{"id":2160,"date":"2017-08-21T13:53:15","date_gmt":"2017-08-21T20:53:15","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/study-new-map-may-lead-to-drug-development-for-complex-brain-disorders\/"},"modified":"2023-11-19T12:25:29","modified_gmt":"2023-11-19T20:25:29","slug":"study-new-map-may-lead-to-drug-development-for-complex-brain-disorders","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/study-new-map-may-lead-to-drug-development-for-complex-brain-disorders\/","title":{"rendered":"Study: New map may lead to drug development for complex brain disorders"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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\n\n \n Press Release<\/span>\n\n\n\n<\/div>\n \n \n
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Study: New map may lead to drug development for complex brain disorders<\/h1>\n\n\n<\/div>\n \n \n
\n Zen Vuong<\/span>\n \n August 21, 2017<\/span>\n <\/div>\n \n \n
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Artist rendition of the postsynaptic protein-protein interactions associated with complex brain disorders. (Illustration\/Steven Park)<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\r\n\r\n\n\n \n \n\n\n\n\n\n\n\n
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Just as parents are not the root of all their children\u2019s problems, a single gene mutation can\u2019t be blamed for complex brain disorders like autism, according to a Keck School of Medicine of USC neuroscientist.
\nTo help researchers see the big picture, Marcelo P. Coba, PhD, created the first map that highlights the brain\u2019s network of protein associations. It\u2019s a first step to developing treatment drugs that operate more like rifles than shotguns.
\n\u201cThe drugs we have now are not working for these brain disorders,\u201d said Coba, senior author of a new study and assistant professor of psychiatry at the Keck School of Medicine. \u201cScientists have not developed a new drug target for complex brain diseases in nearly 60 years. The protein map software my colleagues and I created can help researchers create new therapies that hone in on problem pathways.\u201d
\nThe study was published in late June in Nature Neuroscience<\/em><\/a>. Coba and his colleagues isolated 2,876 protein interactions and figured out where in the brain the protein networks lived, how they communicated and at what age in development those pathways became activated.
\nResearchers stuffed all that information into a software platform that enables users to visualize disease risk factors throughout the brain\u2019s protein networks.
\nTaking off the blinders<\/strong>
\nMany current studies scan patients\u2019 genetics to identify problem genes they label as \u201crisk factors\u201d for developing a disorder.
\n\u201cThe problem is that there is a collection of risk factors contributing to brain disorders,\u201d Coba said. \u201cA single risk factor might explain a very low percentage of the population \u2014 perhaps 2 percent of those who have the disease.\u201d
\nCoba used an analogy. If all flights at a Texas airport were grounded, flight schedules and airports across the country would be affected. A disruption in one location cannot be sustained in that region because the flights are connected in a network of airports, he said.
\nSimilarly, genes produce proteins that interact in a protein network. If a gene is mutated, the protein\u2019s connections may experience delays or disruptions. The disorganized protein-to-protein connections from point A to B to C might be the bedrock of brain disorders such as autism, bipolar disorder and schizophrenia, Coba said.
\nThe study was supported by $420,000 from the National Institute of Child Health and Human Development (MH104603-01), the National Institutes of Health (MH108728) and the Simons Foundation Autism Research Initiative (248429 and 345034). Seventy percent of research funding originated from the federal government.<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"

Just as parents are not the root of all their children\u2019s problems, a single gene mutation can\u2019t be blamed for complex brain disorders like autism, according to a Keck School of Medicine of USC neuroscientist. To help researchers see the big picture, Marcelo P. Coba, PhD, created the first map that highlights the brain\u2019s network of protein associations. It\u2019s a first step to developing treatment drugs that operate more like rifles than shotguns.<\/p>\n","protected":false},"author":60,"featured_media":2162,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[42],"class_list":["post-2160","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-zilkha"],"acf":[],"yoast_head":"\nStudy: New map may lead to drug development for complex brain disorders<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/keck.usc.edu\/news\/study-new-map-may-lead-to-drug-development-for-complex-brain-disorders\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study: New map may lead to drug development for complex brain disorders\" \/>\n<meta property=\"og:description\" content=\"Just as parents are not the root of all their children\u2019s problems, a single gene mutation can\u2019t be blamed for complex brain disorders like autism, according to a Keck School of Medicine of USC neuroscientist. 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