{"id":1594,"date":"2017-03-08T15:41:47","date_gmt":"2017-03-08T23:41:47","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/research-group-awarded-12-million-to-establish-tissue-regeneration-center\/"},"modified":"2023-11-26T08:19:43","modified_gmt":"2023-11-26T16:19:43","slug":"research-group-awarded-12-million-to-establish-tissue-regeneration-center","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/research-group-awarded-12-million-to-establish-tissue-regeneration-center\/","title":{"rendered":"Research group awarded $12 million to establish tissue regeneration center"},"content":{"rendered":"\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--article-hero \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--article-hero\"\n    \n      >\n\n    \n  <div class=\"text-container\">\n              \n<div class=\"f--field f--eyebrow\">\n\n    \n  <span>Press Release<\/span>\n\n\n\n<\/div>\n    \n              \n<div class=\"f--field f--page-title\">\n\n    \n      <h1>Research group awarded $12 million to establish tissue regeneration center<\/h1>\n\n\n<\/div>\n    \n    \n          <div class=\"meta\">\n        \n                  <span class=\"date\">March 08, 2017<\/span>\n              <\/div>\n    \n              \n<div class=\"f--field f--embed\">\n\n    \n  <div class=\"heateor_sss_sharing_container heateor_sss_horizontal_sharing\" data-heateor-ss-offset=\"0\" data-heateor-sss-href='https:\/\/keck.usc.edu\/news\/research-group-awarded-12-million-to-establish-tissue-regeneration-center\/'><div class=\"heateor_sss_sharing_ul\"><a aria-label=\"Facebook\" class=\"heateor_sss_facebook\" href=\"https:\/\/www.facebook.com\/sharer\/sharer.php?u=https%3A%2F%2Fkeck.usc.edu%2Fnews%2Fresearch-group-awarded-12-million-to-establish-tissue-regeneration-center%2F\" title=\"Facebook\" rel=\"nofollow noopener\" target=\"_blank\" 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11.903 5 10.826c0-1.08.382-1.993 1.146-2.738L8.128 6.12C8.873 5.372 9.785 5 10.864 5c1.087 0 2.004.382 2.75 1.146l2.777 2.79c.75.747 1.12 1.66 1.12 2.737 0 1.105-.392 2.045-1.183 2.817l1.186 1.186c.774-.79 1.708-1.186 2.805-1.186 1.078 0 1.995.377 2.75 1.132l2.804 2.804c.754.755 1.13 1.672 1.13 2.75z\"\/><\/svg><\/span><\/a><\/div><div class=\"heateorSssClear\"><\/div><\/div>\n\n\n<\/div>\n        \n  <\/div>\n\n          \n<div class=\"f--field f--image\">\n\n    \n    \n    \n        <figure>\n    \n    \n    \n              \n      <img\n                            data-src=\"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/Yang-Chai-600x432.jpg\"\n                    data-sizes=\"(min-width:1200px) 75vw, (min-width:768px) 83vw, 100vw\"          class=\"lazyload\"\n        \n                alt=\"\"\n\n        \n                \n                                      \/>\n\n    \n          <figcaption>Yang Chai (Photo courtesy of the Ostrow School of Dentistry of USC)<\/figcaption>\n    <\/figure>\n    \n  \n  \n\n<\/div>\n  \n\n  <\/div><\/div>\n\r\n\r\n\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text white\"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p>A research team called <a href=\"http:\/\/c-doctor.org\/\" target=\"_blank\" rel=\"noopener\">C-DOCTOR<\/a> (Center for Dental, Oral and Craniofacial Tissue and Organ Regeneration), initiated by the Ostrow School of Dentistry of USC, is one step closer to developing products that facilitate tissue regeneration, thanks to a $12-million award from the National Institute of Dental and Craniofacial Research (NIDCR).<br \/>\n<span id=\"more-4839\"><\/span>The financial reward stems from a challenge issued by NIDCR two years ago for researchers to develop safe and effective clinical strategies for dental, oral and craniofacial tissue regeneration.<br \/>\n\u201cThis is really about engineering products,\u201d explained Yang Chai, one of the study\u2019s principal investigators. Chai is Ostrow\u2019s associate dean of research, George and MaryLou Boone Professor of Craniofacial Molecular Biology, director of the Center for Craniofacial Molecular Biology, and a professor of stem cell biology and regenerative medicine. \u201cIt\u2019s not only about being able to understand what stem cells can do, but also how you deliver the stem cells for patient care.\u201d<br \/>\nAn example of the projects that the Ostrow-initiated research team\u2014which includes seven other California-based universities and organizations\u2014hopes to develop is an effective way to use a 3-D printed, dissolvable scaffold to help organize stem cells for focused repair and regrowth of bone tissue.<\/p>\n<h3>Using stem cells to regenerate bone<\/h3>\n<p>\u201cBone deficiency is a very common problem that patients face when they need an implant or when they have periodontal disease, traumatic injury or a birth defect,\u201d Chai said. \u201cInstead of stealing bone from other parts of the body, we\u2019re going to be able to use stem cells to regenerate their own bone.\u201d<br \/>\nFrom the NIDCR\u2019s original request for applications, 10 groups were selected as Stage 1 awardees, allowing them to continue competing for Stage 2 funding.<br \/>\nDuring Stage 1, the groups\u2014composed of dental clinicians, researchers, engineers, biomaterials experts and regulatory scientists\u2014worked together to identify areas in which tissue regeneration could improve patient outcomes and make an immediate impact.<br \/>\nOstrow researchers and DDS students also surveyed craniofacial surgeons, oral surgeons and dentists from all specialties to determine areas of clinical need. From the surveys, they determined that bone, soft tissues, tooth structure and periodontal tissues were areas that could be served best by the team\u2019s expertise.<br \/>\nFrom the original 10 awardees, just two were selected, including C-DOCTOR, to continue their work into Stage 2. A University of Michigan-led group is the other awardee.<br \/>\nChai explained that, during Stage 2, the research team will take their study from a small to large animal model to prepare it for a Phase I clinical trial.<\/p>\n<h3>A truly collaborative effort<\/h3>\n<p>\u201cUSC already had a strong history and reputation in developmental biology and stem cell tissue regeneration,\u201d Chai said of C-DOCTOR\u2019s success in the competition. \u201cBut in this case, it was our partnership with really strong academic institutions throughout California that really made this consortium stand out.\u201d<br \/>\nThe California-based C-DOCTOR consortium includes the USC Viterbi School of Engineering, the Keck School of Medicine of USC, Children\u2019s Hospital of Los Angeles and the USC School of Pharmacy. Outside of USC, the University of California, San Francisco; the University of California, Los Angeles; the University of California, Berkeley; the University of California, Davis; the University of California, San Diego; Stanford University; and the City of Hope complete the massive West Coast effort.<br \/>\n\u201cNo one can do everything by themselves,\u201d Chai said. \u201cThis is something that truly has to be done through a collaborative effort.\u201d<br \/>\nIn addition to Chai, Ostrow\u2019s Mark Urata and USC Viterbi\u2019s Yong Chen are principal investigators from USC on the study. Bridget Samuels, also housed at Ostrow, is the senior research coordinator.<br \/>\n\u201cWe are very excited to embark on this journey because we can see that our research will make a direct impact to improve human health care,\u201d Chai said.<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":168,"featured_media":1595,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[20,436],"class_list":["post-1594","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-research","tag-usc-stem-cell"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.2 (Yoast SEO v28.2) - 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