{"id":2775,"date":"2019-03-05T11:36:13","date_gmt":"2019-03-05T19:36:13","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/fasting-mimicking-diet-holds-promise-for-people-with-digestive-problem\/"},"modified":"2023-11-26T08:27:55","modified_gmt":"2023-11-26T16:27:55","slug":"fasting-mimicking-diet-holds-promise-for-people-with-digestive-problem","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/fasting-mimicking-diet-holds-promise-for-people-with-digestive-problem\/","title":{"rendered":"Fasting-mimicking diet holds promise for people with digestive problem"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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\n\n \n Press Release<\/span>\n\n\n\n<\/div>\n \n \n
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Fasting-mimicking diet holds promise for people with digestive problem<\/h1>\n\n\n<\/div>\n \n \n
\n \n March 05, 2019<\/span>\n <\/div>\n \n \n
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What if a special diet could reduce inflammation and repair your gut?<\/strong>
\nUSC researchers provided evidence that a low-calorie \u201cfasting-mimicking\u201d diet has the potential to do just that. Published in the Tuesday edition of Cell Reports<\/a>, the study reports on the health benefits of periodic cycles of the diet for people with inflammation and indicated that the diet reversed inflammatory bowel disease (IBD) pathology in mice.
\nResults showed that fasting-mimicking diet caused a reduction in intestinal inflammation and an increase in intestinal stem cells in part by promoting the expansion of beneficial gut microbiota. Study authors say the reversal of IBD pathology in mice, together with its anti-inflammatory effects demonstrated in a human clinical trial, indicate that the regimen has the potential to mitigate IBD.
\n\u201cThis study for the first time combines two worlds of research,\u201d said Valter Longo<\/a>, a study author and the director of the USC Longevity Institute<\/a> at the USC Leonard Davis School of Gerontology and professor of biological sciences at the USC Dornsife College of Letters, Arts and Sciences. \u201cThe first is about what you should eat every day, and many studies point to a diet rich in vegetables, nuts and olive oil. The second is fasting and its effects on inflammation, regeneration and aging.\u201d
\nFasting and IBD: Reducing inflammation<\/strong>
\nBy combining these fields of research using the fasting-mimicking diet, the authors were able to reduce the inflammation and pathology associated with intestinal diseases.
\nLongo said for people with a poor diet, a \u201conce in a while\u201d fix is the periodic use of a low-calorie, plant-based diet that causes cells to act like the body is fasting. Earlier clinical trials conducted by Longo and colleagues allowed participants to consume between 750 and 1,100 calories per day over a five-day period and contained specific proportions of proteins, fats and carbohydrates. Participants saw reduced risk factors for many life-threatening diseases.
\n\u201cFasting is hard to stick to and it can be dangerous,\u201d Longo said. \u201cWe know that the fasting-mimicking diet is safer and easier than water-only fasting, but the big surprise from this study is that if you replace the fasting-mimicking diet, which includes pre-biotic ingredients, with water, we don\u2019t see the same benefits.\u201d
\nIn the study, one group of mice adhered to a four-day fasting-mimicking diet by consuming approximately 50 percent of their normal caloric intake on the first day and 10 percent of their normal caloric intake from the second through fourth days. Another group fasted with a water-only diet for 48 hours.
\nThe study demonstrated that two cycles of a four-day fasting-mimicking diet followed by a normal diet appeared to be enough to mitigate some, and reverse other, IBD-associated pathologies or symptoms. In contrast, water-only fasting came up short, indicating that certain nutrients in the fasting-mimicking diet contribute to the microbial and anti-inflammatory changes necessary to maximize the effects of the fasting regimen.
\n\u201cWe\u2019ve determined that the dietary components are contributing to the beneficial effects; it\u2019s not just about the cells of the human body but it\u2019s also about the microbes that are affected by both the fasting and the diet,\u201d Longo said. \u201cThe ingredients in the diet pushed the microbes to help the fasting maximize the benefits against IBD.\u201d
\nThe research team observed activation of stem cells and a regenerative effort in the colon and the small intestine, which increased significantly in length only in the presence of multiple cycles of the fasting-mimicking diet. They concluded that fasting primes the body for improvement, but it is the \u201cre-feeding\u201d that provides the opportunity to rebuild cells and tissues.
\nFasting and IBD: Importance of \u201crefeeding\u201d<\/strong>
\n\u201cIt is really remarkable, that in the past 100 years of research into calorie restriction, no one recognized the importance of the re-feeding,\u201d Longo said. \u201cRestriction is like a demolition where you take the building down. But you have to rebuild it. If you don\u2019t do that, there\u2019s no benefit. You are left with an empty lot, and what have you achieved?\u201d
\nIn the current and previous studies, the authors showed that in patients with elevated C-reactive protein, a marker for inflammation, fasting-mimicking diet cycles are able to reduce C-reactive protein and reverse the associated increase in white blood cells. Together with the results in mice, these data indicate that fasting-mimicking diet cycles have the potential to be effective against human IBD, including Crohn\u2019s disease and ulcerative colitis.
\nIBD afflicts an estimated 1.6 million Americans and is associated with acute and chronic inflammation of the intestine. Study authors say a randomized clinical trial involving the use of fasting-mimicking diet cycles to treat IBD is necessary to determine the safety and efficacy of these dietary treatments in humans, and are currently finalizing a clinical trial protocol.<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":168,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[521],"class_list":["post-2775","post","type-post","status-publish","format-standard","hentry","category-press-release","tag-mesh-strategic-partnerships"],"acf":[],"yoast_head":"\nFasting-mimicking diet holds promise for people with digestive problem<\/title>\n<meta name=\"robots\" content=\"index, follow, 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