{"id":2018,"date":"2017-05-10T13:14:27","date_gmt":"2017-05-10T20:14:27","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/science-without-borders-is-needed-to-solve-the-mystery-of-alzheimers-disease\/"},"modified":"2023-11-26T08:22:18","modified_gmt":"2023-11-26T16:22:18","slug":"science-without-borders-is-needed-to-solve-the-mystery-of-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/science-without-borders-is-needed-to-solve-the-mystery-of-alzheimers-disease\/","title":{"rendered":"Science without borders is needed to solve the mystery of Alzheimer\u2019s disease"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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\n\n \n Press Release<\/span>\n\n\n\n<\/div>\n \n \n
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Science without borders is needed to solve the mystery of Alzheimer\u2019s disease<\/h1>\n\n\n<\/div>\n \n \n
\n \n May 10, 2017<\/span>\n <\/div>\n \n \n
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A symposium was designed to fast-track prevention of the disease. (Illustration\/iStock)<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\r\n\r\n\n\n \n \n\n\n\n\n\n\n\n
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Renowned scientists share recent findings at the Zilkha Neurogenetic Institute in a collaborative effort to streamline unpublished research findings toward possible solutions<\/h2>\n

Sixteen of the world\u2019s top Alzheimer\u2019s scientists shared their unpublished research at a symposium designed to fast-track prevention, treatment and a cure for the debilitating disease that affects 1 in 3 seniors.
\nRohit Varma, dean of the Keck School of Medicine of USC, welcomed the elite group to the fourth annual Zilkha Symposium on Alzheimer Disease & Related Disorders.
\n\u201cI am delighted to be hosting this conference, which brings together the best and the brightest physician-scientists from around the world to study the new, basic, translational and clinical efforts in the field of Alzheimer\u2019s and related neurodegenerative disorders,\u201d Varma said. \u201cWe hope that with your wisdom, insight and hard work, we will end the scourge of this disease.\u201d
\nRudolph Tanzi (Harvard University), David Holtzman (Washington University), Virginia Man-Yee Lee and John Trojanowski (University of Pennsylvania), Kaj Blennow (University of Gothenburg in Sweden), Roger Nitsch (University of Zurich), Christer Betsholtz (Uppsala Universitet in Sweden) and Ronald Petersen (Mayo Clinic College of Medicine) were some of the researchers who joined Keck School of Medicine scientists\u00a0Berislav Zlokovic<\/a>\u00a0and\u00a0Paul Aisen<\/a>\u00a0to present their new findings.<\/p>\n

Alzheimer\u2019s starts with amyloid buildup<\/h3>\n

Alzheimer\u2019s symptoms start to appear about 15 years after sticky amyloid proteins dirty the brain, said Aisen, director of the\u00a0USC Alzheimer\u2019s Therapeutic Research Institute<\/a>, which leads eight clinical trials on the disease.
\nCiting data from the ongoing Alzheimer\u2019s Disease Neuroimaging Initiative study, Aisen said about 80 percent of participants with amyloid deposits in their brain but no Alzheimer\u2019s symptoms developed symptoms of the disease during the next nine years. Comparatively, only 20 percent of people without amyloid deposits later developed similar symptoms.
\n\u201cI think we need to carry this study a little further until we can say almost everyone with elevated amyloid will progress to symptomatic AD,\u201d Aisen said. \u201cIt seems reasonable to expect that if we start anti-amyloid therapy 15 years prior to the expected onset of symptoms, we should be able to prevent the development of clinical Alzheimer\u2019s disease.\u201d
\nAisen is enrolling healthy individuals showing no symptoms of Alzheimer\u2019s into clinical studies to trace the development of the disease over time.
\nUnderstanding the illness and how it progresses will aid in the development of a \u201cliquid biopsy\u201d blood test that will inform doctors which individuals are at high-risk for Alzheimer\u2019s.
\nIn the future, once doctors identify that a patient has early buildup of amyloid, they could prescribe a drug to eliminate it. Afterward, individuals might take a drug such as a BACE-inhibitor to prevent amyloid buildup, Aisen said.
\nEventually, doctors will be able to identify people likely to develop Alzheimer\u2019s through biomarkers found in blood draws, Aisen said. This will facilitate preventive treatment.<\/p>\n

The brain\u2019s vascular system<\/h3>\n

Zlokovic, director of the Zilkha Neurogenetic Institute, challenged Aisen\u2019s amyloid hypothesis, saying amyloid isn\u2019t ground zero for neurodegeneration.
\n\u201cI\u2019m a little worried if we say Alzheimer\u2019s is exclusively amyloid-derived neurodegeneration,\u201d Zlokovic said. \u201cI would say that this is a very complex, multifactorial disease that is driven by genetic, vascular and environmental factors that all can influence disease onset and progression.
\n\u201cDisease onset may or may not involve amyloid at all,\u201d he noted.
\nProblems in brain circulation such as subtle damage to the smallest brain vessels \u2014 capillaries \u2014 loss of cerebrovascular integrity and blood flow changes happen early, are integral to disease progression and can precede amyloid and tau pathology, according to recent studies, he explained.
\nZlokovic is performing pioneering research on how leaks in the brain\u2019s vascular system, the blood-brain barrier, cause a cascade of problems, including amyloid buildup. Age-related small vessel disease of the brain is a health epidemic of the 21st century, Zlokovic said. Small vessel disease contributes to about 45 percent of all dementias worldwide, including Alzheimer\u2019s, he added.<\/p>\n

A healthy brain needs healthy blood vessels.
\n-Berislav Zlokovic<\/p><\/blockquote>\n

Zlokovic, recently installed as the Mary Hayley and Selim Zilkha Chair in Alzheimer\u2019s Disease Research said \u201cThe blood-brain barrier prevents entry into the brain of blood-derived toxic products, pathogens and cells.\u201d<\/p>\n

The center of learning and memory<\/h3>\n

The first region of an aging brain to become leaky is the blood-brain barrier around the hippocampus \u2014 the center of learning and memory, Zlokovic said. When the brain\u2019s capillaries become leaky, toxic, blood-derived products flood the brain and can trigger neurodegenerative changes and inflammatory response.
\nDue to the blood vessel problem, delivery of oxygen and glucose (a key energy metabolite for the brain) is grossly impaired and gets worse as Alzheimer\u2019s progresses. Damaged blood vessels lose their ability to clear metabolic waste products from the brain, including amyloid proteins, causing buildup of the dangerous plaques, inflammation, loss of brain connections and ultimately loss of neurons leading to characteristic cognitive problems associated with Alzheimer\u2019s.
\nOther researchers talked about new findings on how genes, germs, tau protein tangles and specific biomarkers are contributing to Alzheimer\u2019s disease. In the end, the consensus was clear: Collaboration is necessary to solve the intricate and colossal Alzheimer\u2019s problem.
\nMore than 70 USC researchers across a range of disciplines are examining the health, societal and political effects and implications of Alzheimer\u2019s.
\n\u201cWe look forward to hosting this symposium again next year,\u201d Zlokovic said. \u201cIt\u2019s critical for top Alzheimer\u2019s experts to get together and share their unpublished findings, concepts and state-of-the art approaches so that scientific barriers are removed, and we all work together to arrest and reverse this devastating disease.<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":168,"featured_media":2019,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[489],"class_list":["post-2018","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-alzheimers-disease"],"acf":[],"yoast_head":"\nScience without borders is 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