{"id":1467,"date":"2017-01-24T13:34:28","date_gmt":"2017-01-24T21:34:28","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/new-research-suggests-possibility-of-small-cell-lung-cancer-immunotherapy\/"},"modified":"2023-11-19T12:17:52","modified_gmt":"2023-11-19T20:17:52","slug":"new-research-suggests-possibility-of-small-cell-lung-cancer-immunotherapy","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/new-research-suggests-possibility-of-small-cell-lung-cancer-immunotherapy\/","title":{"rendered":"New research suggests possibility of small cell lung cancer immunotherapy"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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\n\n \n Press Release<\/span>\n\n\n\n<\/div>\n \n \n
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New research suggests possibility of small cell lung cancer immunotherapy<\/h1>\n\n\n<\/div>\n \n \n
\n \u00a0Mary Dacuma<\/span>\n \n January 24, 2017<\/span>\n <\/div>\n \n \n
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Mario Pulido, PhD, first author of the study, and Ite Laird-Offringa. Their work on isoaspartylation could provide a key to immunotherapy for small cell lung cancer.<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\r\n\r\n\n\n \n \n\n\n\n\n\n\n\n
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A study published in the\u00a0Journal of Neuroimmunology<\/em>\u00a0and led by Ite Laird-Offringa, PhD<\/a>, associate professor of surgery and associate dean of graduate affairs at the Keck School of Medicine of USC, suggests that the human body can detect and create an immune response to small cell lung cancer, which maybe helpful to develop new therapies and detection methods.
\nThe key lies in isoaspartylation, a process that damages amino acids and changes the shape of neuronal ELAVL proteins expressed in the tumors. The immune response of patients to this isoaspartylation spans the gamut from no response to such a strong immune response that patients develop severe and lethal autoimmune disease.
\nAbout one-fifth of patients develop a moderate immune response to isoaspartylation and have better overall survival to small cell lung cancer.
\n\u201cIf we can use isoaspartylated ELAVL proteins to elicit an ideal immune response that can fight small cell lung cancer, we may be able to offer a new therapy for this disease. Who knows \u2026 one day we may even be able to prevent it in people who are most at risk, including current and former smokers,\u201d Laird-Offringa said.<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":46,"featured_media":1468,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[468,20],"class_list":["post-1467","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-department-of-surgery","tag-research"],"acf":[],"yoast_head":"\nNew research suggests possibility of small cell lung cancer immunotherapy<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link 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