{"id":1645,"date":"2017-03-17T13:17:43","date_gmt":"2017-03-17T20:17:43","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/broad-innovation-award-winners-aim-to-reduce-bathroom-breaks-with-stem-cells\/"},"modified":"2023-11-26T08:20:10","modified_gmt":"2023-11-26T16:20:10","slug":"broad-innovation-award-winners-aim-to-reduce-bathroom-breaks-with-stem-cells","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/broad-innovation-award-winners-aim-to-reduce-bathroom-breaks-with-stem-cells\/","title":{"rendered":"Broad Innovation Award winners aim to reduce bathroom breaks with stem cells"},"content":{"rendered":"\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--article-hero \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--article-hero\"\n    \n      >\n\n    \n  <div class=\"text-container\">\n              \n<div class=\"f--field f--eyebrow\">\n\n    \n  <span>Press Release<\/span>\n\n\n\n<\/div>\n    \n              \n<div class=\"f--field f--page-title\">\n\n    \n  <h1>Broad Innovation Award winners aim to reduce bathroom breaks with stem cells<\/h1>\n\n\n<\/div>\n    \n    \n          <div class=\"meta\">\n        \n                  <span class=\"date\">March 17, 2017<\/span>\n              <\/div>\n    \n              \n<div class=\"f--field f--embed\">\n\n    \n  <div class=\"heateor_sss_sharing_container heateor_sss_horizontal_sharing\" data-heateor-ss-offset=\"0\" data-heateor-sss-href='https:\/\/keck.usc.edu\/news\/broad-innovation-award-winners-aim-to-reduce-bathroom-breaks-with-stem-cells\/'><div class=\"heateor_sss_sharing_ul\"><a aria-label=\"Facebook\" class=\"heateor_sss_facebook\" href=\"https:\/\/www.facebook.com\/sharer\/sharer.php?u=https%3A%2F%2Fkeck.usc.edu%2Fnews%2Fbroad-innovation-award-winners-aim-to-reduce-bathroom-breaks-with-stem-cells%2F\" title=\"Facebook\" rel=\"nofollow noopener\" target=\"_blank\" 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11.903 5 10.826c0-1.08.382-1.993 1.146-2.738L8.128 6.12C8.873 5.372 9.785 5 10.864 5c1.087 0 2.004.382 2.75 1.146l2.777 2.79c.75.747 1.12 1.66 1.12 2.737 0 1.105-.392 2.045-1.183 2.817l1.186 1.186c.774-.79 1.708-1.186 2.805-1.186 1.078 0 1.995.377 2.75 1.132l2.804 2.804c.754.755 1.13 1.672 1.13 2.75z\"\/><\/svg><\/span><\/a><\/div><div class=\"heateorSssClear\"><\/div><\/div>\n\n\n<\/div>\n        \n  <\/div>\n\n  \n\n  <\/div><\/div>\n\r\n\r\n\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text white\"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p>Having a baby can change a woman\u2019s life in one way that she is often too embarrassed to mention. Childbirth can cause urinary incontinence, which affects up to 13 million people and incurs $16.3 billion in annual treatment costs in the United States alone.<\/p>\n<p>To address this common problem, this year\u2019s winners of the Eli and Edythe Broad Innovation Award are engineering a stem cell-based, biomaterials approach to promote the regeneration of the urethra. The one-year award provides $100,000 of direct research funding and an additional $20,000 to cover services in relevant core facilities at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC.<\/p>\n<p>The project brings together <a href=\"https:\/\/keck.usc.edu\/faculty\/larissa-rodriguez\/\"><strong>Larissa V. Rodr\u00edguez, MD<\/strong><\/a>, and <a href=\"https:\/\/keck.usc.edu\/faculty\/rong-zhang\/\"><strong>Rong Zhang, PhD, DDS<\/strong><\/a>, from the Catherine and Joseph Aresty Department of Urology at the Keck School of Medicine of USC, with <a href=\"https:\/\/michelson.usc.edu\/eun-ji-chung\/\"><strong>Eun Ji Chung, PhD<\/strong><\/a>, from the Department of Biomedical Engineering at the USC Viterbi School of Engineering.<\/p>\n<p>\n[fusion_youtube id=&#8221;J4Tw-LRhqXQ&#8221; width=&#8221;&#8221; height=&#8221;&#8221; autoplay=&#8221;false&#8221; api_params=&#8221;&#8221; hide_on_mobile=&#8221;small-visibility,medium-visibility,large-visibility&#8221; class=&#8221;&#8221; align=&#8221;aligncenter&#8221;][\/fusion_youtube]<\/p>\n<p>[fusion_separator top_margin=&#8221;&#8221;][\/fusion_separator]<\/p>\n<p>Together, they hope to advance treatments beyond the current industry standard, which involves injecting synthetic bulking agents or slings. These therapies can assist with urethral closure, but do not improve urethral function and may trigger complications including chronic inflammation, abscesses, immune reactions, urinary tract obstruction, urethra or bladder erosion, or even blood clots in the lungs.<\/p>\n<p>As a new approach, Rodr\u00edguez, Zhang and Chung are developing a bioactive hydrogel \u2014 a type of water-logged gel made of peptides, which are the building blocks of proteins. They plan to inject this hydrogel around the urethra as a temporary bulking agent to assist with closure. At the same time, the hydrogel will actively deliver fat-derived stem cells and molecular signals to encourage tissue regeneration and the restoration of muscle tone. Eventually, the hydrogel will completely biodegrade, replaced by a regenerated and fully functional urethra.<\/p>\n<p>The research team currently is testing this approach in rats with urinary incontinence, in hopes of eventually garnering supplementary grant funding to advance this work into clinical trials.<\/p>\n<p>\u201cUrinary incontinence keeps people from enjoying their children, enjoying their grandchildren, going to a movie, doing activities that all of us expect in terms of having a happy life,\u201d said Rodr\u00edguez, who also is associate provost for faculty and student initiatives in health and STEM, director of Female Pelvic Medicine and Reconstructive Surgery (FPMRS) at the Keck Medicine of USC \u2013 Beverly Hills location, vice chair of academics for the Aresty Department of Urology, and director of the FPMRS fellowship at the Keck School. \u201cIt disproportionately affects women. And I feel a moral sense of really giving back to these women, and giving to a population that I treat by advancing the science.\u201d<\/p>\n<p>\u2014 Cristy Lytal<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":168,"featured_media":1646,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[20,17,99],"class_list":["post-1645","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-research","tag-stem-cell","tag-urology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.9 (Yoast SEO v26.9) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Broad Innovation Award winners 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