{"id":2212,"date":"2018-03-09T14:20:35","date_gmt":"2018-03-09T22:20:35","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/for-breast-cancer-survivors-exercise-could-be-key-to-continued-health\/"},"modified":"2023-11-26T08:23:28","modified_gmt":"2023-11-26T16:23:28","slug":"for-breast-cancer-survivors-exercise-could-be-key-to-continued-health","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/for-breast-cancer-survivors-exercise-could-be-key-to-continued-health\/","title":{"rendered":"For breast cancer survivors, exercise could be key to continued health"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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\n\n \n Press Release<\/span>\n\n\n\n<\/div>\n \n \n
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For breast cancer survivors, exercise could be key to continued health<\/h1>\n\n\n<\/div>\n \n \n
\n \n March 09, 2018<\/span>\n <\/div>\n \n \n
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Christina Dieli-Conwright has published a study that is the largest to date in cancer survivors to show such a positive impact of exercise on metabolic syndrome and in such a diverse sample of breast cancer survivors. (Photo\/Christina Gandolfo)<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\r\n\r\n\n\n \n \n\n\n\n\n\n\n\n
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When Carla Sanchez started working out as part of a study on exercise\u2019s impact on women who survived breast cancer, she was surprised at how vigorous it was.<\/p>\n

\u201cI\u2019m 65, so I\u2019m not exactly a young kid,\u201d Sanchez said. \u201cWhen I was younger, women didn\u2019t necessarily lift weights.\u201d Though she was an avid bowler before entering breast cancer treatment, Sanchez said the weights and stationary bike in the gym were all new to her.<\/p>\n

Sanchez, a retired nurse, had taken care of breast cancer patients in the 1970s. At that time, she was taught that breast cancer patients shouldn\u2019t be lifting more than five pounds \u2014 for the rest of their lives. \u201cAnd all of a sudden, here I am, lifting 20, 30 or 40 pounds in a gym,\u201d she said. \u201cI just wanted to get better.\u201d<\/p>\n

Sanchez was part of a pioneering study from Christina Dieli-Conwright, PhD, assistant professor of research at the USC Division of Biokinesiology and Physical Therapy<\/a>.<\/p>\n

More deadly battles ahead\u00a0\u00a0 <\/strong><\/p>\n

Dieli-Conwright explains most women treated with chemotherapy for breast cancer often gain weight.<\/p>\n

\u201cBreast cancer has a relatively high survival rate, and many people don\u2019t realize that the No. 1 cause of death for survivors is actually heart disease,\u201d she said.<\/p>\n

Dieli-Conwright adds that the majority of women who go through four months of chemotherapy develop metabolic syndrome \u2014 a cluster of health conditions that includes high blood pressure, excessive body fat and high cholesterol.<\/p>\n

To look at how exercise might impact the health of breast cancer survivors, the junior researcher developed a study with funding from the National Cancer Institute, tapping into the diverse population around USC and recruiting women who were just finishing treatment for breast cancer.<\/p>\n

The women worked out, supervised, for 16 weeks with a program based on guidelines created by the American Cancer Society and the American College of Sports Medicine. This program included at least 150 minutes of moderate intensity activity spread throughout the week and two days of resistance training with weights.<\/p>\n

As a result of the exercise intervention, health conditions related to metabolic syndrome improved and women lost weight from fat and gained muscle \u2014 compared to a control group of sedentary women.<\/p>\n

Dieli-Conwright presented these findings in the Journal of Clinical Oncology<\/em>, published Jan. 22.<\/p>\n

Dieli-Conwright\u2019s study is the largest to date in cancer survivors to show such a positive impact of exercise on metabolic syndrome and in such a diverse sample of breast cancer survivors.<\/p>\n

Beneficial down to the cellular level <\/strong><\/p>\n

From the same study, Dieli-Conwright took blood samples and fat biopsies from 20 obese patients to determine how the exercise intervention affected systemic and cellular inflammation.<\/p>\n

Inflammation is particularly important because it is believed to be one path through which obesity causes cancer to get worse over time and even recur, said Dieli-Conwright, who published her findings in the journal Breast Cancer Research and Treatment<\/em><\/a>. The findings show that exercise intervention improved systemic inflammation and reduced inflammation in the fat cells.<\/p>\n

She\u2019s quick to point out that this study doesn\u2019t show that exercise prevents cancer recurrence \u2014 but the results are still encouraging.<\/p>\n

\u201cExercise is a form of medicine, and this study can just add to that knowledge,\u201d Dieli-Conwright said.<\/p>\n

Exercise is a part of getting better<\/strong><\/p>\n

Scientists still don\u2019t know exactly why women gain weight during breast cancer treatment.<\/p>\n

\u201cWe don\u2019t know if it\u2019s the chemotherapy that changes some of their basic biology to cause them to gain wait, or changes in lifestyle because they\u2019re fatigued and sedentary from treatment,\u201d Dieli-Conwright explained.<\/p>\n

That\u2019s what happened to Joyce Chen, another participant in Dieli-Conwright\u2019s study. When she first heard about the research, she was just finishing radiation after surgery for breast cancer.<\/p>\n

\u201cI was looking for anything to get back in to the gym. Exercise was one thing I didn\u2019t get to do during treatment,\u201d Chen said. \u201cYour body is all out of whack after surgery.\u201d<\/p>\n

Chen also appreciated having the emotional support of trained exercise specialists and other survivors around her.<\/p>\n

\u201cIt\u2019s good to be with people who have been through it too,\u201d she said. \u201cIt\u2019s a reminder that exercise is part of getting better.\u201d<\/p>\n

Dieli-Conwright hopes to follow up on these studies with a larger trial of more than 300 women. She also would like to test different exercise paradigms to derive newer types of exercise intervention. If women don\u2019t prefer the 150-minute-per week of aerobic exercise, they could try circuit- or interval-type programs, Dieli-Conwright said. \u201cSo we can prescribe exercise on a more individualized basis.\u201d<\/p>\n

\u2014 Katharine Gammon<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"

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