display_name":"Koren Wetmore","author_link":"https:\/\/keck.usc.edu\/news\/author\/koren_wetmore\/"},"featured_img":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/UNIQUE-1_web-300x224.jpg","coauthors":[],"tax_additional":{"categories":{"linked":["<a href=\"https:\/\/keck.usc.edu\/news\/category\/press-release\/\" class=\"advgb-post-tax-term\">Press Release<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">Press Release<\/span>"]},"tags":{"linked":["<a href=\"https:\/\/keck.usc.edu\/news\/category\/press-release\/\" class=\"advgb-post-tax-term\">Cancer<\/a>","<a href=\"https:\/\/keck.usc.edu\/news\/category\/press-release\/\" class=\"advgb-post-tax-term\">Department of Medicine<\/a>","<a href=\"https:\/\/keck.usc.edu\/news\/category\/press-release\/\" class=\"advgb-post-tax-term\">Department of Ophthalmology<\/a>","<a href=\"https:\/\/keck.usc.edu\/news\/category\/press-release\/\" class=\"advgb-post-tax-term\">Department of Population and Public Health Sciences<\/a>","<a href=\"https:\/\/keck.usc.edu\/news\/category\/press-release\/\" class=\"advgb-post-tax-term\">Department of Urology<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">Cancer<\/span>","<span class=\"advgb-post-tax-term\">Department of Medicine<\/span>","<span class=\"advgb-post-tax-term\">Department of Ophthalmology<\/span>","<span class=\"advgb-post-tax-term\">Department of Population and Public Health Sciences<\/span>","<span class=\"advgb-post-tax-term\">Department of Urology<\/span>"]}},"comment_count":"0","relative_dates":{"created":"Posted 10 years ago","modified":"Updated 3 years ago"},"absolute_dates":{"created":"Posted on February 14, 2017","modified":"Updated on November 19, 2023"},"absolute_dates_time":{"created":"Posted on February 14, 2017 5:12 pm","modified":"Updated on November 19, 2023 12:15 pm"},"featured_img_caption":"Illustrations by Chris Gash","series_order":"","_links":{"self":[{"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/posts\/1315","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/users\/124"}],"replies":[{"embeddable":true,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/comments?post=1315"}],"version-history":[{"count":0,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/posts\/1315\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/media\/1316"}],"wp:attachment":[{"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/media?parent=1315"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/categories?post=1315"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/tags?post=1315"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}