{"id":2016,"date":"2017-06-05T13:10:58","date_gmt":"2017-06-05T20:10:58","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/usc-scientist-reprograms-roving-immune-cells-in-alzheimers-research\/"},"modified":"2023-11-26T08:22:16","modified_gmt":"2023-11-26T16:22:16","slug":"usc-scientist-reprograms-roving-immune-cells-in-alzheimers-research","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/usc-scientist-reprograms-roving-immune-cells-in-alzheimers-research\/","title":{"rendered":"USC scientist \u2018reprograms\u2019 roving immune cells in Alzheimer\u2019s research"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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\n\n \n Press Release<\/span>\n\n\n\n<\/div>\n \n \n
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USC scientist \u2018reprograms\u2019 roving immune cells in Alzheimer\u2019s research<\/h1>\n\n\n<\/div>\n \n \n
\n \n June 05, 2017<\/span>\n <\/div>\n \n \n
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Microglia, or immune cells in the brain, could play a role in Alzheimer\u2019s disease. (Photo\/Valerie Hennes, Ishida Lab)<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\r\n\r\n\n\n \n \n\n\n\n\n\n\n\n
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The novel, less invasive approach produces functional nerve cells for patients<\/h2>\n

About 15 percent of the cells in our brains are scavengers \u2014 roving immune cells known as microglia that remove infectious agents, damaged neurons and plaques.
\nBecause it would be damaging to extract microglia directly from the skulls of Alzheimer\u2019s patients,\u00a0USC Stem Cell<\/a>\u00a0scientist Justin Ichida\u2019s\u00a0group<\/a>\u00a0is taking a far less invasive approach. Using small samples of patients\u2019 blood or skin, the team is applying a technique called \u201creprogramming\u201d to transform these cells into microglia.<\/p>\n

We\u2019ve used this approach to produce functional nerve cells and other cell types, but not microglia, so this will be a first.
\n– Justin Ichida<\/p><\/blockquote>\n

Ichida\u2019s team will then use a gene-editing tool called CRISPR to introduce two genes associated with Alzheimer\u2019s disease into the patient-derived microglia.
\nThe researchers will observe how these two genes alter the function of the microglia. These genetic changes could cause a variety of problems, such as triggering inflammation or preventing microglia from cleaning up defective proteins known as amyloid plaques, which are implicated in Alzheimer\u2019s disease.
\nIn addition to revealing how the two Alzheimer\u2019s-related genes affect the function of microglia, the project will pave the way for other researchers to study microglia on a patient-specific basis.<\/p>\n

A positive partnership<\/h3>\n

Ichida\u2019s team is taking a look at the role of microglia in the onset of Alzheimer\u2019s with support from a $100,000 gift from the John Douglas French\u00a0Alzheimer\u2019s\u00a0Foundation.
\n\u201cDr. Ichida is a trailblazer, and our foundation has a long-standing commitment to supporting pioneering approaches to both preventing and finding a cure for Alzheimer\u2019s disease,\u201d said Dan Michel, president of the John Douglas French Alzheimer\u2019s Foundation.
\nCheryl M. Craft, an international scientific adviser and member of the board of directors at the foundation and a professor of ophthalmology and integrative anatomical sciences at the Keck School of Medicine of USC, added: \u201cBy supporting the most creative, cutting-edge researchers, the foundation is accelerating the quest for new treatments for the increasing number of patients suffering from Alzheimer\u2019s dementia.\u201d
\nAs a longtime champion of such innovative research, the John Douglas French Alzheimer\u2019s Foundation has given more than $2.5 million to USC. Its gift to the Ichida Lab honors Michael Minchin, Jr., who passed away while serving as the foundation\u2019s president and CEO.
\n\u201cI\u2019d like to thank the John Douglas French Alzheimer\u2019s Foundation for its support of my lab\u2019s novel approach to studying Alzheimer\u2019s disease,\u201d said Ichida, assistant professor of stem cell biology and regenerative medicine. \u201cTheir partnership enables us to make new strides toward helping the 5.5 million Americans living with this debilitating and often fatal disease.\u201d<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":168,"featured_media":2017,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[489],"class_list":["post-2016","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-alzheimers-disease"],"acf":[],"yoast_head":"\nUSC scientist \u2018reprograms\u2019 roving immune cells in Alzheimer\u2019s research<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/keck.usc.edu\/news\/usc-scientist-reprograms-roving-immune-cells-in-alzheimers-research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta 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