{"id":1821,"date":"2017-05-24T11:13:24","date_gmt":"2017-05-24T18:13:24","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/keck-school-of-medicine-of-usc-receives-2-2-million-nih-grant-to-fund-research-on-healing-difficult-bone-injuries\/"},"modified":"2023-11-26T08:20:51","modified_gmt":"2023-11-26T16:20:51","slug":"keck-school-of-medicine-of-usc-receives-2-2-million-nih-grant-to-fund-research-on-healing-difficult-bone-injuries","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/keck-school-of-medicine-of-usc-receives-2-2-million-nih-grant-to-fund-research-on-healing-difficult-bone-injuries\/","title":{"rendered":"Keck School of Medicine of USC Receives $2.2 Million NIH Grant to Fund Research on Healing Difficult Bone Injuries"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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\n\n \n Press Release<\/span>\n\n\n\n<\/div>\n \n \n
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Keck School of Medicine of USC Receives $2.2 Million NIH Grant to Fund Research on Healing Difficult Bone Injuries<\/h1>\n\n\n<\/div>\n \n \n
\n Erica Rheinschild<\/span>\n \n May 24, 2017<\/span>\n <\/div>\n \n \n
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Keck School of Medicine of USC researcher Dr. Jay R. Lieberman has received a $2.2 million NIH grant to fund gene therapy research for enhancing repair of extensive bone injuries.<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\r\n\r\n\n\n \n \n\n\n\n\n\n\n\n
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Five-year award will support gene therapy research that could help manage challenging bone repairs<\/em>
\nJay R. Lieberman, MD<\/a>, chair and professor of orthopaedic surgery<\/a> at the Keck School of Medicine of USC<\/a> has received a five-year, $2.2 million grant from the National Institutes of Health\u2019s National Institute of Arthritis and Musculoskeletal and Skin Diseases to research gene therapy to enhance repair of extensive bone injuries. Examples of these types of injuries include fractures with extensive bone loss, non-healing fractures, failed spinal fusion and revision of total joint replacement.
\nLieberman will genetically manipulate human bone marrow cells to overproduce bone morphogenetic protein (BMP), which is a protein that spurs progenitor cells to produce bone.
\n\u201cThere are a number of bone injuries that are very difficult to repair and lack satisfactory solutions,\u201d Lieberman says. \u201cMy goal with this grant is to determine whether genetically modifying human bone marrow cells to overproduce BMP will help heal large bone defects in an animal model and, ultimately, provide a better alternative for repairs in humans.\u201d
\nLieberman\u2019s study will determine the efficacy and safety of the gene therapy as well as establish a cellular dose of the genetically manipulated cells that can be scaled up for potential use in humans.
\nAn abstract of the grant, 2R01AR057076-06A1, is available on the NIH RePORTER<\/a>\u00a0website.<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":168,"featured_media":1822,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[38,568,20,436],"class_list":["post-1821","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-administrative","tag-department-of-orthopaedic-surgery","tag-research","tag-usc-stem-cell"],"acf":[],"yoast_head":"\nKeck School of Medicine of USC Receives $2.2 Million NIH Grant to Fund Research on Healing Difficult Bone Injuries<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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