{"id":2921,"date":"2019-08-07T16:07:45","date_gmt":"2019-08-07T23:07:45","guid":{"rendered":"https:\/\/keck.usc.edu\/news\/usc-public-symposium-illustrates-how-to-move-stem-cells-from-petri-dish-to-patient\/"},"modified":"2023-11-26T08:28:56","modified_gmt":"2023-11-26T16:28:56","slug":"usc-public-symposium-illustrates-how-to-move-stem-cells-from-petri-dish-to-patient","status":"publish","type":"post","link":"https:\/\/keck.usc.edu\/news\/usc-public-symposium-illustrates-how-to-move-stem-cells-from-petri-dish-to-patient\/","title":{"rendered":"USC public symposium illustrates how to move stem cells from Petri dish to patient"},"content":{"rendered":"\n \n \n\n\n\n\n\n\n\n
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USC public symposium illustrates how to move stem cells from Petri dish to patient<\/h1>\n\n\n<\/div>\n \n \n
\n \n August 07, 2019<\/span>\n <\/div>\n \n \n
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USC's David Hinton gives a cellular view of a stem cell-based eye implant. (Photo by Cristy Lytal)<\/figcaption>\n <\/figure>\n \n \n \n\n<\/div>\n \n\n <\/div><\/div>\n\r\n\r\n\n\n \n \n\n\n\n\n\n\n\n
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Have you ever wondered how a scientific discovery in the laboratory becomes a new medical treatment for patients in the hospital?<\/p>\n

At the public symposium \u201cBringing Stem Cells to Patients \u2013 Treating Age-Related Blindness,\u201d students, families, patients and local community members gathered on the lawn outside of USC\u2019s stem cell research center to learn about the complex and exciting process of clinical translation. The event described the progress in developing a new stem cell-based treatment for the dry form of age-related macular degeneration, the leading cause of vision loss in the U.S.
\nThe story of this stem cell-based approach, now in clinical trials, began with the voters of California, who approved $3 billion in public funding for stem cell research in 2004. The state\u2019s stem cell agency, the California Institute for Regenerative Medicine (CIRM), has now distributed these research dollars, and the public will decide whether to continue the support through a new ballot proposition in 2020.
\nKevin McCormack, Senior Director for Public Communications and Patient Advocate Outreach for CIRM, highlighted the tremendous impact of the public investment in California stem cell research.
\n\u201cIn the last 15 years,\u201d he said, \u201cwe have funded 55 clinical trials in everything from HIV to heart disease and stroke, spinal cord injury and vision loss.\u201d
\nThe vision loss caused by macular degeneration is particularly debilitating, said Professor Mark Humayan, director of the USC Ginsburg Institute for Biomedical Therapeutics<\/a> and co-director of the USC Roski Eye Institute<\/a>.
\n\u201cIn this condition, what happens is you end up losing the very central vision,\u201d said Humayun, who is both a practicing ophthalmologist and a biomedical engineer at USC. \u201cSo you can\u2019t read; you can\u2019t drive; you can\u2019t recognize faces; you can\u2019t watch television. It takes away your independence.\u201d
\nHumayun then introduced the team of scientists and partners from USC, the University of California, Santa Barbara (UCSB), City of Hope and Regenerative Patch Technologies, who are working together to help these patients.
\nUCSB Professor Dennis Clegg talked about the years spent in the laboratory learning how to make the specific type of cells that support the health of the retina, and that die in macular degeneration. To make these retina-supporting cells, Clegg and his colleagues relied on stem cells.
\n\u201cThere are a lot of different kinds of stem cells, but human embryonic stem cells are the most powerful,\u201d said Clegg. \u201cAnd we turned to the most powerful cell type because this is such a serious disease that currently doesn\u2019t have any treatments.\u201d
\nCollaborators from Caltech then engineered a synthetic membrane or \u201cpatch\u201d upon which to grow these cells.
\nUSC Professor David Hinton described how this cell patch was surgically implanted in lab rats to test its safety and effectiveness in restoring vision.
\n\u201cIt was with experiments like this and many more that we were able to provide the data to get the FDA clearance, and then move on to clinical trials,\u201d he said.
\nBefore beginning clinical trials, the team enlisted a facility to manufacture a version of the cell patch suitable for surgical implantation in patients. Dr. Joseph Gold, Director of Manufacturing at the Center for Biomedicine and Genetics at City of Hope, detailed the process of manufacturing a cell patch that would meet the FDA\u2019s rigorous standards, which are called Good Manufacturing Practices or GMP.
\n\u201cThe manufacturing of the cells may not be the most glamorous part of this whole process,\u201d he said. \u201cIn fact, it can be slow, painstaking and tedious. But the reason you do it right is to make sure you come up with the kind of therapy that is as safe and efficacious as we know how to make it.\u201d
\nOnce the cell patch met these standards, Dr. Amir Kashani from the Keck School of Medicine of USC performed the surgeries to deliver the treatment into patients\u2019 eyes during clinical trials. He acknowledged the brave patients and their critical role: \u201cOver the last several decades, every major advance in medicine has been made because somebody sat in a chair and volunteered their time and part of their body to medicine, to say, \u2018I\u2019m willing to try this, even though I know it may not work.\u2019 \u201d
\nThe initial macular degeneration clinical trials have worked well enough to prompt the formation of a startup, Regenerative Patch Technologies. As the company\u2019s President of Research and Development, Dr. Jane Lebkowski explained the commercialization process that eventually brings treatments from the clinical trial phase into widespread use.
\n\u201cThis is a disease that is very prevalent in our population,\u201d she said. \u201cThere are about 100,000 to 150,000 new cases of age-related macular degeneration every year in the United States, and about an equal number in Europe. This therapy may vastly affect and may have positive implications for our patients.\u201d
\nAnna Kuehl, a patient who received the cell patch during the early clinical trials at USC, described these positive implications in her own life and the improvement in her central vision.
\n\u201cAfter the procedure, my life changed in many ways,\u201d she said. \u201cI could see whole faces on the TV and also the whole face of my husband and other people. My hope for the future is that these cells, these implanted cells, will stay alive and that many more people can experience the same as I have and can be helped.\u201d
\nThe public symposium showcased this success, and also coincided with a much larger showcase of research progress: the annual meeting of the International Society for Stem Cell Research (ISSCR), held for the first time ever in Los Angeles in June 2019. The public symposium was hosted by USC Stem Cell in collaboration with ISSCR, CIRM, the USC Ginsburg Institute for Biomedical Therapeutics, USC Civic Engagement, and the Keck School of Medicine of USC.
\n\u201cThe mission of this event was to give the public a sense of what it requires to take research all the way to pioneering therapeutic clinical trials,\u201d said Andy McMahon, who leads the USC Stem Cell initiative. \u201cBringing stem cells to patients involves a massive, coordinated and collaborative effort uniting scientists, engineers, doctors, industry partners, patients and the voters of California.\u201d<\/p>\n\n\n\n<\/div>\n <\/div>\n\n\n <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":168,"featured_media":2923,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[6],"tags":[17],"class_list":["post-2921","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-press-release","tag-stem-cell"],"acf":[],"yoast_head":"\nUSC public symposium illustrates how to move stem cells from Petri dish to patient<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/keck.usc.edu\/news\/usc-public-symposium-illustrates-how-to-move-stem-cells-from-petri-dish-to-patient\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta 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