{"id":2034,"date":"2017-11-03T14:30:51","date_gmt":"2017-11-03T21:30:51","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/new-big-data-study-will-investigate-link-between-gender-and-alzheimers-risk\/"},"modified":"2023-11-19T12:24:09","modified_gmt":"2023-11-19T20:24:09","slug":"new-big-data-study-will-investigate-link-between-gender-and-alzheimers-risk","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/new-big-data-study-will-investigate-link-between-gender-and-alzheimers-risk\/","title":{"rendered":"New big data study will investigate link between gender and Alzheimer\u2019s risk"},"content":{"rendered":"\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--article-hero \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--article-hero\"\n    \n      >\n\n    \n  <div class=\"text-container\">\n              \n<div class=\"f--field f--eyebrow\">\n\n    \n  <span>Press Release<\/span>\n\n\n\n<\/div>\n    \n              \n<div class=\"f--field f--page-title\">\n\n    \n      <h1>New big data study will investigate link between gender and Alzheimer\u2019s risk<\/h1>\n\n\n<\/div>\n    \n    \n          <div class=\"meta\">\n                  <span class=\"author\">Zara Abrams<\/span>\n        \n                  <span class=\"date\">November 03, 2017<\/span>\n              <\/div>\n    \n              \n<div class=\"f--field f--embed\">\n\n    \n  <div class=\"heateor_sss_sharing_container heateor_sss_horizontal_sharing\" data-heateor-ss-offset=\"0\" data-heateor-sss-href='https:\/\/keck.usc.edu\/news\/new-big-data-study-will-investigate-link-between-gender-and-alzheimers-risk\/'><div class=\"heateor_sss_sharing_ul\"><a aria-label=\"Facebook\" class=\"heateor_sss_facebook\" href=\"https:\/\/www.facebook.com\/sharer\/sharer.php?u=https%3A%2F%2Fkeck.usc.edu%2Fnews%2Fnew-big-data-study-will-investigate-link-between-gender-and-alzheimers-risk%2F\" title=\"Facebook\" rel=\"nofollow noopener\" target=\"_blank\" 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11.903 5 10.826c0-1.08.382-1.993 1.146-2.738L8.128 6.12C8.873 5.372 9.785 5 10.864 5c1.087 0 2.004.382 2.75 1.146l2.777 2.79c.75.747 1.12 1.66 1.12 2.737 0 1.105-.392 2.045-1.183 2.817l1.186 1.186c.774-.79 1.708-1.186 2.805-1.186 1.078 0 1.995.377 2.75 1.132l2.804 2.804c.754.755 1.13 1.672 1.13 2.75z\"\/><\/svg><\/span><\/a><\/div><div class=\"heateorSssClear\"><\/div><\/div>\n\n\n<\/div>\n        \n  <\/div>\n\n          \n<div class=\"f--field f--image\">\n\n    \n    \n    \n    \n    \n    \n              \n      <img\n                            data-src=\"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/brain-image-600x432.jpg\"\n                    data-sizes=\"(min-width:1200px) 75vw, (min-width:768px) 83vw, 100vw\"          class=\"lazyload\"\n        \n                alt=\"New big data study will investigate link between gender and Alzheimer\u2019s risk - brain-image\"\n\n        \n                \n                                      \/>\n\n    \n    \n  \n  \n\n<\/div>\n  \n\n  <\/div><\/div>\n\r\n\r\n\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text white\"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/brain-image.jpg\" alt=\"New big data study will investigate link between gender and Alzheimer\u2019s risk\" width=\"600\" height=\"447\" class=\"aligncenter size-full wp-image-27452\" \/><br \/>\nTwice as many women as men develop Alzheimer\u2019s disease, but even after years of research, aging experts are unsure why. Judy Pa, PhD, assistant professor of neurology at the Keck School of Medicine of USC, will lead a new big data study focused on the link between gender and Alzheimer\u2019s risk.<br \/>\n\u201cWe believe there are distinct biological reasons for why women are at increased risk of Alzheimer\u2019s disease \u2014 reasons that can be probed and discovered from data that already exist,\u201d said Pa, who is based at the USC Mark and Mary Stevens Neuroimaging and Informatics Institute. \u201cPrevious research may have missed these gender-specific variations because the disparities can be subtle. This is why our targeted approach is important and necessary for addressing these questions.\u201d<br \/>\nThe five-year study is funded by a $3.78 million National Institutes of Health award and will use imaging and genetics data to explore the issue. Pa and her team include Alzheimer\u2019s disease investigators across USC in the departments of Neurology, Psychology, Pharmaceutical Sciences and Preventive Medicine.<br \/>\n\u201cMen and women may require specialized treatment strategies for a disease as complex as Alzheimer\u2019s,\u201d said Arthur W. Toga, PhD, Provost Professor of Ophthalmology, Neurology, Psychiatry and the Behavioral Sciences, Radiology and Engineering; Ghada Irani Chair in Neuroscience; and director of the USC Mark and Mary Stevens Neuroimaging and Informatics Institute. \u201cIt\u2019s important to understand these differences so we can develop effective targeted therapies.\u201d<br \/>\nTheories abound as to why women face a higher Alzheimer\u2019s risk than men. For decades, researchers assumed that longevity explained the disparity: women live longer than men, thus they are more often diagnosed. Recent data suggests longevity explains part of the difference, but isn\u2019t the whole story.<br \/>\nOther potential explanations include hormone-related changes, differential stress-induced pathology and educational differences. For example, women experience a change in energy resources throughout the body after menopause, which may impact neurological processes, researchers said.<br \/>\nThe study aims to aggregate clinical, cognitive, imaging, and genetics data from more than 3,000 people, combining multiple existing datasets with comprehensive data types.<br \/>\n\u201cWe\u2019re leveraging existing resources,\u201d Pa said. \u201cThe data are already there, they just need to be managed in specific ways. The tricky thing with big data is harmonizing it \u2014 many attributes will need to be cleaned up and reconciled between datasets. And most importantly, understanding the biological relevance of findings when using a big data approach is critical.\u201d<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":166,"featured_media":2035,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[489,234,20,87,427],"class_list":["post-2034","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-alzheimers-disease","tag-department-of-neurology","tag-research","tag-alzheimer-disease-research-center","tag-usc-mark-and-mary-stevens-neuroimaging-and-informatics-institute"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.2 (Yoast SEO v28.2) - 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