{"id":2441,"date":"2018-05-25T13:48:33","date_gmt":"2018-05-25T20:48:33","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/particle-shows-promise-for-treating-the-most-deadly-type-of-breast-cancer\/"},"modified":"2023-11-26T08:25:23","modified_gmt":"2023-11-26T16:25:23","slug":"particle-shows-promise-for-treating-the-most-deadly-type-of-breast-cancer","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/particle-shows-promise-for-treating-the-most-deadly-type-of-breast-cancer\/","title":{"rendered":"Particle shows promise for treating the most deadly type of breast cancer"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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\n\n \n Press Release<\/span>\n\n\n\n<\/div>\n \n \n
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Particle shows promise for treating the most deadly type of breast cancer<\/h1>\n\n\n<\/div>\n \n \n
\n \n May 25, 2018<\/span>\n <\/div>\n \n \n
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Metastatic breast cancer cells (yellow) interacting with macrophages (magenta) (Image by Oihana Iriondo\/Yu Lab)<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\r\n\r\n\n\n \n \n\n\n\n\n\n\n\n
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USC Stem Cell researchers from the laboratory of Min Yu<\/a> have positive news for patients with triple-negative breast cancer (TNBC), the most deadly type of breast cancer. By inhibiting a protein called TAK1, postdoc Oihana Iriondo and her colleagues reduced lung metastases in mice with TNBC, as described in a new study in Nature Communications<\/a>.<\/p>\n

In the 20 percent of breast cancer patients with TNBC, it appears that TAK1 enables malignant cells from the breast to survive in the unique environment of the lungs, and form new metastatic tumors. Metastases are the most common cause of cancer-related death.<\/p>\n

There\u2019s already a potential drug, called 5Z-7-Oxozeaenol or OXO, that can inhibit TAK1\u2014and presumably make it much more difficult for breast cancers cells to form lung metastases. However, OXO is not stable in the blood, and therefore wouldn\u2019t work in patients.<\/p>\n

To overcome this obstacle, Yu and her lab teamed up with the laboratory of Pin Wang at the USC Viterbi School of Engineering. Wang\u2019s team developed a nanoparticle\u2014consisting of a tiny fatty sac\u2014that can effectively carry drugs through the bloodstream and deliver them to tumors.<\/p>\n

The scientists loaded this nanoparticle with OXO, and used it to treat mice that had been injected with human breast cancer cells. While OXO did not shrink primary tumors in the breast, the potential drug greatly reduced metastatic tumors in the lungs\u2014with minimal toxic side effects.<\/p>\n

\u201cFor patients with triple-negative breast cancer, systemic chemotherapies are largely ineffective and highly toxic,\u201d said Yu, an assistant professor of stem cell biology and regenerative medicine, and principal investigator at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, and the USC Norris Comprehensive Cancer Center. \u201cSo nanoparticles are a promising approach for delivering more targeted treatments, such as OXO, to stop the deadly process of metastasis.\u201d<\/p>\n

\"\"Additional co-authors include Grace Lee, Mostafa Elhodaky, Christian Jimenez, Lin Li, and Julie Lang from the Keck School, and Yarong Liu from USC Viterbi.<\/p>\n

Funding came from the National Cancer Institute (K22 CA175228-01A, DP2CA206653, and P30CA014089) and the USC Ming Hsieh Institute for Engineering Medicine for Cancer.<\/p>\n

– Cristy Lytal<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"

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