{"id":2000,"date":"2017-10-12T16:44:48","date_gmt":"2017-10-12T23:44:48","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/usc-partners-for-12-million-study-on-alzheimers-diversity\/"},"modified":"2023-11-26T08:22:03","modified_gmt":"2023-11-26T16:22:03","slug":"usc-partners-for-12-million-study-on-alzheimers-diversity","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/usc-partners-for-12-million-study-on-alzheimers-diversity\/","title":{"rendered":"USC partners for $12 million study on Alzheimer\u2019s diversity"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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\n\n \n Press Release<\/span>\n\n\n\n<\/div>\n \n \n
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USC partners for $12 million study on Alzheimer\u2019s diversity<\/h1>\n\n\n<\/div>\n \n \n
\n \n October 12, 2017<\/span>\n <\/div>\n \n \n
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Biomedical researchers have increasingly prioritized large-scale health studies of minority populations in recent years, but datasets often remain limited and inconclusive. While Latinos account for nearly one-fifth of the U.S. population, a recent review estimated that only 3 percent of Alzheimer\u2019s disease studies include Latinos in their analyses.
\nTo help change that, the USC Mark and Mary Stevens Neuroimaging and Informatics Institute at the Keck School of Medicine of USC is teaming up with researchers from the University of North Texas (UNT) Health Science Center and the University of California, San Francisco. The new collaborative project, Health and Aging Brain among Latino Elders (HABLE), is funded by a $12 million grant from the National Institutes of Health and seeks to gain a better understanding of aging and Alzheimer\u2019s among Mexican-Americans.
\n\u201cMost of the archives around the world have insufficient numbers of underrepresented groups,\u201d said Arthur W. Toga, PhD, director of the institute and one of the principal investigators of the study. \u201cIt\u2019s important for people of all races and ethnicities to participate in Alzheimer\u2019s clinical trials, because this disease is a problem that affects all of us.\u201d
\nThe five-year study launched in September. Investigators will recruit and test 2,000 volunteers from North Texas \u2014 half Mexican-American and half non-Hispanic white \u2014 and hope to learn something new about how the debilitating disease affects Latinos differentially.
\n\u201cThis is the first project specifically attempting to understand how different biological causes relate to Alzheimer\u2019s disease across ethnicities,\u201d said Sid O\u2019Bryant, PhD, associate professor of internal medicine at UNT in Fort Worth, Texas, and principal investigator of the study. \u201cBy looking at different potential causes related to memory loss, we may be able to target the right pathway, at the right time, with the right intervention.\u201d
\nThe Alzheimer\u2019s Association estimates that Latinos are 1.5 times more likely to develop Alzheimer\u2019s disease than non-Hispanic whites, and with a growing population of elderly Latinos, researchers are eager to better understand this disparity.
\nO\u2019Bryant\u2019s previous work points to one possible explanation for Mexican-Americans\u2019 increased risk: metabolic risk factors such as obesity and Type 2 diabetes.
\n\u201cIt could be that diabetes and metabolic dysfunction or depression, or a combination of both, are of major importance to memory loss and Alzheimer\u2019s disease among Mexican Americans,\u201d O\u2019Bryant said.
\nResearchers will perform cognitive tests, blood work, and brain scans on participants twice during the five-year period to monitor changes in health and behavior over time. O\u2019Bryant\u2019s team even purchased a robot to help handle the mass of data they plan to collect: the bot will process 400,000 blood tubes stored in the university\u2019s biorepository.
\nResearchers at the Keck School are responsible for another large chunk of data: 4,000 brain scans. Toga, Provost Professor of Ophthalmology, Neurology, Psychiatry and the Behavioral Sciences, Radiology and Engineering, and the Ghada Irani Chair in Neuroscience, will oversee image storage and processing, while Yonggang Shi, PhD, assistant professor of neurology, and Meredith Braskie, PhD, assistant professor of research neurology, respectively will process connectivity and structural images.
\nInvestigators have begun recruiting adults age 50 and older in North Texas, saying that one key to their approach is to study those who do not yet have Alzheimer\u2019s.
\n\u201cOnce people have dementia, their brain has already undergone massive and possibly irreversible damage,\u201d Braskie said. \u201cIt\u2019s crucial for scientists to identify very early risk factors and their associated changes in brain measures or cognitive function. This will help us devise treatments that can prevent the onset of Alzheimer\u2019s symptoms.\u201d
\nThe research is supported by the National Institute on Aging in the Institutes of Health (R01AG054073).
\n\u2014 Zara Abrams<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":168,"featured_media":1379,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[79],"class_list":["post-2000","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-neuroimaging-and-informatics"],"acf":[],"yoast_head":"\nUSC partners for $12 million study on Alzheimer\u2019s diversity<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/keck.usc.edu\/news\/usc-partners-for-12-million-study-on-alzheimers-diversity\/\" \/>\n<meta property=\"og:locale\" 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