{"id":2074,"date":"2017-11-30T14:10:59","date_gmt":"2017-11-30T22:10:59","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/creating-new-heart-muscle-out-of-stem-cells-this-grad-student-is-doing-it\/"},"modified":"2023-11-19T12:24:32","modified_gmt":"2023-11-19T20:24:32","slug":"creating-new-heart-muscle-out-of-stem-cells-this-grad-student-is-doing-it","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/creating-new-heart-muscle-out-of-stem-cells-this-grad-student-is-doing-it\/","title":{"rendered":"Creating new heart muscle out of stem cells? This grad student is doing it"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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\n\n \n Press Release<\/span>\n\n\n\n<\/div>\n \n \n
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Creating new heart muscle out of stem cells? This grad student is doing it<\/h1>\n\n\n<\/div>\n \n \n
\n Eric Lindberg<\/span>\n \n November 30, 2017<\/span>\n <\/div>\n \n \n
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Joycelyn Yip says she wishes she could have five different careers. (Photo by Susanica Tam)<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\r\n\r\n\n\n \n \n\n\n\n\n\n\n\n
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In a narrow room not much larger than a closet, Joycelyn Yip reaches behind a glass shield to lower a pipette to a plate of silicon-coated glass.
\nSwaddled in a sterile white cloak, latex gloves and safety goggles, she drizzles a chemical compound onto a colony of stem cells before returning them to a nearby incubator. The cells, once circular and constantly dividing and replicating, lengthen and begin to connect into webs and strands.<\/p>\n

\n<\/span>\u201cOne day, they\u2019ll just start beating on their own,\u201d said Yip, a\u00a0biomedical engineering<\/a>\u00a0PhD student in the laboratory of Megan McCain, assistant professor of biomedical engineering, and stem cell biology and regenerative medicine at USC. \u201cIt creeped me out the first time I saw it.\u201d
\nShe is creating muscle cells that mimic the human heart.
\nHer ultimate goal is to use that living tissue to test new drugs or treatment approaches without putting patients at risk. It\u2019s part of an exciting field known as tissue engineering that could pave the way to more personalized medicine that reduces side effects and helps cure diseases.
\n\u201cWe\u2019ll be able to go to a patient, take their skin cells, make them into stem cells and then create their own personalized cardiac tissues,\u201d she said. Then scientists could try different drugs on that tissue to see which therapy is the safest and most effective for the patient.
\nGrowing heart tissue isn\u2019t Yip\u2019s only research preoccupation. She is collaborating with biologists at Children\u2019s Hospital Los Angeles to explore how zebrafish rapidly regenerate tissue and whether that process can be stimulated in humans. She is also using 3-D printers, laser cutters and milling machines to create new gadgets, such as a device that tests the diffusion of drugs into cardiac tissue.
\nPrevious projects include analyzing the mechanics of a golf swing using force plates, motion trackers and video cameras in the USC Biomechanics Lab and examining ways to create a needle-free vaccine delivery patch as a research assistant at the University of Queensland during a semester abroad in Australia.
\nYip has found the perfect home for her studies at USC, which is increasingly emphasizing convergence, or collaborative research and scholarship that crosses disciplinary boundaries, to solve biomedical and technological challenges.
\n\u201cI\u2019m interested in so many different things,\u201d she said. \u201cIt\u2019s so hard to pick \u2014 I wish I could have five different careers.\u201d<\/p>\n

A pursuit of science<\/h3>\n

A San Marino native, Yip was no stranger to USC as a child. Her parents, Julia \u201988 and Andrew \u201989, are both Trojans, earning bachelor\u2019s degrees in business administration and electrical engineering, respectively. Their names grace a commemorative brick near USC Viterbi, and Yip spent many fall Saturdays cheering on the Trojans at the Coliseum.
\n\u201cI grew up wearing USC onesies,\u201d Yip said. \u201cIt\u2019s in my blood.\u201d
\nAn innate ability to understand how things work is also a family trait. She described her father and grandfather as adept handymen, and though her father ultimately pursued a career in finance, his engineering background likely influenced Yip\u2019s childhood interests. She played with LEGO toys handed down by her cousins and cracked open the case of her first iPod to inspect its complex innards.
\nBy the time she headed to boarding school in Boston, Yip had a sense that she wanted to pursue science. Her experiences in honors biology, chemistry and physics classes solidified her passion for engineering and medicine.
\n\u201cI knew I didn\u2019t want to be a doctor, so I think biomedical engineering really stuck out to me,\u201d she said. \u201cIt lets me create the tools that doctors use while still helping people and applying my love of building and creating things.\u201d<\/p>\n

Homeward bound<\/h3>\n

USC\u2019s strong engineering program, coupled with the university\u2019s proximity to her family and a generous merit-based scholarship package, made it an easy decision for Yip to return to Los Angeles for her undergraduate degree. She enrolled at USC Viterbi in 2011 in mechanical engineering because of her fascination with objects she can construct and manipulate.
\nThe progressive degree doctoral program at USC Viterbi soon followed, allowing her to earn her master\u2019s degree in mechanical engineering earlier this year en route to the planned completion of her PhD in 2020.
\nNow a researcher in the\u00a0USC Laboratory for Living Systems Engineering<\/a>, overseen by Assistant Professor Megan McCain, Yip is focusing her efforts on cardiomyopathy, or diseases that cause the heart to enlarge and become thick or rigid, often triggering heart failure, irregular heartbeat and dangerous conditions like fluid buildup in other areas of the body.
\nCreating and analyzing cardiac tissues is a promising counterpoint to current approaches that use animal models, Yip said, which allow testing of side effects on other organs and systems beyond the heart, but might not translate to people.
\n\u201cSomething that works in pigs and mice doesn\u2019t necessarily work in humans,\u201d she said.<\/p>\n

Flexing her muscles<\/h3>\n

Yip and her collaborators are doing more than culturing and observing cells. They\u2019re using electrodes to test how well the tissues conduct electricity. They\u2019re also building heart cells onto a mechanical cantilever that can assess how much force is generated when the muscle tissue contracts. Those engineering techniques allow the researchers to determine whether certain drugs could cause problems like an irregular heartbeat before they reach clinical trials.
\nFor now, the focus is on creating a model for drug testing and screening, rather than growing healthy tissue to repair a damaged or diseased heart, which Yip described as complicated and \u201cfar down the road, especially because a heart is so complex.\u201d Challenges remain, including making sure the cells they\u2019re creating truly mimic adult cardiac tissue.
\n\u201cWe still have a long way to go to make sure this is ready for mass consumption, either for proving drugs are safe or implanting cells into people,\u201d she said.<\/p>\n

Finding balance<\/h3>\n

Beyond the research lab, Yip is engaged in university leadership as vice president of administration for graduate student government, a continuation of previous roles, including president of the Viterbi Graduate Student Association.
\nAs an undergrad, she minored in art history as a counterbalance to her science-heavy courses at USC Viterbi, which enhanced her appreciation for design aesthetics and how people react to visual and physical cues.
\nDespite her hectic schedule, she still finds time to catch USC football games from the student section and enjoys exploring Los Angeles and traveling. She has studied abroad in Australia, China and Paris, and her varied interests have earned her Discovery Scholar, Renaissance Scholar and Global Scholar accolades at USC.
\nYip views her freedom to engage in many aspects of student life at USC as a credit to the generous scholarship support she has received throughout her studies. As an undergraduate, she earned a Presidential Scholarship, Town and Gown of USC Scholarship and SCion Scholarship, along with support from the USC Alumni Club of the San Gabriel Valley and the Trojan Guild of Los Angeles.
\nHer tuition as a PhD student was previously covered by an Andrew and Erna Viterbi Graduate Student Fellowship, and she is currently supported by an Alfred E. Mann Innovation in Engineering Doctoral Fellowship, both of which also provide an annual stipend.
\n\u201cIt really allows me to focus more of my efforts on just being a student, whether it\u2019s taking classes or doing research or getting involved on campus,\u201d she said. \u201cI have to worry less about picking up odd jobs.\u201d
\nNot that she doesn\u2019t find time to squeeze in a little extra work as a grader and a mentor for undergraduate students at USC, including women interested in engineering careers.
\nWhen she completes her PhD, Yip envisions working for a medical device manufacturer on heart-related engineering projects. Although she enjoys academia, she hopes to develop real-world applications for her research.
\n\u201cWorking in industry would be a really great way to have a more direct impact on people,\u201d she said. \u201cI want to create things that directly help patients and really improve well-being.\u201d\n<\/p><\/div>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":95,"featured_media":2075,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[17],"class_list":["post-2074","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-stem-cell"],"acf":[],"yoast_head":"\nCreating new heart muscle out of stem cells? 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