{"id":1991,"date":"2017-10-05T14:39:27","date_gmt":"2017-10-05T21:39:27","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/the-broad-foundation-awards-1-million-to-early-stage-stem-cell-research-projects\/"},"modified":"2023-11-19T12:23:32","modified_gmt":"2023-11-19T20:23:32","slug":"the-broad-foundation-awards-1-million-to-early-stage-stem-cell-research-projects","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/the-broad-foundation-awards-1-million-to-early-stage-stem-cell-research-projects\/","title":{"rendered":"The Broad Foundation awards $1 million to early-stage stem cell research projects"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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\n\n \n Press Release<\/span>\n\n\n\n<\/div>\n \n \n
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The Broad Foundation awards $1 million to early-stage stem cell research projects<\/h1>\n\n\n<\/div>\n \n \n
\n Cristy Lytal<\/span>\n \n October 05, 2017<\/span>\n <\/div>\n \n \n
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Injury-related damage in a mouse chronic kidney disease model (Image by Jing Liu\/McMahon Lab)<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\r\n\r\n\n\n \n \n\n\n\n\n\n\n\n
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The Eli and Edythe Broad Foundation has awarded two $125,000 grants to early-stage scientific investigations at USC\u2019s stem cell research center. The projects are among eight winners of the $1 million Fund for Innovative Stem Cell Research, established by the Broads to celebrate the tenth anniversary of the three stem cell research centers that they established at USC, UCLA and UC San Francisco.
\n\u201cEdye and I have been impressed by the work of scientists at the Broad stem cell centers,\u201d said Eli Broad. \u201cWe hope that, with these grants and others, they can continue to transform how some of the most devastating diseases are understood and treated.\u201d
\nIn one project, Andy McMahon, director of USC\u2019s stem cell research center, and his colleagues will explore the mechanisms that drive normal repair in the adult kidney. Pietro Cippa, a postdoctoral fellow in the McMahon Lab at USC, and Kun Zhang from UC Diego will bring their expertise to the multi-institutional scientific team.
\nThe scientists will develop a finely tuned experimental protocol for damaging kidneys\u2014but not so severely that they cannot repair. The current protocol is too extreme: after clamping off the kidney\u2019s primary blood supply, the organ fails to repair, becomes fibrotic and ceases to function. By inducing more moderate damage, McMahon\u2019s team aims to more accurately model the typical kidney injuries sustained by patients, and to analyze the gene activity of the cells involved in the natural process of organ repair.
\n\u201cOur longterm goal is to identify and optimize the mechanisms of kidney repair, so that they can be used to enhance healing in patients who have sustained damage to this vital organ,\u201d said McMahon.
\nIn the other USC-based project, Scott E. Fraser and Justin Ichida\u2014faculty members in the Department of Stem Cell Biology and Regenerative Medicine\u2014will develop an improved method for labeling different cell types derived from human induced pluripotent stem cells (iPSCs).
\nThe team will adapt an approach, developed by the Fraser lab, that enables labeling different proteins simply by introducing small pieces of genetic information into human cells. The team will use this method to modify iPSCs such that they express different fluorescent tags when they develop into the various major cell types of the nervous system. By observing the fluorescent tags under a sophisticated microscope, they will be able to visually distinguish the different types of living cells in a brain-like structure.
\n\u201cOur labeling system will make it easier, less expensive and more efficient to use iPSCs from patients to study a wide variety of diseases in a personalized way,\u201d said Ichida.
\nThe Fund for Innovative Stem Cell Research is also supporting projects at UCLA and UC San Francisco addressing heart disease, neurological diseases, asthma, immune diseases and leukemia.
\n\u201cI\u2019d like to thank The Broad Foundation not only for their support of this innovative, early-stage research, but also for their 10 years of unwavering commitment to advancing stem cell research in California and beyond,\u201d said McMahon. \u201cThe Broads\u2019 longterm investment is making it possible for us to usher in the future of medicine.\u201d<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":84,"featured_media":1992,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[436],"class_list":["post-1991","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-usc-stem-cell"],"acf":[],"yoast_head":"\nThe Broad Foundation 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