{"id":2483,"date":"2018-06-04T11:34:42","date_gmt":"2018-06-04T18:34:42","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/perfectly-punctual-or-fashionably-late-it-takes-all-kinds-of-cells-to-build-a-kidney\/"},"modified":"2023-11-19T12:28:59","modified_gmt":"2023-11-19T20:28:59","slug":"perfectly-punctual-or-fashionably-late-it-takes-all-kinds-of-cells-to-build-a-kidney","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/perfectly-punctual-or-fashionably-late-it-takes-all-kinds-of-cells-to-build-a-kidney\/","title":{"rendered":"Perfectly punctual or fashionably late, it takes all kinds of cells to build a kidney"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
\n\n \n
\n \n
\n\n \n Press Release<\/span>\n\n\n\n<\/div>\n \n \n
\n\n \n

Perfectly punctual or fashionably late, it takes all kinds of cells to build a kidney<\/h1>\n\n\n<\/div>\n \n \n
\n Cristy Lytal<\/span>\n \n June 04, 2018<\/span>\n <\/div>\n \n \n
\n\n \n
<\/path><\/svg><\/span><\/a><\/path><\/svg><\/span><\/a><\/path><\/svg><\/span><\/a><\/path><\/path><\/path><\/svg><\/span><\/a><\/path><\/svg><\/span><\/a><\/path><\/path><\/g><\/svg><\/span><\/a><\/svg><\/span><\/a><\/div>
<\/div><\/div>\n\n\n<\/div>\n \n <\/div>\n\n \n
\n\n \n \n \n
\n \n \n \n \n \n\n \n
Depiction of a developing human nephron, the filtering unit of the kidney (Image\/Nils O. Lindstrom and Tracy Tran\/McMahon Lab)<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\r\n\r\n\n\n \n \n\n\n\n\n\n\n\n
\n\n \n
\n \n
\n\n \n

Arriving early or late can have big consequences for early-stage cells that gather to form a new kidney, USC researchers discovered.
\nThe scientists showed how progenitor cells that form the kidney\u2019s filtering units, called nephrons, mature into entirely different types of cells based on when they reach the scene of nephron formation. The results appear in Developmental Cell<\/a>.
\nThe discovery advances understanding of how to assemble building blocks to fashion kidney tissue. Intimate knowledge of kidney cells helps advance drug development and treatment, fabricate kidney components and, ultimately, build new organs. About one in seven adults in the United States \u2014 or 30 million people \u2014 suffer a chronic kidney disease, according to the U.S. Centers for Disease Control and Prevention.
\n\u201cBy studying normal human nephron development, we\u2019re gaining important information about how to replicate this intricate process in the laboratory,\u201d said Andy McMahon<\/a>, director of the Eli and Edythe Broad Center for Regenerative Medicine at USC and Stem Cell Research<\/a> at USC. \u201cThe hope is that laboratory-grown nephrons can be used to further study the process of development, screen potential therapies to treat disease and eventually provide the building blocks to assemble functional kidneys for transplantation into patients.\u201d<\/p>\n

Build a kidney: What\u2019s the blueprint?<\/h3>\n

McMahon led a team of researchers building a blueprint of how the parts fit together and work. The team discovered that timing is critical as the precise arrival of progenitor cells dictates their form and function in the kidney.
\nSpecifically, it takes about 1 million nephrons to form a human kidney. The scientists observed that every time one of these structures forms, the nephron progenitor cells (NPCs) gradually commit to becoming various mature cell types and joining the developing nephron. NPCs that arrive early within the nephron start to differentiate and become the \u201ctubule,\u201d which controls the reabsorption of important compounds back into the blood and carries urine away. NPCs that occur late develop into the \u201cglomerulus,\u201d the structure that filters the blood.
\n\u201cTiming is critical in determining the type of mature cell that each progenitor will become,\u201d said Nils O. Lindstrom, a principal author of the study and a researcher at the stem cell research center, which is part of the Keck School of Medicine of USC.
\nTo show that their predictions were accurate, Lindstrom and colleagues used genetically labeled NPCs in mouse kidneys and grew these under a microscope while capturing images with time-lapse imaging. This allowed them to demonstrate how NPCs gradually move into the newly forming nephron and turn on genes that are specific to particular cell types.<\/p>\n

Analysis and interpretation<\/h3>\n

Working with scientists in the Molecular and Computational Biology unit at the USC Dornsife College of Letters, Arts and Sciences, the scientists developed new techniques to analyze and interpret what is known as \u201csingle-cell RNA sequencing data.\u201d Single-cell RNA sequencing is a novel technique that allows scientists to break apart whole tissues and organs and observe gene activity in every cell. Using this approach, the team documented how NPCs turn into intermediate cell types with specific gene activity, which identifies them as the precursors to particular mature cell types.
\nTo achieve the full diversity of cell types in the nephron, when attempting to grow kidneys in lab settings, scientists need to understand how these precursor cell types form under normal circumstances in the body. Single-cell RNA sequencing provides a view of all the genes and genetic pathways that are activated when specific cell types form in the nephron.
\nKidney failure is a leading cause of death for people in the United States. About 662,000 people live on chronic dialysis or with a kidney transplant. Men are 64 percent more likely than women to suffer end-stage renal disease and the risk for African-Americans is four times higher compared to whites, according to the CDC and the American Kidney Fund.<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"

Arriving early or late can have big consequences for early-stage cells that gather to form a new kidney, USC researchers discovered.<\/p>\n","protected":false},"author":84,"featured_media":2484,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[521],"class_list":["post-2483","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-mesh-strategic-partnerships"],"acf":[],"yoast_head":"\nPerfectly punctual or fashionably late, it takes all kinds of cells to build a kidney<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/keck.usc.edu\/news\/perfectly-punctual-or-fashionably-late-it-takes-all-kinds-of-cells-to-build-a-kidney\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Perfectly punctual or fashionably late, it takes all kinds of cells to build a kidney\" \/>\n<meta property=\"og:description\" content=\"Arriving early or late can have big consequences for early-stage cells that gather to form a new kidney, USC researchers discovered.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/keck.usc.edu\/news\/perfectly-punctual-or-fashionably-late-it-takes-all-kinds-of-cells-to-build-a-kidney\/\" \/>\n<meta property=\"og:site_name\" content=\"Newsroom\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/KECKschoolUSC\/\" \/>\n<meta property=\"article:published_time\" content=\"2018-06-04T18:34:42+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-11-19T20:28:59+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/cells-to-build-a-kidney.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"600\" \/>\n\t<meta property=\"og:image:height\" content=\"447\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Cristy Lytal\u00a0\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@KeckSchool_USC\" \/>\n<meta name=\"twitter:site\" content=\"@KeckSchool_USC\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/perfectly-punctual-or-fashionably-late-it-takes-all-kinds-of-cells-to-build-a-kidney\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/perfectly-punctual-or-fashionably-late-it-takes-all-kinds-of-cells-to-build-a-kidney\\\/\"},\"author\":{\"name\":\"Cristy Lytal\u00a0\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#\\\/schema\\\/person\\\/9af9659d177a1ffc2f67e5940d535394\"},\"headline\":\"Perfectly punctual or fashionably late, it takes all kinds of cells to build a kidney\",\"datePublished\":\"2018-06-04T18:34:42+00:00\",\"dateModified\":\"2023-11-19T20:28:59+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/perfectly-punctual-or-fashionably-late-it-takes-all-kinds-of-cells-to-build-a-kidney\\\/\"},\"wordCount\":15,\"publisher\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/perfectly-punctual-or-fashionably-late-it-takes-all-kinds-of-cells-to-build-a-kidney\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/68\\\/2023\\\/11\\\/cells-to-build-a-kidney.jpg\",\"keywords\":[\"MESH Strategic Partnerships\"],\"articleSection\":[\"Press Release\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/perfectly-punctual-or-fashionably-late-it-takes-all-kinds-of-cells-to-build-a-kidney\\\/\",\"url\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/perfectly-punctual-or-fashionably-late-it-takes-all-kinds-of-cells-to-build-a-kidney\\\/\",\"name\":\"Perfectly punctual or fashionably late, it takes all kinds of cells to build a kidney\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/perfectly-punctual-or-fashionably-late-it-takes-all-kinds-of-cells-to-build-a-kidney\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/perfectly-punctual-or-fashionably-late-it-takes-all-kinds-of-cells-to-build-a-kidney\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/68\\\/2023\\\/11\\\/cells-to-build-a-kidney.jpg\",\"datePublished\":\"2018-06-04T18:34:42+00:00\",\"dateModified\":\"2023-11-19T20:28:59+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/perfectly-punctual-or-fashionably-late-it-takes-all-kinds-of-cells-to-build-a-kidney\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/keck.usc.edu\\\/news\\\/perfectly-punctual-or-fashionably-late-it-takes-all-kinds-of-cells-to-build-a-kidney\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/perfectly-punctual-or-fashionably-late-it-takes-all-kinds-of-cells-to-build-a-kidney\\\/#primaryimage\",\"url\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/68\\\/2023\\\/11\\\/cells-to-build-a-kidney.jpg\",\"contentUrl\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/68\\\/2023\\\/11\\\/cells-to-build-a-kidney.jpg\",\"width\":600,\"height\":447,\"caption\":\"Depiction of a developing human nephron, the filtering unit of the kidney (Image\\\/Nils O. Lindstrom and Tracy Tran\\\/McMahon Lab)\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/perfectly-punctual-or-fashionably-late-it-takes-all-kinds-of-cells-to-build-a-kidney\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Perfectly punctual or fashionably late, it takes all kinds of cells to build a kidney\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#website\",\"url\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/\",\"name\":\"Newsroom\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#organization\",\"name\":\"Keck School of Medicine of USC\",\"alternateName\":\"Keck School of Medicine\",\"url\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/68\\\/2023\\\/11\\\/keck-school-of-medicine-logo-696-square.jpg\",\"contentUrl\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/wp-content\\\/uploads\\\/sites\\\/68\\\/2023\\\/11\\\/keck-school-of-medicine-logo-696-square.jpg\",\"width\":696,\"height\":696,\"caption\":\"Keck School of Medicine of USC\"},\"image\":{\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/KECKschoolUSC\\\/\",\"https:\\\/\\\/x.com\\\/KeckSchool_USC\",\"https:\\\/\\\/www.linkedin.com\\\/school\\\/keckschoolusc\\\/\",\"https:\\\/\\\/www.instagram.com\\\/KeckSchoolUSC\\\/\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UCpL1E1W5ZTfkc5iihwLSFEA\",\"https:\\\/\\\/www.tiktok.com\\\/@keckschoolusc\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/#\\\/schema\\\/person\\\/9af9659d177a1ffc2f67e5940d535394\",\"name\":\"Cristy Lytal\u00a0\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/05aca83ee186ab3490b6e34d94853031466a1bde729268e58c7652355d86f066?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/05aca83ee186ab3490b6e34d94853031466a1bde729268e58c7652355d86f066?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/05aca83ee186ab3490b6e34d94853031466a1bde729268e58c7652355d86f066?s=96&d=mm&r=g\",\"caption\":\"Cristy Lytal\u00a0\"},\"url\":\"https:\\\/\\\/keck.usc.edu\\\/news\\\/author\\\/cristy_lytal\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Perfectly punctual or fashionably late, it takes all kinds of cells to build a kidney","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/keck.usc.edu\/news\/perfectly-punctual-or-fashionably-late-it-takes-all-kinds-of-cells-to-build-a-kidney\/","og_locale":"en_US","og_type":"article","og_title":"Perfectly punctual or fashionably late, it takes all kinds of cells to build a kidney","og_description":"Arriving early or late can have big consequences for early-stage cells that gather to form a new kidney, USC researchers discovered.","og_url":"https:\/\/keck.usc.edu\/news\/perfectly-punctual-or-fashionably-late-it-takes-all-kinds-of-cells-to-build-a-kidney\/","og_site_name":"Newsroom","article_publisher":"https:\/\/www.facebook.com\/KECKschoolUSC\/","article_published_time":"2018-06-04T18:34:42+00:00","article_modified_time":"2023-11-19T20:28:59+00:00","og_image":[{"width":600,"height":447,"url":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/cells-to-build-a-kidney.jpg","type":"image\/jpeg"}],"author":"Cristy Lytal\u00a0","twitter_card":"summary_large_image","twitter_creator":"@KeckSchool_USC","twitter_site":"@KeckSchool_USC","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/keck.usc.edu\/news\/perfectly-punctual-or-fashionably-late-it-takes-all-kinds-of-cells-to-build-a-kidney\/#article","isPartOf":{"@id":"https:\/\/keck.usc.edu\/news\/perfectly-punctual-or-fashionably-late-it-takes-all-kinds-of-cells-to-build-a-kidney\/"},"author":{"name":"Cristy Lytal\u00a0","@id":"https:\/\/keck.usc.edu\/news\/#\/schema\/person\/9af9659d177a1ffc2f67e5940d535394"},"headline":"Perfectly punctual or fashionably late, it takes all kinds of cells to build a kidney","datePublished":"2018-06-04T18:34:42+00:00","dateModified":"2023-11-19T20:28:59+00:00","mainEntityOfPage":{"@id":"https:\/\/keck.usc.edu\/news\/perfectly-punctual-or-fashionably-late-it-takes-all-kinds-of-cells-to-build-a-kidney\/"},"wordCount":15,"publisher":{"@id":"https:\/\/keck.usc.edu\/news\/#organization"},"image":{"@id":"https:\/\/keck.usc.edu\/news\/perfectly-punctual-or-fashionably-late-it-takes-all-kinds-of-cells-to-build-a-kidney\/#primaryimage"},"thumbnailUrl":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/cells-to-build-a-kidney.jpg","keywords":["MESH Strategic Partnerships"],"articleSection":["Press Release"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/keck.usc.edu\/news\/perfectly-punctual-or-fashionably-late-it-takes-all-kinds-of-cells-to-build-a-kidney\/","url":"https:\/\/keck.usc.edu\/news\/perfectly-punctual-or-fashionably-late-it-takes-all-kinds-of-cells-to-build-a-kidney\/","name":"Perfectly punctual or fashionably late, it takes all kinds of cells to build a kidney","isPartOf":{"@id":"https:\/\/keck.usc.edu\/news\/#website"},"primaryImageOfPage":{"@id":"https:\/\/keck.usc.edu\/news\/perfectly-punctual-or-fashionably-late-it-takes-all-kinds-of-cells-to-build-a-kidney\/#primaryimage"},"image":{"@id":"https:\/\/keck.usc.edu\/news\/perfectly-punctual-or-fashionably-late-it-takes-all-kinds-of-cells-to-build-a-kidney\/#primaryimage"},"thumbnailUrl":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/cells-to-build-a-kidney.jpg","datePublished":"2018-06-04T18:34:42+00:00","dateModified":"2023-11-19T20:28:59+00:00","breadcrumb":{"@id":"https:\/\/keck.usc.edu\/news\/perfectly-punctual-or-fashionably-late-it-takes-all-kinds-of-cells-to-build-a-kidney\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/keck.usc.edu\/news\/perfectly-punctual-or-fashionably-late-it-takes-all-kinds-of-cells-to-build-a-kidney\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/keck.usc.edu\/news\/perfectly-punctual-or-fashionably-late-it-takes-all-kinds-of-cells-to-build-a-kidney\/#primaryimage","url":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/cells-to-build-a-kidney.jpg","contentUrl":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/cells-to-build-a-kidney.jpg","width":600,"height":447,"caption":"Depiction of a developing human nephron, the filtering unit of the kidney (Image\/Nils O. Lindstrom and Tracy Tran\/McMahon Lab)"},{"@type":"BreadcrumbList","@id":"https:\/\/keck.usc.edu\/news\/perfectly-punctual-or-fashionably-late-it-takes-all-kinds-of-cells-to-build-a-kidney\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/keck.usc.edu\/news\/"},{"@type":"ListItem","position":2,"name":"Perfectly punctual or fashionably late, it takes all kinds of cells to build a kidney"}]},{"@type":"WebSite","@id":"https:\/\/keck.usc.edu\/news\/#website","url":"https:\/\/keck.usc.edu\/news\/","name":"Newsroom","description":"","publisher":{"@id":"https:\/\/keck.usc.edu\/news\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/keck.usc.edu\/news\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/keck.usc.edu\/news\/#organization","name":"Keck School of Medicine of USC","alternateName":"Keck School of Medicine","url":"https:\/\/keck.usc.edu\/news\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/keck.usc.edu\/news\/#\/schema\/logo\/image\/","url":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/keck-school-of-medicine-logo-696-square.jpg","contentUrl":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/keck-school-of-medicine-logo-696-square.jpg","width":696,"height":696,"caption":"Keck School of Medicine of USC"},"image":{"@id":"https:\/\/keck.usc.edu\/news\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/KECKschoolUSC\/","https:\/\/x.com\/KeckSchool_USC","https:\/\/www.linkedin.com\/school\/keckschoolusc\/","https:\/\/www.instagram.com\/KeckSchoolUSC\/","https:\/\/www.youtube.com\/channel\/UCpL1E1W5ZTfkc5iihwLSFEA","https:\/\/www.tiktok.com\/@keckschoolusc"]},{"@type":"Person","@id":"https:\/\/keck.usc.edu\/news\/#\/schema\/person\/9af9659d177a1ffc2f67e5940d535394","name":"Cristy Lytal\u00a0","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/05aca83ee186ab3490b6e34d94853031466a1bde729268e58c7652355d86f066?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/05aca83ee186ab3490b6e34d94853031466a1bde729268e58c7652355d86f066?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/05aca83ee186ab3490b6e34d94853031466a1bde729268e58c7652355d86f066?s=96&d=mm&r=g","caption":"Cristy Lytal\u00a0"},"url":"https:\/\/keck.usc.edu\/news\/author\/cristy_lytal\/"}]}},"author_meta":{"display_name":"Cristy Lytal\u00a0","author_link":"https:\/\/keck.usc.edu\/news\/author\/cristy_lytal\/"},"featured_img":"https:\/\/keck.usc.edu\/news\/wp-content\/uploads\/sites\/68\/2023\/11\/cells-to-build-a-kidney-300x224.jpg","coauthors":[],"tax_additional":{"categories":{"linked":["<a href=\"https:\/\/keck.usc.edu\/news\/category\/press-release\/\" class=\"advgb-post-tax-term\">Press Release<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">Press Release<\/span>"]},"tags":{"linked":["<a href=\"https:\/\/keck.usc.edu\/news\/category\/press-release\/\" class=\"advgb-post-tax-term\">MESH Strategic Partnerships<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">MESH Strategic Partnerships<\/span>"]}},"comment_count":"0","relative_dates":{"created":"Posted 8 years ago","modified":"Updated 3 years ago"},"absolute_dates":{"created":"Posted on June 4, 2018","modified":"Updated on November 19, 2023"},"absolute_dates_time":{"created":"Posted on June 4, 2018 11:34 am","modified":"Updated on November 19, 2023 12:28 pm"},"featured_img_caption":"Depiction of a developing human nephron, the filtering unit of the kidney (Image\/Nils O. Lindstrom and Tracy Tran\/McMahon Lab)","series_order":"","_links":{"self":[{"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/posts\/2483","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/users\/84"}],"replies":[{"embeddable":true,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/comments?post=2483"}],"version-history":[{"count":0,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/posts\/2483\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/media\/2484"}],"wp:attachment":[{"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/media?parent=2483"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/categories?post=2483"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/keck.usc.edu\/news\/wp-json\/wp\/v2\/tags?post=2483"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}