{"id":2638,"date":"2018-12-14T11:57:04","date_gmt":"2018-12-14T19:57:04","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/keck-school-institute-launches-new-effort-for-global-aging-research\/"},"modified":"2023-11-26T08:26:47","modified_gmt":"2023-11-26T16:26:47","slug":"keck-school-institute-launches-new-effort-for-global-aging-research","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/keck-school-institute-launches-new-effort-for-global-aging-research\/","title":{"rendered":"Keck School institute launches new effort for global aging research"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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\n\n \n Press Release<\/span>\n\n\n\n<\/div>\n \n \n
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Keck School institute launches new effort for global aging research<\/h1>\n\n\n<\/div>\n \n \n
\n \n December 14, 2018<\/span>\n <\/div>\n \n \n
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The ENIGMA World Aging Center combines studies of lifespan, plasticity, epigenetics and Parkinson\u2019s to create a comprehensive picture of the aging brain. (Image\/Courtesy of Paul Thompson)<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\r\n\r\n\n\n \n \n\n\n\n\n\n\n\n
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Paul Thompson, PhD, associate director of the USC Mark and Mary Stevens Neuroimaging and Informatics Institute (INI) and director of the Imaging Genetics Center (IGC) at the Keck School of Medicine of USC, has already united hundreds of researchers in 39 countries with the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) consortium. Through ENIGMA, scientists team up to pool and analyze brain imaging and genetics data \u2014 and they\u2019ve published some of the largest imaging studies of schizophrenia, bipolar disorder, obsessive-compulsive disorder, autism, post-traumatic stress disorder and more.<\/p>\n

But Thompson isn\u2019t stopping there. He and his team just launched the ENIGMA World Aging Center, which will use the consortium\u2019s network and a $682,000 grant from the National Institute on Aging to perform a global study of brain aging. The collaboration will help pinpoint the factors that contribute to healthy aging versus those that increase our risk for Alzheimer\u2019s or Parkinson\u2019s disease.<\/p>\n

\u201cThe goal of the Center is to bring together experts worldwide to understand what helps us age successfully,\u201d Thompson said. \u201cBy analyzing data on brain aging across cultures as diverse as India, the Middle East, Russia and Japan, we are beginning to find sources of risk in our genome and environment \u2014 and new ways to reduce that risk.\u201d<\/p>\n

Genetics and brain aging<\/strong><\/p>\n

Globally, care and treatment for people with dementia costs more than $604 billion every year. As researchers race to find ways to slow or reverse the progression of diseases like Alzheimer\u2019s, pooling resources and subjects through international collaboration is a key tool for discovery.<\/p>\n

\u201cSome of the larger projects screen every letter of our DNA for abnormalities that speed up brain aging, or that increase our risk for Alzheimer\u2019s and Parkinson\u2019s disease,\u201d Thompson said.
\n\u201cWe look at brain scans worldwide to see how genetic variants alter the brain\u2019s wiring and functional synchrony \u2014 and what we can do to resist the brain\u2019s decline as we age.\u201d<\/p>\n

The World Aging Center comprises four component projects, each a key piece of the brain aging puzzle. ENIGMA Lifespan creates statistical charts of various brain measures at different ages, so researchers can detect abnormalities around the world. ENIGMA Plasticity screens the network\u2019s DNA for \u201cspelling mistakes\u201d or \u201csingle-letter\u201d changes that speed up or slow down brain aging.<\/p>\n

Meanwhile, ENIGMA Epigenetics studies our \u201cepigenetic clocks\u201d \u2014 a measure of biological wear and tear \u2014 and relates them to brain aging. ENIGMA Parkinson\u2019s, co-led by the INI\u2019s Neda Jahanshad, PhD, is the largest worldwide imaging study of Parkinson\u2019s disease.<\/p>\n

A global effort<\/strong><\/p>\n

\n

Global reach and cooperation are what makes the ENIGMA consortium and its new World Aging Center truly innovative. Working with researchers around the world means incorporating diverse perspectives and data from a variety of populations, which improves researchers\u2019 understanding of how genetics affects the aging process.<\/p>\n

\u201cA tremendous lack of ethnic diversity exists in the field of neuroscience,\u201d Thompson said. \u201cWe\u2019re working to change that through our international partnerships, which will be central to our understanding of how diverse populations experience aging.\u201d<\/p>\n

The INI leads several other global efforts in the neurosciences, including the Global Alzheimer\u2019s Association Interactive Network, a data-sharing platform that allows researchers to explore and analyze data from hundreds of thousands of dementia patients worldwide. The one-of-a-kind federated network aggregates clinical, genetic, imaging and other data to help advance research into the causes and prevention of Alzheimer\u2019s disease.<\/p>\n

For more information or to join ENIGMA\u2019s effort,\u00a0visit the ENIGMA World Aging Center online<\/a>.<\/p>\n

\u2014 Zara Greenbaum<\/strong><\/p>\n<\/div>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":168,"featured_media":2639,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[56,79],"class_list":["post-2638","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-featured","tag-neuroimaging-and-informatics"],"acf":[],"yoast_head":"\nKeck School institute launches new effort for global aging research<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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