{"id":2001,"date":"2017-09-14T12:28:12","date_gmt":"2017-09-14T19:28:12","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/can-alzheimers-be-stopped-years-before-it-starts\/"},"modified":"2023-11-26T08:22:04","modified_gmt":"2023-11-26T16:22:04","slug":"can-alzheimers-be-stopped-years-before-it-starts","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/can-alzheimers-be-stopped-years-before-it-starts\/","title":{"rendered":"Can Alzheimer\u2019s be stopped years before it starts?"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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\n\n \n Press Release<\/span>\n\n\n\n<\/div>\n \n \n
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Can Alzheimer\u2019s be stopped years before it starts?<\/h1>\n\n\n<\/div>\n \n \n
\n \n September 14, 2017<\/span>\n <\/div>\n \n \n
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Researchers are attempting to delay the onset of Alzheimer\u2019s disease using medication that prevents the buildup of amyloid plaques. (Illustration\/iStock)<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\r\n\r\n\n\n \n \n\n\n\n\n\n\n\n
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USC is among 90 institutions testing a vaccine and oral medication to prevent or delay the disease among older people at higher risk<\/h2>\n

Researchers at the Keck School of Medicine of USC are tackling the sixth-leading cause of death in the United States \u2014 Alzheimer\u2019s disease \u2014 with a new study that intervenes decades before the disease develops.
\nThe school is joining approximately 90 institutions in North America, Europe and Australia in the Generation Study, which is testing a vaccine and oral medication to prevent or delay Alzheimer\u2019s in older adults at increased risk for developing the disease. More than 70 USC researchers across a range of disciplines are dedicated to the prevention, treatment and potential cure of Alzheimer\u2019s.
\nBy focusing on prevention, the study is taking a different approach to halting a disease that affects 47 million people worldwide.
\n\u201cOne of the challenges in developing new medications for Alzheimer\u2019s is that researchers tend to test medications on people with more advanced Alzheimer\u2019s, and the medications are simply not proving to be effective,\u201d said Lon Schneider, the study\u2019s lead investigator. \u201cBy intervening 10 to 12 years before Alzheimer\u2019s manifests, we may be able to stop it before it begins or delay the symptoms.\u201d
\nAdults 60 to 75 years of age with normal cognition who are interested in participating must undergo genetic testing for the apolipoprotein e4 (APOE4) gene, which is associated with an increased risk of developing Alzheimer\u2019s.
\nAbout half of people with Alzheimer\u2019s disease carry the APOE4 gene, which can be inherited from either parent, said Schneider, professor of psychiatry and the behavioral sciences and professor of neurology. About 25 percent of the population carries one copy of the APOE4 gene, and about 2 to 3 percent of the population carries two copies, having received one from each parent. To qualify for the study, participants must have two copies of the gene.<\/p>\n

Delay the disease<\/h3>\n

Qualifying participants may randomly receive either a vaccine, oral medication, placebo vaccine or placebo oral medication. Both the vaccine and oral medication target amyloid beta \u2014 the main component in amyloid plaques in the brain and a culprit in Alzheimer\u2019s \u2014 in two different ways: The vaccine helps the body develop antibodies against amyloid beta, while the oral medication blocks an enzyme that creates amyloid beta. Participants may receive the study medications for five to eight years.<\/p>\n

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If we can delay the onset of Alzheimer\u2019s by five years, for example, the incidence of the illness would drop by half.
\n– Lon Schneider<\/p><\/blockquote>\n<\/div>\n

\n\u201cIf we are able to show that the vaccine or oral medication is effective at delaying Alzheimer\u2019s among people at higher risk, then this would strongly imply that we are on the right track for developing treatments,\u201d Schneider said. \u201cIf we can delay the onset of Alzheimer\u2019s by five years, for example, the incidence of the illness would drop by half. It would also give individuals five more years without symptoms of the illness.\u201d\n<\/div>\n
<\/div>\n

Should the vaccine or oral medication prove to be effective in people with two copies of the APOE4 gene, then it would likely also be effective for other people at risk for Alzheimer\u2019s, according to Schneider.
\n\u201cOur clinician-scientists have been actively involved in clinical drug development for Alzheimer\u2019s disease for more than 30 years,\u201d said Rohit Varma, dean of the Keck School of Medicine. \u201cThis study is a reflection of our continued efforts to conquer one of the greatest health challenges of our time.\u201d
\nFor information about how to participate in the study, contact Nadine Diaz at (323) 442-7600 or ndiaz@usc.edu<\/a>.<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":168,"featured_media":2002,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[489],"class_list":["post-2001","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-alzheimers-disease"],"acf":[],"yoast_head":"\nCan Alzheimer\u2019s be stopped years before it starts?<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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