{"id":2778,"date":"2019-02-21T11:47:20","date_gmt":"2019-02-21T19:47:20","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/usc-dental-researchers-developing-special-film-that-could-revolutionize-the-way-peri-implantitis-treated\/"},"modified":"2023-11-26T08:28:01","modified_gmt":"2023-11-26T16:28:01","slug":"usc-dental-researchers-developing-special-film-that-could-revolutionize-the-way-peri-implantitis-treated","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/usc-dental-researchers-developing-special-film-that-could-revolutionize-the-way-peri-implantitis-treated\/","title":{"rendered":"USC dental researchers developing special film that could revolutionize the way peri-implantitis treated"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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USC dental researchers developing special film that could revolutionize the way peri-implantitis treated<\/h1>\n\n\n<\/div>\n \n \n
\n \n February 21, 2019<\/span>\n <\/div>\n \n \n
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Three million people in the United States currently have dental implants, and every year that number increases by about 500,000.
\nBut, for some, getting a dental implant is not the end of the story. Similar to what occurs with a natural tooth, bacteria can build up on the implant\u2019s base and below the gum line. Over time, the bacteria can cause peri-implantitis, a condition that can eventually lead to the loss of soft and hard tissue (gums and bone) surrounding the implant.
\nIt\u2019s a condition that typically requires surgical intervention.
\nImplants were originally designed for a small population, and they were considered experimental, Professor Malcolm Snead says. \u201cThere has been a major change in the way dentists use implants, and now implants are widely used to replace teeth with a poor prognosis.\u201d However, the implant is just as susceptible to biofilm formation and the patient\u2019s immune response, which attempts to limit the infection but also leads to the loss of supporting hard and soft tissues.
\nA minimally invasive approach<\/strong>
\nEven so, implants are here to stay, and that\u2019s why Snead and two other Ostrow researchers \u2014 Professor Casey Chen and Research Assistant Professor Yan Zhou, along with Professor Candan Tamerler, a collaborator at the University of Kansas \u2014 took on research to create a bifunctional peptide film. This non-surgical intervention is applied in water and can be repeatedly applied to existing implants to reduce bacterial growth. The study, called \u201cRepeatedly Applied Peptide Film Kills Bacteria on Dental Implants,\u201d was published last month in the Journal of the Minerals, Metals and Materials Society<\/em>.
\nThis is how it works: Snead and his colleagues created a peptide (a short chain of amino acids) that binds to titanium and hung different antimicrobial peptides off this anchor \u2014 making a film that kills bacteria, targets the worst pathogens and hopefully reduces the speed of biofilm build up. The therapeutic peptide film could be applied in a dentist\u2019s office but could also work at home, if the FDA approves it for such a use.
\n\u201cSniper, not nuclear bomb\u201d<\/strong>
\nSnead says the implant-protective film would be a water-based rinse, and a patient would swish it around and spit it out.
\nRight now, some people have to go on low-dose antibiotics to stop the bacteria from building up on their implants, but a focused rinse could be much more targeted.
\n\u201cIt\u2019s a sniper rather than a nuclear bomb,\u201d he says, adding that multiple applications could give patients extra years of service from an implant.
\nThe group hopes to refine these peptides, go to FDA safety testing, and then move to large animal models for testing.
\nBigger ambitions<\/strong>
\nEventually, Snead has a much bigger audience in mind: anyone with periodontal disease, one of the world\u2019s most prevalent infectious diseases.
\n\u201cOur real goal is to be able to anchor antimicrobials on the tooth\u2019s mineral component and create an antimicrobial environment just by brushing,\u201d he says. \u201cDoing that would hopefully reduce the amount of periodontal disease in the patient population.\u201d
\nHe likens this initial work on implants to Tesla\u2019s strategy of developing better batteries so their cars can go longer and father. \u201cBy attacking the implant surface, we get the potential of developing a set of tools and molecules that could be applied to everyone\u2019s teeth.\u201d
\nBY Katharine Gammon<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":168,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[521],"class_list":["post-2778","post","type-post","status-publish","format-standard","hentry","category-press-release","tag-mesh-strategic-partnerships"],"acf":[],"yoast_head":"\nUSC dental researchers developing special film that could revolutionize the way peri-implantitis treated<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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